Myasthenia Gravis Symptoms Quiz

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Questions and Answers

What is the cardinal feature of Myasthenia Gravis?

  • Chronic fatigue
  • Sudden onset of symptoms
  • Constant muscle weakness
  • Fluctuating weakness of voluntary muscles (correct)

Which age group of women is more affected by Myasthenia Gravis?

  • 40-50 years old
  • 20-30 years old (correct)
  • 30-40 years old
  • 50-60 years old

What is the annual incidence rate of Myasthenia Gravis?

  • 1 per 400,000
  • 1 per 100,000
  • 1 per 300,000 (correct)
  • 1 per 200,000

What is the main reason for difficulty breathing in Myasthenia Gravis?

<p>Paralysis of the diaphragm (D)</p> Signup and view all the answers

Which muscles are typically first affected in Myasthenia Gravis?

<p>Eye muscles (C)</p> Signup and view all the answers

What is the initial manifestation of Myasthenia Gravis in about half of the cases?

<p><strong>Ptosis</strong> (D)</p> Signup and view all the answers

Myasthenic Hand refers to weakness that spreads from which area?

<p><strong>Cranial muscles</strong> (A)</p> Signup and view all the answers

Which clinical manifestation is characteristic of ocular myasthenia gravis during sustained upgaze?

<p>Increased ptosis (D)</p> Signup and view all the answers

What is a common sign of myasthenic ocular motor weakness during the fatigue test?

<p>Induced or exaggerated ptosis (D)</p> Signup and view all the answers

Which muscle groups are less frequently involved in early stages of myasthenia gravis?

<p>Muscles of the shoulder girdle (C)</p> Signup and view all the answers

What does the Lid-Twitch sign indicate in myasthenia gravis?

<p>Delayed eyelid closure after sustained upgaze (B)</p> Signup and view all the answers

How do sustained upgaze tests help diagnose myasthenia gravis?

<p>By inducing or exaggerating ptosis (C)</p> Signup and view all the answers

Which action during a fatigue test would NOT suggest myasthenic ocular motor weakness?

<p>Reduced fatigue (B)</p> Signup and view all the answers

What percentage of patients with myasthenia gravis experience involvement of facial expression muscles?

<p>~75% (B)</p> Signup and view all the answers

Which muscles are more likely to be involved in early stages of myasthenia gravis?

<p>&gt;90% of mastication muscles (C)</p> Signup and view all the answers

What is a less common early sign of myasthenia gravis compared to involvement of facial expression muscles?

<p>~50% hip extensors involvement (D)</p> Signup and view all the answers

What is the recommended management for Myasthenic Crisis?

<p>Plasma exchange and IVIG (B)</p> Signup and view all the answers

What are the manifestations of Cholinergic Crisis?

<p>Miosis, bradycardia, and diarrhea (D)</p> Signup and view all the answers

In cases of Myasthenic Crisis, what should be done if unable to wean from mechanical ventilation after 2-3 weeks?

<p>Perform tracheostomy (D)</p> Signup and view all the answers

What is a common precipitating factor for Myasthenic Crisis?

<p>Respiratory infection (B)</p> Signup and view all the answers

What is the initial management for Myasthenic Crisis?

<p>Hold anticholinesterase drugs (A)</p> Signup and view all the answers

Which crisis exhibits relatively rapid increase in muscular weakness coupled with muscarinic effects?

<p>Cholinergic Crisis (A)</p> Signup and view all the answers

What is the recommended treatment for Cholinergic Crisis?

<p>Hold acetylcholinesterase inhibitors (C)</p> Signup and view all the answers

What are the manifestations of Myasthenic Crisis?

<p>Restlessness, anxiety, and diaphoresis. (C)</p> Signup and view all the answers

What should be done in cases of poor response to anticholinesterase in Cholinergic Crisis?

<p>Increase dosing of corticosteroids. (C)</p> Signup and view all the answers

What is the sensitivity range of generalized MG?

<p>53%-100% (D)</p> Signup and view all the answers

Which test is the most sensitive for MG, with a sensitivity of over 95%?

<p>Single-fiber EMG (C)</p> Signup and view all the answers

What is the peak time for edrophonium (Tensilon) test?

<p>20 minutes (C)</p> Signup and view all the answers

Which antibody is directed against striated muscle in MG?

<p>Anti-MuSK (D)</p> Signup and view all the answers

What is the duration of clinical improvement after the edrophonium test?

<p>5 minutes (C)</p> Signup and view all the answers

Which pharmacologic treatment is used for MG that involves plasma exchange and IVIg?

<p>Immunosuppressants (D)</p> Signup and view all the answers

What drug is considered a pharmacologic treatment for MG with dose-equivalents including 60 mg (oral), 15 mg (IM), and 0.5 mg (IV)?

<p>Pyridostigmine (A)</p> Signup and view all the answers

Which of the following drugs interfere with calcium ion fluxes at nerve terminals?

<p>Quinolones (C)</p> Signup and view all the answers

Which medication is contraindicated in patients with Myasthenia Gravis?

<p>Penicillamine (B)</p> Signup and view all the answers

What is the function of MuSK in the context of the text?

<p>Muscle-specific kinase (C)</p> Signup and view all the answers

Which antibiotic is listed as causing Myasthenic Syndrome in the text?

<p>Gentamicin (A)</p> Signup and view all the answers

Which category of medications should be used with caution in Myasthenia Gravis patients?

<p>8-Blockers (A)</p> Signup and view all the answers

What does AChE stand for according to the text?

<p>Acetylcholinesterase (B)</p> Signup and view all the answers

Which antibiotic should be avoided in Myasthenia Gravis patients?

<p>Neomycin (A)</p> Signup and view all the answers

What effect do Quinolones have on Myasthenia Gravis?

<p>Worsen symptoms (C)</p> Signup and view all the answers

Which medication can worsen Myasthenia Gravis symptoms?

<p>Calcium channel blockers (C)</p> Signup and view all the answers

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