Nephron Function and Filtration
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Questions and Answers

What primarily determines the formation of concentrated urine in the nephron?

  • Increase in blood pH in the collecting ducts
  • Presence of antidiuretic hormone (ADH) affecting water reabsorption (correct)
  • Decreased glomerular filtration rate
  • High sodium concentration in the proximal convoluted tubule
  • Which process allows the kidney to produce diluted urine?

  • Excessive water reabsorption in the proximal convoluted tubule
  • Decreased reabsorption of solutes in the collecting duct
  • Increased sodium retention in the glomerulus
  • Inhibition of antidiuretic hormone (ADH) (correct)
  • The osmotic gradient established in the nephron aids primarily in:

  • Increasing the filtration rate at the glomerulus
  • Facilitating water reabsorption in the collecting duct (correct)
  • Regulating the pH of the urine
  • Preventing the secretion of urea in the proximal tubule
  • What role does the vasa recta play in the renal system?

    <p>Maintaining the medullary osmotic gradient (A)</p> Signup and view all the answers

    The concentration of urine is influenced by which of the following mechanisms?

    <p>Urea recycling in the nephron loop and collecting duct (D)</p> Signup and view all the answers

    What is the primary function of the filtration membrane in the nephron?

    <p>To allow selective passage of water and solutes from blood to filtrate (C)</p> Signup and view all the answers

    Which mechanism is primarily responsible for sodium reabsorption in the proximal convoluted tubule?

    <p>Active transport via sodium-potassium pumps (C)</p> Signup and view all the answers

    How does increased sympathetic activity affect glomerular filtration?

    <p>Decreases both glomerular filtration pressure and filtration rate (B)</p> Signup and view all the answers

    In the distal convoluted tubule, which of the following mechanisms regulates potassium secretion?

    <p>Active transport through potassium channels (C)</p> Signup and view all the answers

    Which component of the filtrate is primarily reabsorbed in the proximal convoluted tubule?

    <p>Glucose (A)</p> Signup and view all the answers

    Flashcards

    Nephron function

    The nephron, the functional unit of the kidney, filters blood, reabsorbs essential substances, and secretes waste products, forming urine.

    Glomerular filtration

    The process of filtering blood in the glomerulus, producing a filtrate that enters Bowman's capsule.

    Reabsorption in Proximal Convoluted Tubule

    Essential substances (water, glucose, amino acids) are reabsorbed into the bloodstream from the filtrate.

    Urine concentration/dilution

    The kidney controls the concentration of urine to maintain body fluid balance.

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    Sympathetic effect on filtration

    Increased sympathetic activity reduces glomerular pressure and filtration rate.

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    Filtration Membrane

    A specialized barrier in the glomerulus that filters blood, allowing small molecules like water, electrolytes, and glucose to pass but blocking larger molecules like proteins and blood cells.

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    Filtration Pressure

    The pressure difference between the glomerular capillaries and Bowman's capsule that drives the filtration process, pushing fluid and solutes out of the blood and into the nephron.

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    Proximal Convoluted Tubule Reabsorption

    The process of reabsorbing essential substances like water, glucose, amino acids, and electrolytes from the filtrate back into the bloodstream.

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    Distal Convoluted Tubule Exchange

    The exchange of ions like sodium and potassium through active transport mechanisms, further refining the filtrate and adjusting its composition.

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    Concentrated Urine

    Urine with a high concentration of solutes, produced when the body needs to conserve water.

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    Study Notes

    Nephron Function

    • The nephron has vascular (glomerulus, peritubular capillaries) and tubular (Bowman's capsule, proximal and distal convoluted tubules, collecting ducts) components vital for urine formation.

    Glomerular Filtration

    • Filtration occurs in the glomerulus, a specialized capillary bed.
    • The filtration membrane, a selectively permeable barrier, prevents large molecules (proteins) from entering the filtrate.
    • A pressure gradient between the glomerular capillaries and Bowman's capsule (filtration pressure) drives filtration.
    • Filtrate consists primarily of water, electrolytes, glucose, amino acids, and nitrogenous wastes.

    Sympathetic Activity and Glomerular Pressure

    • Increased sympathetic nervous system activity constricts afferent arterioles, reducing glomerular pressure and filtration.

    Proximal Convoluted Tubule Reabsorption

    • The proximal convoluted tubule (PCT) is responsible for significant reabsorption of water and solutes.
    • Complete reabsorption of glucose, amino acids, and most of the filtered bicarbonate occurs here.
    • Partial reabsorption of other substances like electrolytes (e.g., sodium, chloride) occurs in this section.
    • Reabsorption mechanisms include active transport (for solutes) and osmosis (for water).

    Distal Convoluted Tubule and Collecting Duct

    • Distal convoluted tubule (DCT) and collecting ducts modify filtrate further.
    • Reabsorption, secretion, and exchange mechanisms are crucial here.
    • Active transport of sodium and potassium regulate osmotic balance.
    • Water reabsorption in the DCT and collecting ducts is regulated by hormones like ADH (antidiuretic hormone).

    Urine Concentration/Dilution

    • The nephron is responsible for creating both concentrated and diluted urine based on body needs. This is achieved through adjustments in the reabsorption of water and solutes in the DCT and collecting ducts in response to hormones like ADH (antidiuretic hormone).

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    Description

    Explore the complexities of nephron function including glomerular filtration, the structure of the nephron, and the role of the proximal convoluted tubule in reabsorption. This quiz covers key concepts vital for understanding kidney function and fluid balance in the body.

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