23 Questions
Which molecule is responsible for making pores on the surface of target cells?
Perforins
What type of cell presents an identical peptide on MHC I to the CD8+ T cell?
Target cell
Which type of cell will a Th0 cell become based on cytokine signal?
Effector cell (Th1, Th2, Th17)
Which molecule is involved in the interaction of CD4 and MHC II?
TCR
Which molecule is responsible for the ligand-receptor type interaction of B7 and CD28?
CD28
Which signaling molecule is assumed to cause a Th0 cell to become a Th2 cell?
IL4
Which cells release oxidative enzymes into the target cell?
CTL
Which molecule is involved in the interaction of pMHC II and TCR?
TCR
Which molecule is responsible for the release of other soluble factors such as TNF?
CTL
Which molecule is involved in the interaction of CD40 and CD40?
CD40
Which molecule is responsible for the ligand-receptor type interaction of CD40 and CD40?
CD40
Which molecule is involved in the immunological synapse?
CD4 * MHC II
Which T cell subset is responsible for cytokine production and cell-to-cell contact for activation?
Helper (CD3+, CD4+)
Which type of cells recognize microbes via various receptors including pattern-recognition receptors (PRR) and present peptides to T cells for recognition?
Dendritic cells (DC)
What type of mitogen triggers ALL (T or B) lymphocytes to activation, undergo blast transformation, and cause resting cells to divide?
Pokeweed mitogen
What is the function of a superantigen?
Stimulate lymphocytes by binding to the TCR, outside of the antigen-binding site
What is the fate of mature T cells after encountering their specific antigen and receiving appropriate accessory signals?
Proliferate and differentiate into effector or memory cells
Which T cell subset is responsible for cytokine production and cell-to-cell contact for suppression?
Regulatory (CD3+, CD4+)
What triggers blast transformation in T cells?
Concanavalin A (con A)
Which molecule derived from microbial organisms stimulates lymphocytes by binding to the TCR, outside of the antigen-binding site?
Staphylococcal protein enterotoxin B (SEB or SE)
What is the primary function of dendritic cells (DC) in the immune response?
Recognize microbes and present peptides to T cells for recognition
What is the role of polyclonal mitogens in triggering lymphocytes?
Trigger ALL (T or B) lymphocytes to activation and division
What is the consequence of mature T cells encountering their specific antigen and receiving appropriate accessory signals?
Proliferation and differentiation into effector or memory cells
Test your knowledge on the activation of naïve T cells with this quiz. Explore concepts such as lymphocyte activation, direct contact and cytokines, DC and macrophage interactions, MHC presentation, and CD8+ T cell activation and function. Sharpen your understanding of T cell activation pathways and mechanisms.
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