10 Questions
What is the name of the phase where neurons lose function and die but symptoms are not detected in neurodegenerative diseases?
Preclinical phase
In Parkinson's disease, what imbalance is created by the loss of dopaminergic (DA) neurons?
Imbalance between the striatopallidal and striatonigral pathways
Why is pharmacological intervention during the preclinical phase of a neurodegenerative disease crucial?
To delay the onset of symptoms
What effect does the heavier activation of the striatopallidal pathway have on the Thalamus in Parkinson's disease?
Inhibits the VA/VL nuclei
Why is Parkinson's disease classified as a hypokinetic disorder?
Because it results in a decrease in movement and UMN excitability
Which of the following is NOT a cardinal sign of Parkinson's Disease?
Chorea
What is the main pathological hallmark observed in the Substantia Nigra pars compacta (SNc) of individuals with Parkinson's Disease?
Lewy Bodies
What is the compensatory mechanism that occurs in the striatum of individuals with Parkinson's Disease due to the loss of dopaminergic neurons?
Upregulation of D1/D2 receptors
Which theory suggests that free radicals can lead to oxidative damage in the mitochondria, potentially contributing to Parkinson's Disease?
Free Radical Theory
Which factor is NOT associated with an increased risk of developing Parkinson's Disease?
Younger Age
Learn about the natural course of neurodegenerative diseases, including the preclinical and symptomatic phases. Explore the importance of pharmacological interventions and targeting specific biochemical processes for delaying the onset of the disease.
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