Podcast
Questions and Answers
Which type of communication involves a hormone directly influencing the cell that released it?
Which type of communication involves a hormone directly influencing the cell that released it?
- Paracrine
- Endocrine
- Autocrine (correct)
- Neurocrine
Which type of communication is exemplified by the release of digestive enzymes by the pancreas into the lumen of the digestive system?
Which type of communication is exemplified by the release of digestive enzymes by the pancreas into the lumen of the digestive system?
- Autocrine
- Paracrine
- Exocrine (correct)
- Endocrine
Which of the following is NOT a characteristic of neuroendocrine communication?
Which of the following is NOT a characteristic of neuroendocrine communication?
- Target cells are restricted to a specific location (correct)
- Communication is relatively slow
- Involves the release of neurohormones
- Communication is indirect
Which of the following is a hypothalamic releasing factor?
Which of the following is a hypothalamic releasing factor?
What is the primary function of hypothalamic releasing factors?
What is the primary function of hypothalamic releasing factors?
How does somatostatin affect the pituitary gland?
How does somatostatin affect the pituitary gland?
Which of the following is NOT a difference between neuronal and neuroendocrine communication?
Which of the following is NOT a difference between neuronal and neuroendocrine communication?
Which of the following is an example of a neurohormone?
Which of the following is an example of a neurohormone?
Which part of the pituitary gland is associated with the storage and release of hormones produced in the hypothalamus?
Which part of the pituitary gland is associated with the storage and release of hormones produced in the hypothalamus?
What role do neuroendocrine cells play in hormone secretion?
What role do neuroendocrine cells play in hormone secretion?
What type of hormones are produced in the hypothalamus and influence peripheral organs?
What type of hormones are produced in the hypothalamus and influence peripheral organs?
What is the main characteristic of the cleavage process involving prohormone convertases?
What is the main characteristic of the cleavage process involving prohormone convertases?
What initiates the process of neuropeptide expression regulation?
What initiates the process of neuropeptide expression regulation?
Which part of the brain houses neurons that are integral for neuroendocrine function?
Which part of the brain houses neurons that are integral for neuroendocrine function?
Which embryonic layer is responsible for forming the central nervous system (CNS)?
Which embryonic layer is responsible for forming the central nervous system (CNS)?
What role does the hypothalamus play in relation to the pituitary gland?
What role does the hypothalamus play in relation to the pituitary gland?
What structure is formed during the gastrulation period that contributes to the CNS?
What structure is formed during the gastrulation period that contributes to the CNS?
How is the hypothalamic region connected to the blood supply?
How is the hypothalamic region connected to the blood supply?
What term describes a bundle of axonal nerve fibers with a common origin and target?
What term describes a bundle of axonal nerve fibers with a common origin and target?
Which of the following neuropeptides is an example of a neurotransmitter as well as a neurohormone?
Which of the following neuropeptides is an example of a neurotransmitter as well as a neurohormone?
Which area of the hypothalamus is most involved in regulating appetitive behavior?
Which area of the hypothalamus is most involved in regulating appetitive behavior?
Which region of the hypothalamus is characterized by neuroendocrine nuclei and is very close to the 3rd ventricle?
Which region of the hypothalamus is characterized by neuroendocrine nuclei and is very close to the 3rd ventricle?
What type of neurons are predominantly found in the supraoptic nucleus?
What type of neurons are predominantly found in the supraoptic nucleus?
Which hormone is secreted by the anterior lobe of the pituitary gland and is responsible for stimulating the adrenal cortex?
Which hormone is secreted by the anterior lobe of the pituitary gland and is responsible for stimulating the adrenal cortex?
Which cell types in the anterior lobe of the pituitary are responsible for the production of Luteinizing Hormone (LH)?
Which cell types in the anterior lobe of the pituitary are responsible for the production of Luteinizing Hormone (LH)?
Which nucleus is primarily associated with the biological clock of the body?
Which nucleus is primarily associated with the biological clock of the body?
What is the primary function of Melanocyte Stimulating Hormone (MSH)?
What is the primary function of Melanocyte Stimulating Hormone (MSH)?
What triggers the release of renin in the kidneys?
What triggers the release of renin in the kidneys?
Which lobe of the pituitary gland is connected to the hypothalamus via the median eminence?
Which lobe of the pituitary gland is connected to the hypothalamus via the median eminence?
How does apelin affect vasopressin secretion?
How does apelin affect vasopressin secretion?
What role does oxytocin play during childbirth?
What role does oxytocin play during childbirth?
What is the main role of Prolactin (PRL) in the pituitary gland?
What is the main role of Prolactin (PRL) in the pituitary gland?
Which hormone is NOT secreted by the anterior lobe of the pituitary gland?
Which hormone is NOT secreted by the anterior lobe of the pituitary gland?
What effect does apelin have on the volume of urine secreted?
What effect does apelin have on the volume of urine secreted?
What physiological response occurs when there is water deprivation?
What physiological response occurs when there is water deprivation?
Which hypothalamic zone is extensively connected throughout the brain and is involved in motivated behaviors?
Which hypothalamic zone is extensively connected throughout the brain and is involved in motivated behaviors?
Which neuropeptide is involved in the regulation of AVP neurons?
Which neuropeptide is involved in the regulation of AVP neurons?
Which hormone produced by the anterior lobe is primarily responsible for stimulating growth in tissues?
Which hormone produced by the anterior lobe is primarily responsible for stimulating growth in tissues?
What morphological change occurs in oxytocin neurons during late pregnancy?
What morphological change occurs in oxytocin neurons during late pregnancy?
Which nucleus is a mix of magnocellular and parvocellular components in the hypothalamus?
Which nucleus is a mix of magnocellular and parvocellular components in the hypothalamus?
What is the primary structural function of the infundibulum in the context of the pituitary gland?
What is the primary structural function of the infundibulum in the context of the pituitary gland?
What is the primary role of oxytocin during lactation?
What is the primary role of oxytocin during lactation?
Which neurotransmitter's receptors insertion is increased due to stimulation of magnocellular neurons?
Which neurotransmitter's receptors insertion is increased due to stimulation of magnocellular neurons?
Which component of the hypothalamic medio-lateral zones has not been clearly associated with a specific function due to its complexity?
Which component of the hypothalamic medio-lateral zones has not been clearly associated with a specific function due to its complexity?
How are oxytocin and vasopressin related?
How are oxytocin and vasopressin related?
Which physiological effect does oxytocin NOT have?
Which physiological effect does oxytocin NOT have?
What is the primary function of the angiotensin system?
What is the primary function of the angiotensin system?
What leads to the release of oxytocin during labor?
What leads to the release of oxytocin during labor?
What occurs to the somatic cells of oxytocin neurons as pregnancy progresses?
What occurs to the somatic cells of oxytocin neurons as pregnancy progresses?
What is the primary role of FSH during the follicular phase of the menstrual cycle?
What is the primary role of FSH during the follicular phase of the menstrual cycle?
What signifies the transition from negative feedback to positive feedback in the menstrual cycle?
What signifies the transition from negative feedback to positive feedback in the menstrual cycle?
What happens to the corpus luteum if pregnancy does not occur?
What happens to the corpus luteum if pregnancy does not occur?
What is the primary function of GnRH produced by GnRH neurons?
What is the primary function of GnRH produced by GnRH neurons?
How does a frame-shift mutation in the GnRH1 gene affect puberty?
How does a frame-shift mutation in the GnRH1 gene affect puberty?
What physiological effect does high progesterone have during the luteal phase?
What physiological effect does high progesterone have during the luteal phase?
What regulates the episodic release of GnRH in males?
What regulates the episodic release of GnRH in males?
What dual role do the dendrons of GnRH neurons serve?
What dual role do the dendrons of GnRH neurons serve?
What occurs in the preoptic area of the brain concerning GnRH?
What occurs in the preoptic area of the brain concerning GnRH?
In females, what triggers the surge release of GnRH?
In females, what triggers the surge release of GnRH?
How does Kallman's syndrome affect olfactory function?
How does Kallman's syndrome affect olfactory function?
What is a consequence of the lack of GnRH secretion?
What is a consequence of the lack of GnRH secretion?
What characterizes the secretion dynamics of GnRH in the menstrual cycle?
What characterizes the secretion dynamics of GnRH in the menstrual cycle?
During which phase does the dominant follicle release the oocyte?
During which phase does the dominant follicle release the oocyte?
What is the effect of hypertonic saline on OT release in the posterior pituitary during stimulation?
What is the effect of hypertonic saline on OT release in the posterior pituitary during stimulation?
What role do noradrenergic neurons play during parturition in relation to OT release?
What role do noradrenergic neurons play during parturition in relation to OT release?
What is the primary function of Vasopressin (ADH) in the body?
What is the primary function of Vasopressin (ADH) in the body?
How do OT neurons respond to elevated plasma osmolality?
How do OT neurons respond to elevated plasma osmolality?
What impact does oxytocin have on food intake and body weight regulation?
What impact does oxytocin have on food intake and body weight regulation?
Which structure in the hypothalamus produces hormones released directly into the bloodstream?
Which structure in the hypothalamus produces hormones released directly into the bloodstream?
What characterizes the histology of the anterior pituitary gland?
What characterizes the histology of the anterior pituitary gland?
What occurs with vasopressin release in relation to hypertonic stimulation?
What occurs with vasopressin release in relation to hypertonic stimulation?
What triggers the release of corticotropin-releasing hormone (CRH) from the hypothalamus?
What triggers the release of corticotropin-releasing hormone (CRH) from the hypothalamus?
What influences the activation of OT neurons during lactation?
What influences the activation of OT neurons during lactation?
Which statement best describes the relationship between OT and the HPA axis during stress?
Which statement best describes the relationship between OT and the HPA axis during stress?
Where is the main location of gonadotropin production in the hypothalamus?
Where is the main location of gonadotropin production in the hypothalamus?
What is the effect of removing parvocellular OT neurons observed in humans?
What is the effect of removing parvocellular OT neurons observed in humans?
Which type of feedback mechanism involves the target organ sending signals back to the hypothalamus via hormones?
Which type of feedback mechanism involves the target organ sending signals back to the hypothalamus via hormones?
What is the role of pituicytes in the lobus nervosus?
What is the role of pituicytes in the lobus nervosus?
How do the roles of OT during pregnancy and lactation differ from its role in overall osmoregulation?
How do the roles of OT during pregnancy and lactation differ from its role in overall osmoregulation?
Which factor other than noradrenaline modulates OT neurons?
Which factor other than noradrenaline modulates OT neurons?
How does adrenalectomy affect CRH production in the medial eminence?
How does adrenalectomy affect CRH production in the medial eminence?
What distinguishes the parvocellular system in the hypothalamus?
What distinguishes the parvocellular system in the hypothalamus?
What happens to OT release after stress in animals with intact adrenal glands?
What happens to OT release after stress in animals with intact adrenal glands?
During hypertonic stimulation, what differentiates OT release from that of vasopressin?
During hypertonic stimulation, what differentiates OT release from that of vasopressin?
What is a characteristic of the feedback control of hypothalamic hormone release?
What is a characteristic of the feedback control of hypothalamic hormone release?
What effect does the antagonist have on vasopressin secretion in neurons?
What effect does the antagonist have on vasopressin secretion in neurons?
Which neuropeptides are synthesized by CRH neurons in the paraventricular nucleus (PVN)?
Which neuropeptides are synthesized by CRH neurons in the paraventricular nucleus (PVN)?
What is the primary function of extrahypothalamic projections of parvocellular OT neurons?
What is the primary function of extrahypothalamic projections of parvocellular OT neurons?
What is the primary effect of using colchicine in studying CRH neurons?
What is the primary effect of using colchicine in studying CRH neurons?
What distinguishes the magnocellular system in terms of hormone release?
What distinguishes the magnocellular system in terms of hormone release?
Which hormone is primarily associated with the role of stimulating uterine contractions?
Which hormone is primarily associated with the role of stimulating uterine contractions?
Where is oxytocin primarily located within the paraventricular nucleus?
Where is oxytocin primarily located within the paraventricular nucleus?
Which hormone is directly involved in stimulating uterine contractions during childbirth?
Which hormone is directly involved in stimulating uterine contractions during childbirth?
What is the primary action of vasopressin in the kidneys?
What is the primary action of vasopressin in the kidneys?
Which structure contains neurons that predominantly release both oxytocin and vasopressin?
Which structure contains neurons that predominantly release both oxytocin and vasopressin?
What role do neurophysins play in the secretion of oxytocin and vasopressin?
What role do neurophysins play in the secretion of oxytocin and vasopressin?
What kind of neurotransmission do oxytocin and vasopressin utilize in their receptors?
What kind of neurotransmission do oxytocin and vasopressin utilize in their receptors?
Which part of the hypothalamus responds to visceral mechanical stimuli to regulate oxytocin and vasopressin release?
Which part of the hypothalamus responds to visceral mechanical stimuli to regulate oxytocin and vasopressin release?
What happens to vasopressin secretion in response to increased plasma osmolality?
What happens to vasopressin secretion in response to increased plasma osmolality?
Which neuropeptide is likely involved in regulating vasopressin release in the neurohypophysis?
Which neuropeptide is likely involved in regulating vasopressin release in the neurohypophysis?
Which elements are crucial for the structural formation of oxytocin and vasopressin?
Which elements are crucial for the structural formation of oxytocin and vasopressin?
Which hormone is classified as the 'antidiuretic hormone'?
Which hormone is classified as the 'antidiuretic hormone'?
What is a characteristic feature of the anatomy of the paraventricular nucleus compared to the supraoptic nucleus?
What is a characteristic feature of the anatomy of the paraventricular nucleus compared to the supraoptic nucleus?
What typically happens to vasopressin levels during hypotension?
What typically happens to vasopressin levels during hypotension?
What role do inhibins play during the luteal phase with regard to FSH levels?
What role do inhibins play during the luteal phase with regard to FSH levels?
How does myostatin affect FSH production?
How does myostatin affect FSH production?
What is the primary source of the growth hormone for follicles during the follicular phase?
What is the primary source of the growth hormone for follicles during the follicular phase?
What happens to non-dominant follicles at the end of the follicular phase?
What happens to non-dominant follicles at the end of the follicular phase?
Which statement about follicle development is true?
Which statement about follicle development is true?
What triggers the start of meiosis in an oocyte?
What triggers the start of meiosis in an oocyte?
What is the main function of inhibin B during the follicular phase?
What is the main function of inhibin B during the follicular phase?
What effect does the presence of myostatin have on gonadotrope-produced activin B?
What effect does the presence of myostatin have on gonadotrope-produced activin B?
How does the social context influence sugar consumption in subordinate male mice when oxytocin receptor blockade occurs?
How does the social context influence sugar consumption in subordinate male mice when oxytocin receptor blockade occurs?
Why do all females start life with a complete set of oocytes?
Why do all females start life with a complete set of oocytes?
What role do parvocellular oxytocin neurons play in the context of pain perception?
What role do parvocellular oxytocin neurons play in the context of pain perception?
What causes the dominant follicle to continue to develop in the presence of reduced FSH?
What causes the dominant follicle to continue to develop in the presence of reduced FSH?
Which scenario illustrates the influence of oxytocin on maternal behavior in female mammals?
Which scenario illustrates the influence of oxytocin on maternal behavior in female mammals?
In which type of relationships is oxytocin particularly significant?
In which type of relationships is oxytocin particularly significant?
At what stage do follicles become sensitive to FSH?
At what stage do follicles become sensitive to FSH?
What is a consequence of the absence of a father in offspring development?
What is a consequence of the absence of a father in offspring development?
How does circulating estradiol affect FSH levels during the follicular phase?
How does circulating estradiol affect FSH levels during the follicular phase?
What initiates the transition from the luteal phase to the follicular phase?
What initiates the transition from the luteal phase to the follicular phase?
How does oxytocin influence stress responses in females?
How does oxytocin influence stress responses in females?
What changes occur to oxytocin receptor expression around parturition?
What changes occur to oxytocin receptor expression around parturition?
How does oxytocin relate to reproductive processes in males?
How does oxytocin relate to reproductive processes in males?
What role does estradiol play in the regulation of kisspeptin neurons in the ARC nucleus?
What role does estradiol play in the regulation of kisspeptin neurons in the ARC nucleus?
How is the LH surge triggered during the menstrual cycle?
How is the LH surge triggered during the menstrual cycle?
What is a significant difference between prairie voles and montane voles regarding oxytocin receptors?
What is a significant difference between prairie voles and montane voles regarding oxytocin receptors?
Why are animal models like voles valuable for studying social relationships?
Why are animal models like voles valuable for studying social relationships?
What happens to kisspeptin neuron activity during the first two stages of the menstrual cycle?
What happens to kisspeptin neuron activity during the first two stages of the menstrual cycle?
What is the effect of progesterone on kisspeptin neurons after ovulation?
What is the effect of progesterone on kisspeptin neurons after ovulation?
What does oxytocin do in relation to autism spectrum disorders?
What does oxytocin do in relation to autism spectrum disorders?
What is one effect of oxytocin on cardiac synchronization during close relationships?
What is one effect of oxytocin on cardiac synchronization during close relationships?
Why do KO estrogen receptor animals exhibit infertility?
Why do KO estrogen receptor animals exhibit infertility?
Which hormone is primarily responsible for stimulating the release of FSH and LH from the anterior pituitary?
Which hormone is primarily responsible for stimulating the release of FSH and LH from the anterior pituitary?
How does the action of estradiol on kisspeptin neurons differ between the ARC and AVPV?
How does the action of estradiol on kisspeptin neurons differ between the ARC and AVPV?
What do high levels of estrogen stimulate in terms of GnRH secretion?
What do high levels of estrogen stimulate in terms of GnRH secretion?
What is true about estrogen in females during the ovulatory phase?
What is true about estrogen in females during the ovulatory phase?
What pattern of GnRH neuron activity is observed during the LH surge?
What pattern of GnRH neuron activity is observed during the LH surge?
What role does the suprachiasmatic nucleus play in rodent hormone regulation?
What role does the suprachiasmatic nucleus play in rodent hormone regulation?
How does Erα influence kisspeptin expression in the AVPV?
How does Erα influence kisspeptin expression in the AVPV?
What is the main output of KNDy neurons?
What is the main output of KNDy neurons?
What triggers the negative feedback mechanism in the ARC nucleus?
What triggers the negative feedback mechanism in the ARC nucleus?
Which statement describes the roles of kisspeptin in the regulation of GnRH in female rats?
Which statement describes the roles of kisspeptin in the regulation of GnRH in female rats?
What mechanism is primarily responsible for the secretion of LH and FSH?
What mechanism is primarily responsible for the secretion of LH and FSH?
Which neurotransmitter is known to inhibit KNDy neurons?
Which neurotransmitter is known to inhibit KNDy neurons?
What changes occur to the kisspeptin expression when a female is ovariectomized (OVX) and then treated with E2?
What changes occur to the kisspeptin expression when a female is ovariectomized (OVX) and then treated with E2?
What effect does kisspeptin have on GNRH neurons?
What effect does kisspeptin have on GNRH neurons?
What happens after blocking kisspeptin with an antagonist?
What happens after blocking kisspeptin with an antagonist?
Which phase of the menstrual cycle is characterized by negative feedback due to high estradiol levels?
Which phase of the menstrual cycle is characterized by negative feedback due to high estradiol levels?
Where do estrogen receptors (Er) predominantly exert a negative feedback effect?
Where do estrogen receptors (Er) predominantly exert a negative feedback effect?
What is the consequence of knocking out the kisspeptin gene in an organism?
What is the consequence of knocking out the kisspeptin gene in an organism?
What does the presence of estradiol do to kisspeptin mRNA expression in OVX females?
What does the presence of estradiol do to kisspeptin mRNA expression in OVX females?
What type of receptor is KISS1R (kisspeptin receptor)?
What type of receptor is KISS1R (kisspeptin receptor)?
What is the effect of estradiol on KNDy neuronal activity?
What is the effect of estradiol on KNDy neuronal activity?
What is the role of neurokin B in relation to KNDy neurons?
What is the role of neurokin B in relation to KNDy neurons?
What is one result of LH pulse frequency in OVX primates compared to those with their ovaries intact?
What is one result of LH pulse frequency in OVX primates compared to those with their ovaries intact?
What regulates the activity of GNRH and consequently LH release in females?
What regulates the activity of GNRH and consequently LH release in females?
How does the administration of a GNRH receptor antagonist affect LH and FSH levels in postmenopausal women?
How does the administration of a GNRH receptor antagonist affect LH and FSH levels in postmenopausal women?
In Kallman's syndrome, why does pulsatile GNRH administration result in a normal menstrual cycle?
In Kallman's syndrome, why does pulsatile GNRH administration result in a normal menstrual cycle?
What is the role of estrogen in regulating LH and FSH levels?
What is the role of estrogen in regulating LH and FSH levels?
Which of the following statements accurately describes the structure of LH and FSH?
Which of the following statements accurately describes the structure of LH and FSH?
How does the frequency of GNRH pulses influence the secretion of LH and FSH?
How does the frequency of GNRH pulses influence the secretion of LH and FSH?
During the follicular phase of the menstrual cycle, FSH levels are higher than LH levels. Considering the effect of GNRH pulse frequency on LH and FSH secretion, what would you predict about the pulse frequency during this phase?
During the follicular phase of the menstrual cycle, FSH levels are higher than LH levels. Considering the effect of GNRH pulse frequency on LH and FSH secretion, what would you predict about the pulse frequency during this phase?
Which of the following hormones directly inhibits FSH secretion?
Which of the following hormones directly inhibits FSH secretion?
How do activins influence FSH secretion?
How do activins influence FSH secretion?
Which of the following is a factor that contributes to the secondary FSH surge during the estrus cycle in rodents?
Which of the following is a factor that contributes to the secondary FSH surge during the estrus cycle in rodents?
What is the effect of knocking out activin type II receptors in animal models?
What is the effect of knocking out activin type II receptors in animal models?
What is the role of LH in the regulation of ovulation?
What is the role of LH in the regulation of ovulation?
How does FSH differ from LH in terms of its target cells and functions?
How does FSH differ from LH in terms of its target cells and functions?
What is the main difference between the common α subunit of LH and FSH and their unique β subunits?
What is the main difference between the common α subunit of LH and FSH and their unique β subunits?
How is the differential regulation of LH and FSH secretion achieved, even though they are produced in the same cells and share the same α subunit?
How is the differential regulation of LH and FSH secretion achieved, even though they are produced in the same cells and share the same α subunit?
What is the primary mechanism by which inhibins regulate FSH secretion?
What is the primary mechanism by which inhibins regulate FSH secretion?
Flashcards
Neuroendocrine communication
Neuroendocrine communication
A specialized form of communication between nerve cells and hormones in animals.
Autocrine signaling
Autocrine signaling
Hormones or messengers that affect the releasing cell itself.
Paracrine signaling
Paracrine signaling
Hormones that affect nearby target cells, like in epithelial cells.
Endocrine signaling
Endocrine signaling
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Neurocrine signaling
Neurocrine signaling
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Hormone
Hormone
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Hypothalamic releasing factors
Hypothalamic releasing factors
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Neuronal vs Neuroendocrine communication
Neuronal vs Neuroendocrine communication
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Periventricular zone
Periventricular zone
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Lateral Hypothalamic Area (LHA)
Lateral Hypothalamic Area (LHA)
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Supraoptic nucleus
Supraoptic nucleus
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Paraventricular nucleus
Paraventricular nucleus
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Anterior hypothalamus
Anterior hypothalamus
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Pituitary gland
Pituitary gland
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Growth Hormone (GH)
Growth Hormone (GH)
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Adrenocorticotropic Hormone (ACTH)
Adrenocorticotropic Hormone (ACTH)
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Thyroid-stimulating Hormone (TSH)
Thyroid-stimulating Hormone (TSH)
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Follicle-stimulating Hormone (FSH)
Follicle-stimulating Hormone (FSH)
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Luteinizing Hormone (LH)
Luteinizing Hormone (LH)
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Prolactin (PRL)
Prolactin (PRL)
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Melanocyte Stimulating Hormone (MSH)
Melanocyte Stimulating Hormone (MSH)
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Oxytocin
Oxytocin
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Angiotensin system
Angiotensin system
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Renin
Renin
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Apelin
Apelin
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Vasopressin (AVP)
Vasopressin (AVP)
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Osmoregulation
Osmoregulation
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Oxytocin (OT)
Oxytocin (OT)
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Magnocellular neurons
Magnocellular neurons
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Plasticity of magnocellular system
Plasticity of magnocellular system
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Kisspeptin
Kisspeptin
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Dendritic priming
Dendritic priming
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AVP secretion
AVP secretion
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Uterine contraction
Uterine contraction
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Myoepithelial cells
Myoepithelial cells
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Neuropeptides
Neuropeptides
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Social behavior effects of OT
Social behavior effects of OT
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Magnocellular system
Magnocellular system
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Neurophysins
Neurophysins
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AVP and OT gene evolution
AVP and OT gene evolution
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Hormone release mechanism
Hormone release mechanism
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Paraventricular Nucleus (PVN)
Paraventricular Nucleus (PVN)
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Supraoptic Nucleus (SON)
Supraoptic Nucleus (SON)
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GABAergic neurons
GABAergic neurons
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Osmoreceptors
Osmoreceptors
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Aquaporins
Aquaporins
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Blood pressure regulation
Blood pressure regulation
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Vasotocin
Vasotocin
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Cranial nerves IX and X
Cranial nerves IX and X
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Neuroendocrine regulation
Neuroendocrine regulation
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Vasopressin
Vasopressin
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Herring bodies
Herring bodies
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Pituicytes
Pituicytes
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Parvocellular system
Parvocellular system
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Hypophysiotropic hormones
Hypophysiotropic hormones
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Feedback control
Feedback control
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Corticotropin
Corticotropin
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Adrenalectomy
Adrenalectomy
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Median eminence
Median eminence
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Colchicine
Colchicine
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Short feedback
Short feedback
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Ultrashort feedback
Ultrashort feedback
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Neurohypophyseal hormones
Neurohypophyseal hormones
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Neuroendocrine cells
Neuroendocrine cells
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Peptide hormone biosynthesis
Peptide hormone biosynthesis
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Prohormone convertases
Prohormone convertases
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Cleaving process of hormones
Cleaving process of hormones
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Central Nervous System (CNS)
Central Nervous System (CNS)
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Function of myelin
Function of myelin
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CNS development
CNS development
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Hypothalamus
Hypothalamus
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Tropic hormones
Tropic hormones
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Feedback mechanism
Feedback mechanism
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Neural crest
Neural crest
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Preoptic area
Preoptic area
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Diencephalon
Diencephalon
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Somatic nervous system
Somatic nervous system
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Dendritic release
Dendritic release
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Oxytocin (OT) burst
Oxytocin (OT) burst
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Hypertonic saline stimulation
Hypertonic saline stimulation
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Priming effect
Priming effect
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Parvocellular OT neurons
Parvocellular OT neurons
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Noradrenergic neurons
Noradrenergic neurons
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Osmoregulation and OT
Osmoregulation and OT
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OT's role in stress regulation
OT's role in stress regulation
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Postpartum OT release
Postpartum OT release
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Role of CT in appetite regulation
Role of CT in appetite regulation
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Adrenal cortex effect on OT
Adrenal cortex effect on OT
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OT during lactation
OT during lactation
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Stimulation of SFO and OVLT
Stimulation of SFO and OVLT
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OT's effect on body weight
OT's effect on body weight
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Oxytocin receptor antagonist
Oxytocin receptor antagonist
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Hierarchy in social housing
Hierarchy in social housing
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Social behavior and oxytocin
Social behavior and oxytocin
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Oxytocin in males
Oxytocin in males
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Prairie voles vs montane voles
Prairie voles vs montane voles
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Consoling behavior and OT
Consoling behavior and OT
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HPG axis
HPG axis
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GNRH
GNRH
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Negative feedback in hormones
Negative feedback in hormones
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Estrogen positive feedback
Estrogen positive feedback
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OT in autism
OT in autism
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Pain modulation by oxytocin
Pain modulation by oxytocin
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Social bonding evolution
Social bonding evolution
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OT and emotional synchrony
OT and emotional synchrony
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Menstrual Cycle
Menstrual Cycle
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Follicular Phase
Follicular Phase
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Luteal Phase
Luteal Phase
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GnRH (Gonadotropin-Releasing Hormone)
GnRH (Gonadotropin-Releasing Hormone)
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FSH (Follicle-Stimulating Hormone)
FSH (Follicle-Stimulating Hormone)
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LH (Luteinizing Hormone)
LH (Luteinizing Hormone)
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Corpus Luteum
Corpus Luteum
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Progesterone
Progesterone
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Estradiol
Estradiol
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Negative Feedback
Negative Feedback
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Positive Feedback
Positive Feedback
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Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism
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Kallmann’s Syndrome
Kallmann’s Syndrome
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GnRH Pulsatility
GnRH Pulsatility
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Endometrial Proliferation
Endometrial Proliferation
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Pulsatile GNRH secretion
Pulsatile GNRH secretion
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KNDy neurons
KNDy neurons
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Dynorphin
Dynorphin
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Neurokin B (NKB)
Neurokin B (NKB)
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Estradiol feedback
Estradiol feedback
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Kisspeptin antagonists
Kisspeptin antagonists
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Kisspeptin gene knockout
Kisspeptin gene knockout
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Estrogen receptors
Estrogen receptors
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Kisspeptin neuron activity
Kisspeptin neuron activity
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LH surge
LH surge
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Negative feedback sites
Negative feedback sites
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Co-localization of mRNA
Co-localization of mRNA
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Effects of OVX (ovariectomy)
Effects of OVX (ovariectomy)
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LH synthesis requirement
LH synthesis requirement
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FSH and estrogens relationship
FSH and estrogens relationship
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Role of myostatin
Role of myostatin
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Inhibin A and FSH
Inhibin A and FSH
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Dominant follicle
Dominant follicle
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Granulosa cells
Granulosa cells
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Atresia
Atresia
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FSH receptor expression
FSH receptor expression
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LH action on theca cells
LH action on theca cells
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Estradiol's role
Estradiol's role
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Initial recruitment signal
Initial recruitment signal
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GDF11 function
GDF11 function
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FSH deficient state
FSH deficient state
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Cumulus cells
Cumulus cells
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Theca cells
Theca cells
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Follicular phase timeline
Follicular phase timeline
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Role of estradiol
Role of estradiol
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GNRH neurons
GNRH neurons
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Estrogen receptor alpha (Erα)
Estrogen receptor alpha (Erα)
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OVX (Ovariectomy) effect
OVX (Ovariectomy) effect
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Progesterone's role
Progesterone's role
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Two populations of kisspeptin neurons
Two populations of kisspeptin neurons
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Circadian rhythm in reproductive hormones
Circadian rhythm in reproductive hormones
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cFos in GnRH neurons
cFos in GnRH neurons
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Knockout (KO) of estrogen receptor
Knockout (KO) of estrogen receptor
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Menstrual cycle stages
Menstrual cycle stages
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LH
LH
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FSH
FSH
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Activins
Activins
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Inhibins
Inhibins
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Arcuate nucleus
Arcuate nucleus
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GNRH receptor antagonist
GNRH receptor antagonist
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FSHβ expression
FSHβ expression
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Decreased FSH levels
Decreased FSH levels
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Study Notes
Neuroendocrine Communication
- Specialized form of chemical communication between animal cells
- Modes:
- Autocrine: Hormone/messenger directly affects releasing cell.
- Paracrine: Hormone affects neighboring cells (e.g., gastrointestinal system).
- Endocrine: Hormone released into blood, affects distant cells (e.g., thyroid gland).
- Neurocrine: Neurotransmitter released at synapses.
- Neuroendocrine: Neurohormones released by nerve cells into blood or portal circulation.
What is a Hormone?
- Chemical messenger produced by endocrine glands.
- Released into general circulation or interstitial space.
- Influences target cells via specific receptors.
- Phylogenetically old type of intercellular communication.
- Opposite of endocrine glands are exocrine glands (e.g., lacrimal, exocrine pancreas).
Neuronal vs. Neuroendocrine Communication
- Neuronal: Point-to-point connections, rapid communication, restricted target cells.
- Neuroendocrine: Neuron releases neurohormone into bloodstream, reaches many target cells, indirect and relatively slow.
Hormones
- Hypothalamic hormones:
- Hypothalamic releasing factors: Regulate anterior pituitary activity (e.g., stimulating or inhibiting the release of other hormones). Not stored in pituitary.
- Neurohypophyseal hormones: Produced in hypothalamus, stored and released by posterior pituitary.
Neuroendocrine Cells
- Innervated by other neurons, receive neurotransmitter stimuli, and transduce neural information to endocrine outputs.
- Located in specific brain regions (hypothalamus), vital for bodily functions.
- Conserved across species.
Biosynthesis of Peptide Hormones
- Mostly small peptides (3-4 amino acid residues).
- Can have diverse effects (neurotransmitters, neurohormones, paracrine factors).
- Pituitary and peripheral hormones tend to be larger than hypothalamic peptides.
- Diverse structures: amino acids, biogenic amines, peptides.
- Regulation involves transcription factors, processing by endosomal compartments, and secretion.
- Precursor proteins (e.g., POMC) can generate multiple hormones
- Prohormone convertases (PC2, PC3) cleave precursors at diabasic sites (2 basic amino acids).
- Cleavage process occurs in acidic environments (e.g., lysosomes) with order based on accessibility.
Anatomy of Neuron
- Soma/pericarion: Neuron body
- Dendrites: Receive signals from other neurons
- Axon: Transmits signals away from cell body, with a highly structured cytoskeleton for fast communication
- CNS: High energy/oxygen consumption, requiring abundant blood supply.
- Myelin: characteristic of long nerve cell projections.
- Tracts/projections: Bundles of axons with common origin and target.
Development of CNS
- Neurolation forms neural tube from ectoderm.
- Embryonic layers: endoderm (GI tract), mesoderm (muscles), ectoderm (skin).
- Neural crest forms PNS and melanocytes.
- Three brain vesicles (forebrain, midbrain, hindbrain) develop further.
Hypothalamus
- Crucial structure for life, connecting major brain areas.
- Transforms neural inputs into hormonal outputs, regulating pituitary gland, and other glands.
- Hypothalamic nuclei with distinct distributions (preoptic area, medial zone, periventricular zone, lateral zone).
- Contains important neuroendocrine nuclei and has vital circuits like MFB.
Pituitary Gland
- Endocrine gland located at the base of the brain.
- Connected to hypothalamus via portal system.
- Three lobes: anterior, intermediate, and posterior.
Anterior Pituitary Hormones
- Growth hormone (GH/somatotropin): Stimulates growth, protein synthesis, and metabolism.
- Adrenocorticotropic hormone (ACTH): Stimulates cortisol release from adrenal cortex.
- Thyroid-stimulating hormone (TSH/thyrotropin): Stimulates thyroid hormone release.
- Follicle-stimulating hormone (FSH): Stimulates follicle growth and hormone production.
- Luteinizing hormone (LH): Stimulates ovulation, hormone production.
- Prolactin (PRL): Stimulates milk production.
Intermediate Pituitary
- Tiny in humans.
- Produces melanocyte-stimulating hormone (MSH) and β-endorphin.
Posterior Pituitary Hormones
- Oxytocin (OT): Stimulates smooth muscle contractions.
- Vasopressin (AVP/antidiuretic hormone): Promotes water retention and regulates blood pressure.
- Neurophysins: Storage proteins for AVP & OT in Herring bodies.
Hypothalamic Hormone Release Control Systems
- Long feedback: Target organs or sensory input feedback to the hypothalamus.
- Short feedback: Pituitary hormones feedback to hypothalamic neurons.
- Ultrashort feedback: Autocrine/paracrine actions of hypothalamic hormones within a nucleus.
Magnocellular System
- OT and AVP primarily produced in PVN and SON, targeting posterior pituitary.
- Unique structure: Secretion from neuronal dendrites as well as axon terminals.
- Regulation: Visceral stimuli (cranial nerves IX & X), blood pressure sensors, brain stem nuclei (NTS), and limbic system inputs.
- Role: Osmoregulation, uterine contraction, milk ejection, blood pressure regulation.
- Water deprivation triggers OT & AVP secretion.
Oxytocin and the Posterior Pituitary
- Critical during parturition/birth, milk ejection, lactation, osmoregulation, social behaviors (bonding, stress responses).
- Plasticity: Changes in neuron synapses and astrocytic processes, allowing for coordinated neuronal and hormonal activity..
Positive and Negative Feedbacks
- Negative feedback: Steroids inhibit GnRH secretion, kisspeptin activity and synthesis via estrogen receptor-alpha (ERα).
- Positive feedback: High estrogen levels enhance kisspeptin secretion by different populations within the brain; this drives LH surge that triggers ovulation.
Regulation of Gonadotropin Synthesis and Secretion
- Glycoprotein hormones (LH, FSH) with unique beta subunits.
- Frequency of GnRH pulses influences LH and FSH expression.
- Inhibins (A, B) and activins regulate FSH.
Female Reproductive System
- HPG axis: Hypothalamic-pituitary-gonadal axis regulates reproduction through GnRH, FSH, and LH.
- Menstrual cycle with follicular and luteal phases.
- Estrogen and progesterone control ovarian function and uterine changes.
- Gonadal hormones feed back to regulate the hypothalamus.
- Positive vs negative estrogen feedback on kisspeptin release.
- Estrogen receptors ERα and ERβ plays major roles.
Kallman's Syndrome
- Genetic disorder caused by failure of GnRH neurons to migrate.
- Leads to hypogonadotropic hypogonadism (HH) and anosmia (lack of sense of smell).
Conclusion
- Neuroendocrine communication involves complex interactions between neural and hormonal systems.
- Hypothalamus, pituitary, and gonads are key components in controlling reproductive and other essential body functions.
- Numerous feedback mechanisms and precise timing of hormonal pulses are crucial for coordinated bodily functions.
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