Podcast
Questions and Answers
What is one way to approach disease aetiology using iPS cells?
What is one way to approach disease aetiology using iPS cells?
- Comparing the growth of iPS cells with embryonic stem cells
- Studying environmental risk factors in iPS cells
- Comparing the growth of patient-derived neurons with control-derived neurons (correct)
- Inducing mutations in iPS cells with CRISPR-cas9
Where in the adult brain have two neurogenic niches been consistently found in rodents?
Where in the adult brain have two neurogenic niches been consistently found in rodents?
- Subventricular zones of the lateral ventricle and subgranular zone of the dentate gyrus (correct)
- Cerebellum and brainstem
- Frontal lobe and occipital lobe
- Olfactory bulb and hippocampus
What technology development in the early '90s was crucial for proving neurogenesis in the adult brain?
What technology development in the early '90s was crucial for proving neurogenesis in the adult brain?
- Use of genetic engineering
- Invention of advanced microscopes (correct)
- Development of new imaging techniques
- Introduction of neuroimaging software
Which genome editing system is mentioned as one of the ways to induce genetic variation into cells?
Which genome editing system is mentioned as one of the ways to induce genetic variation into cells?
Where do newborn neurons migrate to in the adult brain after being generated in the subventricular zones?
Where do newborn neurons migrate to in the adult brain after being generated in the subventricular zones?
What is the purpose of inducing genetic variants into iPS cells?
What is the purpose of inducing genetic variants into iPS cells?
Who conducted elegant work assessing neurogenesis in postmortem human brains using C14 concentration measurement?
Who conducted elegant work assessing neurogenesis in postmortem human brains using C14 concentration measurement?
What are some examples of genetic variation induction methods mentioned in the text?
What are some examples of genetic variation induction methods mentioned in the text?
What kind of variants can be induced into iPS cells according to the text?
What kind of variants can be induced into iPS cells according to the text?
What does the concentration of nuclear-bomb-test-derived C14 in genomic DNA correlate with in postmortem human brains?
What does the concentration of nuclear-bomb-test-derived C14 in genomic DNA correlate with in postmortem human brains?
Which region besides the hippocampus has demonstrated the generation of new neurons throughout adulthood?
Which region besides the hippocampus has demonstrated the generation of new neurons throughout adulthood?
What is the focus of studying environmental risk factors in relation to disease aetiology?
What is the focus of studying environmental risk factors in relation to disease aetiology?
What was the purpose of the initial experiment where all 24 factors were transfected into fibroblasts?
What was the purpose of the initial experiment where all 24 factors were transfected into fibroblasts?
What is the significance of repeating the experiment with only 23 factors by leaving one out each time?
What is the significance of repeating the experiment with only 23 factors by leaving one out each time?
What is the main idea behind repeating the infection with 23 factors multiple times?
What is the main idea behind repeating the infection with 23 factors multiple times?
Why did the researcher choose to infect fibroblasts with 23 factors instead of all 24 in the subsequent experiments?
Why did the researcher choose to infect fibroblasts with 23 factors instead of all 24 in the subsequent experiments?
What is the main goal of generating blue colonies in the subsequent experiments as mentioned in the text?
What is the main goal of generating blue colonies in the subsequent experiments as mentioned in the text?
What conclusion can be drawn if blue colonies are still observed when one factor is omitted in the experiments?
What conclusion can be drawn if blue colonies are still observed when one factor is omitted in the experiments?
What gene is being referred to as CACNA1C in the text?
What gene is being referred to as CACNA1C in the text?
What is the main focus of the study mentioned in the text?
What is the main focus of the study mentioned in the text?
Which type of cells were generated from patients with Timothy syndrome and control individuals?
Which type of cells were generated from patients with Timothy syndrome and control individuals?
What was the major finding regarding the behavior of the calcium channel in neurons derived from Timothy syndrome patients?
What was the major finding regarding the behavior of the calcium channel in neurons derived from Timothy syndrome patients?
What did the researchers observe when treating cells with an inhibitor of calcium flux?
What did the researchers observe when treating cells with an inhibitor of calcium flux?
Besides neurons, where else are calcium channels highlighted for their importance?
Besides neurons, where else are calcium channels highlighted for their importance?
What is a challenge associated with the variability of cells taken from control individuals?
What is a challenge associated with the variability of cells taken from control individuals?
Why does the text mention that every mouse in a colony is genetically identical?
Why does the text mention that every mouse in a colony is genetically identical?
What is a key characteristic of the disorders being studied according to the text?
What is a key characteristic of the disorders being studied according to the text?
What does the text suggest as a challenge with the iPS system in relation to brain disorders?
What does the text suggest as a challenge with the iPS system in relation to brain disorders?
What kind of properties are considered inaccessible when studying disorders like schizophrenia or autism?
What kind of properties are considered inaccessible when studying disorders like schizophrenia or autism?
Why did the text mention Madeline Lancaster's work with growing cerebral organoids?
Why did the text mention Madeline Lancaster's work with growing cerebral organoids?
