Lecture 1.1b - Cell injury and cell death 1
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Questions and Answers

What is the primary difference between coagulative and liquefactive necrosis?

  • Cellular architecture preservation versus complete dissolution
  • Association with infections versus absence of infection
  • Denaturation of proteins versus release of active proteases (correct)
  • Ghost outline presence versus absence

What is characteristic of oncosis?

  • Cell death with only enzymatic degradation
  • Cell death with no morphological change
  • Cell death with shrinkage
  • Cell death with swelling (correct)

What is the primary mechanism of fat necrosis?

  • Release of reactive oxygen species
  • Action of lipases released into adipose tissue (correct)
  • Infiltration by neutrophils
  • Denaturation of proteins

What is the characteristic appearance of caseous necrosis?

<p>Amorphous debris (D)</p> Signup and view all the answers

What is the result of enzymatic digestion in liquefactive necrosis?

<p>Complete dissolution of necrotic tissue (D)</p> Signup and view all the answers

What is the time frame in which necrosis is typically seen?

<p>12-24 hours after cell death (A)</p> Signup and view all the answers

What is the primary association of caseous necrosis?

<p>Infections, especially tuberculosis (C)</p> Signup and view all the answers

What is the result of saponification in fat necrosis?

<p>Pale yellow/white nodules (C)</p> Signup and view all the answers

Study Notes

Necrosis

  • Defined as the morphological changes that occur in a living organism after a cell has been dead for some time, characterized as non-programmable cell death.
  • Typically seen after 12-24 hours.
  • Oncosis is a type of cell death that occurs with swelling, representing the spectrum of changes that occur in injured cells prior to death.

Types of Necrosis

  • Two main types: coagulative and liquefactive (colliquitive).
  • Two other special types: caseous and fat necrosis.

Coagulative Necrosis

  • Characterized by denaturation of proteins dominating over the release of active proteases.
  • Cellular architecture is somewhat preserved, resulting in a "ghost outline" of cells.

Liquefactive Necrosis

  • Characterized by complete dissolution of necrotic tissue.
  • Typically occurs due to massive infiltration by neutrophils, leading to abscess formation.
  • Release of reactive oxygen species and proteases is prominent.
  • Enzyme degradation is substantially greater than denaturation, leading to enzymatic digestion (liquefaction) of tissues.

Caseous Necrosis

  • Characterized by the presence of amorphous (structureless) debris.
  • Particularly associated with infections, especially tuberculosis.
  • Differs from coagulative necrosis in that it lacks a "ghost outline" of cells.

Fat Necrosis

  • Results from the action of lipases released into adipose tissue.
  • Free fatty acids accumulate and precipitate as calcium soaps (saponification).
  • Grossly visible as pale yellow/white nodules.

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Learn about the different types of necrosis, including coagulative, liquefactive, caseous, and fat necrosis, and understand the characteristics of cell death.

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