Neurodegenerative Diseases: Natural Course
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Questions and Answers

What is the name of the phase where neurons lose function and die but symptoms are not detected in neurodegenerative diseases?

  • Symptomatic phase
  • Diagnostic phase
  • Preclinical phase (correct)
  • Intervention phase
  • In Parkinson's disease, what imbalance is created by the loss of dopaminergic (DA) neurons?

  • Imbalance between inhibitory and excitatory pathways in the motor cortex
  • Imbalance between the cerebellum and the basal ganglia
  • Imbalance between VA and VL of the Thalamus
  • Imbalance between the striatopallidal and striatonigral pathways (correct)
  • Why is pharmacological intervention during the preclinical phase of a neurodegenerative disease crucial?

  • To delay the onset of symptoms (correct)
  • To increase neurogenesis
  • To reverse neuronal cell death
  • To diagnose the disease
  • What effect does the heavier activation of the striatopallidal pathway have on the Thalamus in Parkinson's disease?

    <p>Inhibits the VA/VL nuclei</p> Signup and view all the answers

    Why is Parkinson's disease classified as a hypokinetic disorder?

    <p>Because it results in a decrease in movement and UMN excitability</p> Signup and view all the answers

    Which of the following is NOT a cardinal sign of Parkinson's Disease?

    <p>Chorea</p> Signup and view all the answers

    What is the main pathological hallmark observed in the Substantia Nigra pars compacta (SNc) of individuals with Parkinson's Disease?

    <p>Lewy Bodies</p> Signup and view all the answers

    What is the compensatory mechanism that occurs in the striatum of individuals with Parkinson's Disease due to the loss of dopaminergic neurons?

    <p>Upregulation of D1/D2 receptors</p> Signup and view all the answers

    Which theory suggests that free radicals can lead to oxidative damage in the mitochondria, potentially contributing to Parkinson's Disease?

    <p>Free Radical Theory</p> Signup and view all the answers

    Which factor is NOT associated with an increased risk of developing Parkinson's Disease?

    <p>Younger Age</p> Signup and view all the answers

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