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Questions and Answers
Proprioception is exclusively mediated by receptors located in the skin.
Proprioception is exclusively mediated by receptors located in the skin.
False (B)
The largest-diameter sensory afferents are classified as C fibers.
The largest-diameter sensory afferents are classified as C fibers.
False (B)
Interoception refers to the perception of external physical features of objects.
Interoception refers to the perception of external physical features of objects.
False (B)
Exteroception is solely responsible for the sensation of pain and temperature changes.
Exteroception is solely responsible for the sensation of pain and temperature changes.
The Aβ afferents are larger in diameter compared to the Aδ fibers.
The Aβ afferents are larger in diameter compared to the Aδ fibers.
Receptive field size refers to the area of the skin where stimulation does not affect action potentials.
Receptive field size refers to the area of the skin where stimulation does not affect action potentials.
Different classes of somatosensory afferents have distinct response properties and unique contributions to sensation.
Different classes of somatosensory afferents have distinct response properties and unique contributions to sensation.
Neurons in area 5 are only activated by passive joint movement and do not integrate proprioceptive or tactile information.
Neurons in area 5 are only activated by passive joint movement and do not integrate proprioceptive or tactile information.
Lesions in the primary somatosensory area (SI) in humans result in severe difficulties in complex tactile recognition tasks.
Lesions in the primary somatosensory area (SI) in humans result in severe difficulties in complex tactile recognition tasks.
Projection neurons in the somatosensory parietal cortex fire in response to passive stimuli only after contact with an object.
Projection neurons in the somatosensory parietal cortex fire in response to passive stimuli only after contact with an object.
The more ventral somatosensory stream is primarily involved in guiding movement.
The more ventral somatosensory stream is primarily involved in guiding movement.
Microstimulation of somatosensory areas can lead to involuntary movements if conducted with high enough intensity.
Microstimulation of somatosensory areas can lead to involuntary movements if conducted with high enough intensity.
Smaller arborizations of sensory afferents result in larger receptive fields.
Smaller arborizations of sensory afferents result in larger receptive fields.
Slowly adapting afferents generate a sustained discharge in response to ongoing stimulus.
Slowly adapting afferents generate a sustained discharge in response to ongoing stimulus.
The VPL nucleus of the thalamus exclusively receives information from the trigeminal pathway.
The VPL nucleus of the thalamus exclusively receives information from the trigeminal pathway.
There are four distinct regions in the primary somatosensory cortex, known as Brodmann's areas 1, 2, 3a, and 3b.
There are four distinct regions in the primary somatosensory cortex, known as Brodmann's areas 1, 2, 3a, and 3b.
Area 2 of the primary somatosensory cortex is primarily responsible for detecting changes in muscle length.
Area 2 of the primary somatosensory cortex is primarily responsible for detecting changes in muscle length.
The ventral posterior superior nucleus primarily processes proprioceptive information.
The ventral posterior superior nucleus primarily processes proprioceptive information.
Nissl staining helps to identify the different layers of the cortex by staining Nissl bodies in the axons of the neurons.
Nissl staining helps to identify the different layers of the cortex by staining Nissl bodies in the axons of the neurons.
Receptive fields of neurons in area 3b are significantly larger than those found in area 2.
Receptive fields of neurons in area 3b are significantly larger than those found in area 2.
Motion-sensitive neurons in area 2 can respond to stroking the skin in all directions.
Motion-sensitive neurons in area 2 can respond to stroking the skin in all directions.
The somatosensory area I primarily receives only from sensory thalamic nuclei.
The somatosensory area I primarily receives only from sensory thalamic nuclei.
Area PV has connections mainly with sensory thalamic inputs.
Area PV has connections mainly with sensory thalamic inputs.
Brodmann area 7 is primarily involved in the integration of auditory and tactile stimuli.
Brodmann area 7 is primarily involved in the integration of auditory and tactile stimuli.
Visuo-tactile neurons in the ventral intraparietal areas can only be stimulated by tactile input.
Visuo-tactile neurons in the ventral intraparietal areas can only be stimulated by tactile input.
Neurons in the posterior parietal cortex (PPC) are primarily classified as unimodal.
Neurons in the posterior parietal cortex (PPC) are primarily classified as unimodal.
The distal parts of limbs such as hands and feet have interconnected receptive fields.
The distal parts of limbs such as hands and feet have interconnected receptive fields.
Area 5 in the posterior parietal cortex is involved in sensory guidance of involuntary movements.
Area 5 in the posterior parietal cortex is involved in sensory guidance of involuntary movements.
The centrolateral nucleus of the thalamus connects primarily with the motor cortex.
The centrolateral nucleus of the thalamus connects primarily with the motor cortex.
The parietal rostral area is located posterior to area PV.
The parietal rostral area is located posterior to area PV.
Neurons in the inferior parietal lobe only respond to visual stimuli.
Neurons in the inferior parietal lobe only respond to visual stimuli.
The lateral inhibition in cortical neurons leads to decreased tactile acuity.
The lateral inhibition in cortical neurons leads to decreased tactile acuity.
The primary somatosensory cortex has a uniform distribution of cortical columns across all body parts.
The primary somatosensory cortex has a uniform distribution of cortical columns across all body parts.
Cortical magnification is directly related to the density of receptors in the skin.
Cortical magnification is directly related to the density of receptors in the skin.
The differences in the cortical representation of fingers are primarily due to their sensitivity in touch.
The differences in the cortical representation of fingers are primarily due to their sensitivity in touch.
The secondary somatosensory cortex complex is mainly involved in passive touch.
The secondary somatosensory cortex complex is mainly involved in passive touch.
Layer IV of the cortical layers receives input primarily from the primary somatosensory cortex.
Layer IV of the cortical layers receives input primarily from the primary somatosensory cortex.
D1 (thumb) and D2 (index) fingers show a more distinct representation in the somatosensory cortex compared to fingers D3 to D5.
D1 (thumb) and D2 (index) fingers show a more distinct representation in the somatosensory cortex compared to fingers D3 to D5.
Connections through interneurons generate excitatory activity in the dorsal column nuclei.
Connections through interneurons generate excitatory activity in the dorsal column nuclei.
The primary somatosensory cortex only processes information about touch, not proprioception.
The primary somatosensory cortex only processes information about touch, not proprioception.
The differences in granularities between SII proper and the Parietal Ventral area (PV) reflect their distinct roles in processing sensory information.
The differences in granularities between SII proper and the Parietal Ventral area (PV) reflect their distinct roles in processing sensory information.
Flashcards
Receptive Field Size
Receptive Field Size
The size of an area on the body's surface where a single sensory afferent neuron is activated by a stimulus.
Dorsal Column Medial Lemniscus Pathway
Dorsal Column Medial Lemniscus Pathway
The region in the spinal cord that carries sensory information from the body to the brain.
Trigeminal Pathway
Trigeminal Pathway
The pathway for sensory information from the face to the brain.
Ventral Posterior Complex (VP)
Ventral Posterior Complex (VP)
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Primary Somatosensory Cortex (S1)
Primary Somatosensory Cortex (S1)
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Area 3b
Area 3b
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Area 2
Area 2
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Proprioception
Proprioception
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Interoception
Interoception
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Projection neurons in somatosensory PPC
Projection neurons in somatosensory PPC
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Posterior parietal cortex (PPC)
Posterior parietal cortex (PPC)
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Tactile apraxia
Tactile apraxia
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Stereognosis
Stereognosis
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Phasic responses in the somatosensory cortex
Phasic responses in the somatosensory cortex
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Somatosensory System
Somatosensory System
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Somatosensory Afferents
Somatosensory Afferents
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Axon Diameter
Axon Diameter
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Receptive Field
Receptive Field
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Lateral Inhibition
Lateral Inhibition
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Functional Columns
Functional Columns
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Somatotopic Organization
Somatotopic Organization
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Cortical Magnification
Cortical Magnification
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Secondary Somatosensory Cortex (SII)
Secondary Somatosensory Cortex (SII)
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Active Touch
Active Touch
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Secondary Somatosensory Complex
Secondary Somatosensory Complex
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SII Proper
SII Proper
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Parietal Ventral Area (PV)
Parietal Ventral Area (PV)
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SII Receptive Field Convergence
SII Receptive Field Convergence
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Area PV Thalamic Inputs
Area PV Thalamic Inputs
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Area PV Connections
Area PV Connections
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Area PV and Tactile Memory
Area PV and Tactile Memory
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Parietal Rostral Area (PR)
Parietal Rostral Area (PR)
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PPC Area Inputs
PPC Area Inputs
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PPC Non-Sensory Connections
PPC Non-Sensory Connections
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Somatosensory Association Areas
Somatosensory Association Areas
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Bimodal Neurons in PPC
Bimodal Neurons in PPC
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Study Notes
Somatosensory System Overview
- The somatosensory system transduces sensations like touch, pressure, vibration, limb position, heat, cold, itch, and pain from receptors in the skin, muscles, and joints, transmitting them to the CNS.
- The system is functionally divided into subsystems:
- One for fine touch, vibration, and pressure via cutaneous mechanoreceptors.
- One for proprioception from receptors in muscles, tendons, and joints.
- One for pain, temperature, and non-discriminative touch from related receptors.
- Major functions:
- Proprioception: Body posture and movement sensed by receptors in muscles, joints, and skin.
- Exteroception: Interaction with the external world, sensed by skin receptors, detecting environmental features.
- Interoception: Internal body state perception, like organ function, via visceral receptors.
Somatosensory Afferents
- Axon Diameter: Different classes of afferents are distinguished by axon diameter:
- Largest (Ia) afferents for muscle sensory receptors.
- Slightly smaller (Aβ) afferents for touch information.
- Smallest (Aδ and C) afferents for pain and temperature.
- Receptive Field Size: The area of skin stimulated to trigger significant changes in action potential rate varies across the body. Regions with denser innervation (fingers, lips) have smaller receptive fields than less innervated areas (forearm, back).
- Temporal Dynamics: Some afferents rapidly adapt (fire initially, then cease firing with continued stimulation). Others slowly adapt (sustain firing during continuous stimulation).
Pathways to the CNS
- Touch Information:
- Dorsal Column-Medial Lemniscus (DCML) pathway: Carries information from lower body, upper body, and posterior head to the brainstem.
- Trigeminal pathway: Carries facial information to the brainstem.
- Synapse in Thalamus: Second-order neurons from both pathways synapse in the ventral posterior (VP) complex of the thalamus, divided into:
- VPM nucleus: Trigeminal lemniscus projections (face).
- VPL nucleus: Medial lemniscus projections (body and posterior head).
- Somatotopy in Thalamus: The VP complex displays a gradient in sensory representation, with lower body information laterally, and face information medially. Additional nuclei VPS (proprioception) and VPI (interoception) are recognized.
Primary Somatosensory Cortex (S1)
- Located in the postcentral gyrus of the parietal lobe.
- Composed of Brodmann areas 3a, 3b, 1, and 2, with distinct functions:
- Area 3a: Muscle stretch receptors, proprioception (muscle length changes)
- Area 3b: Fine texture detail, combines tactile info for detailed surface features.
- Area 1: Fine texture detail, similar role to 3b.
- Area 2: Tactile and proprioceptive info, object size and shape, and more abstract features.
- Cortical Organization: Neurons are organized into functional columns detecting different types of stimuli (fast vs. slow adapting).
Higher Somatosensory Areas
- Secondary Somatosensory Cortex (S2/PV):
- Receives input from S1, VP complex nuclei, involved in combined bilateral receptive fields, integration of information across multiple body parts.
- Area PV: Receives input from various thalamic and non-sensory areas, involvement in memory and attention. Integrates tactile and other sensory modalities.
- Parietal Rostral Area (PR):
- Receives input from S2/PV, highly activated in active touch.
- Posterior Parietal Cortex (PPC):
- Areas 5 and 7, sensory guidance of voluntary movement, important for complex tasks.
- Receives input from sensory and non-sensory thalamic nuclei, incorporating visual and other sensory info.
- Visuo-tactile neurons: Neurons integrating visual and tactile information.
- Inferior Parietal Lobe:
- Complex somatosensory receptive fields, oro-facial, hand, etc.
Cortical Magnification and Somatotopy
- Cortical Magnification: Cortical area dedicated to a body part is proportional to its innervation density and thus tactile sensitivity.
- Homunculus: Graphic representation of the cortical representation of the body, with larger areas for higher-sensitivity regions (fingers, lips).
Lesion Effects on Somatosensory Areas
- Lesions in different areas cause varying impairments in tactile discrimination and complex tasks, highlighting distinct roles.
Somatosensory Streams and Responses
- Two somatosensory streams akin to visual streams, with ventral (object recognition and naming) and dorsal (sensorimotor guidance).
- Tonic and phasic responses in cortical areas - phasic in the primary cortex, tonic in S2/PV highlighting different processing levels.
Techniques
- Microstimulation studies demonstrate the correspondence between stimulated areas and resulting movements.
- Lesion studies highlight the role of different cortical areas for complex tasks, like stereognosis and tactile apraxia.
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