Neuroanatomy and Medical Imaging Quiz
44 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which of the following are components of the peripheral nervous system, as indicated in the provided information?

  • Autonomic nerves and brain
  • Spinal nerves and cranial nerves
  • Spinal nerves and autonomic nerves (correct)
  • Brain and spinal cord
  • In neuroanatomical terminology, particularly when describing structures within the brain, the term 'rostral' is often used interchangeably with which other directional term?

  • Posterior
  • Anterior (correct)
  • Caudal
  • Ventral
  • A sagittal plane of section is best described as:

  • Any plane oriented at an angle to the midline.
  • Perpendicular to the long axis, dividing into front and back portions.
  • Horizontal, separating top from bottom portions.
  • Parallel to the midline, dividing into left and right portions. (correct)
  • In Computerized Tomography (CT) scans, image contrast, which allows differentiation of tissues, is primarily based on differences in:

    <p>Density to X-ray beam attenuation. (B)</p> Signup and view all the answers

    What is the fundamental physical principle that forms the basis of Magnetic Resonance Imaging (MRI) but not Computerized Tomography (CT) scans?

    <p>Manipulation and detection of proton spin changes. (C)</p> Signup and view all the answers

    What distinguishes T1 and T2 measurements in MRI?

    <p>T1 measures vertical spin relaxation, while T2 measures horizontal spin relaxation. (D)</p> Signup and view all the answers

    In medical imaging, what is the primary advantage of T1-weighted images compared to T2-weighted images?

    <p>T1-weighted images provide better spatial resolution for anatomical details. (D)</p> Signup and view all the answers

    What is the fundamental principle behind blood oxygen level dependent (BOLD) functional MRI (fMRI)?

    <p>The distinct magnetic properties of oxy-hemoglobin and deoxy-hemoglobin. (B)</p> Signup and view all the answers

    Which of the following cognitive functions is commonly studied using BOLD fMRI by examining activity in Broca's and Wernicke's areas?

    <p>Language processing (C)</p> Signup and view all the answers

    What is the defining characteristic of Positron Emission Tomography (PET) in comparison to MRI and fMRI?

    <p>PET involves the introduction of radioactively tagged substances. (B)</p> Signup and view all the answers

    Which neuronal zone is primarily responsible for converting graded potentials into action potentials?

    <p>Trigger Zone (A)</p> Signup and view all the answers

    What is the primary function of the Nodes of Ranvier in neuronal communication?

    <p>To increase the speed of action potential propagation (B)</p> Signup and view all the answers

    Which type of neuron is characterized by a single neurite that branches into two processes?

    <p>Unipolar (or pseudo-unipolar) (B)</p> Signup and view all the answers

    In neurons, which organelle is most directly involved in the synthesis of proteins destined for the plasma membrane or secretion?

    <p>Rough Endoplasmic Reticulum (A)</p> Signup and view all the answers

    What is the main role of the neuronal cytoskeleton?

    <p>Providing structural support, transport, and signaling pathways (C)</p> Signup and view all the answers

    Which component of the neuronal plasma membrane is primarily responsible for maintaining ion concentration gradients?

    <p>Protein pumps (A)</p> Signup and view all the answers

    What distinguishes metabotropic receptors from ionotropic receptors in neuronal signaling?

    <p>Ionotropic receptors are faster in their action compared to metabotropic receptors. (A)</p> Signup and view all the answers

    Where in the neuron are neurotransmitter enzymes primarily synthesized?

    <p>Soma (cell body) (A)</p> Signup and view all the answers

    Which cytoskeletal component is primarily associated with axonal transport?

    <p>Microtubules (C)</p> Signup and view all the answers

    Single Photon Emission Computerized Tomography (SPECT) is best characterized by which of the following?

    <p>Detection of gamma rays emitted at 180° for functional imaging. (D)</p> Signup and view all the answers

    Which of the following is NOT a function associated with the smooth endoplasmic reticulum (smooth ER) in neurons?

    <p>Protein synthesis (D)</p> Signup and view all the answers

    What is the primary function of kinesin in axonal transport?

    <p>Anterograde transport towards the terminal (D)</p> Signup and view all the answers

    Which type of glial cell is responsible for myelin production in the peripheral nervous system (PNS)?

    <p>Schwann cells (D)</p> Signup and view all the answers

    Astrocytes contribute to the blood-brain barrier (BBB) by:

    <p>Inducing tight junctions in endothelial cells (A)</p> Signup and view all the answers

    What is the primary function of microglia in the central nervous system?

    <p>Phagocytosis of cellular debris and pathogens (A)</p> Signup and view all the answers

    Saltatory conduction, which increases the speed of action potentials, is directly enabled by:

    <p>Myelin sheaths produced by glial cells (A)</p> Signup and view all the answers

    Which of the following is NOT a function of astrocytes?

    <p>Production of myelin in the CNS (B)</p> Signup and view all the answers

    Gliosis, a reactive proliferation of glial cells, is most directly a response to:

    <p>Injury or damage in the central nervous system (A)</p> Signup and view all the answers

    What is the primary finding observed in the MRI scan of the patient's brain, as described?

    <p>Abnormal signal intensity in the peri-ventricular white matter. (A)</p> Signup and view all the answers

    The areas of 'gray, gelatinous discoloration' observed in the coronal section of the brain are pathologically identified as:

    <p>Plaques, corresponding to regions of demyelination. (D)</p> Signup and view all the answers

    In the myelin stain of the spinal cord, what does the reduced or absent black staining, indicated by arrows, signify?

    <p>Tracts compromised due to myelin loss. (D)</p> Signup and view all the answers

    The variable and unpredictable nature of symptoms in multiple sclerosis is best explained by which pathological feature?

    <p>Random distribution of demyelinating plaques throughout the brain and spinal cord. (A)</p> Signup and view all the answers

    The 'abnormal signal' observed in the MRI of the patient's brain in multiple sclerosis primarily reflects changes in:

    <p>Water content and tissue properties due to demyelination. (B)</p> Signup and view all the answers

    The patient's clinical course, characterized by initial weakness followed by periods of improvement and subsequent episodes like vision loss and tremor, is most consistent with which pattern of multiple sclerosis?

    <p>Relapsing-remitting multiple sclerosis. (A)</p> Signup and view all the answers

    Which of the following neurological deficits was NOT reported during the initial presentation of the patient?

    <p>Visual field deficit. (A)</p> Signup and view all the answers

    The primary pathological process directly responsible for the diverse neurological symptoms observed in multiple sclerosis is:

    <p>Inflammation and demyelination of nerve fibers in the central nervous system. (B)</p> Signup and view all the answers

    Where are course materials and announcements primarily located for Clinical Neuroscience (BIOL 4460/5560, PT 5502, OT 5502)?

    <p>The META COURSE Moodle site. (B)</p> Signup and view all the answers

    Which of the following sets of course codes represents Clinical Neuroscience?

    <p>BIOL 4460 / 5560, PT 5502, OT 5502 (D)</p> Signup and view all the answers

    What is the primary format for lecture PowerPoints provided to students?

    <p>PDF files posted before each class. (C)</p> Signup and view all the answers

    If a student misses a reading quiz, what is the policy for receiving partial credit?

    <p>Students can submit a student-generated reading quiz for 50% credit within the same module. (A)</p> Signup and view all the answers

    What is the examination structure for this course?

    <p>Four module exams, with remediation available for Exam ONE only. (D)</p> Signup and view all the answers

    Which of the following is NOT one of the modules covered in this course?

    <p>Cellular Neurobiology: Neuron and Glial cell function. (A)</p> Signup and view all the answers

    The 'brainstem' is comprised of which combination of structures?

    <p>Midbrain, pons, and medulla. (A)</p> Signup and view all the answers

    Which neuroimaging technique primarily provides functional views of the brain?

    <p>Positron Emission Tomography (PET). (D)</p> Signup and view all the answers

    Flashcards

    Central Nervous System (CNS)

    The brain and spinal cord, responsible for processing information and controlling body functions.

    Peripheral Nervous System (PNS)

    The network of nerves that connect the CNS to the rest of the body, carrying signals to and from the brain and spinal cord.

    CT Scan

    A technique that uses a series of X-ray images to create a detailed image of the inside of the body, showing bone and soft tissue.

    MRI Scan

    A technique that uses strong magnetic fields and radio waves to create detailed images of the inside of the body, showing soft tissues and organs in high resolution.

    Signup and view all the flashcards

    PET Scan

    A technique that uses a radioactive tracer to measure brain activity and blood flow.

    Signup and view all the flashcards

    fMRI Scan

    A technique that combines MRI with measuring blood flow changes in the brain, showing areas of increased activity.

    Signup and view all the flashcards

    Neurons

    Specialized cells that transmit information throughout the nervous system.

    Signup and view all the flashcards

    Glial Cells

    Cells that support and protect neurons, providing structural support and nourishment.

    Signup and view all the flashcards

    MRI

    A type of neural imaging that uses magnetic fields and radio waves to create images of the brain and other tissues.

    Signup and view all the flashcards

    Contrast Enhanced CT

    A type of CT scan that uses contrast material (iodine) to enhance the visibility of certain tissues.

    Signup and view all the flashcards

    CT Myelography

    A type of CT scan that uses contrast material (iodine) to enhance the visibility of the spinal canal.

    Signup and view all the flashcards

    Spinal CT

    A type of neural imaging that uses X-rays to create images of the spinal canal.

    Signup and view all the flashcards

    T2 relaxation time

    A measure of the time it takes for the transverse magnetization of a tissue to decay to 37% of its original value. T2 is affected by the local environment of water molecules, including the presence of other molecules and the rate of diffusion.

    Signup and view all the flashcards

    T1 relaxation time

    A measure of the time it takes for the longitudinal magnetization of a tissue to recover to 63% of its original value. T1 is affected by factors like the presence of fat and water.

    Signup and view all the flashcards

    Lateral geniculate nucleus (LGN)

    The area in the brain that receives visual information from the eyes. The visual signals are then sent to the occipital lobe for processing.

    Signup and view all the flashcards

    Dendritic Arbor

    The receiving end of a neuron where synaptic signals are integrated to determine if an action potential is generated.

    Signup and view all the flashcards

    Axon Hillock

    A specialized region at the base of the axon where action potentials are initiated.

    Signup and view all the flashcards

    Axonal Terminal

    The transmitting end of a neuron where neurotransmitters are released to signal other neurons.

    Signup and view all the flashcards

    Ion Channels

    Specialized proteins embedded in the neuronal membrane that allow specific ions to pass through, playing a crucial role in electrical signaling.

    Signup and view all the flashcards

    Ion Pumps

    Active transport mechanisms that maintain the concentration gradients of ions across the neuronal membrane, essential for electrical signaling.

    Signup and view all the flashcards

    Neuronal Transport

    The process of transporting molecules and organelles within neurons, essential for maintaining their structure and function.

    Signup and view all the flashcards

    Anterograde Transport

    The movement of molecules and organelles from the soma to the axon terminal.

    Signup and view all the flashcards

    Retrograde Transport

    The movement of molecules and organelles from the axon terminal towards the soma.

    Signup and view all the flashcards

    Sensory (Afferent) Neuron

    A type of neuron that transmits information from sensory receptors to the central nervous system.

    Signup and view all the flashcards

    Motor (Efferent) Neuron

    A type of neuron that transmits information from the central nervous system to muscles and glands.

    Signup and view all the flashcards

    Axons

    Long, slender projections of neurons that transmit signals away from the cell body.

    Signup and view all the flashcards

    Dendrites

    Short, branched projections of neurons that receive signals from other neurons.

    Signup and view all the flashcards

    Synapse

    A specialized junction where neurons communicate with each other or with target cells.

    Signup and view all the flashcards

    Neurofilaments

    Protein filaments that form the cytoskeleton of neurons, providing structural support and facilitating transport.

    Signup and view all the flashcards

    Oligodendrocytes

    A type of glial cell that forms myelin sheaths around axons in the central nervous system.

    Signup and view all the flashcards

    Schwaan Cells

    A type of glial cell that forms myelin sheaths around axons in the peripheral nervous system.

    Signup and view all the flashcards

    Myelination

    The process of generating myelin sheaths around axons, which increases the speed of nerve impulse conduction.

    Signup and view all the flashcards

    Multiple Sclerosis (MS)

    A neurodegenerative disease that affects the central nervous system, characterized by the destruction of myelin sheaths.

    Signup and view all the flashcards

    MS Plaques

    Areas of demyelination (loss of myelin sheath) in the white matter of the brain and spinal cord, appearing as gray, gelatinous plaques.

    Signup and view all the flashcards

    Cerebral Cortex

    The outermost layer of the brain, responsible for higher cognitive functions, sensory perception, and voluntary movement.

    Signup and view all the flashcards

    Peri-ventricular White Matter

    The white matter region surrounding the ventricles of the brain, often affected in MS.

    Signup and view all the flashcards

    Spinal Cord White Matter

    The white matter of the spinal cord, containing tracts that carry signals to and from the brain.

    Signup and view all the flashcards

    Variable MS Symptoms

    Symptoms of MS can vary widely depending on the location and extent of demyelination, leading to diverse neurological impairments.

    Signup and view all the flashcards

    Weakness (Left Weakness)

    A decrease in strength and mobility, often affecting one side of the body due to nerve damage.

    Signup and view all the flashcards

    Vibratory and Position Sense

    The ability to sense vibration and position of body parts (joints, muscles, etc.).

    Signup and view all the flashcards

    Study Notes

    Lecture 011425

    • Course Description: Includes lectures, objectives, exams, grading, and the Moodle website.
    • Divisions and Orientation: Covers CNS and PNS, planes of section.
    • Imaging: Focuses on anatomical views (MRI, CT) and functional views (PET, f-MRI).
    • Cells of the Nervous System: Explores neurons and glial cells.
    • Case Study: Features Multiple Sclerosis.

    Course Information

    • Moodle: Use of META COURSE for lecture and lab listings (BIOL 4460/5560, PT 5502, OT 5502, BIOL 4415L / 5515L).
    • Syllabus: Includes course description, links to recorded lectures, and a news forum for announcements.
    • Weekly Posts: Lectures in PowerPoint PDF format, posted before class. Objectives include vocabulary terms and concepts for each module. Laboratories include objectives and atlas images.
    • Reading Quizzes: Ten quizzes, 50 points each, open book, during class time (listed in syllabus), missed quizzes can be submitted as a student-generated quiz for 50% credit.

    Examinations

    • Exams: One per module, 100 points each, no cumulative final.
    • Remediation: Opportunity for Exam ONE only, up to 75% credit.

    Course Description (Modules)

    • Modules: Neurobiology (neurophysiology and development); Neuroanatomy (regional neuroanatomy and pathways); Systems Neuroscience I (sensory neurobiology and pathways); Systems Neuroscience II (motor and integrative neurobiology and pathways).
    • Emphases: Mechanisms, pathways, pathology, case studies.

    Basic Divisions of Nervous System

    • Central Nervous System (CNS): Cerebrum, thalamus, midbrain, pons, cerebellum, medulla, spinal cord.
    • Brainstem: Defined as the midbrain, pons, and medulla.
    • Peripheral Nervous System (PNS): Spinal nerves, autonomic nerves.

    Planes of Orientation

    • Planes of Section: Sagittal (midline), axial (horizontal), coronal (perpendicular to long axis).
    • Anatomical Terms: Posterior/anterior, dorsal/ventral, rostral/caudal, superior/inferior.

    Neural Imaging

    • Computerized Tomography (CT): X-ray beam rotates, detecting differing densities (air, blood, bone, brain) to create "slices".
    • Typical CT: Useful for head trauma, tumors, and hemorrhage. Density of air, water, brain matter and bone varies for analysis.
    • Contrast Enhanced CT: Uses iodine injected into a femoral artery.
    • CT Myelography: Spinal canal CT using contrast material.

    Magnetic Resonance Imaging (MRI)

    • MRI: Useful for cerebrovascular accident, tumors, and neurodegenerative disease.
    • Coils: Change proton spin and allow for relaxation, measuring time (T2, T1).
    • T2: Horizontal spin relaxation
    • T1: Vertical spin relaxation
    • Contrast: Differentiates different tissues.

    BOLD Functional MRI

    • BOLD fMRI: Measures blood oxygen level dependent signals in the brain, detects changes in blood flow during sensory or motor tasks (activity).

    Positron Emission Tomography (PET)

    • PET: Introduces radioactively tagged substances to detect gamma rays. Measures changes in blood flow and glucose metabolism.

    Single Photon Emission Computed Tomography (SPECT)

    • SPECT: Uses greater diversity of isotopes compared to PET. Provides lower spatial resolution.

    Neurons - Functional Morphology

    • Neurons: Includes input, trigger, propagation, output zone.
    • Input Zone: Dendrites, soma.
    • Trigger Zone: Axon hillock, initial segment.
    • Propagation Zone: Axon, myelin sheath, nodes of Ranvier.
    • Output Zone: Axon terminal, synaptic boutons.

    Types of Neurons - Morphology

    • Unipolar: Sensory neurons.
    • Bipolar: Photoreceptors.
    • Multipolar: Most neurons in the central and peripheral nervous systems. Includes pyramidal, Purkinje, stellate, granule cells.

    Neuronal Organelles

    • Plasma membrane: Signaling
    • Cytoskeleton: Transport, architecture, signaling.
    • Nucleus: Genetic control center.
    • Rough ER: Protein synthesis.
    • Smooth ER/Golgi: Modification and packaging.
    • Microtubules: Transport in cell body, neurites.
    • Neurofilaments: Architectural cytoskeleton.
    • Microfilaments: Peripheral and cellular signaling.
    • Mitochondria: Metabolism.

    Neurophysiology

    • Plasma membrane: Electrical signaling of neurites
    • Dendritic arbor and spines
    • Axon hillock: (myelinated cable.
    • Axonal terminal and synaptic boutons
    • Protein pumps: Sodium/potassium pumps, calcium pumps
    • Ion channels: Non-gated, gated by specific stimuli
    • Synaptic proteins: For NT release
    • Receptor proteins: Transduction of signal; (ionotropic - ion channels; metabotropic - biochemistry).

    Neuronal Transport

    • Nucleus: Codes for messenger RNA.
    • Rough ER: Ribosomal synthesis of proteins
    • Smooth ER/Golgi: Modification and packaging of proteins.
    • Microtubules: Transport in cell body, neurites.
    • Neurofilaments: Transport of organelles and vesicular NTs
    • Transmitters synthesis: In soma or terminal.

    Glial Cells

    • Microglia: Phagocytes responding to injury, infection.
    • Macroglia: Include CNS (oligodendrocytes, astrocytes) & PNS (Schwann cells).
    • Glial Cell Tumors: Reactive proliferation. (astrocytoma, glioblastoma, oligodendrocytoma, ependymoma, schwannoma).

    Glial Cell Functions

    • Astrocytes: Uptake of extracellular potassium, neurotransmitters, contribute to blood-brain barrier, modulation of neuronal activity.
    • Oligodendrocytes, Schwann cells: Production of myelin - saltatory conduction, framework for neuronal migration.

    Astrocytes

    • Most numerous glial cells: End feet induce blood-brain barrier.
    • Important in K+ and NT Uptake:

    Oligodendrocytes and Schwann Cells

    • Central myelination: Oligodendrocytes.
    • Peripheral myelination: Schwann cells.
    • Glial cell membranes: Interrupted at nodes, Na/K channels.

    Case Study: Multiple Sclerosis

    • Symptoms: Weakness, numbness, tingling in left leg, loss of vibratory and position sense, vision loss, tremor, dysarthria, diplopia
    • Physical Exam: Moderate left weakness, subtle weakness in left leg, loss of vibratory and position sense
    • MRI: Abnormal signal in peri-ventricular white matter and spinal cord.
    • Progression: Gradually improved over the first few months, later experienced loss of vision and other symptoms.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Lecture 011425 PDF

    Description

    Test your knowledge on the components of the peripheral nervous system, neuroanatomical terminology, and the principles behind various medical imaging techniques such as MRI and CT scans. This quiz covers key concepts related to neuroimaging and cognitive functions in the brain. Dive in to assess your understanding of these important topics!

    More Like This

    Exploring Clinical Neuroanatomy
    10 questions
    Brain Structure Identification
    10 questions
    Use Quizgecko on...
    Browser
    Browser