PCOL 4-1 Neuropeptides

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21 Questions

Which of the following best describes neuropeptides?

Peptides that act as neurotransmitters in the nervous system

Which of the following is NOT a characteristic of neuropeptides?

They can act as hormones

What is a challenge in using antagonists to study neuropeptides?

Inverse agonism

What is the purpose of using peptidase inhibitors in neuropeptide research?

To increase the effects of endogenous neuropeptides

Which of the following is NOT a function associated with endogenous opioids?

Memory formation

What effects do opioid agonists cause?

Euphoria and pain relief

Which of the following is negated by naloxone (opioid antagonist)?

Stress-induced analgesia

What are the effects observed in opioid knockout animals?

Decreased anxiety and fear

Which of the following is NOT a characteristic of neuropeptides?

They have a reuptake mechanism

What effects are observed when using peptidase inhibitors in rodents?

Antinociceptive, antidepressant, and anxiolytic effects

Which step occurs after N-terminal cleavage by peptidase during neuropeptide synthesis?

Neuropeptide Synthesis

Which of the following is a characteristic of neuropeptides?

Neuropeptides act more like GABA or Glu than 5-HT or NAd.

What is one limitation of using neuropeptides as drugs?

Neuropeptides have poor blood-brain barrier permeability.

What is the role of neuropeptides in the brain?

Neuropeptides act more like GABA or Glu than 5-HT or NAd.

Which receptor is widely expressed in the central nervous system (CNS)?

CRF1

What is the key role of Corticotrophin Releasing Factor (CRF) in coordinating responses to stress?

Controlling behavioral and metabolic changes

What is the evidence supporting the role of CRF in depression and anxiety?

CRF1 mutations are associated with depression and anxiety

What is the primary action of Corticotrophin Releasing Factor (CRF) on the pituitary gland?

Stimulate corticotrophin release

What is a potential limitation in using neuropeptides as drugs in clinical practice?

Rapid degradation by peptidases

What is the main challenge in studying neuropeptides using antagonists?

Difficulty in determining drug concentrations

What is the role of corticotrophin releasing factor (CRF) in the brain?

Controlling behavioral responses to stress

Test your knowledge on neuropeptides and their effects in the nervous system with this quiz. Explore their functions as neurotransmitters, hormones, and more.

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