Neurogenesis and Adult Neural Stem Cells

<p>It enables the study of stem cell migration and differentiation in their natural environment. (B)</p> Signup and view all the answers

<p>Humans lack the olfactory bulb, which is a major site of neurogenesis in rodents. (D)</p> Signup and view all the answers

<p>It can exacerbate symptoms of the disease. (C)</p> Signup and view all the answers

<p>They have long apical processes that extend towards the ventricular zone. (A)</p> Signup and view all the answers

<p>It contributes to the plasticity and adaptability of the hippocampus. (B)</p> Signup and view all the answers

<p>All of the above (D)</p> Signup and view all the answers

<p>Ascl1CreER(T2)/tdTOMATO labels a more restricted population of stem cells (A)</p> Signup and view all the answers

<p>Enriched environment (D)</p> Signup and view all the answers

<p>Facilitating spatial memory formation (B)</p> Signup and view all the answers

<p>It produces lipids that contribute to the structure and function of new neurons (A)</p> Signup and view all the answers

<p>The mutation disrupts the lipid metabolism within neural stem cells, affecting their ability to proliferate (D)</p> Signup and view all the answers

<p>All of the above (D)</p> Signup and view all the answers

<p>It significantly increases the number of new neurons in the hippocampus (A)</p> Signup and view all the answers

<p>Decreased amplitude of LTP (B)</p> Signup and view all the answers

<p>They are not specific to stem cells, affecting other cell types as well (A)</p> Signup and view all the answers

<p>Assessing the impact of neurogenesis on spatial memory and pattern separation (B)</p> Signup and view all the answers

<p>It reveals how previous cell divisions influence stem cell behavior and responses to stimuli (A)</p> Signup and view all the answers

<p>Enhanced cognitive flexibility (A)</p> Signup and view all the answers

<p>Neurogenesis may play a crucial role in the therapeutic effects of antidepressants (B)</p> Signup and view all the answers

<p>Reduced neurogenesis affects the ability of the hippocampus to distinguish similar experiences (B)</p> Signup and view all the answers

<p>Lipid metabolism plays a critical role in regulating neurogenesis (C)</p> Signup and view all the answers

<p>Intravital Imaging</p> Signup and view all the answers

<p>Ultra-low wavelength photon laser</p> Signup and view all the answers

<p>Intravital imaging</p> Signup and view all the answers

<p>construction of lineage tree, stem cell dynamics, cell division modes, migration and integration, functional properties, self-renewal potential</p> Signup and view all the answers

<p>Exercise, Enriched environment, Learning</p> Signup and view all the answers

<p>Aging, drug and alcohol, neurodegenerative diseases, depression, and chronic stress</p> Signup and view all the answers

<p>subgranular zone</p> Signup and view all the answers

<p>Lower induction threshold for long-term potentiation (LTP), Increased LTP amplitude, Increased intrinsic excitability</p> Signup and view all the answers

<p>impairments in spatial pattern separation</p> Signup and view all the answers

<p>glucose into fatty acids</p> Signup and view all the answers

<p>FASN (Fatty Acid Synthase)</p> Signup and view all the answers

<p>long-term, slow-cycling</p> Signup and view all the answers

<p>transient, rapidly dividing</p> Signup and view all the answers

<p>SHH (A)</p> Signup and view all the answers

<p>Notch (A)</p> Signup and view all the answers

A technique to visualize newly synthesized DNA in cells using BrdU markers.

Identification of newly synthesized neurons by detecting both BrdU and NeuN markers.

A method that uses C14 isotopes to date the age of neurons based on their incorporation during neurogenesis.

The process of generating new neurons in the adult brain, primarily in the hippocampus.

Regions in the brain where new neurons are generated, like the subventricular zone and hippocampus.

Part of the hippocampus involved in deciding which memories are stored long-term.

Reduced neurogenesis is seen in neuro-psychiatric disorders like depression and with aging.

A technique allowing observation of living neural stem cells through a cortical window.

Procedures that do not adversely affect the mice but allow study of stem cells.

A method to label individual stem cells for tracking lineages.

The study of behavior and characteristics of stem cells over time.

Evidence showing that some neural stem cells can renew themselves indefinitely.

Variables such as age, substance abuse, and stress that reduce the production of new neurons.

Exercise has been shown to double the production of new neurons in the hippocampus of mice.

A test to measure learning and memory in mice based on latency and distance.

New neurons have heightened responsiveness and firing potential.

The process of converting glucose into fatty acids in the brain.

Fatty acid synthase is crucial for neural stem cell function and neurogenesis.

A mutation linked to cognitive disorders and deficits in neurogenesis.

The ability of the hippocampus to distinguish similar experiences as unique.

Severe stress leads to significant reductions in the formation of new neurons.

Medications like Prozac can increase the production of neurons over time.

The process of creating new neurons continues into adulthood.