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Match the following terms with their descriptions:
Match the following terms with their descriptions:
Reversible phase = A phase that can be returned to its original state De-energized state = A state where energy is decreased Plasma membrane pump = A mechanism that decreases ATP generation Injury = A result of cellular damage
Match the following terms with their functions:
Match the following terms with their functions:
ATP = Energy storage molecule Plasma membrane pump = Maintains sodium-potassium balance Cell death = Results from injury Reversible phase = Temporary decrease in ATP generation
Match the following terms with their effects:
Match the following terms with their effects:
Increased ATP generation = Enhances sodium-potassium balance Cell damage = Leads to cell death De-energized state = Decreases ATP generation Plasma membrane pump = Increases ATP production
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Match the following terms with their effects on ATP:
Match the following terms with their effects on ATP:
Match the types of necrosis with their characteristics:
Match the types of necrosis with their characteristics:
Match the types of necrosis with their causes:
Match the types of necrosis with their causes:
Match the types of necrosis with their effects:
Match the types of necrosis with their effects:
Match the cell components with their effects on necrosis:
Match the cell components with their effects on necrosis:
Match the types of necrosis with their associated diseases:
Match the types of necrosis with their associated diseases:
Match the effects of necrosis with their underlying mechanisms:
Match the effects of necrosis with their underlying mechanisms:
Match the types of necrosis with their tissue appearance:
Match the types of necrosis with their tissue appearance:
Match the effects of necrosis with their consequences:
Match the effects of necrosis with their consequences:
Match the following processes with their consequences in necrosis:
Match the following processes with their consequences in necrosis:
Match the following types of necrosis with their characteristics:
Match the following types of necrosis with their characteristics:
Match the following necrotic pathways with their effects on the brain:
Match the following necrotic pathways with their effects on the brain:
Match the following statements with their corresponding necrotic processes:
Match the following statements with their corresponding necrotic processes:
Match the following enzymes with their role in necrosis:
Match the following enzymes with their role in necrosis:
Match the following types of cell death with their morphology:
Match the following types of cell death with their morphology:
Match the following cellular processes with their role in necrosis:
Match the following cellular processes with their role in necrosis:
Match the following cellular components with their fate in necrosis:
Match the following cellular components with their fate in necrosis:
Match the following descriptions with their corresponding effects:
Match the following descriptions with their corresponding effects:
Match the following terms with their corresponding descriptions:
Match the following terms with their corresponding descriptions:
Match the following descriptions with their corresponding effects:
Match the following descriptions with their corresponding effects:
Match the following terms with their corresponding descriptions:
Match the following terms with their corresponding descriptions:
Match the following descriptions with their corresponding effects:
Match the following descriptions with their corresponding effects:
Match the following terms with their corresponding descriptions:
Match the following terms with their corresponding descriptions:
Match the following descriptions with their corresponding effects:
Match the following descriptions with their corresponding effects:
Match the following terms with their corresponding descriptions:
Match the following terms with their corresponding descriptions:
Match the following terms related to cell death with their descriptions:
Match the following terms related to cell death with their descriptions:
Match the following terms related to cell death with their characteristics:
Match the following terms related to cell death with their characteristics:
Match the following terms related to cell death with their consequences:
Match the following terms related to cell death with their consequences:
Match the following terms related to cell death with their causes:
Match the following terms related to cell death with their causes:
Match the following terms related to cell death with their mechanisms:
Match the following terms related to cell death with their mechanisms:
Match the following terms related to cell death with their roles:
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Study Notes
Cell Death and Necrosis
- Cell death can occur through various mechanisms, including necrosis, which is a non-physiological and irreversible process.
- Necrosis is characterized by cellular swelling, ATP depletion, and cell membrane damage.
- There are two main forms of necrosis: coagulative necrosis and liquefactive necrosis.
Coagulative Necrosis
- Coagulative necrosis is characterized by the preservation of cellular outlines, with a loss of nuclei and an inflammatory infiltrate.
- It occurs in response to ischemic injury, such as in kidney infarcts.
- The necrotic cells show preserved outlines, but with a loss of nuclei, and an inflammatory infiltrate is present.
Liquefactive Necrosis
- Liquefactive necrosis is characterized by the destruction of cellular membranes, leading to a dissolution of cellular contents.
- It occurs in response to bacterial infections, such as in cases of tuberculosis.
- The necrotic cells are digested by enzymes, leading to a liquefied appearance.
ATP Depletion and Cell Membrane Damage
- ATP depletion is a critical factor in necrosis, as it leads to a loss of cellular function and membrane damage.
- Cell membrane damage is a key feature of necrosis, leading to an influx of calcium and a loss of cellular homeostasis.
Morphology of Necrotic Cells
- Necrotic cells show a more diffuse cytoplasmic appearance, with an increased eosinophilia.
- The nucleus is often lost or pyknotic, and the cell membrane is damaged.
Laboratory Diagnosis of Necrosis
- The laboratory diagnosis of necrosis is made by detecting an increase in serum levels of intracellular proteins, such as enzymes.
- The diagnosis can also be made by observing the morphology of necrotic cells under a microscope.
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