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Myelodysplastic Syndromes (MDS) Disorders

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Myelodysplastic Syndromes (MDS) Disorders

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Questions and Answers

What is the characteristic of megakaryoblasts in Acute Megakaryoblastic Leukemia?

Positive for MPO

Lack of MPO (correct)

Hypercellular bone marrow with normal maturation

Increased tyrosine kinase activity

What is the age range for Acute Megakaryoblastic Leukemia associated with Down syndrome?

Between 20-40 years

Before the age of 5 (correct)

Before the age of 10

After the age of 60

What is the primary complication of Myelodysplastic Syndromes?

Infection or bleeding (correct)

Hyperuricemia and gout

Transformation to acute leukemia

Marrow fibrosis

What is the characteristic of bone marrow in Myelodysplastic Syndromes?

Hypercellular with abnormal maturation Signup and view all the answers

What is the primary driver of Chronic Myeloid Leukemia (CML)?

t(9;22) translocation Signup and view all the answers

What is the first line treatment for Chronic Myeloid Leukemia (CML)?

Imatinib Signup and view all the answers

What is the characteristic feature of the bone marrow in Myelodysplastic Syndromes?

Hypercellularity or normocellularity Signup and view all the answers

What is the percentage of Myelodysplastic Syndromes cases that progress to Acute Myeloid Leukemia?

10% to 40% Signup and view all the answers

What is the term for a chronically enlarged spleen that removes excessive numbers of formed blood elements, leading to anemia, leukopenia, or thrombocytopenia?

Hypersplenism Signup and view all the answers

What is the typical appearance of megakaryocytes in Myelodysplastic Syndromes?

Small with single small nuclei Signup and view all the answers

What is the primary defect in Myelodysplastic Syndromes?

Maturation defects in hematopoiesis Signup and view all the answers

What is the term for a group of clonal stem cell disorders characterized by maturation defects and ineffective hematopoiesis?

Myelodysplastic Syndromes Signup and view all the answers

What is a characteristic of myeloproliferative neoplasms?

Dysregulated growth with increased formed elements Signup and view all the answers

What is the average age of onset for Acute Myeloid Leukemia (AML)?

50-60 years Signup and view all the answers

What is the hallmark of Auer rod AML?

Crystal aggregates of myeloperoxidase Signup and view all the answers