Nervous System I

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Questions and Answers

What effect do inhibitory neurotransmitters have on membrane potential?

  • They hyperpolarize the membrane potential. (correct)
  • They stimulate excitatory neurotransmitters.
  • They generate action potentials.
  • They cause depolarization.

How do sedatives affect inhibitory postsynaptic potentials (IPSPs)?

  • They enhance IPSPs, making it harder to fire an action potential. (correct)
  • They convert IPSPs into excitatory postsynaptic potentials (EPSPs).
  • They weaken IPSPs, making action potentials easier to fire.
  • They have no effect on IPSPs.

Which ions contribute to the depolarization of action potentials?

  • Sodium and calcium. (correct)
  • Calcium and potassium.
  • Sodium and chloride.
  • Potassium and magnesium.

What is the relationship between frequency and stimulus strength?

<p>Higher frequency corresponds to stronger stimulus. (B)</p> Signup and view all the answers

What is the effect of illegal drugs like cocaine on dopamine in neuron synapses?

<p>They cause inhibition of dopamine reuptake. (A)</p> Signup and view all the answers

Which type of receptors in the human eye is primarily responsible for color vision?

<p>Cones (D)</p> Signup and view all the answers

Which sensory receptor is primarily responsible for detecting changes in temperature?

<p>Thermo receptors. (D)</p> Signup and view all the answers

What role does vitamin A play in the function of photoreceptors?

<p>It synthesizes retinal that interacts with proteins. (C)</p> Signup and view all the answers

What role does capsaicin play in sensory perception?

<p>It stimulates pain-stimulating neurons. (A)</p> Signup and view all the answers

How does the frequency of action potentials relate to the perceived temperature?

<p>Higher temperatures lead to a higher frequency of action potentials. (B)</p> Signup and view all the answers

What happens to sodium channels in the presence of light?

<p>They close as rhodopsin becomes active. (D)</p> Signup and view all the answers

What is the function of phosphodiesterase (PDE) in the visual process?

<p>To degrade cyclic GMP and close ion channels. (A)</p> Signup and view all the answers

Which ions are involved in the generation of inhibitory postsynaptic potentials (IPSPs)?

<p>Chloride and potassium. (C)</p> Signup and view all the answers

What initial event occurs when rhodopsin absorbs a photon?

<p>Retinal changes shape. (A)</p> Signup and view all the answers

Which component is considered a prosthetic group in the visual phototransduction process?

<p>Retinal (D)</p> Signup and view all the answers

What is the primary function of the rods in the retina?

<p>Provide night vision. (B)</p> Signup and view all the answers

What does the anterior pituitary store?

<p>Growth hormone, FSH, LH, Endorphins, and ACTH (A)</p> Signup and view all the answers

Which hormones are secreted by the thyroid gland to regulate metabolism?

<p>Thyroxine (T4) and Tri-iodothyronine (T3) (A)</p> Signup and view all the answers

What is the effect of increased levels of T3 and T4 in the body?

<p>Increased basal metabolic rate and heat production (B)</p> Signup and view all the answers

What role does calcitonin play in the body?

<p>Lowers blood calcium levels (D)</p> Signup and view all the answers

How does the hypothalamus regulate the release of thyrotropin releasing hormone (TRH)?

<p>Based on the levels of T3 and T4 in the body (D)</p> Signup and view all the answers

What initiates the release of thyroid stimulating hormone (TSH) from the anterior pituitary?

<p>Communication from thyrotropin releasing hormone (TRH) (A)</p> Signup and view all the answers

What is the primary effect of parathyroid hormone (PTH)?

<p>To raise blood calcium levels (C)</p> Signup and view all the answers

What could be a consequence of a hyperactive thyroid gland?

<p>Secretion of more hormones and potential complications (B)</p> Signup and view all the answers

What type of hormones can pass through cell membranes and enter all cells?

<p>Lipid soluble hormones (A)</p> Signup and view all the answers

Which statement accurately describes the action of water soluble hormones?

<p>They bind to specific membrane surface receptors. (A)</p> Signup and view all the answers

What is a likely consequence when lipid soluble hormones bind to their receptors?

<p>Direct entry into the nucleus to activate gene expression. (D)</p> Signup and view all the answers

What is the role of the G protein in the mechanism of water soluble hormones?

<p>It activates coupling proteins to initiate a signal transduction cascade. (D)</p> Signup and view all the answers

What do all lipid soluble hormones require to exert their effects?

<p>A specific cellular receptor. (A)</p> Signup and view all the answers

What triggers the initiation of an action potential in muscle cells?

<p>Binding of acetylcholine to muscle cell receptors (C)</p> Signup and view all the answers

Which of the following molecules serves as a second messenger in the signaling pathway activated by certain hormones?

<p>Cyclic AMP (D)</p> Signup and view all the answers

What initiates the signal transduction process for water soluble hormones?

<p>The hormone binding to a transmembrane receptor. (B)</p> Signup and view all the answers

What role does the sarcoplasmic reticulum play in muscle contraction?

<p>It stores calcium and releases it to trigger contraction (D)</p> Signup and view all the answers

Which of the following describes the effect of Myasthenia Gravis on muscle function?

<p>Reduced availability of acetylcholine receptors (B)</p> Signup and view all the answers

How do lipid soluble hormones typically affect cellular functions?

<p>By directly interacting with DNA to activate gene expression. (D)</p> Signup and view all the answers

What is the primary effect of Lambert Eaton syndrome on neurotransmission?

<p>Decreased neurotransmitter release due to weakened presynaptic calcium channels (A)</p> Signup and view all the answers

How does tetanus affect muscle contraction?

<p>It leads to continuous muscle contraction (C)</p> Signup and view all the answers

What is the result of calcium-induced calcium release in muscle contraction?

<p>Release of calcium from the sarcoplasmic reticulum into the cytoplasm (B)</p> Signup and view all the answers

What structural feature allows action potentials to propagate within muscle fibers effectively?

<p>T tubules (A)</p> Signup and view all the answers

Which of the following disorders is characterized by the degeneration of motor neurons?

<p>Amyotrophic lateral sclerosis (ALS) (B)</p> Signup and view all the answers

What is the role of Botox in the context of muscle contraction?

<p>Blocks the release of acetylcholine from presynaptic terminals (B)</p> Signup and view all the answers

What distinguishes skeletal muscle contraction from smooth muscle contraction?

<p>Skeletal muscles can contract strongly and rapidly (B)</p> Signup and view all the answers

What is the primary function of macrophages in the immune system?

<p>To engulf and degrade bacteria and dead cells (A)</p> Signup and view all the answers

Which type of immunity is characterized by the production of antibodies by B-cells?

<p>Humoral immunity (B)</p> Signup and view all the answers

What triggers the activation of a B-cell?

<p>Binding of a specific antigen to its corresponding antibody (C)</p> Signup and view all the answers

Which type of T-cell is responsible for recognizing and destroying infected cells?

<p>Cytotoxic T-cells (C)</p> Signup and view all the answers

What role do antibodies play in the immune response?

<p>They tag antigens for engulfment by macrophages (C)</p> Signup and view all the answers

Which statement about immature B-cells is true?

<p>They express antibodies on their surface to identify antigens (A)</p> Signup and view all the answers

What is the result of a B-cell's activation after antigen binding?

<p>It clones itself to create memory B-cells and plasma cells (A)</p> Signup and view all the answers

What is a unique feature of T-cells compared to B-cells?

<p>T-cells can directly destroy infected cells (B)</p> Signup and view all the answers

Flashcards

Higher frequency stimulus

A stimulus with a higher rate of action potentials per unit time.

Inhibitory neurotransmitters

Chemicals that decrease the likelihood of a nerve impulse creating a negative change in the membrane potential.

Mammalian Eye Amplification

The mammalian eye's ability to increase the response to light through a signal transduction cascade.

Glycine/GABA

Two primary inhibitory neurotransmitters in the brain which hyperpolarize the postsynaptic membrane.

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IPSP (inhibitory postsynaptic potential)

A temporary hyperpolarization in the postsynaptic membrane. It makes the postsynaptic neuron less likely to fire an action potential.

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Rods (Vision)

Light-sensitive photoreceptor cells in the retina specialized for low-light vision (black and white).

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Stimulating sedatives

Sedatives increase the effects of inhibitory neurotransmitters.

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Cones (Vision)

Photoreceptor cells in the retina that detect color.

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Receptor ion channels

Ion channels in the postsynaptic membrane that open or close in response to a specific neurotransmitter.

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Rhodopsin

A light-sensitive membrane protein in rod cells, composed of opsin and retinal.

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Retinal

The light-absorbing part of rhodopsin, a prosthetic group for a photon, which converts the receptor protein from inactive state to active state.

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Generator potential

A graded potential in sensory neurons that are triggered by a stimulus.

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Frequency of action potentials

Neurons in the brain process information encoded through the rate at which action potentials occur.

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Visual Transduction Cascade

A series of intracellular events triggered by light absorption, amplifying the initial light signal.

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Hyperpolarization (Vision)

A decrease in membrane potential in a cell, caused by light, resulting in receptor activation, in photoreceptors.

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Capsaicin

A chemical that stimulates pain receptors (thermo and pain related receptors).

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Lipid-soluble hormones

Hormones that can pass through cell membranes and directly affect the nucleus.

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Signal transduction

The process of a hormone's message being carried into the cell and ultimately changing cell behavior.

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Water-soluble hormones

Hormones that bind to membrane receptors and trigger a cascade of intracellular events.

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Membrane surface receptors

Proteins on the cell membrane that bind to water-soluble hormones to initiate a response.

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Second messenger

Molecules activated within the cell by a hormone-receptor interaction, creating internal signaling.

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G protein

A protein that acts as an intermediary between the hormone-receptor complex and an enzyme that produces a second messenger.

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Protein kinase

An enzyme that phosphorylates other proteins, changing their activity.

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Gene expression

The process where a gene's instruction are used to create a protein.

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Muscle Depolarization

Change in electrical charge across a muscle cell membrane, causing muscle contraction initiation.

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Neuromuscular Junction

Where nerve and muscle meet; initiates muscle contraction.

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Action Potential Propagation

Muscle cell's electrical signal spreading along the fiber.

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Sarcoplasmic Reticulum

Muscle structure that stores calcium, crucial for contraction.

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T-tubules

Tunnel-like structures in muscle cells allowing action potentials to reach myofibrils.

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Myasthenia Gravis

Neuromuscular disease affecting acetylcholine receptors, causing weak muscle contractions.

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Amyotrophic Lateral Sclerosis (ALS)

Motor neuron degeneration causing muscle weakness and loss of function.

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Lambert-Eaton Syndrome

Neuromuscular disorder affecting presynaptic calcium channels, reducing neurotransmitter release.

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Calcium-induced Calcium Release

Calcium influx triggers calcium release from sarcoplasmic reticulum.

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Botox

Neurotoxin that inhibits acetylcholine release, causing muscle paralysis.

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Macrophage function

Engulfs and degrades bacteria and dead cells, including antibody-coated and non-antibody-coated cells.

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Adaptive immune response

A specific immune response that is adapted to target a particular invader; it is slower initially but becomes faster with subsequent exposures due to memory.

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Humoral immunity

The antibody response where B cells produce antibodies that target and neutralize free bacteria and viruses.

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Cell-mediated immunity

T cell response. Specialized T cells destroy cells infected with intracellular pathogens, such as viruses.

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Antigen

A foreign molecule, such as a protein or polysaccharide, that triggers an antibody response.

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Antibody

A protein that targets and binds to an antigen, marking it for destruction and complement activation.

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B-cells and Antibody Diversity

There are millions of B-cells producing unique. antibodies, ready to recognize diverse antigens. Activated B-cells differentiate into plasma cells that release antibodies and memory B-cells for faster future response

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Cytotoxic T-cells' role

Cytotoxic T-cells identify and destroy cells that are infected with intracellular pathogens, such as viruses.

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Anterior Pituitary Hormone Storage

The anterior pituitary stores growth hormone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), endorphins, enkephalins (natural opiates), and adrenocorticotropic hormone (ACTH).

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Thyroid Hormone Production

The thyroid gland produces thyroxine (T4) and triiodothyronine (T3) from tyrosine, crucial for basal metabolic rate.

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Thyroid Hormone Effects

Increased T3 and T4 lead to higher blood pressure, body temperature, and weight loss by boosting metabolism.

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Calcitonin Function

Calcitonin, a thyroid hormone, lowers blood calcium levels by inhibiting calcium absorption and reabsorption.

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Parathyroid Hormone (PTH)

Parathyroid hormone raises blood calcium levels by stimulating calcium release from bones and absorption by intestines and kidneys.

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TRH (Thyrotropin-Releasing Hormone)

TRH, released by the hypothalamus, stimulates the anterior pituitary to release thyroid-stimulating hormone (TSH).

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TSH (Thyroid-Stimulating Hormone)

TSH, released by the anterior pituitary, prompts the thyroid gland to produce T3 and T4.

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Negative Feedback (Thyroid)

High levels of T3 and T4 signal the hypothalamus to reduce TSH release, maintaining homeostasis.

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Study Notes

Nervous System I

  • There are approximately 100 billion neurons in the human brain.
  • Neurons have a cell body (soma), dendrites, axon, axon hillock, myelin sheath, nodes of Ranvier, and synaptic end bulbs.
  • Nerve tissue function involves axons as electrical conductors carrying signals from the axon hillock to presynaptic terminals.
  • Potential in neurons involves signals traveling through dendrites, summing in the axon hillock, and transmitting down the axon to synapses.
  • Glial cells (oligodendrocytes and Schwann cells) provide electrical insulation like the myelin sheath.
  • The cell body contains the nucleus and other organelles.
  • Bioelectricity in neurons is a voltage (~-70mV) generated by an ATP-consuming pump in the plasma membrane, creating an ion gradient.
  • The sodium-potassium pump uses ATP to pump 3 sodium ions out and 2 potassium ions in.
  • The inside of the cell is negatively charged.
  • Ion gradients are crucial for nerve function; different ions have specific concentrations inside and outside the axon.

Nerve Tissue Function & Organization

  • Neurons carry electrical signals, and these signals add up in the axon hillock, triggering an action potential.
  • Signals transmit down the axon and across synapses to other neurons.

Potential (Bioelectricity)

  • Neurons have a resting potential of -70mV (though it can range between -40mV and -70mV).
  • The inside of the neuron is more negative than the outside due to unequal ion distribution.
  • The sodium-potassium pump maintains these gradients.
  • The resting potential is maintained by the membrane being impermeable to sodium and permeable to potassium.
  • Potassium leaking out makes the inside more negative, counteracting the sodium influx.
  • Equilibrium potential (EK+) describes the voltage at which the chemical and electrical forces on potassium are equal.
    • The EK+ is approximately -85mV for a 30-fold gradient, and -58mV for a 10-fold gradient.
  • Ion concentrations create gradients: extracellular fluid contains high sodium and chlorine, and the cytoplasm has high potassium concentrations.

Action Potential

  • Action potentials begin at the axon hillock when the membrane suddenly becomes permeable to sodium ions.
  • This depolarization causes further sodium channels to open, leading to a rapid increase in positive charge inside the neuron (reaching up to +50mV).
  • Influx of sodium is followed by repolarization as potassium channels open slowly, allowing potassium to flow out of the neuron, restoring the negative resting potential.
  • Sodium channels become inactivated, preventing the action potential from reversing direction.
  • Action potentials propagate unidirectionally along the axon, jumping between nodes of Ranvier through saltatory conduction.

Propagation (Saltatory Conduction)

  • Myelin sheaths insulate the axon causing faster signal transmission.
  • Signals jump between nodes of Ranvier; which are rich in voltage-gated sodium channels.

Synaptic Transmission

  • Chemical synapses use neurotransmitters to transmit signals across the synaptic cleft to another neuron.
  • Neurotransmitters are stored in vesicles at the presynaptic terminal.
  • Action potentials trigger calcium influx, leading to vesicle fusion and neurotransmitter release into the synaptic cleft.
  • Neurotransmitters bind to receptors on the postsynaptic membrane (often ion channels).
  • Neurotransmitters are removed from the synaptic cleft either by degradation or reuptake.

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