41 Questions
What is the cardinal feature of Myasthenia Gravis?
Fluctuating weakness of voluntary muscles
Which age group of women is more affected by Myasthenia Gravis?
20-30 years old
What is the annual incidence rate of Myasthenia Gravis?
1 per 300,000
What is the main reason for difficulty breathing in Myasthenia Gravis?
Paralysis of the diaphragm
Which muscles are typically first affected in Myasthenia Gravis?
Eye muscles
What is the initial manifestation of Myasthenia Gravis in about half of the cases?
Ptosis
Myasthenic Hand refers to weakness that spreads from which area?
Cranial muscles
Which clinical manifestation is characteristic of ocular myasthenia gravis during sustained upgaze?
Increased ptosis
What is a common sign of myasthenic ocular motor weakness during the fatigue test?
Induced or exaggerated ptosis
Which muscle groups are less frequently involved in early stages of myasthenia gravis?
Muscles of the shoulder girdle
What does the Lid-Twitch sign indicate in myasthenia gravis?
Delayed eyelid closure after sustained upgaze
How do sustained upgaze tests help diagnose myasthenia gravis?
By inducing or exaggerating ptosis
Which action during a fatigue test would NOT suggest myasthenic ocular motor weakness?
Reduced fatigue
What percentage of patients with myasthenia gravis experience involvement of facial expression muscles?
~75%
Which muscles are more likely to be involved in early stages of myasthenia gravis?
>90% of mastication muscles
What is a less common early sign of myasthenia gravis compared to involvement of facial expression muscles?
~50% hip extensors involvement
What is the recommended management for Myasthenic Crisis?
Plasma exchange and IVIG
What are the manifestations of Cholinergic Crisis?
Miosis, bradycardia, and diarrhea
In cases of Myasthenic Crisis, what should be done if unable to wean from mechanical ventilation after 2-3 weeks?
Perform tracheostomy
What is a common precipitating factor for Myasthenic Crisis?
Respiratory infection
What is the initial management for Myasthenic Crisis?
Hold anticholinesterase drugs
Which crisis exhibits relatively rapid increase in muscular weakness coupled with muscarinic effects?
Cholinergic Crisis
What is the recommended treatment for Cholinergic Crisis?
Hold acetylcholinesterase inhibitors
What are the manifestations of Myasthenic Crisis?
Restlessness, anxiety, and diaphoresis.
What should be done in cases of poor response to anticholinesterase in Cholinergic Crisis?
Increase dosing of corticosteroids.
What is the sensitivity range of generalized MG?
53%-100%
Which test is the most sensitive for MG, with a sensitivity of over 95%?
Single-fiber EMG
What is the peak time for edrophonium (Tensilon) test?
20 minutes
Which antibody is directed against striated muscle in MG?
Anti-MuSK
What is the duration of clinical improvement after the edrophonium test?
5 minutes
Which pharmacologic treatment is used for MG that involves plasma exchange and IVIg?
Immunosuppressants
What drug is considered a pharmacologic treatment for MG with dose-equivalents including 60 mg (oral), 15 mg (IM), and 0.5 mg (IV)?
Pyridostigmine
Which of the following drugs interfere with calcium ion fluxes at nerve terminals?
Quinolones
Which medication is contraindicated in patients with Myasthenia Gravis?
Penicillamine
What is the function of MuSK in the context of the text?
Muscle-specific kinase
Which antibiotic is listed as causing Myasthenic Syndrome in the text?
Gentamicin
Which category of medications should be used with caution in Myasthenia Gravis patients?
8-Blockers
What does AChE stand for according to the text?
Acetylcholinesterase
Which antibiotic should be avoided in Myasthenia Gravis patients?
Neomycin
What effect do Quinolones have on Myasthenia Gravis?
Worsen symptoms
Which medication can worsen Myasthenia Gravis symptoms?
Calcium channel blockers
Test your knowledge on the cardinal features and symptoms of myasthenia gravis such as fluctuating weakness of voluntary muscles, facial paralysis, and difficulty walking. Learn about the manifestations and treatment options for this neuromuscular disorder.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
