F1- Somatosensory System

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Questions and Answers

Proprioception is exclusively mediated by receptors located in the skin.

False (B)

The largest-diameter sensory afferents are classified as C fibers.

False (B)

Interoception refers to the perception of external physical features of objects.

False (B)

Exteroception is solely responsible for the sensation of pain and temperature changes.

<p>False (B)</p> Signup and view all the answers

The Aβ afferents are larger in diameter compared to the Aδ fibers.

<p>True (A)</p> Signup and view all the answers

Receptive field size refers to the area of the skin where stimulation does not affect action potentials.

<p>False (B)</p> Signup and view all the answers

Different classes of somatosensory afferents have distinct response properties and unique contributions to sensation.

<p>True (A)</p> Signup and view all the answers

Neurons in area 5 are only activated by passive joint movement and do not integrate proprioceptive or tactile information.

<p>False (B)</p> Signup and view all the answers

Lesions in the primary somatosensory area (SI) in humans result in severe difficulties in complex tactile recognition tasks.

<p>False (B)</p> Signup and view all the answers

Projection neurons in the somatosensory parietal cortex fire in response to passive stimuli only after contact with an object.

<p>False (B)</p> Signup and view all the answers

The more ventral somatosensory stream is primarily involved in guiding movement.

<p>False (B)</p> Signup and view all the answers

Microstimulation of somatosensory areas can lead to involuntary movements if conducted with high enough intensity.

<p>True (A)</p> Signup and view all the answers

Smaller arborizations of sensory afferents result in larger receptive fields.

<p>False (B)</p> Signup and view all the answers

Slowly adapting afferents generate a sustained discharge in response to ongoing stimulus.

<p>True (A)</p> Signup and view all the answers

The VPL nucleus of the thalamus exclusively receives information from the trigeminal pathway.

<p>False (B)</p> Signup and view all the answers

There are four distinct regions in the primary somatosensory cortex, known as Brodmann's areas 1, 2, 3a, and 3b.

<p>True (A)</p> Signup and view all the answers

Area 2 of the primary somatosensory cortex is primarily responsible for detecting changes in muscle length.

<p>False (B)</p> Signup and view all the answers

The ventral posterior superior nucleus primarily processes proprioceptive information.

<p>True (A)</p> Signup and view all the answers

Nissl staining helps to identify the different layers of the cortex by staining Nissl bodies in the axons of the neurons.

<p>False (B)</p> Signup and view all the answers

Receptive fields of neurons in area 3b are significantly larger than those found in area 2.

<p>False (B)</p> Signup and view all the answers

Motion-sensitive neurons in area 2 can respond to stroking the skin in all directions.

<p>True (A)</p> Signup and view all the answers

The somatosensory area I primarily receives only from sensory thalamic nuclei.

<p>False (B)</p> Signup and view all the answers

Area PV has connections mainly with sensory thalamic inputs.

<p>False (B)</p> Signup and view all the answers

Brodmann area 7 is primarily involved in the integration of auditory and tactile stimuli.

<p>False (B)</p> Signup and view all the answers

Visuo-tactile neurons in the ventral intraparietal areas can only be stimulated by tactile input.

<p>False (B)</p> Signup and view all the answers

Neurons in the posterior parietal cortex (PPC) are primarily classified as unimodal.

<p>False (B)</p> Signup and view all the answers

The distal parts of limbs such as hands and feet have interconnected receptive fields.

<p>True (A)</p> Signup and view all the answers

Area 5 in the posterior parietal cortex is involved in sensory guidance of involuntary movements.

<p>False (B)</p> Signup and view all the answers

The centrolateral nucleus of the thalamus connects primarily with the motor cortex.

<p>False (B)</p> Signup and view all the answers

The parietal rostral area is located posterior to area PV.

<p>False (B)</p> Signup and view all the answers

Neurons in the inferior parietal lobe only respond to visual stimuli.

<p>False (B)</p> Signup and view all the answers

The lateral inhibition in cortical neurons leads to decreased tactile acuity.

<p>False (B)</p> Signup and view all the answers

The primary somatosensory cortex has a uniform distribution of cortical columns across all body parts.

<p>False (B)</p> Signup and view all the answers

Cortical magnification is directly related to the density of receptors in the skin.

<p>True (A)</p> Signup and view all the answers

The differences in the cortical representation of fingers are primarily due to their sensitivity in touch.

<p>True (A)</p> Signup and view all the answers

The secondary somatosensory cortex complex is mainly involved in passive touch.

<p>False (B)</p> Signup and view all the answers

Layer IV of the cortical layers receives input primarily from the primary somatosensory cortex.

<p>False (B)</p> Signup and view all the answers

D1 (thumb) and D2 (index) fingers show a more distinct representation in the somatosensory cortex compared to fingers D3 to D5.

<p>True (A)</p> Signup and view all the answers

Connections through interneurons generate excitatory activity in the dorsal column nuclei.

<p>False (B)</p> Signup and view all the answers

The primary somatosensory cortex only processes information about touch, not proprioception.

<p>False (B)</p> Signup and view all the answers

The differences in granularities between SII proper and the Parietal Ventral area (PV) reflect their distinct roles in processing sensory information.

<p>True (A)</p> Signup and view all the answers

Flashcards

Receptive Field Size

The size of an area on the body's surface where a single sensory afferent neuron is activated by a stimulus.

Dorsal Column Medial Lemniscus Pathway

The region in the spinal cord that carries sensory information from the body to the brain.

Trigeminal Pathway

The pathway for sensory information from the face to the brain.

Ventral Posterior Complex (VP)

The part of the thalamus that receives sensory information from the body and face.

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Primary Somatosensory Cortex (S1)

The area of the brain that receives sensory input from the Ventral Posterior Complex (VP) in the thalamus.

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Area 3b

A subregion of the primary somatosensory cortex responsible for processing tactile information from the skin, including details of surface texture.

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Area 2

A subregion of the primary somatosensory cortex that integrates tactile and proprioceptive information to determine the size and shape of objects.

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Proprioception

The ability to sense the position and movement of the body in space.

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Interoception

The sense of internal bodily states, such as hunger, thirst, and pain.

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Projection neurons in somatosensory PPC

Neurons responsible for integrating sensory information from different sources, especially when a goal-directed action is planned or executed. They receive input from motor areas and respond to the intention to move before actual contact with the object.

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Posterior parietal cortex (PPC)

A region in the parietal lobe that receives input from multiple sensory modalities (touch, proprioception, vision) and integrates this information to guide movement. It is involved in complex tactile tasks like identifying objects by touch.

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Tactile apraxia

A type of neurological deficit where a person has difficulty recognizing objects by touch alone, even though they have normal sensation. It often occurs after damage to the posterior parietal cortex.

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Stereognosis

This refers to the ability to perceive and recognize objects by touch alone. It is also known as tactile discrimination or haptic perception.

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Phasic responses in the somatosensory cortex

These types of neural responses are characterized by brief, sharp changes in activity that coincide with the occurrence of a specific stimulus. They often indicate the immediate detection of a sensory event.

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Somatosensory System

The somatosensory system is a network of nerves and receptors that allow us to sense the world around us. It's responsible for sensations like touch, pressure, temperature, pain, and proprioception (awareness of our body's position).

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Somatosensory Afferents

Somatosensory afferents are the nerves that carry sensory information from the body to the brain. These nerves are specialized to transmit different types of sensations, like touch, pressure, pain, and temperature.

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Axon Diameter

The diameter of a somatosensory afferent's axon (the long, thin part of the nerve) is related to the type of information it carries. Larger diameter axons typically carry information about touch and position, while smaller diameter axons carry pain and temperature signals.

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Receptive Field

The receptive field of a somatosensory afferent is the area of skin or body where stimulation causes a change in its activity. Larger receptive fields mean the nerve is less precise in its response, while smaller receptive fields allow us to feel finer details.

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Lateral Inhibition

The phenomenon where stimulation of one area of the skin inhibits the activity of neighboring areas, enhancing tactile acuity.

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Functional Columns

Neurons in the somatosensory cortex are organized into vertical columns, each specialized for processing a specific type of sensory information.

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Somatotopic Organization

The arrangement of the somatosensory cortex where different body parts are mapped out in a specific order, reflecting the density of sensory receptors and the importance of those areas for touch.

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Cortical Magnification

The phenomenon where areas of the somatosensory cortex dedicated to certain body parts are disproportionately larger, reflecting the density of sensory receptors in that area.

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Secondary Somatosensory Cortex (SII)

The secondary somatosensory cortex is involved in higher-level processing of sensory information, playing a role in object recognition and manipulation.

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Active Touch

The ability to process sensory information while actively interacting with the environment.

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Secondary Somatosensory Complex

A complex area involved in higher-level somatosensory processing, located in the dorsal bank of the lateral fissure. It includes the SII proper and the Parietal Ventral area (PV).

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SII Proper

A sub-area of the secondary somatosensory cortex, receiving input from the primary somatosensory cortex and thalamus, involved in processing deep somatic sensations.

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Parietal Ventral Area (PV)

A sub-area of the secondary somatosensory cortex, receiving input from different thalamic nuclei, involved in processing both deep somatic and proprioceptive information.

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SII Receptive Field Convergence

Two tendencies of RF convergence in SII: distal parts of limbs (hand, foot, mouth) are interconnected, and trunk RFs extend towards distal parts and head.

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Area PV Thalamic Inputs

Area PV receives inputs from non-sensory thalamic areas like Area 3B, Area 3A, Mediodorsal nucleus, and Centrolateral nucleus.

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Area PV Connections

Strong connections between area PV and premotor area, frontal eye field, and the mediodorsal nucleus suggest its involvement in memory and attention.

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Area PV and Tactile Memory

Experiment showing area PV's role in tactile memory: Monkeys were trained to associate frequencies to actions, and PV neurons discharged during the delay, suggesting memory encoding.

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Parietal Rostral Area (PR)

Located anterior to PV, the Parietal Rostral Area (PR) receives input from somatosensory regions and is activated only during active touch.

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PPC Area Inputs

Area 5 (SPL) receives input from sensory and non-sensory thalamic nuclei, while Area 7 (IPL) receives mainly from non-sensory nuclei like LP, PuA, and PuM.

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PPC Non-Sensory Connections

These non-sensory nuclei connect to higher-order areas like the temporal, cingulate, and prefrontal cortex, suggesting complex information processing in PPC.

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Somatosensory Association Areas

Areas 5 and 7 are called 'somatosensory association areas' because they combine information from multiple sources to interpret the meaning of touch.

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Bimodal Neurons in PPC

Some neurons in the posterior parietal cortex respond to stimuli in more than one sensory modality, called bimodal neurons.

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Study Notes

Somatosensory System Overview

  • The somatosensory system transduces sensations like touch, pressure, vibration, limb position, heat, cold, itch, and pain from receptors in the skin, muscles, and joints, transmitting them to the CNS.
  • The system is functionally divided into subsystems:
    • One for fine touch, vibration, and pressure via cutaneous mechanoreceptors.
    • One for proprioception from receptors in muscles, tendons, and joints.
    • One for pain, temperature, and non-discriminative touch from related receptors.
  • Major functions:
    • Proprioception: Body posture and movement sensed by receptors in muscles, joints, and skin.
    • Exteroception: Interaction with the external world, sensed by skin receptors, detecting environmental features.
    • Interoception: Internal body state perception, like organ function, via visceral receptors.

Somatosensory Afferents

  • Axon Diameter: Different classes of afferents are distinguished by axon diameter:
    • Largest (Ia) afferents for muscle sensory receptors.
    • Slightly smaller (Aβ) afferents for touch information.
    • Smallest (Aδ and C) afferents for pain and temperature.
  • Receptive Field Size: The area of skin stimulated to trigger significant changes in action potential rate varies across the body. Regions with denser innervation (fingers, lips) have smaller receptive fields than less innervated areas (forearm, back).
  • Temporal Dynamics: Some afferents rapidly adapt (fire initially, then cease firing with continued stimulation). Others slowly adapt (sustain firing during continuous stimulation).

Pathways to the CNS

  • Touch Information:
    • Dorsal Column-Medial Lemniscus (DCML) pathway: Carries information from lower body, upper body, and posterior head to the brainstem.
    • Trigeminal pathway: Carries facial information to the brainstem.
  • Synapse in Thalamus: Second-order neurons from both pathways synapse in the ventral posterior (VP) complex of the thalamus, divided into:
    • VPM nucleus: Trigeminal lemniscus projections (face).
    • VPL nucleus: Medial lemniscus projections (body and posterior head).
  • Somatotopy in Thalamus: The VP complex displays a gradient in sensory representation, with lower body information laterally, and face information medially. Additional nuclei VPS (proprioception) and VPI (interoception) are recognized.

Primary Somatosensory Cortex (S1)

  • Located in the postcentral gyrus of the parietal lobe.
  • Composed of Brodmann areas 3a, 3b, 1, and 2, with distinct functions:
    • Area 3a: Muscle stretch receptors, proprioception (muscle length changes)
    • Area 3b: Fine texture detail, combines tactile info for detailed surface features.
    • Area 1: Fine texture detail, similar role to 3b.
    • Area 2: Tactile and proprioceptive info, object size and shape, and more abstract features.
  • Cortical Organization: Neurons are organized into functional columns detecting different types of stimuli (fast vs. slow adapting).

Higher Somatosensory Areas

  • Secondary Somatosensory Cortex (S2/PV):
    • Receives input from S1, VP complex nuclei, involved in combined bilateral receptive fields, integration of information across multiple body parts.
    • Area PV: Receives input from various thalamic and non-sensory areas, involvement in memory and attention. Integrates tactile and other sensory modalities.
  • Parietal Rostral Area (PR):
    • Receives input from S2/PV, highly activated in active touch.
  • Posterior Parietal Cortex (PPC):
    • Areas 5 and 7, sensory guidance of voluntary movement, important for complex tasks.
    • Receives input from sensory and non-sensory thalamic nuclei, incorporating visual and other sensory info.
    • Visuo-tactile neurons: Neurons integrating visual and tactile information.
  • Inferior Parietal Lobe:
    • Complex somatosensory receptive fields, oro-facial, hand, etc.

Cortical Magnification and Somatotopy

  • Cortical Magnification: Cortical area dedicated to a body part is proportional to its innervation density and thus tactile sensitivity.
  • Homunculus: Graphic representation of the cortical representation of the body, with larger areas for higher-sensitivity regions (fingers, lips).

Lesion Effects on Somatosensory Areas

  • Lesions in different areas cause varying impairments in tactile discrimination and complex tasks, highlighting distinct roles.

Somatosensory Streams and Responses

  • Two somatosensory streams akin to visual streams, with ventral (object recognition and naming) and dorsal (sensorimotor guidance).
  • Tonic and phasic responses in cortical areas - phasic in the primary cortex, tonic in S2/PV highlighting different processing levels.

Techniques

  • Microstimulation studies demonstrate the correspondence between stimulated areas and resulting movements.
  • Lesion studies highlight the role of different cortical areas for complex tasks, like stereognosis and tactile apraxia.

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