Axon Guidance Part 2
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Questions and Answers

What is the primary function of laminins in the extracellular matrix?

  • To provide structural support to the cell
  • To regulate cell-cell adhesion
  • To promote axon outgrowth (correct)
  • To control cell migration

    • What is the composition of integrins in nerve cells?

  • Homodimers of beta subunits
  • Heterodimers of a and b subunits (correct)
  • Heterotrimers of alpha, beta, and gamma subunits
  • Homotrimers of alpha subunits

    • What is the role of the intracellular domain of integrins?

  • To control cell proliferation
  • To interact with cytoskeletal components (correct)
  • To bind to extracellular matrix molecules
  • To regulate cell signaling pathways

    • What is the primary cue that guides retinal ganglion cell axons to the optic nerve head?

    <p>Laminins</p> Signup and view all the answers

    What is the purpose of the cell adhesion assay in identifying NCAMs?

    <p>To identify cell adhesion molecules</p> Signup and view all the answers

    What is the effect of antibodies to the cell surface on the aggregation of neurons in the presence of a NCAM?

    <p>They block the aggregation</p> Signup and view all the answers

    What is the role of unc-5 receptor in axon growth?

    <p>Predominant role in axons that grow away from the midline</p> Signup and view all the answers

    Which of the following molecules is involved in switching Sema3B repulsion?

    <p>SHH</p> Signup and view all the answers

    What is the effect of active RhoGTP on growth cone morphology?

    <p>Causes growth cone collapse</p> Signup and view all the answers

    What is the role of GEFs in the GTPase cycle?

    <p>Act as the 'on' switch</p> Signup and view all the answers

    What is the consequence of binding of netrin to UNC-5-DCC heterodimers?

    <p>Growth cone repulsion</p> Signup and view all the answers

    What is the role of DCC homodimers in netrin receptor signaling?

    <p>Induces growth cone attraction</p> Signup and view all the answers

    What is the primary function of Ephrin A5 in the optic tectum?

    <p>Repulsion of RGC axons from the posterior region</p> Signup and view all the answers

    Which of the following is a characteristic of Ephrin B?

    <p>It has a transmembrane domain and can undergo reverse signaling</p> Signup and view all the answers

    What is the effect of Semaphorin on growth cones?

    <p>It causes growth cones to collapse and retract</p> Signup and view all the answers

    What is the function of Sema5A around the optic nerve?

    <p>It repels RGC axons from the optic nerve</p> Signup and view all the answers

    What is the consequence of ablating Slit-1 and Slit-2 expression?

    <p>Axons form an ectopic chiasm and wander outside of the optic nerve</p> Signup and view all the answers

    What is the attraction cue for commissural neurons in the dorsal neural tube?

    <p>Netrin</p> Signup and view all the answers

    What is the significance of the sequence in the 3’UTR of the mRNA in the regulation of EphA2 expression?

    <p>It regulates the localization of the mRNA in the growth cone</p> Signup and view all the answers

    What is the effect of metalloprotease inhibitors on the response of neurons to Netrin-1?

    <p>They potentiate the responses of neurons to Netrin-1</p> Signup and view all the answers

    What is the role of Robo in the attractive response to Netrin-1?

    <p>It inhibits the attractive response to Netrin-1</p> Signup and view all the answers

    What is the result of treating spinal cord explants with a metalloprotease inhibitor and a low dose of Netrin-1?

    <p>There is neuron growth similar to that with a high dose of Netrin-1</p> Signup and view all the answers

    What is the effect of Slit-Robo signaling on the attractive response to Netrin-1?

    <p>It inhibits the attractive response to Netrin-1</p> Signup and view all the answers

    What is the role of the growth cone in the regulation of EphA2 expression?

    <p>It regulates the localization of the mRNA</p> Signup and view all the answers

    What is the effect of Slit-induced activation of Robo on Cdc42 activity?

    <p>It decreases Cdc42 activity</p> Signup and view all the answers

    Which of the following is NOT a mechanism by which intracellular concentrations of cAMP and cGMP regulate the axonal response to guidance cues?

    <p>Influencing the activity of tyrosine kinases</p> Signup and view all the answers

    What is the consequence of asymmetric Robo activation on the cell surface in response to a gradient of Slit?

    <p>An intracellular gradient of Cdc42 activity driving repulsive migration</p> Signup and view all the answers

    What is the role of local translation of receptors within the growth cone in axon guidance?

    <p>It is required for the responsiveness of axons to chemotropic cues</p> Signup and view all the answers

    Which of the following is a difference between the effects of Netrin on DCC homodimers and DCC-Unc5 heterodimers?

    <p>The sign of the response to Netrin</p> Signup and view all the answers

    What is the consequence of decreasing intracellular cAMP and cGMP levels on the response of Xenopus neurons to Netrin?

    <p>The neurons are repulsed by Netrin</p> Signup and view all the answers

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