NADH Production in Electron Transport Chain
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Questions and Answers

What is produced to carry the electrons in the pathway?

  • FADH2
  • ATP
  • ADP
  • NADH (correct)

Which molecule undergoes dehydrogenation in the pathway?

  • FADH2
  • NADH (correct)
  • ADP
  • ATP

What is the primary purpose of producing NADH in the pathway?

  • Carry electrons (correct)
  • Generate heat
  • Facilitate protein synthesis
  • Store energy

Which of the following molecules is NOT involved in carrying electrons during dehydrogenation in the pathway?

<p>ATP (B)</p> Signup and view all the answers

In the pathway, what role does NADH play with respect to electron transportation?

<p>Carrier of electrons (C)</p> Signup and view all the answers

What happens at this point in the process?

<p>Formation of succinyl CoA (B)</p> Signup and view all the answers

Which structure has not yet been reformed by E2?

<p>Disulfide bond (A)</p> Signup and view all the answers

What is the status of E2's original structure at this point?

<p>Partially reformed (D)</p> Signup and view all the answers

Which molecule is undergoing formation in the process described?

<p>Succinyl CoA (C)</p> Signup and view all the answers

What is the current state of E2's disulfide bond?

<p>Broken down (C)</p> Signup and view all the answers

Which enzyme is responsible for synthesizing citrate?

<p>Isocitrate dehydrogenase (C)</p> Signup and view all the answers

Which enzyme is named after the intermediate aconitate?

<p>Citrate synthase (A)</p> Signup and view all the answers

Which enzyme is involved in converting isocitrate to alpha-ketoglutarate?

<p>Aconitase (C)</p> Signup and view all the answers

What is the main function of malate synthase in the citric acid cycle?

<p>Converting malate to oxaloacetate (C)</p> Signup and view all the answers

Which enzyme is responsible for the conversion of succinate to fumarate in the citric acid cycle?

<p>Aconitase (C)</p> Signup and view all the answers

What is the product of the hydration of Fumarase?

<p>Malate (D)</p> Signup and view all the answers

Which enzyme oxidizes the alcohol group of malate to a keto group?

<p>Malate Dehydrogenase (C)</p> Signup and view all the answers

What is the role of NAD+ in the reaction where malate is converted to oxaloacetate?

<p>Acts as a reducing agent (D)</p> Signup and view all the answers

Which molecule is produced along with NADH when malate is oxidized to oxaloacetate?

<p>CO2 (A)</p> Signup and view all the answers

What happens to the alcohol group of malate during the oxidation process?

<p>It is converted to a carboxyl group (A)</p> Signup and view all the answers

What is the fate of fats in terms of metabolism, according to the text?

<p>Fats are burned in the fire of carbohydrates (A)</p> Signup and view all the answers

Why is it mentioned that fat cannot be converted to glucose?

<p>Due to pyruvate dehydrogenase reaction being irreversible (B)</p> Signup and view all the answers

What is the fate of Acetyl CoA if oxaloacetate is not present?

<p>Acetyl CoA cannot be converted to CO2 (D)</p> Signup and view all the answers

What is the role of CoA in fat metabolism?

<p>CoA is involved in the irreversible step to form fatty acids (B)</p> Signup and view all the answers

Why is it essential for oxaloacetate to be present for Acetyl CoA metabolism?

<p>To ensure Acetyl CoA can enter the Krebs cycle (D)</p> Signup and view all the answers

What needs to be converted in succinate to a keto group?

<p>CH2–CH2 (C)</p> Signup and view all the answers

Which carbon atom needs to be reformed in the middle?

<p>Carbon in CH2 (C)</p> Signup and view all the answers

What is the targeted group for conversion in the process described?

<p>Keto group (C)</p> Signup and view all the answers

What is the aim of reforming the carbon in the middle?

<p>To convert succinate to fumarate (B)</p> Signup and view all the answers

In succinate, what will be the result of converting CH2–CH2 to a keto group?

<p>Conversion to fumarate (B)</p> Signup and view all the answers

What is the final electron acceptor in the electron transport chain during oxidative phosphorylation?

<p>Water (A)</p> Signup and view all the answers

Which process requires oxygen as a crucial component in cellular respiration?

<p>Citric acid cycle (C)</p> Signup and view all the answers

What is the primary role of the electron transport chain in cellular respiration?

<p>Generation of ATP (A)</p> Signup and view all the answers

Which molecule serves as an intermediate carrier of electrons in the electron transport chain?

<p>FADH2 (D)</p> Signup and view all the answers

What is the essential requirement for the efficient functioning of oxidative phosphorylation in mitochondria?

<p>Availability of oxygen (A)</p> Signup and view all the answers

What is the product of the eighth reaction in the pathway?

<p>Ketone (B)</p> Signup and view all the answers

Which reaction converts 5 carbon to 4 carbon in the pathway?

<p>Third reaction (C)</p> Signup and view all the answers

In which reaction of the pathway does the conversion from an alkane to an alkene occur?

<p>Fifth reaction (C)</p> Signup and view all the answers

What happens to Acetyl CoA if oxaloacetate is absent in the pathway?

<p>It accumulates in its original form (D)</p> Signup and view all the answers

Which group is formed when alcohol is converted to a ketone in the pathway?

<p>Carboxyl group (C)</p> Signup and view all the answers

What type of reaction catalyzes the final dehydrogenation in the process described?

<p>Dehydration (B)</p> Signup and view all the answers

In the described process, which molecule acts as the catalyst for the reaction?

<p>Malate (D)</p> Signup and view all the answers

What is the overall effect of oxidation in this process?

<p>Production of NADH (A)</p> Signup and view all the answers

Which type of reaction is NOT involved in the process described?

<p>Reduction (D)</p> Signup and view all the answers

What is the specific enzyme responsible for catalyzing the final dehydrogenation reaction?

<p>Malate dehydrogenase (C)</p> Signup and view all the answers

Which process inhibits aconitase from converting citrate to aconitate?

<p>Noncompetitive inhibition by fluoroacetate (A)</p> Signup and view all the answers

What type of inhibition affects the activity of aconitase in the citric acid cycle?

<p>Noncompetitive inhibition (C)</p> Signup and view all the answers

What effect does fluoroacetate have on the function of aconitase in the citric acid cycle?

<p>Inhibits aconitase function (D)</p> Signup and view all the answers

Which compound causes noncompetitive inhibition of aconitase in the citric acid cycle?

<p>Fluoroacetate (D)</p> Signup and view all the answers

What impact does fluoroacetate have on the conversion of citrate to aconitate by aconitase?

<p>Blocks the enzyme's active site (C)</p> Signup and view all the answers

What type of functional group does citrate contain that cannot be oxidized?

<p>Tertiary alcohol group (D)</p> Signup and view all the answers

How many carboxylic groups are present in citrate that cannot be oxidized?

<p>3 (A)</p> Signup and view all the answers

In citrate, what is the oxidation status of the carboxylic groups?

<p>They cannot be oxidized (C)</p> Signup and view all the answers

What characteristic of the hydroxyl group in citrate makes it resistant to oxidation?

<p>It's a tertiary alcohol (A)</p> Signup and view all the answers

Which type of functional group in citrate plays a role in its resistance to oxidation?

<p>Hydroxyl group (D)</p> Signup and view all the answers

What is the fate of the H molecule that comes out as H+ during the reaction catalyzed by isocitrate dehydrogenase?

<p>It binds with NAD+ to produce NADH (B)</p> Signup and view all the answers

What serves as the electron carrier in the reaction catalyzed by isocitrate dehydrogenase?

<p>NAD+ (D)</p> Signup and view all the answers

Which molecule binds to the other released hydrogen atom during the reaction catalyzed by isocitrate dehydrogenase?

<p>NAD+ (C)</p> Signup and view all the answers

What is the end product of the conversion of isocitrate catalyzed by isocitrate dehydrogenase?

<p>Alpha-ketoglutarate (C)</p> Signup and view all the answers

What happens to the H- ion that is produced during the reaction catalyzed by isocitrate dehydrogenase?

<p>It binds with NAD+ to form NADH (B)</p> Signup and view all the answers

What is the most likely effect of Ca+2 on the rate-limiting enzyme isocitrate dehydrogenase?

<p>Activation (A)</p> Signup and view all the answers

Which molecule is most likely to have an inhibitory effect on isocitrate dehydrogenase?

<p>NADH (A)</p> Signup and view all the answers

What is the probable impact of the absence of ADP on the regulation of isocitrate dehydrogenase?

<p>Inhibition (D)</p> Signup and view all the answers

How does the presence of NADH likely affect the activity of isocitrate dehydrogenase?

<p>Inhibition (A)</p> Signup and view all the answers

Which factor is most likely to have a dual regulatory effect on isocitrate dehydrogenase?

<p>ADP (A)</p> Signup and view all the answers

Which step in the Krebs cycle is mentioned as the only irreversible one?

<p>Conversion of Succinyl CoA to α-Ketoglutarate (C)</p> Signup and view all the answers

What reaction in the Krebs cycle involves the conversion of Fumarate to Malate?

<p>Conversion of Malate to Oxaloacetate (B)</p> Signup and view all the answers

Which compound is formed by converting Citrate to Isocitrate in the Krebs cycle?

<p>Malate (C)</p> Signup and view all the answers

In the Krebs cycle, which reaction converts Succinate to Fumarate?

<p>Conversion of Fumarate to Malate (A)</p> Signup and view all the answers

Which compound is involved in the conversion from Citrate to Isocitrate in the Krebs cycle?

<p>Succinate (C)</p> Signup and view all the answers

Which type of inhibition is exhibited by fluoroacetate on aconitase in the citric acid cycle?

<p>Noncompetitive inhibition (B)</p> Signup and view all the answers

What impact does fluoroacetate have on the activity of aconitase in the citric acid cycle?

<p>Irreversibly inhibits the enzyme (C)</p> Signup and view all the answers

What is the specific effect of fluoroacetate on the conversion process carried out by aconitase?

<p>Alters the enzyme's active site (B)</p> Signup and view all the answers

Why does fluoroacetate inhibit aconitase through noncompetitive inhibition rather than competitive inhibition?

<p>To bind to a site other than the active site (C)</p> Signup and view all the answers

What distinguishes fluoroacetate's inhibition of aconitase from competitive inhibition?

<p>Binding to the active site (A)</p> Signup and view all the answers

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