Podcast
Questions and Answers
During axonal trafficking, which enzymes are co-localised with neuropeptides?
During axonal trafficking, which enzymes are co-localised with neuropeptides?
- Aminopeptidase and Neprilysin
- Insulin degrading enzyme and Angiotensin converting enzyme
- PC1 and PC2 (correct)
- All of the above
Which of the following opioids are generated by cleavage of precursor protein DPYN by PC1 and PC2?
Which of the following opioids are generated by cleavage of precursor protein DPYN by PC1 and PC2?
- Aminopeptidase and Angiotensin converting enzyme
- Neprilysin and Insulin degrading enzyme
- Dynorphins A and B, and alpha-neoendodorphin (correct)
- Enkephalins and endorphins
What is the role of Neurokinin 1 (NK1) receptors in chemotherapy associated nausea?
What is the role of Neurokinin 1 (NK1) receptors in chemotherapy associated nausea?
- They mediate signalling for chemotherapy associated nausea (correct)
- They are responsible for the termination of neuropeptide signalling
- They mediate signalling for nociception
- They are involved in the processing of neuropeptides
How do neuropeptides terminate their signalling?
How do neuropeptides terminate their signalling?
What is the result of a rationale search for molecules that mimicked the analgesic actions of morphine?
What is the result of a rationale search for molecules that mimicked the analgesic actions of morphine?
What is the effect of opioids on perception of pain?
What is the effect of opioids on perception of pain?
What is the primary mechanism by which neuropeptide actions are terminated?
What is the primary mechanism by which neuropeptide actions are terminated?
What is the typical concentration of neuropeptides in vesicles compared to classical neurotransmitters?
What is the typical concentration of neuropeptides in vesicles compared to classical neurotransmitters?
What is the primary release site for neuropeptides in terms of neuronal structure?
What is the primary release site for neuropeptides in terms of neuronal structure?
What is the characteristic of neuropeptide binding to receptors compared to classical neurotransmitters?
What is the characteristic of neuropeptide binding to receptors compared to classical neurotransmitters?
What is the primary mechanism by which neuropeptide release is regulated?
What is the primary mechanism by which neuropeptide release is regulated?
What is the characteristic of neuropeptide signalling compared to classical neurotransmitters?
What is the characteristic of neuropeptide signalling compared to classical neurotransmitters?
What is the primary function of substance P in the nervous system?
What is the primary function of substance P in the nervous system?
What is the characteristic of neuropeptide synthesis and processing?
What is the characteristic of neuropeptide synthesis and processing?
What is the primary difference between neuropeptide and classical neurotransmitter release?
What is the primary difference between neuropeptide and classical neurotransmitter release?
What is the primary function of the large dense-core vesicles in neuropeptide release?
What is the primary function of the large dense-core vesicles in neuropeptide release?
What is unique about the synthesis of neuropeptides?
What is unique about the synthesis of neuropeptides?
How many different neuropeptides have been identified in the mammalian brain?
How many different neuropeptides have been identified in the mammalian brain?
What is a function of some neuropeptides producd in the hypothalamus?
What is a function of some neuropeptides producd in the hypothalamus?
What is a characteristic of neuropeptide signalling?
What is a characteristic of neuropeptide signalling?
What is a feature of the genes that encode neuropeptide precursors?
What is a feature of the genes that encode neuropeptide precursors?
