Podcast
Questions and Answers
Which of the following compensatory mechanisms reduces oxygen consumption in a heart affected by chronic pressure overload?
Which of the following compensatory mechanisms reduces oxygen consumption in a heart affected by chronic pressure overload?
- Myocardial hypertrophy (correct)
- Increased heart rate
- Elevated systolic ventricular pressure
- Increased ventricular radius
A patient's ECG shows ST-segment depressions and T-wave inversions during an episode of chest pain. Which condition is MOST likely causing these changes?
A patient's ECG shows ST-segment depressions and T-wave inversions during an episode of chest pain. Which condition is MOST likely causing these changes?
- Subendocardial ischemia (correct)
- Pericarditis
- Acute myocardial infarction
- Severe hyperkalemia
A patient with an atherosclerotic lesion experiences angina. The imbalance between myocardial oxygen supply and demand is most likely caused by which factor?
A patient with an atherosclerotic lesion experiences angina. The imbalance between myocardial oxygen supply and demand is most likely caused by which factor?
- Increased oxygen extraction by the myocardium
- Vasodilatation induced by nitric oxide
- Increased diastolic filling time
- Impaired coronary perfusion pressure distal to the stenosis (correct)
Which is the MOST likely mechanism by which sublingual nitroglycerin alleviates angina symptoms?
Which is the MOST likely mechanism by which sublingual nitroglycerin alleviates angina symptoms?
Which of the following is a potential adverse effect of nonselective beta-blockers in patients with underlying asthma?
Which of the following is a potential adverse effect of nonselective beta-blockers in patients with underlying asthma?
After CABG surgery, what type of graft is LEAST likely to develop atherosclerosis?
After CABG surgery, what type of graft is LEAST likely to develop atherosclerosis?
A patient with a history of variant angina is MOST likely experiencing which physiological condition?
A patient with a history of variant angina is MOST likely experiencing which physiological condition?
What is a key characteristic of 'stunned' myocardium?
What is a key characteristic of 'stunned' myocardium?
Endothelial cell dysfunction contributes to myocardial ischemia through which mechanism?
Endothelial cell dysfunction contributes to myocardial ischemia through which mechanism?
A clinician suspects a patient has fixed-threshold angina. What is the MAIN characteristic of this condition?
A clinician suspects a patient has fixed-threshold angina. What is the MAIN characteristic of this condition?
What is the underlying cause of 'hibernating myocardium'?
What is the underlying cause of 'hibernating myocardium'?
Which class of medication can mask the warning signs of hypoglycemia in insuling-treated diabetic patients?
Which class of medication can mask the warning signs of hypoglycemia in insuling-treated diabetic patients?
According to Poiseuille's Law, what geometric component has the greatest effect on vascular resistance?
According to Poiseuille's Law, what geometric component has the greatest effect on vascular resistance?
A patient with atherosclerosis is given intracoronary acetylcholine (ACh) during cardiac catheterization. What paradoxical result suggests endothelial dysfunction?
A patient with atherosclerosis is given intracoronary acetylcholine (ACh) during cardiac catheterization. What paradoxical result suggests endothelial dysfunction?
What immediate action would be MOST appropriate for a patient experiencing an acute angina attack?
What immediate action would be MOST appropriate for a patient experiencing an acute angina attack?
A patient is taking long-acting nitrates for angina. What strategy would best minimize the development of drug tolerance?
A patient is taking long-acting nitrates for angina. What strategy would best minimize the development of drug tolerance?
When would coronary angiography be MOST appropriate for a patient with angina?
When would coronary angiography be MOST appropriate for a patient with angina?
What is the PRIMARY limitation of relying solely on coronary angiography for diagnosing clinically significant CAD?
What is the PRIMARY limitation of relying solely on coronary angiography for diagnosing clinically significant CAD?
In myocardial perfusion imaging, what does a 'cold spot' that fills in on a delayed scan MOST likely indicate?
In myocardial perfusion imaging, what does a 'cold spot' that fills in on a delayed scan MOST likely indicate?
Regarding the use of drug-eluting stents, what is the MOST concerning risk associated with the delayed endothelialization?
Regarding the use of drug-eluting stents, what is the MOST concerning risk associated with the delayed endothelialization?
Which vessel is typically used for bypass in CABG due to its resistance to atherosclerosis?
Which vessel is typically used for bypass in CABG due to its resistance to atherosclerosis?
A patient reports chest discomfort, but also generalized sympathetic stimulation. What is a common symptom?
A patient reports chest discomfort, but also generalized sympathetic stimulation. What is a common symptom?
When inquiring about triggers for angina, what conditions do NOT increase myocardial oxygen demand?
When inquiring about triggers for angina, what conditions do NOT increase myocardial oxygen demand?
Which is NOT necessarily a good test to order to confirm myocardial ischemia as the cause?
Which is NOT necessarily a good test to order to confirm myocardial ischemia as the cause?
Which action is MOST responsible for the pain relief caused by sublingual nitroglycerin?
Which action is MOST responsible for the pain relief caused by sublingual nitroglycerin?
What are non-invasive diagnostic tool(s) for detection of a stenoses that reduce the size of vessel lumens?
What are non-invasive diagnostic tool(s) for detection of a stenoses that reduce the size of vessel lumens?
The use of aggressive lipid-lowering drug therapy after which surgery improves the long-term patency rates?
The use of aggressive lipid-lowering drug therapy after which surgery improves the long-term patency rates?
What is measured when using coronary angiography to identify coronary artery stenoses??
What is measured when using coronary angiography to identify coronary artery stenoses??
A condition called a superflous branch of each subclavian are used in what procedure?
A condition called a superflous branch of each subclavian are used in what procedure?
Which of the following is likely to be a potential sign related to the myocardium during ischemia that can lead dyspnea?
Which of the following is likely to be a potential sign related to the myocardium during ischemia that can lead dyspnea?
Select the option that is typically NOT present itself with patients that have CAD?
Select the option that is typically NOT present itself with patients that have CAD?
What are a few factors of major importance in order to determine the net impact on vascular tone?
What are a few factors of major importance in order to determine the net impact on vascular tone?
A patient lacks no coronary artery calcification (CAC), what does this indicate?
A patient lacks no coronary artery calcification (CAC), what does this indicate?
What is the relationship between low-dose anticoagulants plus aspiring compared to just taking aspiring alone?
What is the relationship between low-dose anticoagulants plus aspiring compared to just taking aspiring alone?
If the standard radionuclide test is between 85% sensitive and 70-90% specific for the detection of clinically significant what cardiovascular decease?
If the standard radionuclide test is between 85% sensitive and 70-90% specific for the detection of clinically significant what cardiovascular decease?
In a normal state what promotes vascular smooth muscle relaxation through elaboration of substace?
In a normal state what promotes vascular smooth muscle relaxation through elaboration of substace?
Which of the following conditions lowers the risk of coronary disease events?
Which of the following conditions lowers the risk of coronary disease events?
Which of the following contributes to the reduction in coronary blood supply
Which of the following contributes to the reduction in coronary blood supply
Increasing the rate of contraction will make what physiological event occur?
Increasing the rate of contraction will make what physiological event occur?
If a patient has cardiac ischemia causes the inability to perfuse what may this result too?
If a patient has cardiac ischemia causes the inability to perfuse what may this result too?
What are the two ways abnormal endothelial cell function can contribute to the pathophysiology of ischemia?
What are the two ways abnormal endothelial cell function can contribute to the pathophysiology of ischemia?
During periods of increased heart rate, which compensatory mechanism becomes MOST critical for maintaining adequate myocardial oxygen supply?
During periods of increased heart rate, which compensatory mechanism becomes MOST critical for maintaining adequate myocardial oxygen supply?
A patient with risk factors for atherosclerosis undergoes cardiac catheterization. Intracoronary acetylcholine administration causes vasoconstriction instead of vasodilation. This paradoxical response is MOST indicative of:
A patient with risk factors for atherosclerosis undergoes cardiac catheterization. Intracoronary acetylcholine administration causes vasoconstriction instead of vasodilation. This paradoxical response is MOST indicative of:
A patient experiences chest pain that occurs unpredictably, often at rest, and is promptly relieved by nitroglycerin. ECG during pain shows ST-segment elevation. This clinical presentation is MOST consistent with:
A patient experiences chest pain that occurs unpredictably, often at rest, and is promptly relieved by nitroglycerin. ECG during pain shows ST-segment elevation. This clinical presentation is MOST consistent with:
A physician aims to reduce myocardial oxygen demand in a patient with stable angina using pharmacological interventions. According to the determinants of myocardial oxygen demand, which of the following drug classes would be MOST effective in achieving this goal?
A physician aims to reduce myocardial oxygen demand in a patient with stable angina using pharmacological interventions. According to the determinants of myocardial oxygen demand, which of the following drug classes would be MOST effective in achieving this goal?
While coronary angiography is effective in identifying anatomical stenoses, what is its PRIMARY limitation in assessing the clinical significance of coronary artery disease?
While coronary angiography is effective in identifying anatomical stenoses, what is its PRIMARY limitation in assessing the clinical significance of coronary artery disease?
Flashcards
Ischemic Heart Disease
Ischemic Heart Disease
Imbalance between myocardial oxygen supply and demand, often due to atherosclerosis.
Angina Pectoris
Angina Pectoris
Uncomfortable sensation in the chest due to myocardial ischemia.
Stable Angina
Stable Angina
Transient angina, precipitated by activity or upset, relieved by rest.
Variant Angina
Variant Angina
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Silent Ischemia
Silent Ischemia
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Unstable Angina
Unstable Angina
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Myocardial Infarction
Myocardial Infarction
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Myocardial Oxygen Supply
Myocardial Oxygen Supply
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Myocardial Oxygen Demand
Myocardial Oxygen Demand
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Oxygen Content
Oxygen Content
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Coronary Blood Flow
Coronary Blood Flow
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External Compression
External Compression
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Intrinsic Control of Arterial Tone
Intrinsic Control of Arterial Tone
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Metabolic factors for Coronary Control
Metabolic factors for Coronary Control
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Endothelial Vasodilators
Endothelial Vasodilators
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Ventricular Wall Stress
Ventricular Wall Stress
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Fixed Vessel Narrowing
Fixed Vessel Narrowing
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Hemodynamic Significance factors.
Hemodynamic Significance factors.
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Coronary Artery Anatomy
Coronary Artery Anatomy
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Endothelial Dysfunction
Endothelial Dysfunction
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Consequences of Ischemia
Consequences of Ischemia
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Stunned Myocardium
Stunned Myocardium
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Hibernating Myocardium
Hibernating Myocardium
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Stable Angina
Stable Angina
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Unstable Angina
Unstable Angina
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Variant or Prinzmetal Angina
Variant or Prinzmetal Angina
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Silent Ischemia
Silent Ischemia
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Microvascular Angina
Microvascular Angina
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Angina Quality
Angina Quality
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Angina Precipitant
Angina Precipitant
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Angina Location
Angina Location
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Angina Symptoms
Angina Symptoms
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Angina Risk factors
Angina Risk factors
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Angina Assessment
Angina Assessment
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Diagnostic studies.
Diagnostic studies.
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Exercise testing
Exercise testing
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Nuclear Imaging studies.
Nuclear Imaging studies.
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Exercise echocardiography
Exercise echocardiography
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Pharmacologic stress studies
Pharmacologic stress studies
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Coronary Angiography
Coronary Angiography
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Noninvasive imaging
Noninvasive imaging
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Sublingual nitroglycerin.
Sublingual nitroglycerin.
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Beta Blockers
Beta Blockers
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Calcium channel blockers.
Calcium channel blockers.
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Ranolazine
Ranolazine
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Study Notes
- Major factors determining myocardial oxygen supply include oxygen content, coronary blood flow, coronary perfusion pressure and vascular resistance, as well as external compression and intrinsic regulation.
- The heart cannot increase oxygen extraction, so additional oxygen must be met by an increase in blood flow regulated by coronary vascular resistance.
- Coronary artery flow is directly proportional to perfusion pressure and inversely proportional to vascular resistance.
- Blood flow happens during diastole with systolic flow impaired by compression from the contracting myocardium.
- Perfusion pressure is approximated by aortic diastolic pressure.
- Conditions that lower aortic diastolic pressure can decrease myocardial oxygen supply.
- Coronary vascular resistance is dynamically modulated by external forces and factors altering intrinsic coronary tone.
External Compression
- External compression is exerted on coronary vessels during the cycle by surrounding myocardial contraction.
- Subendocardium is more vulnerable to ischemic damage due to its proximity and the great force over outer layers.
Intrinsic Control of Coronary Arterial Tone
- Autoregulation of vascular resistance is the most important mediator.
- Accumulation of local metabolites, endothelium-derived substances, and neural innervation all participate.
- Tissue hypoxia inhibits aerobic metabolism, reducing high-energy phosphates
- Leads to an accumulation of adenosine which is potent vasodilator.
- Other vasodilators include lactate, acetate, hydrogen ions, and carbon dioxide.
Endothelial Factors
- Endothelial cells lining arterial walls produce vasoactive substances that regulate vascular tone.
- Vasodilators produced by the endothelium include nitric oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor (EDHF).
- Endothelin-1 is an example of an endothelium-derived vasoconstrictor.
Myocardial Oxygen Demand
- The three major determinants include ventricular wall stress, heart rate, and contractility
- Small amounts of oxygen are consumed for basal cardiac metabolism and depolarization
Ventricular Wall Stress
- Tangential force acting on myocardial fibers; is directly proportional to systolic ventricular pressure
- Wall stress is also directly proportional to the radius.
- Hypertrophied hearts have lower wall stress.
Pathophysiology of Ischemia: Fluid Mechanics
- Poiseuille's Law states that flow depends on pressure difference and vessel's geometry with radius having a huge impact.
- Hemodynamic significance of a stenotic lesion depends on its length and degree of narrowing.
Anatomy Consideration
- Coronary arteries consist of proximal epicardial segments and distal resistance vessels.
- Distal vessels can adjust vasomotor tone to meet metabolic needs. The vessels increase in diameter with exertion meeting oxygen demand.
Collateral Flow
- Collateral connections can buffer myocardial oxygen supply but not enough during exertion in critically narrowed vessels.
Endothelial Cell Dysfunction
- Suppresses myocardial oxygen supply due to the inappropriate vasoconstriction and loss of anti-thrombotic properties.
- physical activity or mental stress results in measurable coronary artery vasodilatation in normal persons due to endothelial-derived vasodilators such as NO.
- endothelial dysfunction, impaired release of vasodilator increases catecholamine effects resulting in vasoconstriction instead.
- Even vasodilatory effect is attenuated in patients with dysfunctional endothelium.
Factors Released by Endothelial Cells
- Endothelial cells release of NO and prostacyclin also limits further platelet aggregation.
- Endothelial dysfunctional causes a compromise increasing the arterial lumen in the presence of platelet-derived products.
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