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Questions and Answers
Which of the following are components of the peripheral nervous system, as indicated in the provided information?
Which of the following are components of the peripheral nervous system, as indicated in the provided information?
In neuroanatomical terminology, particularly when describing structures within the brain, the term 'rostral' is often used interchangeably with which other directional term?
In neuroanatomical terminology, particularly when describing structures within the brain, the term 'rostral' is often used interchangeably with which other directional term?
A sagittal plane of section is best described as:
A sagittal plane of section is best described as:
In Computerized Tomography (CT) scans, image contrast, which allows differentiation of tissues, is primarily based on differences in:
In Computerized Tomography (CT) scans, image contrast, which allows differentiation of tissues, is primarily based on differences in:
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What is the fundamental physical principle that forms the basis of Magnetic Resonance Imaging (MRI) but not Computerized Tomography (CT) scans?
What is the fundamental physical principle that forms the basis of Magnetic Resonance Imaging (MRI) but not Computerized Tomography (CT) scans?
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What distinguishes T1 and T2 measurements in MRI?
What distinguishes T1 and T2 measurements in MRI?
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In medical imaging, what is the primary advantage of T1-weighted images compared to T2-weighted images?
In medical imaging, what is the primary advantage of T1-weighted images compared to T2-weighted images?
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What is the fundamental principle behind blood oxygen level dependent (BOLD) functional MRI (fMRI)?
What is the fundamental principle behind blood oxygen level dependent (BOLD) functional MRI (fMRI)?
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Which of the following cognitive functions is commonly studied using BOLD fMRI by examining activity in Broca's and Wernicke's areas?
Which of the following cognitive functions is commonly studied using BOLD fMRI by examining activity in Broca's and Wernicke's areas?
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What is the defining characteristic of Positron Emission Tomography (PET) in comparison to MRI and fMRI?
What is the defining characteristic of Positron Emission Tomography (PET) in comparison to MRI and fMRI?
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Which neuronal zone is primarily responsible for converting graded potentials into action potentials?
Which neuronal zone is primarily responsible for converting graded potentials into action potentials?
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What is the primary function of the Nodes of Ranvier in neuronal communication?
What is the primary function of the Nodes of Ranvier in neuronal communication?
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Which type of neuron is characterized by a single neurite that branches into two processes?
Which type of neuron is characterized by a single neurite that branches into two processes?
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In neurons, which organelle is most directly involved in the synthesis of proteins destined for the plasma membrane or secretion?
In neurons, which organelle is most directly involved in the synthesis of proteins destined for the plasma membrane or secretion?
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What is the main role of the neuronal cytoskeleton?
What is the main role of the neuronal cytoskeleton?
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Which component of the neuronal plasma membrane is primarily responsible for maintaining ion concentration gradients?
Which component of the neuronal plasma membrane is primarily responsible for maintaining ion concentration gradients?
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What distinguishes metabotropic receptors from ionotropic receptors in neuronal signaling?
What distinguishes metabotropic receptors from ionotropic receptors in neuronal signaling?
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Where in the neuron are neurotransmitter enzymes primarily synthesized?
Where in the neuron are neurotransmitter enzymes primarily synthesized?
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Which cytoskeletal component is primarily associated with axonal transport?
Which cytoskeletal component is primarily associated with axonal transport?
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Single Photon Emission Computerized Tomography (SPECT) is best characterized by which of the following?
Single Photon Emission Computerized Tomography (SPECT) is best characterized by which of the following?
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Which of the following is NOT a function associated with the smooth endoplasmic reticulum (smooth ER) in neurons?
Which of the following is NOT a function associated with the smooth endoplasmic reticulum (smooth ER) in neurons?
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What is the primary function of kinesin in axonal transport?
What is the primary function of kinesin in axonal transport?
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Which type of glial cell is responsible for myelin production in the peripheral nervous system (PNS)?
Which type of glial cell is responsible for myelin production in the peripheral nervous system (PNS)?
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Astrocytes contribute to the blood-brain barrier (BBB) by:
Astrocytes contribute to the blood-brain barrier (BBB) by:
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What is the primary function of microglia in the central nervous system?
What is the primary function of microglia in the central nervous system?
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Saltatory conduction, which increases the speed of action potentials, is directly enabled by:
Saltatory conduction, which increases the speed of action potentials, is directly enabled by:
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Which of the following is NOT a function of astrocytes?
Which of the following is NOT a function of astrocytes?
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Gliosis, a reactive proliferation of glial cells, is most directly a response to:
Gliosis, a reactive proliferation of glial cells, is most directly a response to:
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What is the primary finding observed in the MRI scan of the patient's brain, as described?
What is the primary finding observed in the MRI scan of the patient's brain, as described?
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The areas of 'gray, gelatinous discoloration' observed in the coronal section of the brain are pathologically identified as:
The areas of 'gray, gelatinous discoloration' observed in the coronal section of the brain are pathologically identified as:
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In the myelin stain of the spinal cord, what does the reduced or absent black staining, indicated by arrows, signify?
In the myelin stain of the spinal cord, what does the reduced or absent black staining, indicated by arrows, signify?
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The variable and unpredictable nature of symptoms in multiple sclerosis is best explained by which pathological feature?
The variable and unpredictable nature of symptoms in multiple sclerosis is best explained by which pathological feature?
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The 'abnormal signal' observed in the MRI of the patient's brain in multiple sclerosis primarily reflects changes in:
The 'abnormal signal' observed in the MRI of the patient's brain in multiple sclerosis primarily reflects changes in:
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The patient's clinical course, characterized by initial weakness followed by periods of improvement and subsequent episodes like vision loss and tremor, is most consistent with which pattern of multiple sclerosis?
The patient's clinical course, characterized by initial weakness followed by periods of improvement and subsequent episodes like vision loss and tremor, is most consistent with which pattern of multiple sclerosis?
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Which of the following neurological deficits was NOT reported during the initial presentation of the patient?
Which of the following neurological deficits was NOT reported during the initial presentation of the patient?
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The primary pathological process directly responsible for the diverse neurological symptoms observed in multiple sclerosis is:
The primary pathological process directly responsible for the diverse neurological symptoms observed in multiple sclerosis is:
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Where are course materials and announcements primarily located for Clinical Neuroscience (BIOL 4460/5560, PT 5502, OT 5502)?
Where are course materials and announcements primarily located for Clinical Neuroscience (BIOL 4460/5560, PT 5502, OT 5502)?
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Which of the following sets of course codes represents Clinical Neuroscience?
Which of the following sets of course codes represents Clinical Neuroscience?
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What is the primary format for lecture PowerPoints provided to students?
What is the primary format for lecture PowerPoints provided to students?
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If a student misses a reading quiz, what is the policy for receiving partial credit?
If a student misses a reading quiz, what is the policy for receiving partial credit?
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What is the examination structure for this course?
What is the examination structure for this course?
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Which of the following is NOT one of the modules covered in this course?
Which of the following is NOT one of the modules covered in this course?
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The 'brainstem' is comprised of which combination of structures?
The 'brainstem' is comprised of which combination of structures?
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Which neuroimaging technique primarily provides functional views of the brain?
Which neuroimaging technique primarily provides functional views of the brain?
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Flashcards
Central Nervous System (CNS)
Central Nervous System (CNS)
The brain and spinal cord, responsible for processing information and controlling body functions.
Peripheral Nervous System (PNS)
Peripheral Nervous System (PNS)
The network of nerves that connect the CNS to the rest of the body, carrying signals to and from the brain and spinal cord.
CT Scan
CT Scan
A technique that uses a series of X-ray images to create a detailed image of the inside of the body, showing bone and soft tissue.
MRI Scan
MRI Scan
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PET Scan
PET Scan
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fMRI Scan
fMRI Scan
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Neurons
Neurons
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Glial Cells
Glial Cells
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MRI
MRI
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Contrast Enhanced CT
Contrast Enhanced CT
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CT Myelography
CT Myelography
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Spinal CT
Spinal CT
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T2 relaxation time
T2 relaxation time
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T1 relaxation time
T1 relaxation time
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Lateral geniculate nucleus (LGN)
Lateral geniculate nucleus (LGN)
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Dendritic Arbor
Dendritic Arbor
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Axon Hillock
Axon Hillock
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Axonal Terminal
Axonal Terminal
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Ion Channels
Ion Channels
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Ion Pumps
Ion Pumps
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Neuronal Transport
Neuronal Transport
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Anterograde Transport
Anterograde Transport
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Retrograde Transport
Retrograde Transport
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Sensory (Afferent) Neuron
Sensory (Afferent) Neuron
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Motor (Efferent) Neuron
Motor (Efferent) Neuron
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Axons
Axons
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Dendrites
Dendrites
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Synapse
Synapse
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Neurofilaments
Neurofilaments
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Oligodendrocytes
Oligodendrocytes
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Schwaan Cells
Schwaan Cells
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Myelination
Myelination
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Multiple Sclerosis (MS)
Multiple Sclerosis (MS)
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MS Plaques
MS Plaques
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Cerebral Cortex
Cerebral Cortex
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Peri-ventricular White Matter
Peri-ventricular White Matter
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Spinal Cord White Matter
Spinal Cord White Matter
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Variable MS Symptoms
Variable MS Symptoms
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Weakness (Left Weakness)
Weakness (Left Weakness)
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Vibratory and Position Sense
Vibratory and Position Sense
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Study Notes
Lecture 011425
- Course Description: Includes lectures, objectives, exams, grading, and the Moodle website.
- Divisions and Orientation: Covers CNS and PNS, planes of section.
- Imaging: Focuses on anatomical views (MRI, CT) and functional views (PET, f-MRI).
- Cells of the Nervous System: Explores neurons and glial cells.
- Case Study: Features Multiple Sclerosis.
Course Information
- Moodle: Use of META COURSE for lecture and lab listings (BIOL 4460/5560, PT 5502, OT 5502, BIOL 4415L / 5515L).
- Syllabus: Includes course description, links to recorded lectures, and a news forum for announcements.
- Weekly Posts: Lectures in PowerPoint PDF format, posted before class. Objectives include vocabulary terms and concepts for each module. Laboratories include objectives and atlas images.
- Reading Quizzes: Ten quizzes, 50 points each, open book, during class time (listed in syllabus), missed quizzes can be submitted as a student-generated quiz for 50% credit.
Examinations
- Exams: One per module, 100 points each, no cumulative final.
- Remediation: Opportunity for Exam ONE only, up to 75% credit.
Course Description (Modules)
- Modules: Neurobiology (neurophysiology and development); Neuroanatomy (regional neuroanatomy and pathways); Systems Neuroscience I (sensory neurobiology and pathways); Systems Neuroscience II (motor and integrative neurobiology and pathways).
- Emphases: Mechanisms, pathways, pathology, case studies.
Basic Divisions of Nervous System
- Central Nervous System (CNS): Cerebrum, thalamus, midbrain, pons, cerebellum, medulla, spinal cord.
- Brainstem: Defined as the midbrain, pons, and medulla.
- Peripheral Nervous System (PNS): Spinal nerves, autonomic nerves.
Planes of Orientation
- Planes of Section: Sagittal (midline), axial (horizontal), coronal (perpendicular to long axis).
- Anatomical Terms: Posterior/anterior, dorsal/ventral, rostral/caudal, superior/inferior.
Neural Imaging
- Computerized Tomography (CT): X-ray beam rotates, detecting differing densities (air, blood, bone, brain) to create "slices".
- Typical CT: Useful for head trauma, tumors, and hemorrhage. Density of air, water, brain matter and bone varies for analysis.
- Contrast Enhanced CT: Uses iodine injected into a femoral artery.
- CT Myelography: Spinal canal CT using contrast material.
Magnetic Resonance Imaging (MRI)
- MRI: Useful for cerebrovascular accident, tumors, and neurodegenerative disease.
- Coils: Change proton spin and allow for relaxation, measuring time (T2, T1).
- T2: Horizontal spin relaxation
- T1: Vertical spin relaxation
- Contrast: Differentiates different tissues.
BOLD Functional MRI
- BOLD fMRI: Measures blood oxygen level dependent signals in the brain, detects changes in blood flow during sensory or motor tasks (activity).
Positron Emission Tomography (PET)
- PET: Introduces radioactively tagged substances to detect gamma rays. Measures changes in blood flow and glucose metabolism.
Single Photon Emission Computed Tomography (SPECT)
- SPECT: Uses greater diversity of isotopes compared to PET. Provides lower spatial resolution.
Neurons - Functional Morphology
- Neurons: Includes input, trigger, propagation, output zone.
- Input Zone: Dendrites, soma.
- Trigger Zone: Axon hillock, initial segment.
- Propagation Zone: Axon, myelin sheath, nodes of Ranvier.
- Output Zone: Axon terminal, synaptic boutons.
Types of Neurons - Morphology
- Unipolar: Sensory neurons.
- Bipolar: Photoreceptors.
- Multipolar: Most neurons in the central and peripheral nervous systems. Includes pyramidal, Purkinje, stellate, granule cells.
Neuronal Organelles
- Plasma membrane: Signaling
- Cytoskeleton: Transport, architecture, signaling.
- Nucleus: Genetic control center.
- Rough ER: Protein synthesis.
- Smooth ER/Golgi: Modification and packaging.
- Microtubules: Transport in cell body, neurites.
- Neurofilaments: Architectural cytoskeleton.
- Microfilaments: Peripheral and cellular signaling.
- Mitochondria: Metabolism.
Neurophysiology
- Plasma membrane: Electrical signaling of neurites
- Dendritic arbor and spines
- Axon hillock: (myelinated cable.
- Axonal terminal and synaptic boutons
- Protein pumps: Sodium/potassium pumps, calcium pumps
- Ion channels: Non-gated, gated by specific stimuli
- Synaptic proteins: For NT release
- Receptor proteins: Transduction of signal; (ionotropic - ion channels; metabotropic - biochemistry).
Neuronal Transport
- Nucleus: Codes for messenger RNA.
- Rough ER: Ribosomal synthesis of proteins
- Smooth ER/Golgi: Modification and packaging of proteins.
- Microtubules: Transport in cell body, neurites.
- Neurofilaments: Transport of organelles and vesicular NTs
- Transmitters synthesis: In soma or terminal.
Glial Cells
- Microglia: Phagocytes responding to injury, infection.
- Macroglia: Include CNS (oligodendrocytes, astrocytes) & PNS (Schwann cells).
- Glial Cell Tumors: Reactive proliferation. (astrocytoma, glioblastoma, oligodendrocytoma, ependymoma, schwannoma).
Glial Cell Functions
- Astrocytes: Uptake of extracellular potassium, neurotransmitters, contribute to blood-brain barrier, modulation of neuronal activity.
- Oligodendrocytes, Schwann cells: Production of myelin - saltatory conduction, framework for neuronal migration.
Astrocytes
- Most numerous glial cells: End feet induce blood-brain barrier.
- Important in K+ and NT Uptake:
Oligodendrocytes and Schwann Cells
- Central myelination: Oligodendrocytes.
- Peripheral myelination: Schwann cells.
- Glial cell membranes: Interrupted at nodes, Na/K channels.
Case Study: Multiple Sclerosis
- Symptoms: Weakness, numbness, tingling in left leg, loss of vibratory and position sense, vision loss, tremor, dysarthria, diplopia
- Physical Exam: Moderate left weakness, subtle weakness in left leg, loss of vibratory and position sense
- MRI: Abnormal signal in peri-ventricular white matter and spinal cord.
- Progression: Gradually improved over the first few months, later experienced loss of vision and other symptoms.
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Description
Test your knowledge on the components of the peripheral nervous system, neuroanatomical terminology, and the principles behind various medical imaging techniques such as MRI and CT scans. This quiz covers key concepts related to neuroimaging and cognitive functions in the brain. Dive in to assess your understanding of these important topics!