Podcast
Questions and Answers
In the context of neuroimaging for dementia diagnosis, which condition is most likely to present with disproportionate bilateral atrophy of the hippocampi?
In the context of neuroimaging for dementia diagnosis, which condition is most likely to present with disproportionate bilateral atrophy of the hippocampi?
- Fronto Temporal Dementia
- Alzheimer's Dementia (correct)
- Vascular Dementia
- Semantic Dementia
A patient's MRI reveals diffuse white matter lesions, particularly in the anterior temporal lobes and external capsules. Which type of dementia is most suggested by these findings?
A patient's MRI reveals diffuse white matter lesions, particularly in the anterior temporal lobes and external capsules. Which type of dementia is most suggested by these findings?
- Lewy Body Dementia
- Alzheimer's Dementia
- Fronto Temporal Dementia
- Vascular Dementia (correct)
A patient presents with temporal lobe atrophy, more pronounced on the left side, and greater atrophy in the anterior temporal lobe compared to the posterior temporal lobe. Which type of dementia is most likely?
A patient presents with temporal lobe atrophy, more pronounced on the left side, and greater atrophy in the anterior temporal lobe compared to the posterior temporal lobe. Which type of dementia is most likely?
- Fronto Temporal Dementia
- Alzheimer's Dementia
- Vascular Dementia
- Semantic Dementia (correct)
What is the most likely finding in neuroimaging for a patient with Huntington's Disease?
What is the most likely finding in neuroimaging for a patient with Huntington's Disease?
Which neuroimaging modality is most useful to demonstrate low dopamine transporter uptake in the basal ganglia?
Which neuroimaging modality is most useful to demonstrate low dopamine transporter uptake in the basal ganglia?
In cases of CJD, which neuroimaging finding is most indicative of the disease when present?
In cases of CJD, which neuroimaging finding is most indicative of the disease when present?
Which of the following dementias is characterized by bifrontal and temporal atrophy on MRI scans?
Which of the following dementias is characterized by bifrontal and temporal atrophy on MRI scans?
In the context of Huntington's disease, which of the following represents an early neuroimaging finding, even before evident atrophy on MRI?
In the context of Huntington's disease, which of the following represents an early neuroimaging finding, even before evident atrophy on MRI?
A clinician suspects CJD in a patient presenting with rapid cognitive decline. If initial CT imaging is unremarkable, which subsequent imaging technique would be most informative?
A clinician suspects CJD in a patient presenting with rapid cognitive decline. If initial CT imaging is unremarkable, which subsequent imaging technique would be most informative?
Why is SPECT or positron emission tomography imaging important in the differential diagnosis of Lewy Body Dementia compared to Alzheimer's Disease?
Why is SPECT or positron emission tomography imaging important in the differential diagnosis of Lewy Body Dementia compared to Alzheimer's Disease?
Flashcards
Huntington's Disease (Neuroimaging)
Huntington's Disease (Neuroimaging)
Bilateral atrophy of the caudate nucleus head, putamen and globus pallidus.
CJD (Creutzfeldt-Jakob disease) MRI
CJD (Creutzfeldt-Jakob disease) MRI
May show high signal changes in the putamen and caudate head, and cortical hypersensitivity on FLAIR sequences
Lewy Body Dementia (imaging)
Lewy Body Dementia (imaging)
Low dopamine transporter uptake in the basal ganglia demonstrated by SPECT or positron emission tomography imaging.
Semantic Dementia (features)
Semantic Dementia (features)
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FrontoTemporal Dementia (imaging)
FrontoTemporal Dementia (imaging)
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Vascular Dementia (MRI findings)
Vascular Dementia (MRI findings)
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Alzheimer's Dementia (brain)
Alzheimer's Dementia (brain)
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Study Notes
- Neuroimaging is used to study dementias
Huntington's Disease
- Neuroimaging shows bilateral atrophy of the head of the caudate nucleus, putamen, and globus pallidus
- Single-photon emission computed tomography scans show cerebral hypoperfusion in the basal ganglia
- Cerebral hypoperfusion in the basal ganglia can occur even before atrophy is evident on MRI scan
CJD (Creutzfeldt-Jakob disease)
- Computed tomography imaging is often normal or shows non-specific atrophy
- Magnetic resonance imaging (MRI) may show high signal changes in the putamen and caudate head
- MRI may show cortical hypersensitivity on fluid-attenuated inversion recovery (FLAIR) sequences
Lewy Body Dementia
- There is low dopamine transporter uptake in the basal ganglia
- This is demonstrated by SPECT or positron emission tomography imaging
Semantic Dementia
- Includes temporal lobe atrophy, more prominent on the left side
- Atrophy of the anterior temporal lobe is characteristically more pronounced than that of the posterior temporal lobe
FrontoTemporal Dementia
- MRI scans show bifrontal and temporal atrophy
Vascular Dementia
- Magnetic resonance imaging (MRI) reveals diffuse white matter lesions of the cerebral hemispheres
- White matter lesions especially occur in the anterior temporal lobes and external capsules
Alzheimer's Dementia
- Disproportionate bilateral atrophy of the hippocampi
- Generalized cortical atrophy is typically present
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