Nanoparticles in Medicine
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Nanoparticles in Medicine

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Questions and Answers

What is one of the main applications of noble metal nanoparticles mentioned?

  • Thermal insulation
  • Food preservation
  • Water purification
  • Photo-activated gene silencing (correct)

    • Which methodology is associated with the synthesis of silver nanoparticles from Pongamia pinnata?

  • Electrochemical synthesis
  • Chemical reduction
  • Mechanical milling
  • Green method (correct)

    • What specific cellular activity is enhanced by photo release in silver nanoparticles?

  • Cell death
  • Cellular uptake (correct)
  • Cell migration
  • Cell division

    • Which organism showed positive results when exposed to silver nanoparticles?

    <p>Larvae of certain aquatic insects</p> Signup and view all the answers

    What technique is NOT mentioned in conjunction with the analysis of silver nanoparticles?

    <p>Electrophoresis</p> Signup and view all the answers

    Which property of silver nanoparticles makes them suitable as transfection vectors?

    <p>Good consistency to nucleases</p> Signup and view all the answers

    What is the significance of the photo-activated vectors mentioned in the content?

    <p>They support controlled drug release.</p> Signup and view all the answers

    Which microscopy technique is employed in the study of silver nanoparticles?

    <p>Confocal fluorescence microscopy</p> Signup and view all the answers

    What is one function of polyamidoamine nanoparticles in drug delivery?

    <p>Deliver anti-malarial drugs to targeted sites</p> Signup and view all the answers

    What effect does the union of doxorubicin and polymers have on drug delivery?

    <p>Enhances blood half-life of the drug</p> Signup and view all the answers

    What is one advantage of using nanocarriers in drug delivery?

    <p>They enhance targeting to disease sites</p> Signup and view all the answers

    Which imaging technique is mentioned for characterizing nanoparticles?

    <p>Confocal laser scanning microscopy</p> Signup and view all the answers

    How do polyamidoamine nanoparticles decrease toxicity in drug delivery?

    <p>By localizing drug action to targeted sites</p> Signup and view all the answers

    What role do electroporation and nanocarriers play in drug delivery?

    <p>They assist in delivering drugs effectively</p> Signup and view all the answers

    Which of the following diseases is explicitly mentioned in relation to polyamidoamine nanoparticles?

    <p>Malaria</p> Signup and view all the answers

    What is a characteristic benefit of using nanomaterials in drug delivery?

    <p>They improve the solubility and targeting of drugs</p> Signup and view all the answers

    What effect does tacrine have when enhanced in concentration inside the brain?

    <p>It reduces the whole-dose quantity.</p> Signup and view all the answers

    What is the primary purpose of using Solid Lipid Nanoparticles (SLNPs)?

    <p>To enhance drug retention in brain areas.</p> Signup and view all the answers

    Which drug was loaded onto solid lipid nanoparticles through an intraperitoneal route to decrease plaques?

    <p>Piperine</p> Signup and view all the answers

    What cognitive improvement does Huperzine A offer?

    <p>Enhanced cognitive functions.</p> Signup and view all the answers

    What was clozapine loaded on to ensure safe delivery into the brain microenvironment?

    <p>Dynasan 116 lipid matrix</p> Signup and view all the answers

    Which surfactant was used to coat the lipid matrix of Vitamin A for its delivery across the BBB?

    <p>Hydroxypropyl distarch</p> Signup and view all the answers

    Liposomes are considered advantageous for what purpose?

    <p>Facilitating targeted drug delivery to the brain.</p> Signup and view all the answers

    What effect does the coating of SLNPs with polysorbate have?

    <p>Enhances drug bioavailability.</p> Signup and view all the answers

    What is the primary function of Piperine loaded on SLNPs when injected intraperitoneally?

    <p>To stop plaque formation across the BBB</p> Signup and view all the answers

    Which type of nanomedicine is used for Tacrine delivery inside the brain?

    <p>Polymeric nanoparticles</p> Signup and view all the answers

    What is one benefit of using Tacrine-loaded polymeric NPs?

    <p>They are reserved in the brain for a long time</p> Signup and view all the answers

    Which nanomedicine is noted for increasing oxidative stress?

    <p>Rivastigmine-loaded polymeric NPs</p> Signup and view all the answers

    What is a drawback of Piperine-loaded SLNPs?

    <p>They are easily cleared by the RES</p> Signup and view all the answers

    Which advantage is attributed to folic-acid-loaded liposomes?

    <p>They are highly stable and bioavailable</p> Signup and view all the answers

    Which nanomedicine is known for its capability to hydrolyze both hydrophobic and hydrophilic drugs?

    <p>Beta-Asarone-loaded nanoemulsions</p> Signup and view all the answers

    What is a disadvantage of beta-Asarone-loaded nanoemulsions?

    <p>They are thermodynamically unstable</p> Signup and view all the answers

    What is a common feature of liposomes used for drug delivery?

    <p>They can cross the blood-brain barrier</p> Signup and view all the answers

    What is one of the main issues associated with the use of nanomedicines?

    <p>They sometimes cause uncertain toxicity</p> Signup and view all the answers

    What type of nanoparticles showed cytotoxicity against brain cancer according to the content?

    <p>Gold-iron oxide nanocomposites</p> Signup and view all the answers

    Which compound was mentioned as enhancing the delivery of docetaxel into brain melanoma cells?

    <p>Tocopherol polyethylene glycol</p> Signup and view all the answers

    What is the effect of the synergistic influence of nanoparticles mentioned in the content?

    <p>Increased cytotoxicity</p> Signup and view all the answers

    Which type of cancer cells were tested with methotrexate-loaded nanoparticles?

    <p>C6 glioma cells</p> Signup and view all the answers

    What was the primary benefit of using glycol chitosan nanoparticles in cancer treatment?

    <p>Enhanced cellular uptake</p> Signup and view all the answers

    Which of the following outcomes was observed in standard astrocyte cells in comparison to U87MG cells?

    <p>Increased resistance to drugs</p> Signup and view all the answers

    What is one effect of tocopherol polyethylene glycol chitosan nanoparticles on cancer cells?

    <p>Increased drug delivery effectiveness</p> Signup and view all the answers

    What role does glutathione play in relation to the content provided?

    <p>It is a conjugate used in forming nanocomposites.</p> Signup and view all the answers

    Study Notes

    Noble Metal Nanoparticles

    • One of the main applications of noble metal nanoparticles is in biosensing.
    • Silver nanoparticles can be synthesized from Pongamia pinnata using a green synthesis methodology

    Silver Nanoparticles and Cellular Activity

    • Photo release in silver nanoparticles enhances antibacterial activity.
    • Organisms showing positive results when exposed to silver nanoparticles include bacteria, fungi, and algae.

    Analyzing Silver Nanoparticles

    • Transmission electron microscopy is used to analyze silver nanoparticles. However, the content doesn't mention atomic force microscopy.
    • Silver nanoparticles are suitable as transfection vectors due to their high surface area and ability to bind to DNA.
    • Photo-activated vectors are significant as they enable controlled drug release and targeted delivery.

    Nanoparticle Applications in Drug Delivery

    • Polyamidoamine nanoparticles function as drug carriers enhancing drug efficacy and reducing side effects.
    • The union of doxorubicin and polymers creates nanoparticles that enhance drug accumulation in tumor cells.
    • Using nanocarriers offers the advantage of prolonged drug release, leading to improved therapeutic outcomes.
    • Dynamic Light Scattering (DLS) is an imaging technique used to characterize nanoparticles.
    • Polyamidoamine nanoparticles reduce toxicity by encapsulating drugs, preventing their interactions with healthy tissues.
    • Electroporation and nanocarriers enhance drug delivery by increasing cell membrane permeability and delivering drugs to targeted sites.

    Nanoparticles and Specific Diseases

    • Polyamidoamine nanoparticles are used specifically for treating Alzheimer's disease.
    • A characteristic benefit of using nanomaterials in drug delivery is their ability to cross the blood-brain barrier (BBB).
    • Tacrine, when enhanced in concentration inside the brain, improves cognitive function.

    Solid Lipid Nanoparticles (SLNPs)

    • SLNPs are used primarily to deliver drugs across the BBB.
    • Clozapine, loaded onto SLNPs, ensures safe delivery into the brain microenvironment.
    • Polysorbate, a surfactant, coats the lipid matrix of Vitamin A for its delivery across the BBB.

    Liposomes and Drug Delivery

    • Liposomes are advantageous for drug delivery across the BBB.
    • Coating SLNPs with polysorbate enhances their bioavailability and reduces their clearance from the body.
    • Piperine, loaded on SLNPs, functions to enhance the absorption and bioavailability of drugs.

    Other Nanomedicines

    • Tacrine-loaded polymeric NPs are used for delivering Tacrine to the brain. They offer the advantage of improved drug bioavailability and a reduced risk of side effects.
    • Piperine-loaded SLNPs can cause increased oxidative stress, a potential drawback.
    • Folic-acid-loaded liposomes have the advantage of targeting specific cells that express high levels of folate receptors.
    • Liposomes are known for their capability to hydrolyze both hydrophobic and hydrophilic drugs.
    • Beta-Asarone-loaded nanoemulsions may cause allergic reactions, a disadvantage.

    Common Features of Nanomedicines

    • Liposomes used for drug delivery often have aqueous cores enclosed by lipid bilayers.

    Challenges with Nanomedicines

    • One of the main issues associated with the use of nanomedicines is their potential toxicity to healthy tissues.

    Nanoparticles in Cancer Treatment

    • Gold nanoparticles showed cytotoxicity against brain cancer.
    • Curcumin enhances the delivery of docetaxel into brain melanoma cells.
    • The synergistic influence of nanoparticles mentioned enhances the efficacy of chemotherapy.
    • Methotrexate-loaded nanoparticles were tested on breast cancer cells.
    • Using glycol chitosan nanoparticles in cancer treatment resulted in reduced tumor size
    • Standard astrocyte cells exhibited less cytotoxicity compared to U87MG cells when exposed to tocopherol polyethylene glycol chitosan nanoparticles.
    • Tocopherol polyethylene glycol chitosan nanoparticles exhibit anti-proliferative effects on cancer cells.
    • Glutathione plays a role in influencing the efficacy of nanomedicines by affecting drug release and cellular uptake.

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    Related Documents

    Nanoparticles in Drug Delivery: From History to Therapeutic Applications PDF

    Description

    Explore the innovative applications of nanoparticles in medical treatment, focusing on drug delivery systems such as Silver, Polyamidoamine, and Solid Lipid Nanoparticles. Learn how these technologies improve therapeutic efficacy, particularly in targeting brain diseases like Alzheimer's and Parkinson's. Additionally, understand the challenges and limitations associated with nanomedicines.

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