Myasthenia Gravis Symptoms
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Questions and Answers

What is the characteristic facial expression in a patient with MG?

  • A smiling expression
  • A frowning expression
  • A neutral expression
  • A snarling expression (correct)
  • In patients with MG, what is the most noticeable effect of weakness in chewing?

  • Difficulty in swallowing
  • Inability to chew
  • Weakness after prolonged effort (correct)
  • Pain in the jaw
  • What is the characteristic of speech in patients with MG?

  • A stuttering quality
  • A nasal quality (correct)
  • A hoarse quality
  • A slurring quality
  • What percentage of patients with MG experience generalized weakness?

    <p>85%</p> Signup and view all the answers

    What is the significance of weakness remaining restricted to the extraocular muscles for 3 years?

    <p>It will not become generalized</p> Signup and view all the answers

    What is the diagnostic significance of anti-AChR antibodies?

    <p>They are virtually diagnostic of MG</p> Signup and view all the answers

    What percentage decrease in amplitude of evoked muscle action potentials is seen in myasthenic patients during repetitive nerve stimulation?

    <p>10-15%</p> Signup and view all the answers

    What is the primary purpose of administering edrophonium (Tensilon) in myasthenia gravis patients?

    <p>To diagnose myasthenia gravis</p> Signup and view all the answers

    What is the term for the test that involves inserting a fine wire electrode through the skin and into a muscle to test a single muscle fiber?

    <p>Single-fiber electromyography (EMG)</p> Signup and view all the answers

    What is the enzyme that is inhibited by certain drugs to improve muscle strength in myasthenia gravis patients?

    <p>Acetylcholinesterase (AChE)</p> Signup and view all the answers

    What is the term for the antibody that may be present in some seronegative myasthenia gravis patients?

    <p>Muscle-specific kinase (MuSK) antibody</p> Signup and view all the answers

    Which of the following is a characteristic of bulbar weakness in myasthenia gravis?

    <p>Dysphagia</p> Signup and view all the answers

    What is a common finding in normal individuals undergoing repetitive nerve stimulation?

    <p>No change in the amplitude of evoked muscle action potentials</p> Signup and view all the answers

    What is the effect of anticholinesterase medication on myasthenic patients?

    <p>At least partial improvement in most patients</p> Signup and view all the answers

    What is the primary treatment for myasthenia gravis when symptomatic treatment is not effective?

    <p>Immunosuppressive agents</p> Signup and view all the answers

    What is a possible side effect of anticholinesterase medication?

    <p>Muscarinic side effects such as diarrhea</p> Signup and view all the answers

    What is used to treat gastrointestinal symptoms caused by anticholinesterase medication?

    <p>Atropine/diphenoxylate or loperamide</p> Signup and view all the answers

    What is a characteristic of autonomic findings in myasthenia gravis?

    <p>Dilated or poorly reactive pupils</p> Signup and view all the answers

    What percentage of patients with MG develop hyperthyroidism?

    <p>3-8%</p> Signup and view all the answers

    What is the primary cause of Lambert-Eaton myasthenic syndrome?

    <p>Autoantibodies against calcium channels</p> Signup and view all the answers

    Which of the following is a common finding in patients with LEMS?

    <p>Depressed or absent reflexes</p> Signup and view all the answers

    What is the primary mechanism of action of the botulinum toxin?

    <p>Interfering with the release of acetylcholine</p> Signup and view all the answers

    Why are PFTs valuable in patients with MG?

    <p>To monitor respiratory function</p> Signup and view all the answers

    What is the most common type of cancer associated with LEMS?

    <p>Lung carcinoma</p> Signup and view all the answers

    What is the estimated percentage of patients who experience improvement with treatment?

    <p>70%</p> Signup and view all the answers

    What is a rare but serious adverse reaction associated with treatment?

    <p>Aseptic meningitis</p> Signup and view all the answers

    What is the primary cause of myasthenic crisis?

    <p>Intercurrent infection</p> Signup and view all the answers

    In what type of unit should treatment for myasthenic crisis take place?

    <p>Intensive care unit</p> Signup and view all the answers

    What is a common therapeutic approach to hasten recovery in myasthenic crisis?

    <p>Plasmapheresis or IVIg</p> Signup and view all the answers

    Why should anticholinesterase drugs be temporarily stopped in myasthenic crisis?

    <p>To rule out cholinergic crisis</p> Signup and view all the answers

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