21 Questions
During axonal trafficking, which enzymes are co-localised with neuropeptides?
PC1 and PC2
Which of the following opioids are generated by cleavage of precursor protein DPYN by PC1 and PC2?
Dynorphins A and B, and alpha-neoendodorphin
What is the role of Neurokinin 1 (NK1) receptors in chemotherapy associated nausea?
They mediate signalling for chemotherapy associated nausea
How do neuropeptides terminate their signalling?
Through the action of a small number of enzymes
What is the result of a rationale search for molecules that mimicked the analgesic actions of morphine?
Discovery of opioids
What is the effect of opioids on perception of pain?
Decrease perception of pain
What is the primary mechanism by which neuropeptide actions are terminated?
Enzymatic degradation by extracellular proteases
What is the typical concentration of neuropeptides in vesicles compared to classical neurotransmitters?
10 times lower
What is the primary release site for neuropeptides in terms of neuronal structure?
Extrasynaptic regions
What is the characteristic of neuropeptide binding to receptors compared to classical neurotransmitters?
Higher affinity
What is the primary mechanism by which neuropeptide release is regulated?
High frequency or burst firing
What is the characteristic of neuropeptide signalling compared to classical neurotransmitters?
Slower and more modulatory
What is the primary function of substance P in the nervous system?
Association with inflammatory processes and pain
What is the characteristic of neuropeptide synthesis and processing?
All of the above
What is the primary difference between neuropeptide and classical neurotransmitter release?
All of the above
What is the primary function of the large dense-core vesicles in neuropeptide release?
Release of neuropeptides into the synapse
What is unique about the synthesis of neuropeptides?
They are derived from larger precursors
How many different neuropeptides have been identified in the mammalian brain?
More than 100
What is a function of some neuropeptides producd in the hypothalamus?
Acting as neurohormones in peripheral tissues
What is a characteristic of neuropeptide signalling?
It is widely used in invertebrates
What is a feature of the genes that encode neuropeptide precursors?
Some genes encode multiple neuropeptides
This quiz covers the processing and modification of neuropeptides during axonal trafficking, and the termination of neuropeptide signaling. It also explores the role of Neurokinin 1 (NK1) receptors in chemotherapy-associated nausea.
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