Myasthenia Gravis Symptoms Quiz
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Questions and Answers

What is the cardinal feature of Myasthenia Gravis?

  • Chronic fatigue
  • Sudden onset of symptoms
  • Constant muscle weakness
  • Fluctuating weakness of voluntary muscles (correct)
  • Which age group of women is more affected by Myasthenia Gravis?

  • 40-50 years old
  • 20-30 years old (correct)
  • 30-40 years old
  • 50-60 years old
  • What is the annual incidence rate of Myasthenia Gravis?

  • 1 per 400,000
  • 1 per 100,000
  • 1 per 300,000 (correct)
  • 1 per 200,000
  • What is the main reason for difficulty breathing in Myasthenia Gravis?

    <p>Paralysis of the diaphragm</p> Signup and view all the answers

    Which muscles are typically first affected in Myasthenia Gravis?

    <p>Eye muscles</p> Signup and view all the answers

    What is the initial manifestation of Myasthenia Gravis in about half of the cases?

    <p><strong>Ptosis</strong></p> Signup and view all the answers

    Myasthenic Hand refers to weakness that spreads from which area?

    <p><strong>Cranial muscles</strong></p> Signup and view all the answers

    Which clinical manifestation is characteristic of ocular myasthenia gravis during sustained upgaze?

    <p>Increased ptosis</p> Signup and view all the answers

    What is a common sign of myasthenic ocular motor weakness during the fatigue test?

    <p>Induced or exaggerated ptosis</p> Signup and view all the answers

    Which muscle groups are less frequently involved in early stages of myasthenia gravis?

    <p>Muscles of the shoulder girdle</p> Signup and view all the answers

    What does the Lid-Twitch sign indicate in myasthenia gravis?

    <p>Delayed eyelid closure after sustained upgaze</p> Signup and view all the answers

    How do sustained upgaze tests help diagnose myasthenia gravis?

    <p>By inducing or exaggerating ptosis</p> Signup and view all the answers

    Which action during a fatigue test would NOT suggest myasthenic ocular motor weakness?

    <p>Reduced fatigue</p> Signup and view all the answers

    What percentage of patients with myasthenia gravis experience involvement of facial expression muscles?

    <p>~75%</p> Signup and view all the answers

    Which muscles are more likely to be involved in early stages of myasthenia gravis?

    <p>&gt;90% of mastication muscles</p> Signup and view all the answers

    What is a less common early sign of myasthenia gravis compared to involvement of facial expression muscles?

    <p>~50% hip extensors involvement</p> Signup and view all the answers

    What is the recommended management for Myasthenic Crisis?

    <p>Plasma exchange and IVIG</p> Signup and view all the answers

    What are the manifestations of Cholinergic Crisis?

    <p>Miosis, bradycardia, and diarrhea</p> Signup and view all the answers

    In cases of Myasthenic Crisis, what should be done if unable to wean from mechanical ventilation after 2-3 weeks?

    <p>Perform tracheostomy</p> Signup and view all the answers

    What is a common precipitating factor for Myasthenic Crisis?

    <p>Respiratory infection</p> Signup and view all the answers

    What is the initial management for Myasthenic Crisis?

    <p>Hold anticholinesterase drugs</p> Signup and view all the answers

    Which crisis exhibits relatively rapid increase in muscular weakness coupled with muscarinic effects?

    <p>Cholinergic Crisis</p> Signup and view all the answers

    What is the recommended treatment for Cholinergic Crisis?

    <p>Hold acetylcholinesterase inhibitors</p> Signup and view all the answers

    What are the manifestations of Myasthenic Crisis?

    <p>Restlessness, anxiety, and diaphoresis.</p> Signup and view all the answers

    What should be done in cases of poor response to anticholinesterase in Cholinergic Crisis?

    <p>Increase dosing of corticosteroids.</p> Signup and view all the answers

    What is the sensitivity range of generalized MG?

    <p>53%-100%</p> Signup and view all the answers

    Which test is the most sensitive for MG, with a sensitivity of over 95%?

    <p>Single-fiber EMG</p> Signup and view all the answers

    What is the peak time for edrophonium (Tensilon) test?

    <p>20 minutes</p> Signup and view all the answers

    Which antibody is directed against striated muscle in MG?

    <p>Anti-MuSK</p> Signup and view all the answers

    What is the duration of clinical improvement after the edrophonium test?

    <p>5 minutes</p> Signup and view all the answers

    Which pharmacologic treatment is used for MG that involves plasma exchange and IVIg?

    <p>Immunosuppressants</p> Signup and view all the answers

    What drug is considered a pharmacologic treatment for MG with dose-equivalents including 60 mg (oral), 15 mg (IM), and 0.5 mg (IV)?

    <p>Pyridostigmine</p> Signup and view all the answers

    Which of the following drugs interfere with calcium ion fluxes at nerve terminals?

    <p>Quinolones</p> Signup and view all the answers

    Which medication is contraindicated in patients with Myasthenia Gravis?

    <p>Penicillamine</p> Signup and view all the answers

    What is the function of MuSK in the context of the text?

    <p>Muscle-specific kinase</p> Signup and view all the answers

    Which antibiotic is listed as causing Myasthenic Syndrome in the text?

    <p>Gentamicin</p> Signup and view all the answers

    Which category of medications should be used with caution in Myasthenia Gravis patients?

    <p>8-Blockers</p> Signup and view all the answers

    What does AChE stand for according to the text?

    <p>Acetylcholinesterase</p> Signup and view all the answers

    Which antibiotic should be avoided in Myasthenia Gravis patients?

    <p>Neomycin</p> Signup and view all the answers

    What effect do Quinolones have on Myasthenia Gravis?

    <p>Worsen symptoms</p> Signup and view all the answers

    Which medication can worsen Myasthenia Gravis symptoms?

    <p>Calcium channel blockers</p> Signup and view all the answers

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