10 Questions
What is the mechanism for the adverse drug reaction (ADR) causing prolongation of the QT interval on the electrocardiogram?
Additional (secondary) pharmacological actions
Which of the following is an example of a unique syndrome caused only by a specific drug?
Vaginal cancer in young women caused by maternal exposure to diethylstilboestrol
Which adverse effect is mentioned to be caused by practolol?
Oculomucocutaneous syndrome
What is the adverse effect caused by some l‐tryptophan products?
Eosinophilia‐myalgia syndrome
Which of the following represents triggering an immunological response as a mechanism for adverse drug reactions?
Anaphylaxis due to many drugs
What is the main advantage of selective serotonin re‐uptake inhibitors (SSRIs) over older tricyclic antidepressants?
They are less toxic to the heart in overdose
What controversial issues have been associated with the use of SSRIs?
Withdrawal reactions and increased risk of suicide
Which specific SSRI was identified to have a higher incidence of withdrawal reactions?
Paroxetine (Seroxat)
What is the potential risk associated with depressed patients taking an overdose of older tricyclic antidepressants?
Toxicity to the heart
What contributed to the widespread use of selective serotonin re‐uptake inhibitors (SSRIs) over older tricyclic antidepressants?
They are less toxic to the heart in overdose
Test your knowledge about the nature and mechanisms of Adverse Drug Reactions (ADRs) in the context of clinical research and pharmacovigilance. Understand how ADRs mimic natural diseases or syndromes, and learn about the assessment of potential adverse effects.
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