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Questions and Answers
What is the primary mechanism of action of neuromuscular blocking drugs at the neuromuscular junction (NMJ)?
What is the primary mechanism of action of neuromuscular blocking drugs at the neuromuscular junction (NMJ)?
- Directly stimulating muscle cell depolarization
- Inhibiting acetylcholinesterase
- Enhancing acetylcholine (ACh) release
- Blocking acetylcholine (ACh) (correct)
Which condition is typically a contraindication for the use of neuromuscular blocking drugs?
Which condition is typically a contraindication for the use of neuromuscular blocking drugs?
- Myasthenia gravis (correct)
- Osteoporosis
- Diabetes mellitus
- Hypertension
What is a common therapeutic indication for using neuromuscular blocking drugs?
What is a common therapeutic indication for using neuromuscular blocking drugs?
- Lowering blood pressure
- Treating infections
- Reducing pain
- Facilitating mechanical intubation (correct)
Which of the following is a potential adverse effect associated with neuromuscular blocking drugs?
Which of the following is a potential adverse effect associated with neuromuscular blocking drugs?
A patient with a history of malignant hyperthermia should be approached with caution when considering the use of which type of drug?
A patient with a history of malignant hyperthermia should be approached with caution when considering the use of which type of drug?
Neuromuscular blocking drugs are often used as an adjunct to what other type of medication during surgical procedures?
Neuromuscular blocking drugs are often used as an adjunct to what other type of medication during surgical procedures?
Which of the following is a 'CURONIUM' neuromuscular blocking drug?
Which of the following is a 'CURONIUM' neuromuscular blocking drug?
What is the primary reason for using neuromuscular blocking drugs in patients on mechanical ventilators?
What is the primary reason for using neuromuscular blocking drugs in patients on mechanical ventilators?
In which patient scenario should neuromuscular blocking drugs be used with caution?
In which patient scenario should neuromuscular blocking drugs be used with caution?
Besides depressed respiration, what is another potential cardiovascular-related adverse effect of neuromuscular blocking drugs?
Besides depressed respiration, what is another potential cardiovascular-related adverse effect of neuromuscular blocking drugs?
Flashcards
Neuromuscular Blocking Agents
Neuromuscular Blocking Agents
Drugs that block acetylcholine at the neuromuscular junction (NMJ), preventing muscle cell depolarization and causing paralysis.
Therapeutic Uses of Neuromuscular Blockers
Therapeutic Uses of Neuromuscular Blockers
Used during surgery to prevent muscle reflexes, facilitate mechanical intubation, and enable respiratory muscle paralysis for ventilator support.
Contraindications for Neuromuscular Blockers
Contraindications for Neuromuscular Blockers
Conditions like myasthenia gravis, renal or hepatic disease, and pregnancy may increase risks.
Adverse Effects of Neuromuscular Blockers
Adverse Effects of Neuromuscular Blockers
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Examples of Neuromuscular Blockers
Examples of Neuromuscular Blockers
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Study Notes
- Neuromuscular blocking drugs antagonize acetylcholine (ACh) at the neuromuscular junction (NMJ).
- This action prevents muscle cell depolarization.
Names
- Atracurium
- Cisatracurium
- Pancuronium
- Rocuronium
- Vecuronium
- Generic names include "curonium" or "curium" suffixes
Therapeutic Actions and Indications
- These drugs are used with general anesthetics during surgery.
- They prevent reflex muscle movement that could interfere with the procedure or anesthesia delivery.
- They support mechanical intubation.
- They induce respiratory muscle paralysis to prevent patients from resisting the ventilator.
Contraindications
- Myasthenia gravis
- Renal or hepatic disease
- Pregnancy
Cautions
- History of malignant hyperthermia
- Pulmonary or cardiovascular dysfunction
- Altered fluid and electrolyte balance
- Lactation
Adverse Effects
- Depressed respiration
- Bronchospasm
- Apnea
- Hypotension
- Cardiac arrhythmias
- GI dysfunction
- Pressure ulcers
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