8 Questions
What is the primary difference between coagulative and liquefactive necrosis?
Denaturation of proteins versus release of active proteases
What is characteristic of oncosis?
Cell death with swelling
What is the primary mechanism of fat necrosis?
Action of lipases released into adipose tissue
What is the characteristic appearance of caseous necrosis?
Amorphous debris
What is the result of enzymatic digestion in liquefactive necrosis?
Complete dissolution of necrotic tissue
What is the time frame in which necrosis is typically seen?
12-24 hours after cell death
What is the primary association of caseous necrosis?
Infections, especially tuberculosis
What is the result of saponification in fat necrosis?
Pale yellow/white nodules
Study Notes
Necrosis
- Defined as the morphological changes that occur in a living organism after a cell has been dead for some time, characterized as non-programmable cell death.
- Typically seen after 12-24 hours.
- Oncosis is a type of cell death that occurs with swelling, representing the spectrum of changes that occur in injured cells prior to death.
Types of Necrosis
- Two main types: coagulative and liquefactive (colliquitive).
- Two other special types: caseous and fat necrosis.
Coagulative Necrosis
- Characterized by denaturation of proteins dominating over the release of active proteases.
- Cellular architecture is somewhat preserved, resulting in a "ghost outline" of cells.
Liquefactive Necrosis
- Characterized by complete dissolution of necrotic tissue.
- Typically occurs due to massive infiltration by neutrophils, leading to abscess formation.
- Release of reactive oxygen species and proteases is prominent.
- Enzyme degradation is substantially greater than denaturation, leading to enzymatic digestion (liquefaction) of tissues.
Caseous Necrosis
- Characterized by the presence of amorphous (structureless) debris.
- Particularly associated with infections, especially tuberculosis.
- Differs from coagulative necrosis in that it lacks a "ghost outline" of cells.
Fat Necrosis
- Results from the action of lipases released into adipose tissue.
- Free fatty acids accumulate and precipitate as calcium soaps (saponification).
- Grossly visible as pale yellow/white nodules.
Learn about the different types of necrosis, including coagulative, liquefactive, caseous, and fat necrosis, and understand the characteristics of cell death.
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