Musculoskeletal Pathology: Ewing Sarcoma
27 Questions
3 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the most common site for giant cell tumors?

  • Soft tissue surrounding the joint
  • Proximal fibula
  • Distal femur and proximal tibia (correct)
  • metaphyseal of long bone
  • What percentage of giant cell tumors develop lung metastasis?

  • 6%
  • 4% (correct)
  • 2%
  • 8%
  • What is the typical age of onset for giant cell tumors?

  • Adolescence
  • Third decade of life (correct)
  • Childhood
  • Elderly
  • What is the composition of a giant cell tumor?

    <p>Primitive mononuclear cells and reactive osteoclasts</p> Signup and view all the answers

    What is the radiographic appearance of a giant cell tumor of the proximal fibula?

    <p>Predominantly lytic and expansile with cortical destruction</p> Signup and view all the answers

    What is the most common site for an Aneurysmal Bone Cyst (ABC)?

    <p>Vertebra</p> Signup and view all the answers

    Which cells are typically seen in the background of an Aneurysmal Bone Cyst?

    <p>Neoplastic cells</p> Signup and view all the answers

    What structures are the septa in an Aneurysmal Bone Cyst composed of?

    <p>Plump uniform fibroblasts, multinucleated giant cells, and woven bone</p> Signup and view all the answers

    What age group is most commonly affected by Aneurysmal Bone Cysts?

    <p>Adolescents</p> Signup and view all the answers

    What is a common symptom associated with Aneurysmal Bone Cysts?

    <p>Pathologic fracture</p> Signup and view all the answers

    What type of tumor is Ewing sarcoma?

    <p>A highly malignant tumor</p> Signup and view all the answers

    What percentage of primary malignant bone tumors is Ewing sarcoma?

    <p>10%</p> Signup and view all the answers

    Which of the following is NOT a characteristic of Ewing sarcoma?

    <p>The cell of origin is exactly known</p> Signup and view all the answers

    What is the most common genetic abnormality found in Ewing sarcoma?

    <p>Balanced translocation</p> Signup and view all the answers

    What are the two genes involved in the characteristic balanced translocation of Ewing sarcoma?

    <p>EWSR1 and FLI1</p> Signup and view all the answers

    What is the most common tissue of origin for Ewing sarcoma?

    <p>Bone</p> Signup and view all the answers

    What type of lesion is described in the text?

    <p>Aneurysmal bone cyst</p> Signup and view all the answers

    What is the appearance of the lesion as described in the text?

    <p>Hemorrhagic and spongelike</p> Signup and view all the answers

    Which of the following is NOT mentioned as a feature of the aneurysmal bone cyst in the text?

    <p>Malignant cells</p> Signup and view all the answers

    What type of cells are indicated by the red arrows in the image description?

    <p>Osteoclast-type giant cells</p> Signup and view all the answers

    What is the function of the structure indicated by the yellow arrow in the image description?

    <p>Bone formation</p> Signup and view all the answers

    What is the primary cause of uncontrolled growth and abnormal differentiation in long bones?

    <p>The resultant protein binds DNA and dysregulates transcription</p> Signup and view all the answers

    Where do tumors typically arise in long bones?

    <p>The medulla, middle part, and diaphysis (shaft)</p> Signup and view all the answers

    What radiographic feature is described as an 'onion skin' appearance?

    <p>Periosteal reaction of multiple layers</p> Signup and view all the answers

    What is the morphological feature of Ewing sarcoma cells observed under light microscopy?

    <p>Primitive, small, round cells with minimal cytoplasm</p> Signup and view all the answers

    What is the significance of Homer-Wright rosettes in Ewing sarcoma?

    <p>They represent primitive neuron-like structures</p> Signup and view all the answers

    How does the behavior of giant cell tumors compare to completely benign and malignant tumors?

    <p>They are in the middle, more benign but can cause damage</p> Signup and view all the answers

    More Like This

    Musculoskeletal Tumor I: Bone Tumors
    22 questions
    Patologi Muskuloskeletal 2024
    40 questions
    Patologi Anatomi Muskuloskeletal_2
    40 questions
    Use Quizgecko on...
    Browser
    Browser