Myasthenia Gravis Symptoms
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Questions and Answers

What is the characteristic facial expression in a patient with MG?

  • A smiling expression
  • A frowning expression
  • A neutral expression
  • A snarling expression (correct)

In patients with MG, what is the most noticeable effect of weakness in chewing?

  • Difficulty in swallowing
  • Inability to chew
  • Weakness after prolonged effort (correct)
  • Pain in the jaw

What is the characteristic of speech in patients with MG?

  • A stuttering quality
  • A nasal quality (correct)
  • A hoarse quality
  • A slurring quality

What percentage of patients with MG experience generalized weakness?

<p>85% (C)</p> Signup and view all the answers

What is the significance of weakness remaining restricted to the extraocular muscles for 3 years?

<p>It will not become generalized (A)</p> Signup and view all the answers

What is the diagnostic significance of anti-AChR antibodies?

<p>They are virtually diagnostic of MG (A)</p> Signup and view all the answers

What percentage decrease in amplitude of evoked muscle action potentials is seen in myasthenic patients during repetitive nerve stimulation?

<p>10-15% (D)</p> Signup and view all the answers

What is the primary purpose of administering edrophonium (Tensilon) in myasthenia gravis patients?

<p>To diagnose myasthenia gravis (C)</p> Signup and view all the answers

What is the term for the test that involves inserting a fine wire electrode through the skin and into a muscle to test a single muscle fiber?

<p>Single-fiber electromyography (EMG) (B)</p> Signup and view all the answers

What is the enzyme that is inhibited by certain drugs to improve muscle strength in myasthenia gravis patients?

<p>Acetylcholinesterase (AChE) (D)</p> Signup and view all the answers

What is the term for the antibody that may be present in some seronegative myasthenia gravis patients?

<p>Muscle-specific kinase (MuSK) antibody (C)</p> Signup and view all the answers

Which of the following is a characteristic of bulbar weakness in myasthenia gravis?

<p>Dysphagia (B)</p> Signup and view all the answers

What is a common finding in normal individuals undergoing repetitive nerve stimulation?

<p>No change in the amplitude of evoked muscle action potentials (C)</p> Signup and view all the answers

What is the effect of anticholinesterase medication on myasthenic patients?

<p>At least partial improvement in most patients (B)</p> Signup and view all the answers

What is the primary treatment for myasthenia gravis when symptomatic treatment is not effective?

<p>Immunosuppressive agents (C)</p> Signup and view all the answers

What is a possible side effect of anticholinesterase medication?

<p>Muscarinic side effects such as diarrhea (D)</p> Signup and view all the answers

What is used to treat gastrointestinal symptoms caused by anticholinesterase medication?

<p>Atropine/diphenoxylate or loperamide (D)</p> Signup and view all the answers

What is a characteristic of autonomic findings in myasthenia gravis?

<p>Dilated or poorly reactive pupils (B)</p> Signup and view all the answers

What percentage of patients with MG develop hyperthyroidism?

<p>3-8% (B)</p> Signup and view all the answers

What is the primary cause of Lambert-Eaton myasthenic syndrome?

<p>Autoantibodies against calcium channels (D)</p> Signup and view all the answers

Which of the following is a common finding in patients with LEMS?

<p>Depressed or absent reflexes (A)</p> Signup and view all the answers

What is the primary mechanism of action of the botulinum toxin?

<p>Interfering with the release of acetylcholine (A)</p> Signup and view all the answers

Why are PFTs valuable in patients with MG?

<p>To monitor respiratory function (A)</p> Signup and view all the answers

What is the most common type of cancer associated with LEMS?

<p>Lung carcinoma (D)</p> Signup and view all the answers

What is the estimated percentage of patients who experience improvement with treatment?

<p>70% (C)</p> Signup and view all the answers

What is a rare but serious adverse reaction associated with treatment?

<p>Aseptic meningitis (D)</p> Signup and view all the answers

What is the primary cause of myasthenic crisis?

<p>Intercurrent infection (C)</p> Signup and view all the answers

In what type of unit should treatment for myasthenic crisis take place?

<p>Intensive care unit (A)</p> Signup and view all the answers

What is a common therapeutic approach to hasten recovery in myasthenic crisis?

<p>Plasmapheresis or IVIg (A)</p> Signup and view all the answers

Why should anticholinesterase drugs be temporarily stopped in myasthenic crisis?

<p>To rule out cholinergic crisis (D)</p> Signup and view all the answers

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