T2 L8: Physiology of Pain 1 (AD)

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Questions and Answers

According to the text, what is the definition of pain?

  • A pleasant sensory experience
  • A reflex triggered by touching something hot
  • An unpleasant sensory experience associated with injuring tissues (correct)
  • A signal that goes into the somatosensory cortex

What is the purpose of feeling pain, according to the text?

  • To warn us of harmful situations (correct)
  • To trigger a reflex response
  • To prevent injury
  • To provide a pleasant sensory experience

What can happen to individuals who cannot feel pain?

  • They experience more intense pain
  • They have a mutation in a sodium channel associated with motion sensors (correct)
  • They have a longer lifespan
  • They have a higher pain tolerance

Which region of the spinal cord is known as the substantial gelatinous?

<p>Substantial gelatinous (D)</p> Signup and view all the answers

What are the layers one and two of the spinal cord's grey matter called?

<p>Substantial gelatinous (A)</p> Signup and view all the answers

Which neurotransmitters are released when the second order neurons in the dorsal horn are activated?

<p>Glutamate and substance P (A)</p> Signup and view all the answers

What can activate motion sensors?

<p>Chemicals (C)</p> Signup and view all the answers

What are the peripheral transduction mechanisms?

<p>All of the above (D)</p> Signup and view all the answers

Which ion channel responds to very hot temperatures?

<p>Trip V one (B)</p> Signup and view all the answers

What chemical activates the V one receptor and makes curries feel hot?

<p>Capsaicin (A)</p> Signup and view all the answers

Which of the following can directly activate motion sensors and switch on the pain pathway?

<p>Lactic acid (C)</p> Signup and view all the answers

What term is used to describe a painful response that is exaggerated compared to the stimulus?

<p>Hyperalgesia (B)</p> Signup and view all the answers

What term is used to describe a stimulus that is not painful but produces a painful response?

<p>Aladin (B)</p> Signup and view all the answers

What is the main cause of neurogenic inflammation?

<p>Direct activation of nociceptors (D)</p> Signup and view all the answers

Which nerve fibers respond predominantly to light touch?

<p>Alpha and beta nerve fibers (B)</p> Signup and view all the answers

What type of nerve fibers are responsible for a sharp pricking sensation when activated?

<p>Delta and C fibers (B)</p> Signup and view all the answers

Which type of nerve fibers are responsible for a slow, dull ache when activated?

<p>Beta and C fibers (C)</p> Signup and view all the answers

Which type of nerve fibers are poorly localized and innovating the organs of the body?

<p>Delta and C fibers (A)</p> Signup and view all the answers

What are the two main types of pain classified in the text?

<p>Deceptive and neuropathic (B)</p> Signup and view all the answers

What are the characteristics of alpha and beta nerve fibers mentioned in the text?

<p>Large diameter, lots of myelin, fast conduction (A)</p> Signup and view all the answers

What is the average conduction speed of C fibers mentioned in the text?

<p>Approximately one meter per second (D)</p> Signup and view all the answers

What is the relationship between itch and pain pathways mentioned in the text?

<p>They share the same spinal thalamic tracts (D)</p> Signup and view all the answers

What is peripheral sensitisation triggered by?

<p>Tissue damage and inflammation (D)</p> Signup and view all the answers

What is the major mechanism in neuropathic pain?

<p>Central sensitisation (A)</p> Signup and view all the answers

What is the purpose of hyperalgesia or hypersensitivity?

<p>It helps healing by ensuring contact with injured tissues (A)</p> Signup and view all the answers

What causes an exaggerated pain response in peripheral sensitisation?

<p>Activation of transient receptor potential Lloyd one receptor (B)</p> Signup and view all the answers

What is the average conduction speed of A delta fibers mentioned in the text?

<p>5-30 meters per second (B)</p> Signup and view all the answers

What is the purpose of itch, according to the text?

<p>It is a normal function of our pain fibers (A)</p> Signup and view all the answers

What are the two main types of pain classified in the text?

<p>Deceptive and neuropathic (C)</p> Signup and view all the answers

What is the major mechanism in peripheral sensitization, according to the text?

<p>Activation of C fibers (A)</p> Signup and view all the answers

What is the term used to describe a painful response that is exaggerated compared to the stimulus?

<p>Hyperalgesia (C)</p> Signup and view all the answers

What chemical can directly activate motion sensors and switch on the pain pathway?

<p>ATP (C)</p> Signup and view all the answers

What is the major cause of neurogenic inflammation?

<p>Activation of nose receptors (B)</p> Signup and view all the answers

What is the purpose of hyperalgesia or hypersensitivity?

<p>To enhance the perception of pain (B)</p> Signup and view all the answers

What type of nerve fibers are responsible for a sharp pricking sensation when activated?

<p>Delta nerve fibers (C)</p> Signup and view all the answers

What is the purpose of feeling pain, according to the text?

<p>To locate the source of the pain (A)</p> Signup and view all the answers

Which region of the spinal cord is known as the substantial gelatinous?

<p>Delta nerve fibers (B)</p> Signup and view all the answers

What are the two main types of pain classified in the text?

<p>Localised and poorly localised pain (B)</p> Signup and view all the answers

According to the text, what is the purpose of feeling pain?

<p>To warn us of harmful situations and prevent injury (C)</p> Signup and view all the answers

What is the relationship between itch and pain pathways mentioned in the text?

<p>Itch and pain pathways are interconnected and can influence each other (D)</p> Signup and view all the answers

What can happen to individuals who cannot feel pain, according to the text?

<p>They may end up injuring themselves or even dying (B)</p> Signup and view all the answers

What is the major mechanism in neuropathic pain, as mentioned in the text?

<p>Peripheral sensitisation (B)</p> Signup and view all the answers

What type of ion channels respond to acids and are also mechanically responsive?

<p>Acid sensing ion channels (B)</p> Signup and view all the answers

Which channel responds to very hot temperatures and is also activated by capsaicin?

<p>Trip V one channels (A)</p> Signup and view all the answers

What is the purpose of the transient receptor potential (TRP) family of channels?

<p>To respond to different temperatures (C)</p> Signup and view all the answers

What is the main characteristic of poly modal CE fiber nociceptors?

<p>They respond to different stimuli (D)</p> Signup and view all the answers

Which type of pain is associated with peripheral sensitisation?

<p>Hyperalgesia (D)</p> Signup and view all the answers

What are the two major mechanisms of pain hypersensitivity mentioned in the text?

<p>Peripheral and central sensitisation (C)</p> Signup and view all the answers

What is the purpose of hyperalgesia or hypersensitivity, according to the text?

<p>To avoid resting injured tissue on objects that may cause more injury (A)</p> Signup and view all the answers

What is the main cause of peripheral sensitisation?

<p>Tissue damage and inflammation (D)</p> Signup and view all the answers

Which region of the spinal cord is responsible for the activation of second order neurons in the dorsal horn?

<p>Substantial gelatinous (B)</p> Signup and view all the answers

What is the function of the lamina in the grey matter of the spinal cord?

<p>To divide the grey matter into different layers (B)</p> Signup and view all the answers

Which neurotransmitters are released when the second order neurons in the dorsal horn are activated?

<p>Glutamate and substance P (A)</p> Signup and view all the answers

What is the role of the second order neurons in the pain pathway?

<p>To cross the midline and ascend the introduction column (D)</p> Signup and view all the answers

What is the average conduction speed of C fibers mentioned in the text?

<p>Slow (D)</p> Signup and view all the answers

What is the purpose of hyperalgesia or hypersensitivity?

<p>To enhance the pain response (D)</p> Signup and view all the answers

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