Myocardial Oxygen Supply

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Questions and Answers

Which of the following compensatory mechanisms reduces oxygen consumption in a heart affected by chronic pressure overload?

  • Myocardial hypertrophy (correct)
  • Increased heart rate
  • Elevated systolic ventricular pressure
  • Increased ventricular radius

A patient's ECG shows ST-segment depressions and T-wave inversions during an episode of chest pain. Which condition is MOST likely causing these changes?

  • Subendocardial ischemia (correct)
  • Pericarditis
  • Acute myocardial infarction
  • Severe hyperkalemia

A patient with an atherosclerotic lesion experiences angina. The imbalance between myocardial oxygen supply and demand is most likely caused by which factor?

  • Increased oxygen extraction by the myocardium
  • Vasodilatation induced by nitric oxide
  • Increased diastolic filling time
  • Impaired coronary perfusion pressure distal to the stenosis (correct)

Which is the MOST likely mechanism by which sublingual nitroglycerin alleviates angina symptoms?

<p>Reduced venous return (D)</p> Signup and view all the answers

Which of the following is a potential adverse effect of nonselective beta-blockers in patients with underlying asthma?

<p>Bronchospasm (A)</p> Signup and view all the answers

After CABG surgery, what type of graft is LEAST likely to develop atherosclerosis?

<p>Internal mammary artery graft (D)</p> Signup and view all the answers

A patient with a history of variant angina is MOST likely experiencing which physiological condition?

<p>Focal coronary artery spasm (A)</p> Signup and view all the answers

What is a key characteristic of 'stunned' myocardium?

<p>Prolonged contractile dysfunction after an ischemic episode (B)</p> Signup and view all the answers

Endothelial cell dysfunction contributes to myocardial ischemia through which mechanism?

<p>Inappropriate vasoconstriction of coronary arteries (A)</p> Signup and view all the answers

A clinician suspects a patient has fixed-threshold angina. What is the MAIN characteristic of this condition?

<p>Required level of activity to trigger angina is fairly constant (A)</p> Signup and view all the answers

What is the underlying cause of 'hibernating myocardium'?

<p>Persistently reduced blood supply (D)</p> Signup and view all the answers

Which class of medication can mask the warning signs of hypoglycemia in insuling-treated diabetic patients?

<p>Beta-blockers (C)</p> Signup and view all the answers

According to Poiseuille's Law, what geometric component has the greatest effect on vascular resistance?

<p>Vessel radius (C)</p> Signup and view all the answers

A patient with atherosclerosis is given intracoronary acetylcholine (ACh) during cardiac catheterization. What paradoxical result suggests endothelial dysfunction?

<p>Paradoxical vasoconstriction (A)</p> Signup and view all the answers

What immediate action would be MOST appropriate for a patient experiencing an acute angina attack?

<p>Cease physical activity (A)</p> Signup and view all the answers

A patient is taking long-acting nitrates for angina. What strategy would best minimize the development of drug tolerance?

<p>Providing a nitrate-free interval each day (D)</p> Signup and view all the answers

When would coronary angiography be MOST appropriate for a patient with angina?

<p>Noninvasive testing suggests severe CAD (D)</p> Signup and view all the answers

What is the PRIMARY limitation of relying solely on coronary angiography for diagnosing clinically significant CAD?

<p>It only provides anatomic information (A)</p> Signup and view all the answers

In myocardial perfusion imaging, what does a 'cold spot' that fills in on a delayed scan MOST likely indicate?

<p>Transient ischemia (A)</p> Signup and view all the answers

Regarding the use of drug-eluting stents, what is the MOST concerning risk associated with the delayed endothelialization?

<p>Thrombus formation (B)</p> Signup and view all the answers

Which vessel is typically used for bypass in CABG due to its resistance to atherosclerosis?

<p>Internal mammary artery (A)</p> Signup and view all the answers

A patient reports chest discomfort, but also generalized sympathetic stimulation. What is a common symptom?

<p>Diaphoresis (B)</p> Signup and view all the answers

When inquiring about triggers for angina, what conditions do NOT increase myocardial oxygen demand?

<p>Increased activity (D)</p> Signup and view all the answers

Which is NOT necessarily a good test to order to confirm myocardial ischemia as the cause?

<p>Blood test for Troponin (B)</p> Signup and view all the answers

Which action is MOST responsible for the pain relief caused by sublingual nitroglycerin?

<p>Vasodilatation (C)</p> Signup and view all the answers

What are non-invasive diagnostic tool(s) for detection of a stenoses that reduce the size of vessel lumens?

<p>Coronary CT angiography (D)</p> Signup and view all the answers

The use of aggressive lipid-lowering drug therapy after which surgery improves the long-term patency rates?

<p>CABG (D)</p> Signup and view all the answers

What is measured when using coronary angiography to identify coronary artery stenoses??

<p>Atherosclerotic lesions (D)</p> Signup and view all the answers

A condition called a superflous branch of each subclavian are used in what procedure?

<p>Coronary Artery ByPass Graft(CABG) Surgergy (A)</p> Signup and view all the answers

Which of the following is likely to be a potential sign related to the myocardium during ischemia that can lead dyspnea?

<p>transient dysfunction (D)</p> Signup and view all the answers

Select the option that is typically NOT present itself with patients that have CAD?

<p>A good lifestyle (A)</p> Signup and view all the answers

What are a few factors of major importance in order to determine the net impact on vascular tone?

<p>Neural (B)</p> Signup and view all the answers

A patient lacks no coronary artery calcification (CAC), what does this indicate?

<p>It strongly predicts the absence of CAD (C)</p> Signup and view all the answers

What is the relationship between low-dose anticoagulants plus aspiring compared to just taking aspiring alone?

<p>Further reduces the risk of death and ischemic complications (A)</p> Signup and view all the answers

If the standard radionuclide test is between 85% sensitive and 70-90% specific for the detection of clinically significant what cardiovascular decease?

<p>CAD (C)</p> Signup and view all the answers

In a normal state what promotes vascular smooth muscle relaxation through elaboration of substace?

<p>NO (B)</p> Signup and view all the answers

Which of the following conditions lowers the risk of coronary disease events?

<p>LDL cholesterol reduction (C)</p> Signup and view all the answers

Which of the following contributes to the reduction in coronary blood supply

<p>Constriction (B)</p> Signup and view all the answers

Increasing the rate of contraction will make what physiological event occur?

<p>Increase oxygen (B)</p> Signup and view all the answers

If a patient has cardiac ischemia causes the inability to perfuse what may this result too?

<p>The lack of oxygen (C)</p> Signup and view all the answers

What are the two ways abnormal endothelial cell function can contribute to the pathophysiology of ischemia?

<p>Both A and B (C)</p> Signup and view all the answers

During periods of increased heart rate, which compensatory mechanism becomes MOST critical for maintaining adequate myocardial oxygen supply?

<p>Enhanced diastolic filling time for coronary perfusion (B)</p> Signup and view all the answers

A patient with risk factors for atherosclerosis undergoes cardiac catheterization. Intracoronary acetylcholine administration causes vasoconstriction instead of vasodilation. This paradoxical response is MOST indicative of:

<p>Endothelial dysfunction (C)</p> Signup and view all the answers

A patient experiences chest pain that occurs unpredictably, often at rest, and is promptly relieved by nitroglycerin. ECG during pain shows ST-segment elevation. This clinical presentation is MOST consistent with:

<p>Variant angina due to coronary artery spasm (B)</p> Signup and view all the answers

A physician aims to reduce myocardial oxygen demand in a patient with stable angina using pharmacological interventions. According to the determinants of myocardial oxygen demand, which of the following drug classes would be MOST effective in achieving this goal?

<p>Beta-blockers (A)</p> Signup and view all the answers

While coronary angiography is effective in identifying anatomical stenoses, what is its PRIMARY limitation in assessing the clinical significance of coronary artery disease?

<p>Limited information on plaque composition and vulnerability (A)</p> Signup and view all the answers

Flashcards

Ischemic Heart Disease

Imbalance between myocardial oxygen supply and demand, often due to atherosclerosis.

Angina Pectoris

Uncomfortable sensation in the chest due to myocardial ischemia.

Stable Angina

Transient angina, precipitated by activity or upset, relieved by rest.

Variant Angina

Angina at rest due to coronary artery spasm, not increased oxygen demand.

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Silent Ischemia

Asymptomatic episodes of myocardial ischemia, detected by electrocardiogram.

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Unstable Angina

Increased frequency and duration of angina episodes, even at rest.

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Myocardial Infarction

Myocardial necrosis from prolonged blood supply cessation.

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Myocardial Oxygen Supply

Oxygen content and coronary blood flow.

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Myocardial Oxygen Demand

Wall stress, heart rate, and contractility.

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Oxygen Content

Hemoglobin concentration and oxygen saturation.

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Coronary Blood Flow

Perfusion pressure and vascular resistance.

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External Compression

Compression during cardiac cycle by surrounding myocardium.

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Intrinsic Control of Arterial Tone

Autoregulation via local factors, endothelium, and nerves.

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Metabolic factors for Coronary Control

Lactate, acetate, hydrogen ions, and carbon dioxide.

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Endothelial Vasodilators

Nitric oxide (NO), prostacyclin, and EDHF.

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Ventricular Wall Stress

Tangential force on myocardial fibers.

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Fixed Vessel Narrowing

Fixed plaques narrow lumen, limiting blood supply.

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Hemodynamic Significance factors.

Lumen diameter and lesion length.

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Coronary Artery Anatomy

Large epicardial segments and smaller distal arterioles.

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Endothelial Dysfunction

Inappropriate vasoconstriction and loss of antithrombotic properties.

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Consequences of Ischemia

Inadequate oxygen, metabolic waste accumulation.

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Stunned Myocardium

Prolonged contractile dysfunction after transient ischemia without necrosis.

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Hibernating Myocardium

Chronic dysfunction due to persistently reduced blood supply.

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Stable Angina

Predictable chest discomfort during exertion.

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Unstable Angina

Sudden increase in ischemic episodes, even at rest.

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Variant or Prinzmetal Angina

Focal artery spasm in absence of atherosclerotic lesions.

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Silent Ischemia

Cardiac ischemia without perceptible discomfort.

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Microvascular Angina

Angina pectoris without significant coronary stenoses.

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Angina Quality

Pressure, tightness, burning or heaviness

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Angina Precipitant

Increase myocardial oxygen

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Angina Location

Retrosternal, radiates to shoulders and arms.

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Angina Symptoms

Tachycardia, diaphoresis and nausea.

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Angina Risk factors

Atherosclerosis, smoking, and hypertension.

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Angina Assessment

transient physical symptoms.

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Diagnostic studies.

Used to confirm myocardial

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Exercise testing

exercise progressively.

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Nuclear Imaging studies.

Use of radionuclide with exercise

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Exercise echocardiography

Assess LV function & cardiac output.

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Pharmacologic stress studies

Those unable to exercise.

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Coronary Angiography

Most direct ID of CAD is by.

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Noninvasive imaging

Determine if intervention Is needed.

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Sublingual nitroglycerin.

Long term angina treatment and relief is by

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Beta Blockers

Reduce cardiac workload by heart.

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Calcium channel blockers.

Antagonize voltage calcium heart channels.

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Ranolazine

Reduces the frequency of cardiac.

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Study Notes

  • Major factors determining myocardial oxygen supply include oxygen content, coronary blood flow, coronary perfusion pressure and vascular resistance, as well as external compression and intrinsic regulation.
  • The heart cannot increase oxygen extraction, so additional oxygen must be met by an increase in blood flow regulated by coronary vascular resistance.
  • Coronary artery flow is directly proportional to perfusion pressure and inversely proportional to vascular resistance.
  • Blood flow happens during diastole with systolic flow impaired by compression from the contracting myocardium.
  • Perfusion pressure is approximated by aortic diastolic pressure.
  • Conditions that lower aortic diastolic pressure can decrease myocardial oxygen supply.
  • Coronary vascular resistance is dynamically modulated by external forces and factors altering intrinsic coronary tone.

External Compression

  • External compression is exerted on coronary vessels during the cycle by surrounding myocardial contraction.
  • Subendocardium is more vulnerable to ischemic damage due to its proximity and the great force over outer layers.

Intrinsic Control of Coronary Arterial Tone

  • Autoregulation of vascular resistance is the most important mediator.
  • Accumulation of local metabolites, endothelium-derived substances, and neural innervation all participate.
  • Tissue hypoxia inhibits aerobic metabolism, reducing high-energy phosphates
  • Leads to an accumulation of adenosine which is potent vasodilator.
  • Other vasodilators include lactate, acetate, hydrogen ions, and carbon dioxide.

Endothelial Factors

  • Endothelial cells lining arterial walls produce vasoactive substances that regulate vascular tone.
  • Vasodilators produced by the endothelium include nitric oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor (EDHF).
  • Endothelin-1 is an example of an endothelium-derived vasoconstrictor.

Myocardial Oxygen Demand

  • The three major determinants include ventricular wall stress, heart rate, and contractility
  • Small amounts of oxygen are consumed for basal cardiac metabolism and depolarization

Ventricular Wall Stress

  • Tangential force acting on myocardial fibers; is directly proportional to systolic ventricular pressure
  • Wall stress is also directly proportional to the radius.
  • Hypertrophied hearts have lower wall stress.

Pathophysiology of Ischemia: Fluid Mechanics

  • Poiseuille's Law states that flow depends on pressure difference and vessel's geometry with radius having a huge impact.
  • Hemodynamic significance of a stenotic lesion depends on its length and degree of narrowing.

Anatomy Consideration

  • Coronary arteries consist of proximal epicardial segments and distal resistance vessels.
  • Distal vessels can adjust vasomotor tone to meet metabolic needs. The vessels increase in diameter with exertion meeting oxygen demand.

Collateral Flow

  • Collateral connections can buffer myocardial oxygen supply but not enough during exertion in critically narrowed vessels.

Endothelial Cell Dysfunction

  • Suppresses myocardial oxygen supply due to the inappropriate vasoconstriction and loss of anti-thrombotic properties.
  • physical activity or mental stress results in measurable coronary artery vasodilatation in normal persons due to endothelial-derived vasodilators such as NO.
  • endothelial dysfunction, impaired release of vasodilator increases catecholamine effects resulting in vasoconstriction instead.
  • Even vasodilatory effect is attenuated in patients with dysfunctional endothelium.

Factors Released by Endothelial Cells

  • Endothelial cells release of NO and prostacyclin also limits further platelet aggregation.
  • Endothelial dysfunctional causes a compromise increasing the arterial lumen in the presence of platelet-derived products.

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