21 Questions
Which of the following best describes neuropeptides?
Peptides that act as neurotransmitters in the nervous system
Which of the following is NOT a characteristic of neuropeptides?
They can act as hormones
What is a challenge in using antagonists to study neuropeptides?
Inverse agonism
What is the purpose of using peptidase inhibitors in neuropeptide research?
To increase the effects of endogenous neuropeptides
Which of the following is NOT a function associated with endogenous opioids?
Memory formation
What effects do opioid agonists cause?
Euphoria and pain relief
Which of the following is negated by naloxone (opioid antagonist)?
Stress-induced analgesia
What are the effects observed in opioid knockout animals?
Decreased anxiety and fear
Which of the following is NOT a characteristic of neuropeptides?
They have a reuptake mechanism
What effects are observed when using peptidase inhibitors in rodents?
Antinociceptive, antidepressant, and anxiolytic effects
Which step occurs after N-terminal cleavage by peptidase during neuropeptide synthesis?
Neuropeptide Synthesis
Which of the following is a characteristic of neuropeptides?
Neuropeptides act more like GABA or Glu than 5-HT or NAd.
What is one limitation of using neuropeptides as drugs?
Neuropeptides have poor blood-brain barrier permeability.
What is the role of neuropeptides in the brain?
Neuropeptides act more like GABA or Glu than 5-HT or NAd.
Which receptor is widely expressed in the central nervous system (CNS)?
CRF1
What is the key role of Corticotrophin Releasing Factor (CRF) in coordinating responses to stress?
Controlling behavioral and metabolic changes
What is the evidence supporting the role of CRF in depression and anxiety?
CRF1 mutations are associated with depression and anxiety
What is the primary action of Corticotrophin Releasing Factor (CRF) on the pituitary gland?
Stimulate corticotrophin release
What is a potential limitation in using neuropeptides as drugs in clinical practice?
Rapid degradation by peptidases
What is the main challenge in studying neuropeptides using antagonists?
Difficulty in determining drug concentrations
What is the role of corticotrophin releasing factor (CRF) in the brain?
Controlling behavioral responses to stress
Test your knowledge on neuropeptides and their effects in the nervous system with this quiz. Explore their functions as neurotransmitters, hormones, and more.
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