Lecture 18: Endocrine System
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Questions and Answers

What is the primary mechanism of signaling used by the nervous system for long-distance communication?

  • Neurotransmitters
  • Chemical signals
  • Electrical signals (correct)
  • Hormones

    • Which type of hormone can cross the phospholipid bilayer and bind to receptors in the cytoplasm or nucleus?

  • Peptide hormones
  • Catecholamines
  • Steroid hormones (correct)
  • Protein hormones

    • What is the primary mechanism of regulating hormone levels in the body?

  • Negative feedback (correct)
  • Positive feedback
  • Neuroendocrine reflexes
  • Diurnal rhythms

    • Which hormone is regulated by negative feedback, neuroendocrine reflexes, and diurnal rhythms?

    <p>Cortisol</p> Signup and view all the answers

    What is the main difference between the nervous system and the endocrine system?

    <p>The speed of signaling</p> Signup and view all the answers

    Which hormone has highest levels at night?

    <p>Growth hormone</p> Signup and view all the answers

    What is the role of hormones in the endocrine system?

    <p>To regulate body functions</p> Signup and view all the answers

    Which of the following is NOT a mechanism of regulating hormone levels?

    <p>Positive feedback</p> Signup and view all the answers

    What is the main difference between hydrophobic and hydrophilic hormones?

    <p>Their mechanism of action</p> Signup and view all the answers

    Which hormone is regulated by multiple mechanisms?

    <p>Cortisol</p> Signup and view all the answers

    The nervous system uses hormones as chemical messengers for long-distance signaling.

    <p>False</p> Signup and view all the answers

    All hormones can cross the phospholipid bilayer and bind to receptors in the cytoplasm or nucleus.

    <p>False</p> Signup and view all the answers

    Negative feedback is the only mechanism for regulating hormone levels in the body.

    <p>False</p> Signup and view all the answers

    Cortisol levels are highest at night.

    <p>False</p> Signup and view all the answers

    Growth hormone levels are regulated by negative feedback.

    <p>False</p> Signup and view all the answers

    The endocrine system is responsible for quick and short-term communication.

    <p>False</p> Signup and view all the answers

    Hydrophilic hormones can bind to receptors in the cytoplasm or nucleus.

    <p>False</p> Signup and view all the answers

    The nervous system and the endocrine system use the same type of chemical messengers.

    <p>False</p> Signup and view all the answers

    Hormone levels are always constant and do not change throughout the day.

    <p>False</p> Signup and view all the answers

    All hormones are regulated by the same mechanism.

    <p>False</p> Signup and view all the answers

    Which hormone released by the hypothalamus regulates the release of growth hormone from the anterior pituitary?

    <p>GHRH</p> Signup and view all the answers

    Which of the following hormones is NOT released by the anterior pituitary?

    <p>GnRH</p> Signup and view all the answers

    What is the target gland of thyrotropin-releasing hormone (TRH) released by the hypothalamus?

    <p>Thyroid gland</p> Signup and view all the answers

    Which hormone released by the anterior pituitary has a trophic effect on the mammary glands?

    <p>PRL</p> Signup and view all the answers

    What is the role of the hypothalamus in regulating endocrine functions?

    <p>It regulates both the anterior and posterior pituitary glands.</p> Signup and view all the answers

    How does the hypothalamus regulate the posterior pituitary?

    <p>Through a neural connection.</p> Signup and view all the answers

    What is the effect of excessive levels of anterior pituitary hormones on their target glands?

    <p>Hypertrophy</p> Signup and view all the answers

    Which hormone released by the hypothalamus inhibits the release of prolactin from the anterior pituitary?

    <p>PIH</p> Signup and view all the answers

    What is the function of antidiuretic hormone (ADH) or vasopressin?

    <p>It stimulates water retention and increases blood pressure.</p> Signup and view all the answers

    How does the hypothalamus regulate the anterior pituitary?

    <p>Through a vascular connection.</p> Signup and view all the answers

    What is the target tissue of growth hormone released by the anterior pituitary?

    <p>Liver, skeletal muscle, and adipose tissue</p> Signup and view all the answers

    What is the function of oxytocin?

    <p>It stimulates uterine contractions during childbirth and milk letdown.</p> Signup and view all the answers

    What is the role of the hypothalamus in the endocrine system?

    <p>It is the master gland that regulates other glands.</p> Signup and view all the answers

    What is the relationship between the hypothalamus and the pituitary gland?

    <p>The hypothalamus regulates the pituitary gland.</p> Signup and view all the answers

    The hypothalamus regulates the anterior pituitary through a neural connection.

    <p>False</p> Signup and view all the answers

    The posterior pituitary releases oxytocin and insulin.

    <p>False</p> Signup and view all the answers

    The hypothalamus produces hormones that are released by the anterior pituitary.

    <p>False</p> Signup and view all the answers

    Antidiuretic hormone (ADH) or vasopressin stimulates uterine contractions during childbirth.

    <p>False</p> Signup and view all the answers

    The hypothalamus is part of the endocrine system.

    <p>True</p> Signup and view all the answers

    Oxytocin is involved in regulating blood pressure.

    <p>False</p> Signup and view all the answers

    The hypothalamus is considered the 'master gland' because it controls both the anterior and posterior pituitary glands.

    <p>True</p> Signup and view all the answers

    Gonadotropin-releasing hormone (GnRH) is released by the anterior pituitary.

    <p>False</p> Signup and view all the answers

    Adrenocorticotropic hormone (ACTH) is released by the hypothalamus.

    <p>False</p> Signup and view all the answers

    Prolactin-inhibiting hormone (PIH) stimulates the release of prolactin from the anterior pituitary.

    <p>False</p> Signup and view all the answers

    Thyroid-stimulating hormone (TSH) targets the adrenal cortex.

    <p>False</p> Signup and view all the answers

    Growth hormone (GH) has a trophic effect on the mammary glands.

    <p>False</p> Signup and view all the answers

    The anterior pituitary releases hormones that target the hypothalamus.

    <p>False</p> Signup and view all the answers

    Excessive levels of anterior pituitary hormones can lead to atrophy of the target glands.

    <p>False</p> Signup and view all the answers

    What is the function of FSH and LH in the body?

    <p>Regulation of hormone secretion in the gonads</p> Signup and view all the answers

    Which hormone stimulates the adrenal cortex to release cortisol?

    <p>ACTH</p> Signup and view all the answers

    What is the function of prolactin in the body?

    <p>Regulation of milk production in the mammary glands</p> Signup and view all the answers

    Which hormone targets various tissues, including the liver, skeletal muscle, adipose tissue, and bone, to regulate growth and metabolism?

    <p>GH</p> Signup and view all the answers

    What is the function of the hypothalamus in regulating the anterior pituitary?

    <p>Releasing hormones that stimulate the anterior pituitary's secretions</p> Signup and view all the answers

    Which hormone is released by the anterior pituitary in response to TRH from the hypothalamus?

    <p>TSH</p> Signup and view all the answers

    What is the acronym used to remember the six hormones released by the anterior pituitary?

    <p>FLAT PG</p> Signup and view all the answers

    Which hormone is inhibited by a prolactin-inhibiting hormone from the hypothalamus when not needed?

    <p>Prolactin</p> Signup and view all the answers

    How many hormones are released by the hypothalamus that regulate the anterior pituitary?

    <p>6</p> Signup and view all the answers

    What is the target gland of FSH and LH?

    <p>Gonads</p> Signup and view all the answers

    The hypothalamus releases four hormones that regulate the anterior pituitary.

    <p>False</p> Signup and view all the answers

    FSH and LH regulate hormone secretion in the adrenal glands.

    <p>False</p> Signup and view all the answers

    ACTH stimulates the thyroid gland to release thyroxine.

    <p>False</p> Signup and view all the answers

    Prolactin is released by the anterior pituitary in response to TRH from the hypothalamus.

    <p>False</p> Signup and view all the answers

    Growth hormone targets the thyroid gland to regulate growth and metabolism.

    <p>False</p> Signup and view all the answers

    The anterior pituitary releases seven hormones that affect various endocrine glands and tissues.

    <p>False</p> Signup and view all the answers

    TSH is released by the anterior pituitary in response to GHRH from the hypothalamus.

    <p>False</p> Signup and view all the answers

    Prolactin-inhibiting hormone from the hypothalamus stimulates the release of prolactin from the anterior pituitary.

    <p>False</p> Signup and view all the answers

    GHRH and GHRIH are released by the anterior pituitary to regulate growth hormone.

    <p>False</p> Signup and view all the answers

    The hypothalamus regulates the posterior pituitary through a vascular connection.

    <p>False</p> Signup and view all the answers

    What is the primary function of growth hormone?

    <p>Regulating the release of insulin-like growth factor-1 (IGF-1) from the liver</p> Signup and view all the answers

    Which of the following is a metabolic effect of growth hormone?

    <p>Promoting glycogen breakdown in the liver and elevating blood sugar levels</p> Signup and view all the answers

    What is the role of the hypothalamus in regulating growth hormone release?

    <p>Releasing growth hormone-releasing hormone (GHRH) into the blood</p> Signup and view all the answers

    What is the target tissue of insulin-like growth factor-1 (IGF-1)?

    <p>Bone, cartilage, and soft tissues</p> Signup and view all the answers

    What is the negative feedback mechanism that regulates growth hormone levels?

    <p>Growth hormone and IGF-1 stimulate the hypothalamus to release growth hormone-inhibiting hormone</p> Signup and view all the answers

    What is the effect of growth hormone on bone growth?

    <p>Stimulating cell division and growth of bone in children with open epiphyseal plates</p> Signup and view all the answers

    What is the diurnal pattern of growth hormone secretion?

    <p>Highest levels at night, lowest in the morning</p> Signup and view all the answers

    What is the effect of adequate sleep on growth hormone production?

    <p>Essential for growth hormone production in children</p> Signup and view all the answers

    What is the target of growth hormone released by the anterior pituitary gland?

    <p>The liver</p> Signup and view all the answers

    Growth hormone is released by the hypothalamus.

    <p>False</p> Signup and view all the answers

    Growth hormone stimulates the release of insulin-like growth factor-1 (IGF-1) from the liver.

    <p>True</p> Signup and view all the answers

    Growth hormone promotes glycogen synthesis in the liver, lowering blood sugar levels.

    <p>False</p> Signup and view all the answers

    Adequate sleep is essential for growth hormone production in adults.

    <p>False</p> Signup and view all the answers

    Growth hormone-inhibiting hormone stimulates growth hormone release from the anterior pituitary.

    <p>False</p> Signup and view all the answers

    Insulin-like growth factor-1 (IGF-1) targets only bone and cartilage.

    <p>False</p> Signup and view all the answers

    Growth hormone increases amino acid uptake and protein breakdown in skeletal muscle cells.

    <p>False</p> Signup and view all the answers

    Growth hormone has a consistent secretion pattern throughout the day.

    <p>False</p> Signup and view all the answers

    The hypothalamus releases growth hormone-releasing hormone (GHRH) into the blood.

    <p>True</p> Signup and view all the answers

    What is the primary function of thyroxine (T3 and T4) in the body?

    <p>To promote metabolic rate and influence body temperature</p> Signup and view all the answers

    What is the effect of iodine deficiency on the body?

    <p>It leads to an underactive thyroid gland</p> Signup and view all the answers

    What is the role of the hypothalamus in regulating thyroxine production?

    <p>It releases TRH, which stimulates the release of TSH from the anterior pituitary</p> Signup and view all the answers

    What is the effect of thyroxine on the nervous system?

    <p>It enhances the effects of epinephrine and norepinephrine</p> Signup and view all the answers

    What is the characteristic of hypothyroidism in infants?

    <p>It leads to intellectual disability and shorter stature if left untreated</p> Signup and view all the answers

    What is the cause of hyperthyroidism?

    <p>Graves' disease, an autoimmune disorder</p> Signup and view all the answers

    What is the effect of thyroxine on basal metabolic rate?

    <p>It increases basal metabolic rate</p> Signup and view all the answers

    What is the role of the anterior pituitary in regulating thyroxine production?

    <p>It releases TSH, which stimulates the release of thyroxine from the thyroid gland</p> Signup and view all the answers

    What is the characteristic of hyperthyroidism?

    <p>It is characterized by an increased metabolic rate</p> Signup and view all the answers

    What is the effect of thyroxine on growth and development?

    <p>It enhances growth and development, particularly in infancy and childhood</p> Signup and view all the answers

    Thyroxine contains sulfur, which is essential for its production.

    <p>False</p> Signup and view all the answers

    The hypothalamus directly regulates the thyroid gland.

    <p>False</p> Signup and view all the answers

    Thyroxine promotes metabolic rate, decreasing basal metabolic rate.

    <p>False</p> Signup and view all the answers

    Hypothyroidism in adults can lead to shorter stature and intellectual disability.

    <p>False</p> Signup and view all the answers

    Hyperthyroidism is characterized by a decreased metabolic rate.

    <p>False</p> Signup and view all the answers

    Graves' disease is an autoimmune disorder that leads to an underactive thyroid gland.

    <p>False</p> Signup and view all the answers

    Iodized salt is used to ensure sufficient vitamin intake.

    <p>False</p> Signup and view all the answers

    Thyrotropin-releasing hormone (TRH) is released by the anterior pituitary.

    <p>False</p> Signup and view all the answers

    Thyroxine is an inhibitor of epinephrine and norepinephrine.

    <p>False</p> Signup and view all the answers

    The anterior pituitary directly regulates the thyroid gland.

    <p>True</p> Signup and view all the answers

    What is released by the hypothalamus to stimulate the release of ACTH?

    <p>CRH</p> Signup and view all the answers

    What is the effect of cortisol on the release of ACTH and CRH?

    <p>It inhibits the release of ACTH and CRH</p> Signup and view all the answers

    What is the diurnal pattern of cortisol levels?

    <p>Highest in the morning</p> Signup and view all the answers

    What is cortisol used to treat?

    <p>Inflammatory conditions such as asthma and rheumatoid arthritis</p> Signup and view all the answers

    How is cortisol absorbed through the skin?

    <p>Topically</p> Signup and view all the answers

    What is the effect of using pharmacological cortisol on the hypothalamic-pituitary-adrenal axis?

    <p>It disrupts the hypothalamic-pituitary-adrenal axis</p> Signup and view all the answers

    What is the role of cortisol in the body?

    <p>To suppress inflammation and immune response</p> Signup and view all the answers

    What is the relationship between the hypothalamus, anterior pituitary, and adrenal cortex in cortisol regulation?

    <p>The hypothalamus releases CRH, which stimulates the anterior pituitary, which then releases ACTH, which stimulates the adrenal cortex</p> Signup and view all the answers

    Why is cortisol used in topical creams and inhalers?

    <p>Because it can be absorbed directly into the tissues and cells through the skin</p> Signup and view all the answers

    What is the meaning of 'renal' in the term 'adrenal glands'?

    <p>relating to the kidney</p> Signup and view all the answers

    What is the main function of epinephrine released by the adrenal medulla?

    <p>initiating the 'fight or flight' response</p> Signup and view all the answers

    What is the role of aldosterone released by the adrenal cortex?

    <p>regulating sodium and potassium levels</p> Signup and view all the answers

    What is the effect of cortisol on blood glucose levels?

    <p>increase</p> Signup and view all the answers

    What is the function of the hypothalamus in the stress response?

    <p>mediating the stress response</p> Signup and view all the answers

    What is the difference between the short-term and long-term stress responses?

    <p>short-term involves epinephrine, long-term involves cortisol</p> Signup and view all the answers

    What is the effect of cortisol on immune function?

    <p>decrease</p> Signup and view all the answers

    What is the role of the adrenal cortex in the adrenal gland?

    <p>regulating sodium and potassium levels</p> Signup and view all the answers

    What is the effect of cortisol on protein breakdown?

    <p>increase</p> Signup and view all the answers

    The adrenal glands are located at the bottom of each kidney.

    <p>False</p> Signup and view all the answers

    The adrenal medulla releases the hormone aldosterone.

    <p>False</p> Signup and view all the answers

    Cortisol is responsible for the 'fight or flight' response.

    <p>False</p> Signup and view all the answers

    The adrenal cortex releases weak androgens.

    <p>True</p> Signup and view all the answers

    The short-term stress response involves the release of cortisol.

    <p>False</p> Signup and view all the answers

    The hypothalamus and brainstem do not mediate the stress response.

    <p>False</p> Signup and view all the answers

    The adrenal medulla is controlled by the parasympathetic division.

    <p>False</p> Signup and view all the answers

    Epinephrine is a glucocorticoid.

    <p>False</p> Signup and view all the answers

    Aldosterone is a glucocorticoid.

    <p>False</p> Signup and view all the answers

    The hypothalamus releases ACTH, which binds to receptors on the anterior pituitary, leading to the release of cortisol.

    <p>False</p> Signup and view all the answers

    Cortisol has a positive feedback effect, stimulating the release of ACTH and CRH.

    <p>False</p> Signup and view all the answers

    Cortisol levels are highest at night.

    <p>False</p> Signup and view all the answers

    Pharmacological cortisol can be absorbed directly into the bloodstream through the skin.

    <p>False</p> Signup and view all the answers

    Using pharmacological cortisol can increase the levels of CRH and ACTH.

    <p>False</p> Signup and view all the answers

    Cortisol is used to treat conditions such as diabetes and hypertension.

    <p>False</p> Signup and view all the answers

    The hypothalamic-pituitary-adrenal axis is not involved in the regulation of cortisol.

    <p>False</p> Signup and view all the answers

    Cortisol is not used as a medication to suppress inflammation and immune response.

    <p>False</p> Signup and view all the answers

    The hypothalamus releases cortisol, which binds to receptors on the adrenal cortex.

    <p>False</p> Signup and view all the answers

    Study Notes

    Nervous System vs. Endocrine System

    • The nervous system is responsible for quick and short-term communication, using electrical signals for long-distance signaling and chemical signals (neurotransmitters) for short-distance signaling.
    • The endocrine system is responsible for slower, long-term regulation of the body, using hormones as chemical messengers that travel through the blood to reach target cells.

    Hormone Function

    • Hormones can be hydrophobic (nonpolar) or hydrophilic (polar) types, which affects their mechanism of action.
    • Hydrophobic hormones (e.g., steroid hormones like testosterone, estrogen, and cortisol) can cross the phospholipid bilayer and bind to receptors in the cytoplasm or nucleus, leading to changes in gene expression.
    • Hydrophilic hormones (e.g., peptide hormones, catecholamines) cannot cross the phospholipid bilayer and bind to receptors in the cell membrane, leading to changes in the cell through signal transduction.

    Regulation of Hormone Levels

    • The level of a hormone in the blood depends on the regulation of its secretion and clearance from the body.
    • Negative feedback is a common mechanism for regulating hormone levels, where the hormone shuts off its own secretion indirectly.
    • Other mechanisms include neuroendocrine reflexes and diurnal/circadian rhythms, which regulate hormone secretion in response to environmental stimuli or day-night cycles.

    Examples of Hormone Regulation

    • Cortisol levels are regulated by negative feedback, neuroendocrine reflexes, and diurnal rhythms, with highest levels in the morning.
    • Growth hormone levels are regulated by diurnal rhythms, with highest levels at night.
    • Other hormones have different mechanisms of regulation, and some hormones have multiple mechanisms.

    Nervous System vs. Endocrine System

    • The nervous system uses electrical signals for long-distance signaling and chemical signals (neurotransmitters) for short-distance signaling, enabling quick and short-term communication.
    • The endocrine system, on the other hand, regulates the body over a longer period, using hormones as chemical messengers that travel through the blood to reach target cells.

    Hormone Function

    • Hormones can be classified into two types: hydrophobic (nonpolar) and hydrophilic (polar), which determines their mechanism of action.
    • Hydrophobic hormones (e.g., steroid hormones like testosterone, estrogen, and cortisol) can cross the phospholipid bilayer and bind to receptors in the cytoplasm or nucleus, leading to changes in gene expression.
    • Hydrophilic hormones (e.g., peptide hormones, catecholamines) cannot cross the phospholipid bilayer and bind to receptors in the cell membrane, leading to changes in the cell through signal transduction.

    Regulation of Hormone Levels

    • The level of a hormone in the blood depends on the regulation of its secretion and clearance from the body.
    • Negative feedback is a common mechanism for regulating hormone levels, where the hormone shuts off its own secretion indirectly.
    • Other mechanisms include neuroendocrine reflexes and diurnal/circadian rhythms, which regulate hormone secretion in response to environmental stimuli or day-night cycles.

    Examples of Hormone Regulation

    • Cortisol levels are regulated by negative feedback, neuroendocrine reflexes, and diurnal rhythms, with highest levels in the morning.
    • Growth hormone levels are regulated by diurnal rhythms, with highest levels at night.
    • Different hormones have unique regulation mechanisms, and some hormones have multiple mechanisms.

    Nervous System vs. Endocrine System

    • The nervous system uses electrical signals for long-distance signaling and chemical signals (neurotransmitters) for short-distance signaling, enabling quick and short-term communication.
    • The endocrine system, on the other hand, regulates the body over a longer period, using hormones as chemical messengers that travel through the blood to reach target cells.

    Hormone Function

    • Hormones can be classified into two types: hydrophobic (nonpolar) and hydrophilic (polar), which determines their mechanism of action.
    • Hydrophobic hormones (e.g., steroid hormones like testosterone, estrogen, and cortisol) can cross the phospholipid bilayer and bind to receptors in the cytoplasm or nucleus, leading to changes in gene expression.
    • Hydrophilic hormones (e.g., peptide hormones, catecholamines) cannot cross the phospholipid bilayer and bind to receptors in the cell membrane, leading to changes in the cell through signal transduction.

    Regulation of Hormone Levels

    • The level of a hormone in the blood depends on the regulation of its secretion and clearance from the body.
    • Negative feedback is a common mechanism for regulating hormone levels, where the hormone shuts off its own secretion indirectly.
    • Other mechanisms include neuroendocrine reflexes and diurnal/circadian rhythms, which regulate hormone secretion in response to environmental stimuli or day-night cycles.

    Examples of Hormone Regulation

    • Cortisol levels are regulated by negative feedback, neuroendocrine reflexes, and diurnal rhythms, with highest levels in the morning.
    • Growth hormone levels are regulated by diurnal rhythms, with highest levels at night.
    • Different hormones have unique regulation mechanisms, and some hormones have multiple mechanisms.

    The Hypothalamus and its Role in Regulating the Pituitary

    • The hypothalamus is a major control center in the brain, responsible for regulating temperature, osmoregulation, emotions, and endocrine functions.

    Hypothalamic Regulation of the Posterior Pituitary

    • The hypothalamus regulates the posterior pituitary through a neural connection.
    • The posterior pituitary releases two hormones:
      • Antidiuretic hormone (ADH) or vasopressin, which stimulates water retention and increases blood pressure.
      • Oxytocin, which stimulates uterine contractions during childbirth, milk letdown, and is involved in pair bonding.

    Hypothalamic Regulation of the Anterior Pituitary

    • The hypothalamus regulates the anterior pituitary through a vascular connection or endocrine connection.
    • The hypothalamus releases hormones that stimulate or inhibit the release of hormones by the anterior pituitary, including:
      • Gonadotropin-releasing hormone (GnRH)
      • Corticotropin-releasing hormone (CRH)
      • Thyrotropin-releasing hormone (TRH)
      • Prolactin-inhibiting hormone (PIH)
      • Growth hormone-inhibiting hormone (GHIH)
      • Growth hormone-releasing hormone (GHRH)

    Hormones Released by the Anterior Pituitary

    • The anterior pituitary releases hormones in response to the hypothalamic hormones, including:
      • Follicle-stimulating hormone (FSH)
      • Luteinizing hormone (LH)
      • Adrenocorticotropic hormone (ACTH)
      • Thyroid-stimulating hormone (TSH)
      • Prolactin (PRL)
      • Growth hormone (GH)

    Targets of Anterior Pituitary Hormones

    • The targets of the hormones released by the anterior pituitary include:
      • FSH and LH: testes and ovaries
      • ACTH: adrenal cortex
      • TSH: thyroid gland
      • PRL: mammary glands
      • GH: liver, skeletal muscle, and adipose tissue

    Trophic Effects of Anterior Pituitary Hormones

    • Many of the hormones released by the anterior pituitary have trophic effects, maintaining the normal size of the target glands.
    • Excessive or deficient levels of these hormones can lead to hypertrophy or atrophy of the target glands.

    The Hypothalamus and its Role in Regulating the Pituitary

    • The hypothalamus is a major control center in the brain, responsible for regulating temperature, osmoregulation, emotions, and endocrine functions.

    Hypothalamic Regulation of the Posterior Pituitary

    • The hypothalamus regulates the posterior pituitary through a neural connection.
    • The posterior pituitary releases two hormones:
      • Antidiuretic hormone (ADH) or vasopressin, which stimulates water retention and increases blood pressure.
      • Oxytocin, which stimulates uterine contractions during childbirth, milk letdown, and is involved in pair bonding.

    Hypothalamic Regulation of the Anterior Pituitary

    • The hypothalamus regulates the anterior pituitary through a vascular connection or endocrine connection.
    • The hypothalamus releases hormones that stimulate or inhibit the release of hormones by the anterior pituitary, including:
      • Gonadotropin-releasing hormone (GnRH)
      • Corticotropin-releasing hormone (CRH)
      • Thyrotropin-releasing hormone (TRH)
      • Prolactin-inhibiting hormone (PIH)
      • Growth hormone-inhibiting hormone (GHIH)
      • Growth hormone-releasing hormone (GHRH)

    Hormones Released by the Anterior Pituitary

    • The anterior pituitary releases hormones in response to the hypothalamic hormones, including:
      • Follicle-stimulating hormone (FSH)
      • Luteinizing hormone (LH)
      • Adrenocorticotropic hormone (ACTH)
      • Thyroid-stimulating hormone (TSH)
      • Prolactin (PRL)
      • Growth hormone (GH)

    Targets of Anterior Pituitary Hormones

    • The targets of the hormones released by the anterior pituitary include:
      • FSH and LH: testes and ovaries
      • ACTH: adrenal cortex
      • TSH: thyroid gland
      • PRL: mammary glands
      • GH: liver, skeletal muscle, and adipose tissue

    Trophic Effects of Anterior Pituitary Hormones

    • Many of the hormones released by the anterior pituitary have trophic effects, maintaining the normal size of the target glands.
    • Excessive or deficient levels of these hormones can lead to hypertrophy or atrophy of the target glands.

    Hypothalamic-Pituitary Axis

    • Hypothalamus regulates anterior pituitary through vascular or endocrine connection, releasing hormones into the blood to affect anterior pituitary secretions.
    • Hypothalamus releases six hormones that regulate anterior pituitary, which releases six hormones affecting various endocrine glands and tissues.

    Anterior Pituitary Hormones

    • Anterior pituitary releases six hormones, remembered by FLAT PG acronym:
      • FSH (follicle-stimulating hormone)
      • LH (luteinizing hormone)
      • ACTH (adrenocorticotropic hormone)
      • TSH (thyroid-stimulating hormone)
      • Prolactin
      • Growth Hormone

    FSH and LH Functions

    • FSH and LH regulate hormone secretion in gonads (testes and ovaries) in response to GnRH from hypothalamus.
    • FSH and LH trigger testosterone release from testes and estrogen and progesterone release from ovaries.

    ACTH Functions

    • ACTH released by anterior pituitary in response to CRH from hypothalamus.
    • ACTH stimulates adrenal cortex to release cortisol.

    TSH Functions

    • TSH released by anterior pituitary in response to TRH from hypothalamus.
    • TSH stimulates thyroid gland to release thyroxine.

    Prolactin Functions

    • Prolactin regulates milk production in mammary glands.
    • Prolactin is inhibited by prolactin-inhibiting hormone from hypothalamus when not needed.

    Growth Hormone Functions

    • Growth hormone released by anterior pituitary in response to GHRH and GHRIH from hypothalamus.
    • Growth hormone targets liver, skeletal muscle, adipose tissue, and bone to regulate growth and metabolism.

    Trophic Effects

    • Hormones released by anterior pituitary have trophic effects, maintaining normal size of target glands and tissues.
    • Abnormal concentrations of these hormones can lead to hypertrophy or atrophy of target glands and tissues.

    Hypothalamic-Pituitary Axis

    • Hypothalamus regulates anterior pituitary through vascular or endocrine connection, releasing hormones into the blood to affect anterior pituitary secretions.
    • Hypothalamus releases six hormones that regulate anterior pituitary, which releases six hormones affecting various endocrine glands and tissues.

    Anterior Pituitary Hormones

    • Anterior pituitary releases six hormones, remembered by FLAT PG acronym:
      • FSH (follicle-stimulating hormone)
      • LH (luteinizing hormone)
      • ACTH (adrenocorticotropic hormone)
      • TSH (thyroid-stimulating hormone)
      • Prolactin
      • Growth Hormone

    FSH and LH Functions

    • FSH and LH regulate hormone secretion in gonads (testes and ovaries) in response to GnRH from hypothalamus.
    • FSH and LH trigger testosterone release from testes and estrogen and progesterone release from ovaries.

    ACTH Functions

    • ACTH released by anterior pituitary in response to CRH from hypothalamus.
    • ACTH stimulates adrenal cortex to release cortisol.

    TSH Functions

    • TSH released by anterior pituitary in response to TRH from hypothalamus.
    • TSH stimulates thyroid gland to release thyroxine.

    Prolactin Functions

    • Prolactin regulates milk production in mammary glands.
    • Prolactin is inhibited by prolactin-inhibiting hormone from hypothalamus when not needed.

    Growth Hormone Functions

    • Growth hormone released by anterior pituitary in response to GHRH and GHRIH from hypothalamus.
    • Growth hormone targets liver, skeletal muscle, adipose tissue, and bone to regulate growth and metabolism.

    Trophic Effects

    • Hormones released by anterior pituitary have trophic effects, maintaining normal size of target glands and tissues.
    • Abnormal concentrations of these hormones can lead to hypertrophy or atrophy of target glands and tissues.

    Growth Hormone

    • Primary function is to regulate growth and maintain metabolic reactions
    • Produced and released by the anterior pituitary gland
    • Regulated by the hypothalamus, which releases growth hormone-releasing hormone (GHRH)

    Mechanism of Action

    • GHRH binds to its receptor in the anterior pituitary, triggering growth hormone release
    • Growth hormone targets the liver and other tissues

    Liver and IGF-1

    • Growth hormone stimulates the liver to release insulin-like growth factor-1 (IGF-1)
    • IGF-1 promotes cell division and growth in bone, cartilage, and soft tissues

    Effects on Bone Growth

    • IGF-1 stimulates bone growth in children with open epiphyseal plates
    • Continues to stimulate cell division in cartilage and soft tissues after puberty

    Metabolic Effects

    • Increases fatty acid levels in the blood by breaking down fats in adipose tissue
    • Increases amino acid uptake and protein synthesis in skeletal muscle cells
    • Promotes glycogen breakdown in the liver, elevating blood sugar levels

    Regulation of Growth Hormone Release

    • Growth hormone and IGF-1 stimulate the hypothalamus to release growth hormone-inhibiting hormone
    • Growth hormone-inhibiting hormone shuts down growth hormone release from the anterior pituitary
    • Negative feedback loop maintains stable growth hormone levels

    Circadian Rhythm

    • Growth hormone has a diurnal secretion pattern, with highest levels at night
    • Adequate sleep is essential for growth hormone production in children

    Growth Hormone

    • Primary function is to regulate growth and maintain metabolic reactions
    • Produced and released by the anterior pituitary gland
    • Regulated by the hypothalamus, which releases growth hormone-releasing hormone (GHRH)

    Mechanism of Action

    • GHRH binds to its receptor in the anterior pituitary, triggering growth hormone release
    • Growth hormone targets the liver and other tissues

    Liver and IGF-1

    • Growth hormone stimulates the liver to release insulin-like growth factor-1 (IGF-1)
    • IGF-1 promotes cell division and growth in bone, cartilage, and soft tissues

    Effects on Bone Growth

    • IGF-1 stimulates bone growth in children with open epiphyseal plates
    • Continues to stimulate cell division in cartilage and soft tissues after puberty

    Metabolic Effects

    • Increases fatty acid levels in the blood by breaking down fats in adipose tissue
    • Increases amino acid uptake and protein synthesis in skeletal muscle cells
    • Promotes glycogen breakdown in the liver, elevating blood sugar levels

    Regulation of Growth Hormone Release

    • Growth hormone and IGF-1 stimulate the hypothalamus to release growth hormone-inhibiting hormone
    • Growth hormone-inhibiting hormone shuts down growth hormone release from the anterior pituitary
    • Negative feedback loop maintains stable growth hormone levels

    Circadian Rhythm

    • Growth hormone has a diurnal secretion pattern, with highest levels at night
    • Adequate sleep is essential for growth hormone production in children

    Thyroid Gland and Thyroxine

    • Thyroxine, a hormone released by the thyroid gland, is a ringed structure that can move through the plasma membrane and bind to receptors on the inside of cells.
    • Thyroxine contains iodine, which is essential for its production.
    • Iodine deficiency can lead to hypothyroidism, a condition characterized by low thyroxine levels.
    • Iodized salt is used to ensure sufficient iodine intake.

    Regulation of Thyroxine

    • The thyroid gland is regulated directly by the anterior pituitary and indirectly by the hypothalamus.
    • The hypothalamus releases TRH (thyrotropin-releasing hormone), which stimulates the release of TSH (thyroid-stimulating hormone) from the anterior pituitary.
    • TSH binds to receptors on the thyroid, stimulating the release of thyroxine (T3 and T4).

    Effects of Thyroxine

    • Thyroxine promotes metabolic rate, increasing basal metabolic rate and influencing body temperature.
    • It enhances growth and development, particularly in infancy and childhood.
    • Thyroxine is necessary for normal nervous system function.
    • It also enhances the effects of epinephrine and norepinephrine, influencing heart rate and blood pressure.

    Hypothyroidism

    • A lack of iodine in the diet can lead to hypothyroidism.
    • Symptoms of hypothyroidism in adults include weight gain, fatigue, lower pulse rate, slower reflexes, and cold intolerance.
    • In infants, hypothyroidism can lead to shorter stature and intellectual disability if left untreated.

    Hyperthyroidism

    • High levels of thyroxine can cause hyperthyroidism, characterized by an increased metabolic rate.
    • Symptoms of hyperthyroidism include weight loss, increased heart rate, excessive perspiration, heat intolerance, irritability, and bulging eyes.
    • Causes of hyperthyroidism include Graves' disease, an autoimmune disorder that leads to an overactive thyroid gland.

    Thyroid Gland and Thyroxine

    • Thyroxine, a hormone released by the thyroid gland, is a ringed structure that can move through the plasma membrane and bind to receptors on the inside of cells.
    • Thyroxine contains iodine, which is essential for its production.
    • Iodine deficiency can lead to hypothyroidism, a condition characterized by low thyroxine levels.
    • Iodized salt is used to ensure sufficient iodine intake.

    Regulation of Thyroxine

    • The thyroid gland is regulated directly by the anterior pituitary and indirectly by the hypothalamus.
    • The hypothalamus releases TRH (thyrotropin-releasing hormone), which stimulates the release of TSH (thyroid-stimulating hormone) from the anterior pituitary.
    • TSH binds to receptors on the thyroid, stimulating the release of thyroxine (T3 and T4).

    Effects of Thyroxine

    • Thyroxine promotes metabolic rate, increasing basal metabolic rate and influencing body temperature.
    • It enhances growth and development, particularly in infancy and childhood.
    • Thyroxine is necessary for normal nervous system function.
    • It also enhances the effects of epinephrine and norepinephrine, influencing heart rate and blood pressure.

    Hypothyroidism

    • A lack of iodine in the diet can lead to hypothyroidism.
    • Symptoms of hypothyroidism in adults include weight gain, fatigue, lower pulse rate, slower reflexes, and cold intolerance.
    • In infants, hypothyroidism can lead to shorter stature and intellectual disability if left untreated.

    Hyperthyroidism

    • High levels of thyroxine can cause hyperthyroidism, characterized by an increased metabolic rate.
    • Symptoms of hyperthyroidism include weight loss, increased heart rate, excessive perspiration, heat intolerance, irritability, and bulging eyes.
    • Causes of hyperthyroidism include Graves' disease, an autoimmune disorder that leads to an overactive thyroid gland.

    Adrenal Glands

    • Located on top of the kidneys, the adrenal glands release hormones and consist of two main parts: the adrenal medulla and the adrenal cortex.

    Adrenal Medulla

    • Located in the middle of the adrenal gland, controlled by the sympathetic division
    • Releases hormone epinephrine, responsible for the "fight or flight" response
    • Epinephrine has adrenaline effects

    Adrenal Cortex

    • Located on the outer part of the adrenal gland
    • Releases aldosterone, regulating sodium and potassium levels, blood volume, and blood pressure
    • Aldosterone is a mineralocorticoid due to its regulation of sodium and potassium
    • Releases cortisol, a glucocorticoid responsible for regulating metabolism, including blood glucose levels
    • Releases weak androgens, weak sex steroids

    Cortisol

    • Released from the adrenal cortex, cortisol is the stress hormone
    • Has a glucocorticoid effect, increasing blood glucose levels, and also increases protein breakdown, suppresses immune function, and reinforces epinephrine effects
    • Has a negative feedback effect, inhibiting release of ACTH by the anterior pituitary and CRH by the hypothalamus

    Stress Response

    • Caused by physical, physiological, psychological, or emotional stressors
    • Short-term stress response involves activation of the sympathetic division and release of epinephrine and norepinephrine
    • Long-term stress response involves release of cortisol, slower but longer-lasting
    • Hypothalamus and brainstem mediate the stress response

    Regulation of Cortisol

    • Hypothalamus releases CRH, binding to receptors on the anterior pituitary, leading to release of ACTH
    • ACTH travels through the blood to the adrenal cortex, causing release of cortisol
    • Cortisol has a negative feedback effect, inhibiting release of ACTH and CRH
    • Cortisol has diurnal regulations, with highest levels in the morning

    Pharmacological Uses of Cortisol

    • Used as a medication to suppress inflammation and immune response
    • Treats conditions such as asthma, rheumatoid arthritis, and other inflammatory conditions
    • Can be absorbed directly into tissues and cells through the skin, making it useful for topical creams and inhalers

    Regulation of Cortisol and Pharmacological Uses

    • Using pharmacological cortisol can affect levels of CRH and ACTH
    • Hypothalamic-pituitary-adrenal axis is involved in cortisol regulation, and introducing external cortisol can disrupt this axis

    Adrenal Glands

    • Located on top of the kidneys, the adrenal glands release hormones and consist of two main parts: the adrenal medulla and the adrenal cortex.

    Adrenal Medulla

    • Located in the middle of the adrenal gland, controlled by the sympathetic division
    • Releases hormone epinephrine, responsible for the "fight or flight" response
    • Epinephrine has adrenaline effects

    Adrenal Cortex

    • Located on the outer part of the adrenal gland
    • Releases aldosterone, regulating sodium and potassium levels, blood volume, and blood pressure
    • Aldosterone is a mineralocorticoid due to its regulation of sodium and potassium
    • Releases cortisol, a glucocorticoid responsible for regulating metabolism, including blood glucose levels
    • Releases weak androgens, weak sex steroids

    Cortisol

    • Released from the adrenal cortex, cortisol is the stress hormone
    • Has a glucocorticoid effect, increasing blood glucose levels, and also increases protein breakdown, suppresses immune function, and reinforces epinephrine effects
    • Has a negative feedback effect, inhibiting release of ACTH by the anterior pituitary and CRH by the hypothalamus

    Stress Response

    • Caused by physical, physiological, psychological, or emotional stressors
    • Short-term stress response involves activation of the sympathetic division and release of epinephrine and norepinephrine
    • Long-term stress response involves release of cortisol, slower but longer-lasting
    • Hypothalamus and brainstem mediate the stress response

    Regulation of Cortisol

    • Hypothalamus releases CRH, binding to receptors on the anterior pituitary, leading to release of ACTH
    • ACTH travels through the blood to the adrenal cortex, causing release of cortisol
    • Cortisol has a negative feedback effect, inhibiting release of ACTH and CRH
    • Cortisol has diurnal regulations, with highest levels in the morning

    Pharmacological Uses of Cortisol

    • Used as a medication to suppress inflammation and immune response
    • Treats conditions such as asthma, rheumatoid arthritis, and other inflammatory conditions
    • Can be absorbed directly into tissues and cells through the skin, making it useful for topical creams and inhalers

    Regulation of Cortisol and Pharmacological Uses

    • Using pharmacological cortisol can affect levels of CRH and ACTH
    • Hypothalamic-pituitary-adrenal axis is involved in cortisol regulation, and introducing external cortisol can disrupt this axis

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    Compare and contrast the nervous system and endocrine system, including their functions, signals, and messengers. Learn about the differences in communication and regulation of the body.

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