Podcast
Questions and Answers
What was Substance P initially isolated from?
What was Substance P initially isolated from?
- GI tract
- Salivary glands
- Brain
- Gut (correct)
Who discovered enkephalins while searching for endogenous compounds that mimicked the effect of morphine?
Who discovered enkephalins while searching for endogenous compounds that mimicked the effect of morphine?
- Gaddum
- Kosterlitz (correct)
- Von Euler
- Euler and Gaddum
What is the name of the peptides that include Substance P, NKA, and NKB?
What is the name of the peptides that include Substance P, NKA, and NKB?
- Neurokinins
- Enkephalins
- Opioid peptides
- Tachykinins (correct)
What technique led to an explosion in the discovery of bioactive neuropeptides in the CNS, PNS, and ENS?
What technique led to an explosion in the discovery of bioactive neuropeptides in the CNS, PNS, and ENS?
What is the function of Substance P in the nervous system?
What is the function of Substance P in the nervous system?
What is the origin of the name 'Substance P'?
What is the origin of the name 'Substance P'?
Where are neuropeptides expressed, apart from in the nervous system?
Where are neuropeptides expressed, apart from in the nervous system?
In which organisms are neuropeptides expressed?
In which organisms are neuropeptides expressed?
What is the primary function of Dale's Principle in the context of neurotransmission?
What is the primary function of Dale's Principle in the context of neurotransmission?
Which of the following scientists is credited with proposing the co-transmitter hypothesis?
Which of the following scientists is credited with proposing the co-transmitter hypothesis?
What is the term for the process by which neurotransmitters are removed from the synaptic cleft?
What is the term for the process by which neurotransmitters are removed from the synaptic cleft?
What is the primary function of neuropeptide Y (NPY) in the context of neurotransmission?
What is the primary function of neuropeptide Y (NPY) in the context of neurotransmission?
What is the significance of the work of Henry Dale in the context of neurotransmission?
What is the significance of the work of Henry Dale in the context of neurotransmission?
What is the term for the process by which neurotransmitters are prepared for release?
What is the term for the process by which neurotransmitters are prepared for release?
What is the significance of John Eccles' proposal in 1957?
What is the significance of John Eccles' proposal in 1957?
What is the crucial structural motif involved in receptor interaction?
What is the crucial structural motif involved in receptor interaction?
Which enzyme is responsible for degrading met- and Leu-enkephalins?
Which enzyme is responsible for degrading met- and Leu-enkephalins?
What is the effect of Phosphoramidon on NKs?
What is the effect of Phosphoramidon on NKs?
What determines which peptidase breaks down a neuropeptide?
What determines which peptidase breaks down a neuropeptide?
What is the result of NPY being degraded by dipeptidyl peptidase IV?
What is the result of NPY being degraded by dipeptidyl peptidase IV?
What is the role of NEP in neurokinin degradation?
What is the role of NEP in neurokinin degradation?
What is the effect of post-secretory processing on receptor selectivity?
What is the effect of post-secretory processing on receptor selectivity?
What is the potential therapeutic application of NK receptor antagonists?
What is the potential therapeutic application of NK receptor antagonists?
What is the primary function of angiotensin converting enzyme (ACE)?
What is the primary function of angiotensin converting enzyme (ACE)?
Which of the following is NOT a characteristic of neuropeptide degradation?
Which of the following is NOT a characteristic of neuropeptide degradation?
What is the result of cleavage of two amino acids from NPY?
What is the result of cleavage of two amino acids from NPY?
What is the primary mechanism of release in response to low-frequency action potentials?
What is the primary mechanism of release in response to low-frequency action potentials?
What is the characteristic of the autonomic neuroeffector junction?
What is the characteristic of the autonomic neuroeffector junction?
What is the primary difference between neuropeptide release and classic transmitter release?
What is the primary difference between neuropeptide release and classic transmitter release?
What is the role of dipeptidyl peptidase in neuropeptide metabolism?
What is the role of dipeptidyl peptidase in neuropeptide metabolism?
What is the result of high-frequency action potentials or pulsatile nerve stimulation on neuropeptide release?
What is the result of high-frequency action potentials or pulsatile nerve stimulation on neuropeptide release?
What is the primary difference in response times between neuropeptides and fast neurotransmitters?
What is the primary difference in response times between neuropeptides and fast neurotransmitters?
What type of receptors are peptide receptors generally coupled to?
What type of receptors are peptide receptors generally coupled to?
What is the effect of degrading NPY by DPPIV?
What is the effect of degrading NPY by DPPIV?
What is the importance of the amidated C-terminal of NPY?
What is the importance of the amidated C-terminal of NPY?
What is the effect of NPY on intracellular cAMP levels?
What is the effect of NPY on intracellular cAMP levels?
What is the difference between NPY and pancreatic polypeptide (PP) in terms of their effects on Y receptors?
What is the difference between NPY and pancreatic polypeptide (PP) in terms of their effects on Y receptors?
What is the structure of NPY in solution?
What is the structure of NPY in solution?
What is the effect of NPY on intracellular Ca++ levels?
What is the effect of NPY on intracellular Ca++ levels?
