Neurophysiological Disorders: Epilepsy Review
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Questions and Answers

What type of epilepsy includes absence, myoclonic, atonic, tonic, and tonic–clonic seizures?

  • Focal aware seizures
  • Bilateral tonic–clonic epilepsy
  • Focal non-motor seizures
  • Generalized epilepsy (correct)

Which phase temporarily suppresses neuronal activity in the affected area?

  • Hyperpolarization (correct)
  • Synchronous Discharges
  • Shortened Hyperpolarization
  • Interictal Activity

What arises from a group of neurons firing together before a seizure occurs?

  • Hyperpolarization
  • Shortened Hyperpolarization
  • Synchronous Discharges
  • Interictal Activity (correct)

Which type of seizures are characterized by a depolarizing shift in the membrane potential of neurons?

<p>Focal motor seizures (D)</p> Signup and view all the answers

What happens if a sufficient number of neurons become activated and the inhibition from local inhibitory interneurons is overcome?

<p>Synchronous Discharges (A)</p> Signup and view all the answers

During which phase does the period of hyperpolarization become shorter, leading to further depolarization of neurons?

<p>Shortened Hyperpolarization (D)</p> Signup and view all the answers

What is the most common surgical operation for refractory patients with epilepsy?

<p>Temporal lobe resection (B)</p> Signup and view all the answers

Which of the following medications inhibits a spike generating Ca2+ current in thalamic neurones?

<p>Ethosuximide (B)</p> Signup and view all the answers

What proportion of refractory patients benefit from a surgical approach if an underlying structural lesion is identified?

<p>Small proportion (A)</p> Signup and view all the answers

What is the chance of a patient being seizure-free after a temporal lobe resection surgery?

<p>60–70% (C)</p> Signup and view all the answers

Which research article provides a practical clinical definition of epilepsy?

<p>Fisher et al. (2014) (A)</p> Signup and view all the answers

Who published 'Essential Med Notes 2020 Comprehensive Medical Reference & Review'?

<p>Thieme Medical Publishers, Inc. (B)</p> Signup and view all the answers

What is a seizure?

<p>A transient occurrence of signs and/or symptoms due to abnormal hyper-synchronization of neurons (D)</p> Signup and view all the answers

Which of the following can be a cause of a seizure?

<p>All of the above (D)</p> Signup and view all the answers

According to the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE), how should epilepsy be considered?

<p>A disease (D)</p> Signup and view all the answers

What is a reflex seizure?

<p>A seizure caused by a specific stimulus, such as fever or concussion (C)</p> Signup and view all the answers

After a single unprovoked seizure, what is the risk of having another seizure?

<p>40-52% (D)</p> Signup and view all the answers

If a person has two unprovoked, non-febrile seizures, what is the chance of having another seizure within 4 years?

<p>73% (D)</p> Signup and view all the answers

How long must a person be seizure-free to be considered as having resolved epilepsy?

<p>10 years, with at least the last 5 years off antiseizure medicines (A)</p> Signup and view all the answers

What is the key clinical tool in evaluating an individual presenting with seizures?

<p>Epilepsy classification (A)</p> Signup and view all the answers

Which of the following does the epilepsy classification framework help in understanding?

<p>All of the above (D)</p> Signup and view all the answers

What studies are taken into account when classifying seizure type and epilepsy type?

<p>Electroencephalography (EEG) and neuroimaging studies (B)</p> Signup and view all the answers

What are the three levels of the new Classification of the Epilepsies based on available resources?

<p>Seizure type, Epilepsy type, Epilepsy syndrome (D)</p> Signup and view all the answers

What types of epilepsies are included in the focal epilepsies category?

<p>Both unifocal and multifocal disorders, as well as seizures involving one hemisphere (D)</p> Signup and view all the answers

What is the primary inhibitory neurotransmitter that helps regulate neuronal excitability during a seizure?

<p>GABA (B)</p> Signup and view all the answers

Which of the following is NOT a common automatism observed during a seizure?

<p>Singing (B)</p> Signup and view all the answers

Which type of seizure is characterized by whole-body muscle rigidity in flexion or extension?

<p>Tonic (C)</p> Signup and view all the answers

What is the mechanism of action for anticonvulsant drugs like phenytoin, carbamazepine, valproate, and lamotrigine?

<p>Use-dependent blockade of sodium channels (D)</p> Signup and view all the answers

Which type of seizure is characterized by whole-body repetitive rhythmic jerking movements?

<p>Clonic (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of an absence (petit mal) seizure?

<p>Violent convulsions (B)</p> Signup and view all the answers
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