Neuromuscular Blocking Agents: Structure-Activity Relationships
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Questions and Answers

What is the primary mechanism of interaction between agonists or antagonists and their binding sites?

  • Ion channels
  • Second messenger systems
  • Multiple sites of interaction (correct)
  • Gated receptors

    • What is a critical factor in the binding of agonists or antagonists to their binding sites?

  • The concentration of the agonist or antagonist
  • The number of binding sites available
  • The binding affinity of the agonist or antagonist (correct)
  • The presence of other molecules in the binding site

    • What is the result of the interaction between an agonist and its binding site?

  • Enhancement of the response (correct)
  • Complete blockade of the response
  • No effect on the response
  • Inhibition of the response

    • What is the primary function of antagonists in the binding site?

    <p>To inhibit the response</p> Signup and view all the answers

    What is the consequence of the binding of an agonist or antagonist to its binding site?

    <p>Changes in the response to the agonist or antagonist</p> Signup and view all the answers

    What is the primary characteristic of rigid bulky molecules with amine functions incorporated into ring structures?

    <p>Neuromuscular blocking activity</p> Signup and view all the answers

    Which of the following techniques is NOT used to study neuromuscular blocking activity?

    <p>Electroencephalography</p> Signup and view all the answers

    What do structure-activity relationships of NMBAs affect?

    <p>Neuromuscular blocking activity, pharmacokinetic properties, and side effect profiles</p> Signup and view all the answers

    What is the common feature among mechanomyography, electromyography, kinemyography, and acceleromyography?

    <p>They are all used to study neuromuscular blocking activity</p> Signup and view all the answers

    What has changed significantly in our understanding of NMBAs since their early classification?

    <p>Their structure-activity relationships</p> Signup and view all the answers

    What is the primary factor that determines the speed of onset of neuromuscular block after administration of an NMBA?

    <p>Metabolism and redistribution of the NMBA</p> Signup and view all the answers

    What is the minimum ED95 required for a rapid onset of effect of an NMBA?

    <p>0.1 mg/kg</p> Signup and view all the answers

    Why do equipotent doses of mivacurium have a slower onset of effect in patients who are homozygous for atypical butyrylcholinesterase?

    <p>Due to slower equilibration between the plasma and effect compartment</p> Signup and view all the answers

    What is a necessary step for an NMBA to exert its effect?

    <p>Entering the neuromuscular junction</p> Signup and view all the answers

    What is the primary mechanism of action of an NMBA?

    <p>Inhibition of the nicotinic receptor</p> Signup and view all the answers

    What is the relationship between the speed of onset of neuromuscular block and the speed of recovery of neuromuscular function?

    <p>They are directly proportional</p> Signup and view all the answers

    What is involved in binding the agonist or antagonist?

    <p>Several different sites of interaction</p> Signup and view all the answers

    What is a result of the binding of an agonist or antagonist to its binding site?

    <p>Activation of the binding site</p> Signup and view all the answers

    How do agonists and antagonists interact with their binding sites?

    <p>Through multiple points of interaction</p> Signup and view all the answers

    What determines the speed of onset of neuromuscular block after administration of an NMBA?

    <p>The speed of absorption of the NMBA</p> Signup and view all the answers

    What is affected by the structure-activity relationships of NMBAs?

    <p>The potency and duration of action of the NMBA</p> Signup and view all the answers

    What is the primary factor that facilitates the entry of an NMBA into the neuromuscular junction?

    <p>Its lipophilicity</p> Signup and view all the answers

    What is the consequence of rapid equilibration between the plasma and effect compartment of an NMBA?

    <p>Faster onset of neuromuscular block</p> Signup and view all the answers

    What determines the number of antagonist molecules needed to establish block?

    <p>ED95</p> Signup and view all the answers

    Why do different NMBAs have varying durations of action?

    <p>Due to differences in their rates of metabolism and redistribution</p> Signup and view all the answers

    What is the relationship between the speed of onset of neuromuscular block and the speed of recovery of neuromuscular function?

    <p>They are directly proportional</p> Signup and view all the answers

    What is the consequence of having a homozygous atypical butyrylcholinesterase in patients?

    <p>Slower onset of effect of mivacurium</p> Signup and view all the answers

    What is a primary way structure-activity relationships of NMBAs affect their function?

    <p>Neuromuscular blocking activity</p> Signup and view all the answers

    What is a characteristic of NMBAs since their early classification?

    <p>They are rigid bulky molecules with amine functions incorporated into ring structures</p> Signup and view all the answers

    Which technique is commercially available to study neuromuscular blocking activity?

    <p>All of the above</p> Signup and view all the answers

    What do mechanomyography, electromyography, kinemyography, and acceleromyography have in common?

    <p>They are all used to study neuromuscular blocking activity</p> Signup and view all the answers

    What has changed significantly in our understanding of NMBAs?

    <p>Our understanding of the relationships between their structures and function as neuromuscular blockers</p> Signup and view all the answers

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