Podcast
Questions and Answers
What is a mutation?
What is a mutation?
- A change in the protein sequence of an organism
- A modification in the structure of a chromosome
- An alteration in the nucleic acid sequence of the genome (correct)
- A variation in the phenotype of an organism
What is a polymorphism?
What is a polymorphism?
- A mutation resulting in altered phenotype
- The occurrence of two or more alternative genotypes in a population (correct)
- A change in the DNA sequence of a gene
- A genetic disorder caused by chromosomal abnormalities
What defines a locus as polymorphic?
What defines a locus as polymorphic?
- If the rarer allele has a frequency of 0.01 or more (correct)
- If the rarer allele has a frequency of 0.5 or more
- If the rarer allele has a frequency of 0.1 or more
- If the rarer allele has a frequency of 0.001 or more
What is the result of a silent mutation?
What is the result of a silent mutation?
What may cause a defective protein?
What may cause a defective protein?
Which type of mutation will make a shorter protein?
Which type of mutation will make a shorter protein?
What is the typical length of a gene in base pairs?
What is the typical length of a gene in base pairs?
What is the result of a frameshift mutation?
What is the result of a frameshift mutation?
What does a mutant allele result from?
What does a mutant allele result from?
What is the consequence of a nonsense mutation?
What is the consequence of a nonsense mutation?
What is the impact of a missense mutation?
What is the impact of a missense mutation?
What defines a locus as polymorphic?
What defines a locus as polymorphic?
What type of mutation results in the insertion or deletion of bases, causing a shift in the reading frame?
What type of mutation results in the insertion or deletion of bases, causing a shift in the reading frame?
Which type of DNA damage is induced by UV light, resulting in the formation of pyrimidine dimers?
Which type of DNA damage is induced by UV light, resulting in the formation of pyrimidine dimers?
Which repair system detects and excises mismatched bases in newly replicated DNA in E. coli?
Which repair system detects and excises mismatched bases in newly replicated DNA in E. coli?
What is the result of the presence of a thymine dimer blocking replication in postreplication repair?
What is the result of the presence of a thymine dimer blocking replication in postreplication repair?
What is the major form of spontaneous DNA damage resulting from the loss of purine bases?
What is the major form of spontaneous DNA damage resulting from the loss of purine bases?
Which repair mechanism uses photoreactivation to repair UV-induced thymine dimers?
Which repair mechanism uses photoreactivation to repair UV-induced thymine dimers?
What is the result of alkylation of the O6 position of guanine in DNA?
What is the result of alkylation of the O6 position of guanine in DNA?
Which repair system excises an oligonucleotide containing damaged bases after DNA damage recognition?
Which repair system excises an oligonucleotide containing damaged bases after DNA damage recognition?
What distinguishes the newly replicated DNA strand in mammalian cells for mismatch repair?
What distinguishes the newly replicated DNA strand in mammalian cells for mismatch repair?
Which type of mutation involves the addition of methyl or ethyl groups to various positions on the DNA bases?
Which type of mutation involves the addition of methyl or ethyl groups to various positions on the DNA bases?
What is the result of insertion of three bases in DNA?
What is the result of insertion of three bases in DNA?
Which repair mechanism involves the bypass of a thymine dimer by DNA polymerase in the presence of a lesion?
Which repair mechanism involves the bypass of a thymine dimer by DNA polymerase in the presence of a lesion?
