Neuropeptide Signaling and Processing

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During axonal trafficking, which enzymes are co-localised with neuropeptides?

Aminopeptidase and Neprilysin

Insulin degrading enzyme and Angiotensin converting enzyme

PC1 and PC2 (correct)

All of the above

Which of the following opioids are generated by cleavage of precursor protein DPYN by PC1 and PC2?

Aminopeptidase and Angiotensin converting enzyme

Neprilysin and Insulin degrading enzyme

Dynorphins A and B, and alpha-neoendodorphin (correct)

Enkephalins and endorphins

What is the role of Neurokinin 1 (NK1) receptors in chemotherapy associated nausea?

They mediate signalling for chemotherapy associated nausea (correct)

They are responsible for the termination of neuropeptide signalling

They mediate signalling for nociception

They are involved in the processing of neuropeptides

How do neuropeptides terminate their signalling?

Through the action of a small number of enzymes Signup and view all the answers

What is the result of a rationale search for molecules that mimicked the analgesic actions of morphine?

Discovery of opioids Signup and view all the answers

What is the effect of opioids on perception of pain?

Decrease perception of pain Signup and view all the answers

What is the primary mechanism by which neuropeptide actions are terminated?

Enzymatic degradation by extracellular proteases Signup and view all the answers

What is the typical concentration of neuropeptides in vesicles compared to classical neurotransmitters?

10 times lower Signup and view all the answers

What is the primary release site for neuropeptides in terms of neuronal structure?

Extrasynaptic regions Signup and view all the answers

What is the characteristic of neuropeptide binding to receptors compared to classical neurotransmitters?

Higher affinity Signup and view all the answers

What is the primary mechanism by which neuropeptide release is regulated?

High frequency or burst firing Signup and view all the answers

What is the characteristic of neuropeptide signalling compared to classical neurotransmitters?

Slower and more modulatory Signup and view all the answers

What is the primary function of substance P in the nervous system?

Association with inflammatory processes and pain Signup and view all the answers

What is the characteristic of neuropeptide synthesis and processing?

All of the above Signup and view all the answers

What is the primary difference between neuropeptide and classical neurotransmitter release?

All of the above Signup and view all the answers

What is the primary function of the large dense-core vesicles in neuropeptide release?

Release of neuropeptides into the synapse Signup and view all the answers

What is unique about the synthesis of neuropeptides?

They are derived from larger precursors Signup and view all the answers

How many different neuropeptides have been identified in the mammalian brain?

More than 100 Signup and view all the answers

What is a function of some neuropeptides producd in the hypothalamus?

Acting as neurohormones in peripheral tissues Signup and view all the answers

What is a characteristic of neuropeptide signalling?

It is widely used in invertebrates Signup and view all the answers

What is a feature of the genes that encode neuropeptide precursors?

Some genes encode multiple neuropeptides Signup and view all the answers