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Questions and Answers
What was the purpose of the experiment described in the text?
What was the purpose of the experiment described in the text?
- To investigate the impact of light on retinal axon development
- To analyze the migration patterns of ganglion cells
- To study how cues guide the formation of the optic tract (correct)
- To determine the number of axons present in the optic chiasm
What happened to the direction of axon growth when grafts were rotated 90 degrees counterclockwise?
What happened to the direction of axon growth when grafts were rotated 90 degrees counterclockwise?
- Axons changed their growth direction entirely
- Axons grew away from the original position
- Axons grew toward their original position (correct)
- Axons grew in a random pattern
What was the role of Ganglion Cells in the experiment?
What was the role of Ganglion Cells in the experiment?
- To label retinal axons before reaching the optic chiasm
- To study the embryonic optic tract
- To observe axon growth patterns at the chiasm
- To make decisions at the optic chiasm (correct)
What did the experiment aim to visualize using microscopy?
What did the experiment aim to visualize using microscopy?
How did retinal axons behave after crossing the optic chiasm?
How did retinal axons behave after crossing the optic chiasm?
What was significant about the decisions made by Ganglion Cells at the optic chiasm?
What was significant about the decisions made by Ganglion Cells at the optic chiasm?
What is the main responsibility of the growth cone at the end of an axon?
What is the main responsibility of the growth cone at the end of an axon?
What are filopodia and lamellipodia in the growth cone mainly composed of?
What are filopodia and lamellipodia in the growth cone mainly composed of?
What happens when cytochalasins inhibit actin polymerization in the growth cone?
What happens when cytochalasins inhibit actin polymerization in the growth cone?
Which structure within the growth cone guides pioneer microtubules along and helps traverse through the F-actin network?
Which structure within the growth cone guides pioneer microtubules along and helps traverse through the F-actin network?
What is a key role of receptors on the growth cone?
What is a key role of receptors on the growth cone?
In which domain of the growth cone are microtubules hindered by F-actin arcs acting as barriers?
In which domain of the growth cone are microtubules hindered by F-actin arcs acting as barriers?
What is the effect of microtubule stabilizers placed on a specific side of the growth cone?
What is the effect of microtubule stabilizers placed on a specific side of the growth cone?
How does Cytochalasin B affect actin filaments in the growth cone?
How does Cytochalasin B affect actin filaments in the growth cone?
What is the role of adhesions between the growth cone and extracellular matrix (ECM)?
What is the role of adhesions between the growth cone and extracellular matrix (ECM)?
What is the consequence of a loss of F-actin from the periphery of the growth cone?
What is the consequence of a loss of F-actin from the periphery of the growth cone?
How do retrograde flow of actin and microtubule interactions influence other structures in the growth cone?
How do retrograde flow of actin and microtubule interactions influence other structures in the growth cone?
What is the function of chemoattraction in growth cone propulsion?
What is the function of chemoattraction in growth cone propulsion?
Which molecules are major components of basal laminae and promote axon outgrowth?
Which molecules are major components of basal laminae and promote axon outgrowth?
In the experiment involving cell adhesion assay to identify NCAMs, which type of cell adhesion molecules are examples of calcium-independent adhesion?
In the experiment involving cell adhesion assay to identify NCAMs, which type of cell adhesion molecules are examples of calcium-independent adhesion?
What happens when Ephrin binds to Eph receptors?
What happens when Ephrin binds to Eph receptors?
Which class of Ephrins has a GPI anchor?
Which class of Ephrins has a GPI anchor?
What is the function of Ephrin Bs in the optic tectum?
What is the function of Ephrin Bs in the optic tectum?
How do integrins interact with the extracellular matrix?
How do integrins interact with the extracellular matrix?
Which type of signaling occurs through Ephrin A5?
Which type of signaling occurs through Ephrin A5?
What type of proteins are Ephrin As?
What type of proteins are Ephrin As?
Which molecule is responsible for the attraction of axons to the floor plate in commissural neurons?
Which molecule is responsible for the attraction of axons to the floor plate in commissural neurons?
Which factor prevents RGC axons from wandering outside of the optic nerve according to the text?
Which factor prevents RGC axons from wandering outside of the optic nerve according to the text?
Which receptors are required for attraction in the context of Netrins according to the text?
Which receptors are required for attraction in the context of Netrins according to the text?
What is responsible for repulsion in axons that grow away from the midline according to the text?
What is responsible for repulsion in axons that grow away from the midline according to the text?
Which GTPase promotes growth cone collapse?
Which GTPase promotes growth cone collapse?
What is the function of GAPs in the GTPase cycle?
What is the function of GAPs in the GTPase cycle?
Which netrin receptor complex induces growth cone attraction?
Which netrin receptor complex induces growth cone attraction?
What is the role of Ephexin in intracellular signaling?
What is the role of Ephexin in intracellular signaling?
What mechanism leads to Slit-induced repulsive migration?
What mechanism leads to Slit-induced repulsive migration?
Which process is correlated with the activation of Rac and Cdc42?
Which process is correlated with the activation of Rac and Cdc42?
What is the effect of activating DCC homodimers?
What is the effect of activating DCC homodimers?
Which GTPase promotes the formation of Filopodia?
Which GTPase promotes the formation of Filopodia?
Which intracellular mechanism leads to cytoskeletal rearrangements?
Which intracellular mechanism leads to cytoskeletal rearrangements?
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