Musculoskeletal Pathology: Ewing Sarcoma
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Questions and Answers

What is the most common site for giant cell tumors?

  • Soft tissue surrounding the joint
  • Proximal fibula
  • Distal femur and proximal tibia (correct)
  • metaphyseal of long bone

What percentage of giant cell tumors develop lung metastasis?

  • 6%
  • 4% (correct)
  • 2%
  • 8%

What is the typical age of onset for giant cell tumors?

  • Adolescence
  • Third decade of life (correct)
  • Childhood
  • Elderly

What is the composition of a giant cell tumor?

<p>Primitive mononuclear cells and reactive osteoclasts (D)</p> Signup and view all the answers

What is the radiographic appearance of a giant cell tumor of the proximal fibula?

<p>Predominantly lytic and expansile with cortical destruction (A)</p> Signup and view all the answers

What is the most common site for an Aneurysmal Bone Cyst (ABC)?

<p>Vertebra (D)</p> Signup and view all the answers

Which cells are typically seen in the background of an Aneurysmal Bone Cyst?

<p>Neoplastic cells (B)</p> Signup and view all the answers

What structures are the septa in an Aneurysmal Bone Cyst composed of?

<p>Plump uniform fibroblasts, multinucleated giant cells, and woven bone (B)</p> Signup and view all the answers

What age group is most commonly affected by Aneurysmal Bone Cysts?

<p>Adolescents (D)</p> Signup and view all the answers

What is a common symptom associated with Aneurysmal Bone Cysts?

<p>Pathologic fracture (D)</p> Signup and view all the answers

What type of tumor is Ewing sarcoma?

<p>A highly malignant tumor (B)</p> Signup and view all the answers

What percentage of primary malignant bone tumors is Ewing sarcoma?

<p>10% (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of Ewing sarcoma?

<p>The cell of origin is exactly known (B)</p> Signup and view all the answers

What is the most common genetic abnormality found in Ewing sarcoma?

<p>Balanced translocation (C)</p> Signup and view all the answers

What are the two genes involved in the characteristic balanced translocation of Ewing sarcoma?

<p>EWSR1 and FLI1 (A)</p> Signup and view all the answers

What is the most common tissue of origin for Ewing sarcoma?

<p>Bone (D)</p> Signup and view all the answers

What type of lesion is described in the text?

<p>Aneurysmal bone cyst (D)</p> Signup and view all the answers

What is the appearance of the lesion as described in the text?

<p>Hemorrhagic and spongelike (D)</p> Signup and view all the answers

Which of the following is NOT mentioned as a feature of the aneurysmal bone cyst in the text?

<p>Malignant cells (A)</p> Signup and view all the answers

What type of cells are indicated by the red arrows in the image description?

<p>Osteoclast-type giant cells (A)</p> Signup and view all the answers

What is the function of the structure indicated by the yellow arrow in the image description?

<p>Bone formation (C)</p> Signup and view all the answers

What is the primary cause of uncontrolled growth and abnormal differentiation in long bones?

<p>The resultant protein binds DNA and dysregulates transcription (D)</p> Signup and view all the answers

Where do tumors typically arise in long bones?

<p>The medulla, middle part, and diaphysis (shaft) (D)</p> Signup and view all the answers

What radiographic feature is described as an 'onion skin' appearance?

<p>Periosteal reaction of multiple layers (D)</p> Signup and view all the answers

What is the morphological feature of Ewing sarcoma cells observed under light microscopy?

<p>Primitive, small, round cells with minimal cytoplasm (C)</p> Signup and view all the answers

What is the significance of Homer-Wright rosettes in Ewing sarcoma?

<p>They represent primitive neuron-like structures (A)</p> Signup and view all the answers

How does the behavior of giant cell tumors compare to completely benign and malignant tumors?

<p>They are in the middle, more benign but can cause damage (D)</p> Signup and view all the answers

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