Neurons and Neuroglia Overview

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Questions and Answers

What is the primary function of astrocytes in the nervous system?

  • Regulate the chemical environment of the extracellular space (correct)
  • Provide structural support to neurons
  • Myelinate neurons in the peripheral nervous system
  • Engulf cell debris and waste

What distinguishes a multipolar neuron from other types of neurons?

  • Having one short axon and multiple long dendrites
  • Being exclusively found in the peripheral nervous system
  • Having no axon, only dendrites
  • Possessing multiple short dendrites and a single long axon (correct)

Which type of neuroglia is responsible for myelinating neurons in the central nervous system?

  • Astrocytes
  • Schwann Cells
  • Oligodendrocytes (correct)
  • Microglia

What role do microglia serve in the nervous system?

<p>Engulf cell debris and waste (C)</p> Signup and view all the answers

What percentage of the total cell population in the nervous system is made up of neuroglia?

<p>50% (A)</p> Signup and view all the answers

What is the main function of dendrites in a neuron?

<p>To receive information from other neurons. (C)</p> Signup and view all the answers

What distinguishes the structure of a unipolar neuron from other neuron types?

<p>Its dendrites and axon are continuous. (A)</p> Signup and view all the answers

What does the long axon of a neuron primarily do?

<p>Carries the electrical signal to its target. (A)</p> Signup and view all the answers

Which of the following is NOT a component of a neuron's structure?

<p>Synaptic cleft (A)</p> Signup and view all the answers

Which type of neuron is commonly found in the central nervous system (CNS)?

<p>Multipolar neurons (A)</p> Signup and view all the answers

What aspect of neurons is crucial for their ability to transmit information?

<p>Electrical and chemical signaling (D)</p> Signup and view all the answers

In the structure of a bipolar neuron, how is the arrangement of processes characterized?

<p>One long axon and one long dendrite (A)</p> Signup and view all the answers

Which term best describes the overall function of neurons within the nervous system?

<p>Conductive (A)</p> Signup and view all the answers

What does the NatK pump primarily do?

<p>Pumps both sodium and potassium across the membrane (D)</p> Signup and view all the answers

What is the equilibrium potential for potassium ($E_{k+}$)?

<p>-90mV (B)</p> Signup and view all the answers

Which ion exerts a dominant effect on the resting membrane potential?

<p>Potassium (K+) (A)</p> Signup and view all the answers

What primarily regulates the membrane channels?

<p>Membrane potential and electrical signals (C)</p> Signup and view all the answers

What could cause the membrane to open or close?

<p>Touch sensations and chemicals (D)</p> Signup and view all the answers

What is the primary effect of ion movement across the plasma membrane?

<p>It leads to the production of electrical signals. (D)</p> Signup and view all the answers

What is the status of sodium concentration inside the cell compared to outside?

<p>Lower inside the cell than outside (B)</p> Signup and view all the answers

What does the concentration difference of Na+ and K+ primarily create?

<p>An electrical resting potential across the membrane (B)</p> Signup and view all the answers

What type of conduction is characterized by action potentials jumping from node to node?

<p>Saltatory conduction (B)</p> Signup and view all the answers

What is the primary mechanism by which sodium ions are transported into the cell?

<p>Sodium-potassium pump (C)</p> Signup and view all the answers

What is a characteristic of electrical synapses in neurons?

<p>They are connected directly by gap junctions. (C)</p> Signup and view all the answers

How many high-affinity sites for sodium does the sodium-potassium pump have?

<p>3 (A)</p> Signup and view all the answers

Which type of conduction is slower due to propagation through segments?

<p>Continuous conduction (C)</p> Signup and view all the answers

What happens to ion distribution after an action potential (AP) is restored?

<p>It is slightly disrupted. (A)</p> Signup and view all the answers

In chemical synapses, how is information transmitted between neurons?

<p>Using chemical messengers (B)</p> Signup and view all the answers

How many low-affinity sites for potassium does the sodium-potassium pump have?

<p>2 (B)</p> Signup and view all the answers

What is the role of voltage-gated calcium channels in synaptic transmission?

<p>They allow an influx of Ca2+ into the presynaptic terminal. (A)</p> Signup and view all the answers

Which structure connects the axon of the presynaptic neuron to the dendrite of the postsynaptic neuron?

<p>Synaptic cleft (C)</p> Signup and view all the answers

What initiates the release of neurotransmitters from the presynaptic neuron?

<p>The depolarization of the presynaptic terminal (A)</p> Signup and view all the answers

Which calcium ion (Ca2+) role is critical in the process of synaptic transmission?

<p>It signals the docking of synaptic vesicles. (D)</p> Signup and view all the answers

What is the first step that occurs in the presynaptic terminal during synaptic transmission?

<p>Depolarization of the presynaptic terminal (A)</p> Signup and view all the answers

What role do neurotransmitters play in synaptic transmission?

<p>They bind to receptors on the postsynaptic terminal. (A)</p> Signup and view all the answers

How do excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs) affect the postsynaptic neuron?

<p>EPSPs bring the neuron closer to threshold, while IPSPs move it further from threshold. (A)</p> Signup and view all the answers

What mechanism is involved in terminating the action of acetylcholine in the synaptic cleft?

<p>Breakdown by acetylcholinesterase. (C)</p> Signup and view all the answers

What type of ion channel is primarily involved in the action of EPSPs?

<p>Chemically-gated ion channels. (A)</p> Signup and view all the answers

What is a key feature of synaptic integration in the neuronal pathways?

<p>Neurons can be linked through converging and diverging pathways. (A)</p> Signup and view all the answers

What effect does the breakdown of acetylcholine by acetylcholinesterase have on synaptic activity?

<p>It effectively terminates the synaptic transmission. (B)</p> Signup and view all the answers

What is the primary function of graded potentials in synaptic transmission?

<p>To modulate the strength of the signal received by the neuron. (C)</p> Signup and view all the answers

What determines whether a postsynaptic neuron will reach threshold?

<p>The total summed effect of EPSPs and IPSPs. (D)</p> Signup and view all the answers

Flashcards

Neuron Structure

Neurons are cells that transmit information electrically and chemically in the nervous system. They have a cell body, dendrites, and an axon.

Dendrites

Short, branched extensions of a neuron that receive signals from other neurons.

Axon

A long, single extension of a neuron that transmits electrical signals (action potentials) to other cells.

Cell Body (Neuron)

The central part of a neuron containing organelles necessary for the neuron's survival.

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Bipolar Neuron

A neuron with one dendrite and one axon.

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Unipolar Neuron

A neuron with a single extension that acts as both dendrite and axon.

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Nervous System

Part of the body that uses electrical/chemical processes in cells to manage sensory/motor actions

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Action Potential

Electrical signal transmitted along a neuron's axon.

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Multipolar Neuron Structure

Neurons with multiple branching dendrites and a single axon.

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Neuroglia Role

Support neuronal function and is about 50% of the brain's cell population.

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Astrocytes Function

Regulate the chemical environment surrounding neurons.

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Oligodendrocytes/Schwann Cells

Myelinating glial cells in CNS/PNS respectively. Myelinates neurons.

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Microglia Role

Phagocytic cells that engulf cell debris in the brain.

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Sodium-Potassium Pump

Actively transports sodium out of and potassium into the cell against their concentration gradients.

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Equilibrium Potential

The membrane potential at which the net movement of an ion across the membrane is zero.

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Potassium Equilibrium Potential (EK)

Membrane potential at which the movement of potassium ions is equal in both directions; approximately -90mV.

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Sodium Equilibrium Potential (ENa)

Membrane potential at which the movement of sodium ions is equal in both directions; approximately +60mV.

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Membrane Resting Potential

The steady voltage difference across the cell membrane in a resting neuron; primarily influenced by potassium concentration gradients, and slightly less by sodium.

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Membrane Channels

Proteins in the cell membrane that allow ions to passively move across the membrane.

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Ion Movement

The movement of ions down their concentration gradients across the membrane.

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Electrical Signals

Changes in ion movement across the plasma membrane create electrical signals.

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Synaptic Cleft

A tiny gap between the axon terminal of one neuron and the dendrite of another, where chemical communication occurs.

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Synaptic Vesicles

Small sacs within the axon terminal that store and release neurotransmitters into the synaptic cleft.

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Neurotransmitter Release

The process by which neurotransmitters are released from synaptic vesicles into the synaptic cleft.

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Calcium Ions (Ca2+)

Ions that trigger the release of neurotransmitters from synaptic vesicles.

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Voltage-Gated Calcium Channels

Channels in the axon terminal that open when a neuron receives a signal, allowing calcium ions to flow in.

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Neurotransmitter

A chemical messenger released from the axon terminal of a neuron that transmits information to the next neuron.

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Receptor

A protein on the postsynaptic membrane that binds to neurotransmitters, triggering a response in the receiving neuron.

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Excitatory Postsynaptic Potential (EPSP)

A temporary depolarization of the postsynaptic membrane, making it more likely for the neuron to fire an action potential.

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Inhibitory Postsynaptic Potential (IPSP)

A temporary hyperpolarization of the postsynaptic membrane, making it less likely for the neuron to fire an action potential.

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Synaptic Integration

The process of combining multiple EPSPs and IPSPs to determine whether a neuron will fire an action potential.

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Converging Pathway

Many neurons synapsing on one neuron.

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Diverging Pathway

One axon branching to synapse on many neurons.

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Sodium-Potassium Pump Binding Sites

The pump has 3 high-affinity binding sites for sodium ions (Na+) and 2 low-affinity binding sites for potassium ions (K+).

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Node of Ranvier

Gaps in the myelin sheath of an axon, where action potentials are regenerated. Sodium and potassium channels are concentrated in these areas.

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Contiguous Conduction

Slow propagation of an action potential along an unmyelinated axon, where the signal spreads continuously.

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Saltatory Conduction

Fast propagation of an action potential along a myelinated axon, where the signal jumps from node to node.

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Synapse

Junction between two neurons where information is transmitted from one neuron to another.

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Electrical Synapse

A type of synapse where neurons are connected directly by gap junctions. This type is relatively uncommon in humans.

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Chemical Synapse

A type of synapse where chemical messengers called neurotransmitters transmit information from one neuron to another.

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Study Notes

Neurons

  • Neurons are conducting cells in the nervous system, transmitting information electrically and chemically.
  • Structure:
    • Soma (cell body): Contains organelles essential for survival.
    • Dendrites: Short, highly branched; receive information from other neurons.
    • Axon: Long, single axon; carries electrical signals (action potentials) to target.
  • Types:
    • Bipolar neuron: One long dendrite, one long axon.
    • Unipolar neuron: Dendrites and axon continuous; soma to one side.
    • Multipolar neuron: Multiple short dendrites, one long axon.

Neuroglia

  • Supports neuronal function and is ~50% of total nervous system (NS) cells.
  • Types:
    • Astrocytes: Regulate chemical environment; surround neurons.
    • Myelinating glia:
      • Oligodendrocytes (CNS): Myelinate neurons.
      • Schwann cells (PNS): Myelinate neurons.
    • Microglia: Phagocytic role (engulf cell debris and waste).
    • Ependymal: Produce cerebrospinal fluid (CSF) in brain ventricles.

Neural Communication

  • Nerve and muscle cells are excitable tissues.
  • Neurons produce, process, transmit, and receive electrical and/or chemical signals.

Resting Membrane Potential

  • Membrane potential: -70 mV (polarized).
  • Resting potential established due to unequal distribution of ions (sodium (Na+), potassium (K+), chloride (Cl-), and negatively charged proteins) inside and outside the cell.
  • Na+/K+ pump moves 3 Na+ out and 2 K+ in (maintains concentration gradients).
  • Membrane more permeable to K+, which diffuses out and causes net negative charge inside.

Membrane Channels

  • Leaky channels: Channels always open, allowing ions to pass through.
  • Gated channels: Open/close in response to stimuli (voltage, chemicals, physical force, temperature).

Graded Potentials

  • Local changes in membrane potential, varying in magnitude.
  • Only spreads throughout dendrites and soma.

Action Potentials

  • Brief, rapid, large change in membrane potential (all-or-none).
  • Changes membrane permeability; ion movement across membrane.
  • Propagated from axon hillock to axon terminals.

Voltage-gated Na+ and K+ Channels

  • Voltage-gated Na+ channels: Open rapidly in response to depolarization; inactivation gates close.
  • Voltage-gated K+ channels: Open slowly after depolarization; K+ diffuses out of the cell, returning the membrane to resting potential.

Synaptic Transmission

  • Synapses: Junctions between neurons or between neurons and muscle/gland cells.
  • Electrical synapses: Direct connections; fast.
  • Chemical synapses: Transmit signals via neurotransmitters.
  • Transmission steps:
    • Action potential arrives at pre-synaptic axon terminal.
    • Depolarization opens voltage-gated calcium channels, allowing calcium influx.
    • Calcium influx causes synaptic vesicles to release neurotransmitters into the synaptic cleft.
    • Neurotransmitters bind to receptors on post-synaptic membrane, initiating changes in membrane potential.
    • Neurotransmitters are removed from the synapse(e.g., enzymatic degradation or reuptake).

Myelination

  • Myelin sheath: Fatty insulation around some axons; formed by Schwann cells (PNS) or oligodendrocytes (CNS).
  • Myelination speeds up action potential propagation through saltatory conduction (jumps between Nodes of Ranvier).

Types of Conduction

  • Contiguous conduction: Slower; propagation of AP along entire axon.
  • Saltatory conduction: Faster; AP "jumps" between Nodes of Ranvier; more efficient.

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