Neurology 1: Introduction

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Questions and Answers

What is a function of acetylcholine (ACh)?

  • Transmits chronic pain signals
  • Modulates arousal and attention
  • Regulates mood and appetite
  • Involved in muscle contraction (correct)

Which neurotransmitter is primarily linked to Parkinson's disease due to low levels?

  • Noradrenaline
  • Serotonin
  • Acetylcholine
  • Dopamine (correct)

What is the primary role of GABA in the central nervous system?

  • Regulates fight or flight response
  • Inhibitory neurotransmitter (correct)
  • Excitatory neurotransmitter
  • Modulates memory and learning

Which neurotransmitter is associated with depression and anxiety due to low levels?

<p>Serotonin (C)</p> Signup and view all the answers

Which of the following neurotransmitters is linked to the fight or flight response?

<p>Noradrenaline (C)</p> Signup and view all the answers

What symptom is associated with excessive glutamate activity?

<p>Excitotoxicity (C)</p> Signup and view all the answers

Which type of sensory fiber is responsible for transmitting fast, sharp pain signals?

<p>Aδ Fibers (A)</p> Signup and view all the answers

What is a characteristic of Aα fibers?

<p>Large, myelinated fibers for motor control (A)</p> Signup and view all the answers

What is the main function of the axon terminal?

<p>To release neurotransmitters (A)</p> Signup and view all the answers

Which type of neuron is characterized by having one axon and one dendrite?

<p>Bipolar Neurons (D)</p> Signup and view all the answers

During which phase of the action potential do voltage-gated sodium channels open?

<p>Depolarisation (C)</p> Signup and view all the answers

What triggers the action potential when the membrane potential reaches which value?

<p>-55 mV (B)</p> Signup and view all the answers

Which type of conduction occurs in myelinated axons?

<p>Saltatory Conduction (D)</p> Signup and view all the answers

What is the role of the sodium-potassium pump during the resting state of a neuron?

<p>It maintains the resting membrane potential (C)</p> Signup and view all the answers

What typically happens during the hyperpolarisation phase?

<p>The membrane becomes more negative than the resting potential (D)</p> Signup and view all the answers

Which type of neuron is most commonly found throughout the CNS?

<p>Multipolar Neurons (A)</p> Signup and view all the answers

What is the primary function of leakage ion channels in the neuron membrane?

<p>Contribute to resting membrane potential (D)</p> Signup and view all the answers

Which type of neuroglia acts as the immune cells of the CNS?

<p>Microglia (A)</p> Signup and view all the answers

Which of the following channels opens in response to the binding of a neurotransmitter?

<p>Ligand-gated channels (C)</p> Signup and view all the answers

What triggers the opening of voltage-gated calcium channels at the axon terminal?

<p>Change in membrane potential (A)</p> Signup and view all the answers

What is the role of astrocytes in the nervous system?

<p>Regulate ionic environment around neurons (C)</p> Signup and view all the answers

Which process occurs first when an action potential arrives at the axon terminal?

<p>Calcium influx (D)</p> Signup and view all the answers

What is the main function of Schwann cells in the peripheral nervous system?

<p>Produce myelin sheath around axons (A)</p> Signup and view all the answers

What happens to neurotransmitters after they bind to receptors on the postsynaptic membrane?

<p>They alter the postsynaptic membrane potential (D)</p> Signup and view all the answers

Which fibers are primarily affected by local anaesthetics first?

<p>Aδ fibers (A), C fibers (B)</p> Signup and view all the answers

What effect do local anaesthetics have on touch and pressure sensations?

<p>They are preserved (A)</p> Signup and view all the answers

Which ion channel is blocked by local anaesthetics to inhibit pain sensation?

<p>Sodium channels (D)</p> Signup and view all the answers

What is the primary mechanism through which local anaesthetics work?

<p>Blocking sodium channels (D)</p> Signup and view all the answers

Which type of neuron is primarily targeted by local anaesthetics?

<p>Sensory neurons (D)</p> Signup and view all the answers

During action potential generation, which phase is characterized by sodium ions entering the neuron?

<p>Depolarization phase (D)</p> Signup and view all the answers

Which of the following sensations is maintained when local anaesthetics are applied?

<p>Pressure sensation (D)</p> Signup and view all the answers

What happens to the membrane potential during hyperpolarization?

<p>It becomes less negative than resting potential (B)</p> Signup and view all the answers

What is the primary function of the Central Nervous System (CNS)?

<p>Processing and integrating information received from the body (C)</p> Signup and view all the answers

Which part of the neuron is primarily responsible for conducting electrical impulses away from the cell body?

<p>Axon (D)</p> Signup and view all the answers

What role do the Nodes of Ranvier play in the action potential process?

<p>They increase the speed of signal transmission (A)</p> Signup and view all the answers

Which system within the Peripheral Nervous System is responsible for controlling voluntary movements?

<p>Somatic Nervous System (A)</p> Signup and view all the answers

What is the function of the myelin sheath in neurons?

<p>To increase the speed of impulse transmission (C)</p> Signup and view all the answers

What are the two main components of the Peripheral Nervous System?

<p>Afferent and Efferent pathways (A)</p> Signup and view all the answers

Where are action potentials primarily initiated in a neuron?

<p>Axon Hillock (C)</p> Signup and view all the answers

Which of the following describes the autonomic nervous system's sympathetic branch?

<p>It is responsible for fight or flight responses. (B)</p> Signup and view all the answers

What triggers the release of neurotransmitters at the axon terminal?

<p>Action potential reaching the axon terminal (A)</p> Signup and view all the answers

What is the primary role of dopamine in the basal ganglia?

<p>To modulate and regulate movement (A)</p> Signup and view all the answers

How does the deficiency of dopamine lead to motor symptoms in Parkinson's disease?

<p>Reduced modulation of basal ganglia activity (B)</p> Signup and view all the answers

What is the function of myelin in the nervous system?

<p>To insulate axons and facilitate rapid conduction (B)</p> Signup and view all the answers

What effect does demyelination have on nerve conduction in multiple sclerosis?

<p>It disrupts the transmission of nerve impulses (B)</p> Signup and view all the answers

What symptom is typically associated with a deficiency of dopamine?

<p>Muscle rigidity (A)</p> Signup and view all the answers

What is a common treatment option for Parkinson's disease?

<p>Levodopa (D)</p> Signup and view all the answers

Which of the following best describes the condition of multiple sclerosis?

<p>A condition characterized by episodic demyelination in the CNS (A)</p> Signup and view all the answers

Flashcards

Axon Terminal

The endpoint of the axon where neurotransmitters are released to communicate with other neurons or muscles.

Bipolar Neuron

A type of neuron with two processes extending from the cell body: one axon and one dendrite. Found in sensory organs like the retina.

Interneuron

Multipolar neurons that connect sensory and motor neurons within the CNS, playing a role in reflexes and neural circuits.

Sensory Neuron

Carry sensory information from receptors in the body to the CNS.

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Multipolar Neuron

The most common type of neuron, with one axon and multiple dendrites. Found throughout the CNS.

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Pyramidal Neuron

A type of multipolar neuron found in the cerebral cortex, involved in motor control and cognitive functions.

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Golgi Type I Neuron

Have long axons that can extend far across the body, such as those found in the spinal cord.

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Golgi Type II Neuron

Have short axons and are typically found in the cerebral cortex and retina, often acting as local circuit neurons.

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What is the Central Nervous System (CNS)?

The control center of the body, processing information received from the body and coordinating activities like movement, sensory perception, emotions, thoughts, and memory.

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What is the Peripheral Nervous System (PNS)?

Includes all nerves outside the CNS, responsible for carrying information between the CNS and the rest of the body.

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What is the Afferent system of the PNS?

Carries sensory information from the body to the CNS, like touch, taste, smell, sight, and sound.

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What is the Efferent system of the PNS ?

Carries motor commands from the CNS to muscles and glands, controlling movement and bodily functions.

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What does the Somatic Nervous System do?

Controls voluntary movements by innervating skeletal muscles, allowing you to consciously move.

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What does the Autonomic Nervous System do?

Controls automatic functions like heart rate, digestion, and breathing, operating without conscious thought.

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What is the Cell Body (Soma) of a neuron?

The main body of a neuron, containing the nucleus and organelles, responsible for maintaining its structure and function.

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What are the Dendrites of a neuron?

Branch-like extensions of a neuron that receive signals from other neurons and transmit them towards the cell body.

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Leakage Ion Channels

Channels that allow ions to passively cross the membrane, playing a role in maintaining resting membrane potential.

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Mechanically Gated Channels

Respond to mechanical deformation of the membrane, like stretching or pressure, opening to allow ion flow.

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Voltage-Gated Channels

Open in response to changes in the membrane potential, crucial for generating action potentials.

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Ligand-Gated Channels

Open when a neurotransmitter or other chemical messenger binds to them.

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Schwann Cells

Produce myelin sheath around axons in the peripheral nervous system (PNS) for faster signal transmission.

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Satellite Cells

Support neuron cell bodies in ganglia, regulating material exchange between neurons and their environment.

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Oligodendrocytes

Produce myelin sheath around axons in the central nervous system (CNS), similar to Schwann cells but in the CNS.

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Astrocytes

Star-shaped cells in the CNS that maintain the blood-brain barrier, provide structural support, and regulate the ionic environment around neurons.

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Acetylcholine (ACh)

A neurotransmitter involved in muscle contraction, autonomic functions (like heart rate and digestion), and cognitive processes like learning and memory.

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Dopamine

A neurotransmitter that regulates movement, motivation, and reward pathways. It's associated with feelings of pleasure and satisfaction.

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Serotonin

A neurotransmitter that modulates mood, appetite, sleep, and pain perception. It's often associated with feelings of happiness and well-being.

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Noradrenaline (Norepinephrine)

A neurotransmitter involved in the fight-or-flight response, arousal, and attention. It helps us respond to stress and danger.

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Gamma-Aminobutyric Acid (GABA)

The primary inhibitory neurotransmitter in the central nervous system (CNS). It slows down or reduces neuronal activity, calming the brain.

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Glutamate

The primary excitatory neurotransmitter in the CNS. It increases neuronal activity, contributing to learning and memory.

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G Protein-Coupled Receptors

These receptors are located on the surface of cells and act as receivers for neurotransmitters. They activate intracellular signaling pathways, causing a response within the cell.

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Aα Fibers

Large, myelinated fibers that transmit information about body position and movement.

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Resting Membrane Potential

The resting membrane potential, typically -70 mV, is the stable, negative charge inside the neuron when it's not sending a signal.

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Action Potential

A rapid, short-lasting change in membrane potential, where the inside of the neuron becomes temporarily positive, allowing the transmission of a signal.

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Action Potential Propagation

The process of transmitting a signal from the neuron's cell body along the axon to the terminal where neurotransmitters are released.

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Refractory Period

The period after an action potential where the neuron is less likely to fire another action potential.

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Depolarization Phase

The opening of voltage-gated sodium channels leads to sodium ions rushing into the neuron, causing depolarization and further pushing the membrane potential closer to the threshold.

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Repolarization Phase

The opening of voltage-gated potassium channels allows potassium ions to exit the cell, making the inside of the neuron more negative again, returning to its resting potential.

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Inhibitory Neurotransmitter

The neurotransmitter GABA is responsible for inhibiting neural activity. It reduces the likelihood of an action potential being triggered, calming down the nervous system.

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Neurotransmitter function

A chemical messenger released from the presynaptic neuron, diffusing across the synaptic cleft and binding to receptors on the postsynaptic neuron, triggering a response.

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Synaptic Cleft

The tiny space between the presynaptic and postsynaptic neurons where neurotransmitters are released and bind to receptors.

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Neurotransmitter release

The process by which neurotransmitters are released from the presynaptic neuron into the synaptic cleft.

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Synapse

The point where the axon terminal of a neuron comes into close proximity with another neuron or effector cell.

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Neurotransmitter binding

The process of a neurotransmitter binding to a receptor on the postsynaptic neuron, causing ion channels to open or close.

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Postsynaptic potential (PSP)

A change in the electrical potential of the postsynaptic neuron's membrane, which can trigger an action potential if it reaches the threshold.

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Threshold

The level of electrical potential a neuron must reach for an action potential to be triggered.

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Study Notes

Neurology 1: Introduction

  • This unit introduces neurology, focusing on the central and peripheral nervous systems, neuron structure, action potentials, and synapses.
  • It covers the roles and potential dysfunctions of neurotransmitters.

1. Introduction to Neurology

Central Nervous System (CNS)

  • Composed of the brain and spinal cord.
  • Responsible for processing and integrating body information.
  • Regulates bodily functions, including movement, sensory perception, emotions, thoughts, and memory.

Peripheral Nervous System (PNS)

  • Includes nerves outside the CNS.
  • Divided into afferent (sensory) and efferent (motor) pathways.
  • Afferent system carries sensory information to the CNS.
  • Efferent system carries motor commands from the CNS to muscles and glands.
  • Further divided into:
    • Somatic nervous system: controls voluntary skeletal muscle movements.
    • Autonomic nervous system: controls involuntary functions (e.g., heart rate, digestion).
      • Further divided into sympathetic (fight-or-flight) and parasympathetic (rest-and-digest) systems.

2. The Neuron: Structure and Types

Neuron Structure

  • Cell body (soma): contains the nucleus and organelles, maintaining the neuron's structure and function.
  • Dendrites: branch-like structures receiving signals from other neurons and transmitting them to the cell body.
  • Axon: a long projection conducting electrical impulses (action potentials) away from the cell body to other neurons or muscles.
  • Axon hillock: the junction between the cell body and axon, where action potentials are initiated.

3. The Action Potential

Resting Membrane Potential

  • The neuron is at rest with a membrane potential of approximately -70 mV.
  • Maintained by the sodium-potassium pump (3 Na+ out, 2 K+ in) and leakage channels.

Phases of Action Potential

  • Threshold (-55 mV): stimulus depolarizes the membrane to trigger an action potential.
  • Depolarization (+30 mV): voltage-gated sodium channels open, allowing Na+ influx.
  • Repolarization: voltage-gated potassium channels open, allowing K+ efflux.
  • Hyperpolarization (-90 mV): membrane becomes more negative than resting potential due to further K+ efflux.
  • Return to Resting State (-70 mV): sodium-potassium pump restores resting membrane potential.

4. Protein Channels in the Neuron Membrane

  • Leakage ion channels: allow ions to passively move.
  • Mechanically gated channels: open in response to mechanical deformation.
  • Voltage-gated channels: open in response to membrane potential changes.
  • Ligand-gated channels: open in response to neurotransmitter binding.

5. Neuroglia: Supporting Cells in the Nervous System

  • PNS: Schwann cells produce myelin sheaths, and satellite cells provide support and regulate neuron environment.
  • CNS: Oligodendrocytes produce myelin, astrocytes maintain the blood-brain barrier, microglia act as immune cells, and ependymal cells produce/circulate cerebrospinal fluid (CSF).

6. The Synapse: Communication Between Neurons

  • Action potential arrival triggers voltage-gated calcium channels opening.
  • Calcium influx causes synaptic vesicles to fuse with the presynaptic membrane.
  • Neurotransmitter release into the synaptic cleft.
  • Neurotransmitter binding to receptors on the postsynaptic membrane.
  • Postsynaptic potential change (alteration in membrane potential).
  • Neurotransmitter inactivation occurs by reuptake, enzymatic degradation, or diffusion.

7. Neurotransmitters: Functions and Examples of Malfunctions

  • Acetylcholine (ACh): muscle contraction, autonomic functions, cognition (Alzheimer's disease with decreased ACh).
  • Dopamine: movement, motivation, reward (Parkinson's disease with low dopamine, schizophrenia with excess dopamine).
  • Serotonin: mood, appetite, sleep, pain perception (depression and anxiety with low levels).
  • Noradrenaline/Norepinephrine: fight-or-flight, arousal, attention (mood disorders).
  • Gamma-Aminobutyric Acid (GABA): primary inhibitory neurotransmitter, reducing neuronal excitability (anxiety disorders and epilepsy).
  • Glutamate: primary excitatory neurotransmitter, learning and memory (excitotoxicity in Alzheimer's).

8. Sensory Fibers in the Skin and Local Anaesthesia

  • Sensory fibre types:
    • Aα fibres: proprioception and motor control
    • Aβ fibres: touch and pressure
    • Aδ fibres: fast pain and temperature
    • C fibres: slow pain, temperature, and itch
  • Local anaesthetics block sodium channels, preventing action potential initiation/propagation, inhibiting pain/temperature sensations and preserving touch/pressure.

Multiple Choice Questions (MCQs) & Short Answer Questions (SAQs)

  • The provided text includes multiple choice questions and short answer questions (SAQs) on specific neurology concepts. These questions cover neuron types, membrane potential, neurotransmitters, synapse function, etc. (See the OCR text for specific question text and answer choices.)

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