6 Questions
What is found in the rainbow trout nasal cavity lining?
Lymphoepithelium
What do lymphocyte aggregates in the rainbow trout nasal cavity contain?
50% CD4+, 40% IgM+, 5% CD8α+, and 5% IgT+ lymphocytes
What is the function of organized NALT (O-NALT) in mammals?
Supports affinity maturation of the adaptive immune response in the nasopharyngeal cavity
What triggers expansions of B and T cells in rainbow trout upon i.n. vaccination?
Live attenuated infectious hematopoietic necrosis virus
Which type of lymphocytes undergo proliferation and apoptosis within O-NALT upon prime but not boost i.n. vaccination in rainbow trout?
IgM+ B cells
What is the main difference between NALT in teleost fish and O-NALT in mammals?
Absence of lymphoepithelium vs. presence of lymphoepithelium
Explore the ancient and conserved nasal immunity system in vertebrates, including the implementation of nasopharynx-associated lymphoid tissue (NALT) in teleost fish and mammals. Learn about the innate and adaptive immune responses triggered by NALT during nasal infections or vaccinations.
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