Nervous System I
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Questions and Answers

What effect do inhibitory neurotransmitters have on membrane potential?

  • They hyperpolarize the membrane potential. (correct)
  • They stimulate excitatory neurotransmitters.
  • They generate action potentials.
  • They cause depolarization.
  • How do sedatives affect inhibitory postsynaptic potentials (IPSPs)?

  • They enhance IPSPs, making it harder to fire an action potential. (correct)
  • They convert IPSPs into excitatory postsynaptic potentials (EPSPs).
  • They weaken IPSPs, making action potentials easier to fire.
  • They have no effect on IPSPs.
  • Which ions contribute to the depolarization of action potentials?

  • Sodium and calcium. (correct)
  • Calcium and potassium.
  • Sodium and chloride.
  • Potassium and magnesium.
  • What is the relationship between frequency and stimulus strength?

    <p>Higher frequency corresponds to stronger stimulus. (B)</p> Signup and view all the answers

    What is the effect of illegal drugs like cocaine on dopamine in neuron synapses?

    <p>They cause inhibition of dopamine reuptake. (A)</p> Signup and view all the answers

    Which type of receptors in the human eye is primarily responsible for color vision?

    <p>Cones (D)</p> Signup and view all the answers

    Which sensory receptor is primarily responsible for detecting changes in temperature?

    <p>Thermo receptors. (D)</p> Signup and view all the answers

    What role does vitamin A play in the function of photoreceptors?

    <p>It synthesizes retinal that interacts with proteins. (C)</p> Signup and view all the answers

    What role does capsaicin play in sensory perception?

    <p>It stimulates pain-stimulating neurons. (A)</p> Signup and view all the answers

    How does the frequency of action potentials relate to the perceived temperature?

    <p>Higher temperatures lead to a higher frequency of action potentials. (B)</p> Signup and view all the answers

    What happens to sodium channels in the presence of light?

    <p>They close as rhodopsin becomes active. (D)</p> Signup and view all the answers

    What is the function of phosphodiesterase (PDE) in the visual process?

    <p>To degrade cyclic GMP and close ion channels. (A)</p> Signup and view all the answers

    Which ions are involved in the generation of inhibitory postsynaptic potentials (IPSPs)?

    <p>Chloride and potassium. (C)</p> Signup and view all the answers

    What initial event occurs when rhodopsin absorbs a photon?

    <p>Retinal changes shape. (A)</p> Signup and view all the answers

    Which component is considered a prosthetic group in the visual phototransduction process?

    <p>Retinal (D)</p> Signup and view all the answers

    What is the primary function of the rods in the retina?

    <p>Provide night vision. (B)</p> Signup and view all the answers

    What does the anterior pituitary store?

    <p>Growth hormone, FSH, LH, Endorphins, and ACTH (A)</p> Signup and view all the answers

    Which hormones are secreted by the thyroid gland to regulate metabolism?

    <p>Thyroxine (T4) and Tri-iodothyronine (T3) (A)</p> Signup and view all the answers

    What is the effect of increased levels of T3 and T4 in the body?

    <p>Increased basal metabolic rate and heat production (B)</p> Signup and view all the answers

    What role does calcitonin play in the body?

    <p>Lowers blood calcium levels (D)</p> Signup and view all the answers

    How does the hypothalamus regulate the release of thyrotropin releasing hormone (TRH)?

    <p>Based on the levels of T3 and T4 in the body (D)</p> Signup and view all the answers

    What initiates the release of thyroid stimulating hormone (TSH) from the anterior pituitary?

    <p>Communication from thyrotropin releasing hormone (TRH) (A)</p> Signup and view all the answers

    What is the primary effect of parathyroid hormone (PTH)?

    <p>To raise blood calcium levels (C)</p> Signup and view all the answers

    What could be a consequence of a hyperactive thyroid gland?

    <p>Secretion of more hormones and potential complications (B)</p> Signup and view all the answers

    What type of hormones can pass through cell membranes and enter all cells?

    <p>Lipid soluble hormones (A)</p> Signup and view all the answers

    Which statement accurately describes the action of water soluble hormones?

    <p>They bind to specific membrane surface receptors. (A)</p> Signup and view all the answers

    What is a likely consequence when lipid soluble hormones bind to their receptors?

    <p>Direct entry into the nucleus to activate gene expression. (D)</p> Signup and view all the answers

    What is the role of the G protein in the mechanism of water soluble hormones?

    <p>It activates coupling proteins to initiate a signal transduction cascade. (D)</p> Signup and view all the answers

    What do all lipid soluble hormones require to exert their effects?

    <p>A specific cellular receptor. (A)</p> Signup and view all the answers

    What triggers the initiation of an action potential in muscle cells?

    <p>Binding of acetylcholine to muscle cell receptors (C)</p> Signup and view all the answers

    Which of the following molecules serves as a second messenger in the signaling pathway activated by certain hormones?

    <p>Cyclic AMP (D)</p> Signup and view all the answers

    What initiates the signal transduction process for water soluble hormones?

    <p>The hormone binding to a transmembrane receptor. (B)</p> Signup and view all the answers

    What role does the sarcoplasmic reticulum play in muscle contraction?

    <p>It stores calcium and releases it to trigger contraction (D)</p> Signup and view all the answers

    Which of the following describes the effect of Myasthenia Gravis on muscle function?

    <p>Reduced availability of acetylcholine receptors (B)</p> Signup and view all the answers

    How do lipid soluble hormones typically affect cellular functions?

    <p>By directly interacting with DNA to activate gene expression. (D)</p> Signup and view all the answers

    What is the primary effect of Lambert Eaton syndrome on neurotransmission?

    <p>Decreased neurotransmitter release due to weakened presynaptic calcium channels (A)</p> Signup and view all the answers

    How does tetanus affect muscle contraction?

    <p>It leads to continuous muscle contraction (C)</p> Signup and view all the answers

    What is the result of calcium-induced calcium release in muscle contraction?

    <p>Release of calcium from the sarcoplasmic reticulum into the cytoplasm (B)</p> Signup and view all the answers

    What structural feature allows action potentials to propagate within muscle fibers effectively?

    <p>T tubules (A)</p> Signup and view all the answers

    Which of the following disorders is characterized by the degeneration of motor neurons?

    <p>Amyotrophic lateral sclerosis (ALS) (B)</p> Signup and view all the answers

    What is the role of Botox in the context of muscle contraction?

    <p>Blocks the release of acetylcholine from presynaptic terminals (B)</p> Signup and view all the answers

    What distinguishes skeletal muscle contraction from smooth muscle contraction?

    <p>Skeletal muscles can contract strongly and rapidly (B)</p> Signup and view all the answers

    What is the primary function of macrophages in the immune system?

    <p>To engulf and degrade bacteria and dead cells (A)</p> Signup and view all the answers

    Which type of immunity is characterized by the production of antibodies by B-cells?

    <p>Humoral immunity (B)</p> Signup and view all the answers

    What triggers the activation of a B-cell?

    <p>Binding of a specific antigen to its corresponding antibody (C)</p> Signup and view all the answers

    Which type of T-cell is responsible for recognizing and destroying infected cells?

    <p>Cytotoxic T-cells (C)</p> Signup and view all the answers

    What role do antibodies play in the immune response?

    <p>They tag antigens for engulfment by macrophages (C)</p> Signup and view all the answers

    Which statement about immature B-cells is true?

    <p>They express antibodies on their surface to identify antigens (A)</p> Signup and view all the answers

    What is the result of a B-cell's activation after antigen binding?

    <p>It clones itself to create memory B-cells and plasma cells (A)</p> Signup and view all the answers

    What is a unique feature of T-cells compared to B-cells?

    <p>T-cells can directly destroy infected cells (B)</p> Signup and view all the answers

    Flashcards

    Higher frequency stimulus

    A stimulus with a higher rate of action potentials per unit time.

    Inhibitory neurotransmitters

    Chemicals that decrease the likelihood of a nerve impulse creating a negative change in the membrane potential.

    Mammalian Eye Amplification

    The mammalian eye's ability to increase the response to light through a signal transduction cascade.

    Glycine/GABA

    Two primary inhibitory neurotransmitters in the brain which hyperpolarize the postsynaptic membrane.

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    IPSP (inhibitory postsynaptic potential)

    A temporary hyperpolarization in the postsynaptic membrane. It makes the postsynaptic neuron less likely to fire an action potential.

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    Rods (Vision)

    Light-sensitive photoreceptor cells in the retina specialized for low-light vision (black and white).

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    Stimulating sedatives

    Sedatives increase the effects of inhibitory neurotransmitters.

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    Cones (Vision)

    Photoreceptor cells in the retina that detect color.

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    Receptor ion channels

    Ion channels in the postsynaptic membrane that open or close in response to a specific neurotransmitter.

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    Rhodopsin

    A light-sensitive membrane protein in rod cells, composed of opsin and retinal.

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    Retinal

    The light-absorbing part of rhodopsin, a prosthetic group for a photon, which converts the receptor protein from inactive state to active state.

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    Generator potential

    A graded potential in sensory neurons that are triggered by a stimulus.

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    Frequency of action potentials

    Neurons in the brain process information encoded through the rate at which action potentials occur.

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    Visual Transduction Cascade

    A series of intracellular events triggered by light absorption, amplifying the initial light signal.

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    Hyperpolarization (Vision)

    A decrease in membrane potential in a cell, caused by light, resulting in receptor activation, in photoreceptors.

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    Capsaicin

    A chemical that stimulates pain receptors (thermo and pain related receptors).

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    Lipid-soluble hormones

    Hormones that can pass through cell membranes and directly affect the nucleus.

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    Signal transduction

    The process of a hormone's message being carried into the cell and ultimately changing cell behavior.

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    Water-soluble hormones

    Hormones that bind to membrane receptors and trigger a cascade of intracellular events.

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    Membrane surface receptors

    Proteins on the cell membrane that bind to water-soluble hormones to initiate a response.

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    Second messenger

    Molecules activated within the cell by a hormone-receptor interaction, creating internal signaling.

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    G protein

    A protein that acts as an intermediary between the hormone-receptor complex and an enzyme that produces a second messenger.

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    Protein kinase

    An enzyme that phosphorylates other proteins, changing their activity.

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    Gene expression

    The process where a gene's instruction are used to create a protein.

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    Muscle Depolarization

    Change in electrical charge across a muscle cell membrane, causing muscle contraction initiation.

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    Neuromuscular Junction

    Where nerve and muscle meet; initiates muscle contraction.

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    Action Potential Propagation

    Muscle cell's electrical signal spreading along the fiber.

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    Sarcoplasmic Reticulum

    Muscle structure that stores calcium, crucial for contraction.

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    T-tubules

    Tunnel-like structures in muscle cells allowing action potentials to reach myofibrils.

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    Myasthenia Gravis

    Neuromuscular disease affecting acetylcholine receptors, causing weak muscle contractions.

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    Amyotrophic Lateral Sclerosis (ALS)

    Motor neuron degeneration causing muscle weakness and loss of function.

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    Lambert-Eaton Syndrome

    Neuromuscular disorder affecting presynaptic calcium channels, reducing neurotransmitter release.

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    Calcium-induced Calcium Release

    Calcium influx triggers calcium release from sarcoplasmic reticulum.

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    Botox

    Neurotoxin that inhibits acetylcholine release, causing muscle paralysis.

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    Macrophage function

    Engulfs and degrades bacteria and dead cells, including antibody-coated and non-antibody-coated cells.

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    Adaptive immune response

    A specific immune response that is adapted to target a particular invader; it is slower initially but becomes faster with subsequent exposures due to memory.

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    Humoral immunity

    The antibody response where B cells produce antibodies that target and neutralize free bacteria and viruses.

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    Cell-mediated immunity

    T cell response. Specialized T cells destroy cells infected with intracellular pathogens, such as viruses.

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    Antigen

    A foreign molecule, such as a protein or polysaccharide, that triggers an antibody response.

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    Antibody

    A protein that targets and binds to an antigen, marking it for destruction and complement activation.

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    B-cells and Antibody Diversity

    There are millions of B-cells producing unique. antibodies, ready to recognize diverse antigens. Activated B-cells differentiate into plasma cells that release antibodies and memory B-cells for faster future response

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    Cytotoxic T-cells' role

    Cytotoxic T-cells identify and destroy cells that are infected with intracellular pathogens, such as viruses.

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    Anterior Pituitary Hormone Storage

    The anterior pituitary stores growth hormone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), endorphins, enkephalins (natural opiates), and adrenocorticotropic hormone (ACTH).

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    Thyroid Hormone Production

    The thyroid gland produces thyroxine (T4) and triiodothyronine (T3) from tyrosine, crucial for basal metabolic rate.

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    Thyroid Hormone Effects

    Increased T3 and T4 lead to higher blood pressure, body temperature, and weight loss by boosting metabolism.

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    Calcitonin Function

    Calcitonin, a thyroid hormone, lowers blood calcium levels by inhibiting calcium absorption and reabsorption.

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    Parathyroid Hormone (PTH)

    Parathyroid hormone raises blood calcium levels by stimulating calcium release from bones and absorption by intestines and kidneys.

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    TRH (Thyrotropin-Releasing Hormone)

    TRH, released by the hypothalamus, stimulates the anterior pituitary to release thyroid-stimulating hormone (TSH).

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    TSH (Thyroid-Stimulating Hormone)

    TSH, released by the anterior pituitary, prompts the thyroid gland to produce T3 and T4.

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    Negative Feedback (Thyroid)

    High levels of T3 and T4 signal the hypothalamus to reduce TSH release, maintaining homeostasis.

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    Study Notes

    Nervous System I

    • There are approximately 100 billion neurons in the human brain.
    • Neurons have a cell body (soma), dendrites, axon, axon hillock, myelin sheath, nodes of Ranvier, and synaptic end bulbs.
    • Nerve tissue function involves axons as electrical conductors carrying signals from the axon hillock to presynaptic terminals.
    • Potential in neurons involves signals traveling through dendrites, summing in the axon hillock, and transmitting down the axon to synapses.
    • Glial cells (oligodendrocytes and Schwann cells) provide electrical insulation like the myelin sheath.
    • The cell body contains the nucleus and other organelles.
    • Bioelectricity in neurons is a voltage (~-70mV) generated by an ATP-consuming pump in the plasma membrane, creating an ion gradient.
    • The sodium-potassium pump uses ATP to pump 3 sodium ions out and 2 potassium ions in.
    • The inside of the cell is negatively charged.
    • Ion gradients are crucial for nerve function; different ions have specific concentrations inside and outside the axon.

    Nerve Tissue Function & Organization

    • Neurons carry electrical signals, and these signals add up in the axon hillock, triggering an action potential.
    • Signals transmit down the axon and across synapses to other neurons.

    Potential (Bioelectricity)

    • Neurons have a resting potential of -70mV (though it can range between -40mV and -70mV).
    • The inside of the neuron is more negative than the outside due to unequal ion distribution.
    • The sodium-potassium pump maintains these gradients.
    • The resting potential is maintained by the membrane being impermeable to sodium and permeable to potassium.
    • Potassium leaking out makes the inside more negative, counteracting the sodium influx.
    • Equilibrium potential (EK+) describes the voltage at which the chemical and electrical forces on potassium are equal.
      • The EK+ is approximately -85mV for a 30-fold gradient, and -58mV for a 10-fold gradient.
    • Ion concentrations create gradients: extracellular fluid contains high sodium and chlorine, and the cytoplasm has high potassium concentrations.

    Action Potential

    • Action potentials begin at the axon hillock when the membrane suddenly becomes permeable to sodium ions.
    • This depolarization causes further sodium channels to open, leading to a rapid increase in positive charge inside the neuron (reaching up to +50mV).
    • Influx of sodium is followed by repolarization as potassium channels open slowly, allowing potassium to flow out of the neuron, restoring the negative resting potential.
    • Sodium channels become inactivated, preventing the action potential from reversing direction.
    • Action potentials propagate unidirectionally along the axon, jumping between nodes of Ranvier through saltatory conduction.

    Propagation (Saltatory Conduction)

    • Myelin sheaths insulate the axon causing faster signal transmission.
    • Signals jump between nodes of Ranvier; which are rich in voltage-gated sodium channels.

    Synaptic Transmission

    • Chemical synapses use neurotransmitters to transmit signals across the synaptic cleft to another neuron.
    • Neurotransmitters are stored in vesicles at the presynaptic terminal.
    • Action potentials trigger calcium influx, leading to vesicle fusion and neurotransmitter release into the synaptic cleft.
    • Neurotransmitters bind to receptors on the postsynaptic membrane (often ion channels).
    • Neurotransmitters are removed from the synaptic cleft either by degradation or reuptake.

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    Description

    This quiz explores the fundamental aspects of the human nervous system, focusing on the structure and function of neurons and glial cells. It covers the components of nerve tissue, including the cell body, axons, and the role of ion gradients in bioelectricity. Test your knowledge on how these elements work together to enable nerve signaling.

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