30 Questions
What is the shape of a smooth muscle cell?
Spindle
What is the location of the nucleus in a smooth muscle cell?
Central, single nucleus
What is the mechanism of contraction in smooth muscle?
Actin-myosin binding occurs with myosin phosphorylation by MLCK triggered when calmodulin binds Ca2+
What is the function of fibroblasts similar to in smooth muscle?
Myofibroblasts and pericytes
What is the characteristic of the sarcoplasmic reticulum in smooth muscle?
Irregular smooth ER
What type of junctions do smooth muscle cells have?
Gap junctions
What is a characteristic of skeletal muscle cells?
Multinucleated cells
What is the function of the sarcoplasmic reticulum in muscle cells?
To store calcium ions
What is the term for the cell membrane of a muscle fiber?
Sarcolemma
What is the characteristic of cardiac muscle cells?
Involuntary and rhythmic
What is the name of the structure that surrounds individual muscle fibers?
Endomysium
What is the term for the unit of structure and function of muscle fibers?
Sarcomere
What is the characteristic of smooth muscle cells?
Fusiform and involuntary
What is the term for the dark transverse line that bisects the I band?
Z line
Where are cardiac muscle cells typically found?
In the wall of the heart and proximal portions of the aorta and the venae
What is a characteristic of cardiac muscle cells?
Involuntary striated muscle
What is a feature of the ultrastructure of cardiac muscle cells?
Small terminal cisternae
What is the function of desmosomes in cardiac muscle cells?
To bind the cardiac cells together
Where is smooth muscle typically found?
In the wall of blood vessels and hollow viscera
What is a characteristic of smooth muscle cells?
Non-striated cells
What is a feature of the ultrastructure of smooth muscle cells?
Rudimentary sarcoplasmic reticulum
What is applicable to smooth muscle?
Sliding filament hypothesis
What is the function of troponin in muscle contraction?
To inhibit the actin-myosin interaction
What is the site of rapid conduction of impulses in muscle cells?
Transverse tubules
What is the role of calcium ions in muscle contraction?
To trigger muscle contraction
What is the structure of a thin filament?
A filamentous polymer composed of actin, tropomyosin, and troponin
What is the function of myosin heads in muscle contraction?
To form crossbridges with actin
What is the site of calcium ion storage in muscle cells?
Sarcoplasmic reticulum
What is the mechanism of muscle contraction?
Sliding filament hypothesis
What is the structure of a triad?
A T-tubule and two terminal cisternae
Study Notes
Classification of Muscle Types
- Skeletal muscle: long, multinucleated cells with cross-striations, voluntary, and forceful
- Cardiac muscle: branched cells with cross-striations, intercalated discs, involuntary, and rhythmic
- Smooth muscle: fusiform cells without striations, involuntary, and slow
Specialized Terms
- Sarcolemma: the cell membrane
- Sarcoplasm: the cytoplasm
- Sarcoplasmic reticulum (SER): a type of smooth endoplasmic reticulum
Organization of Skeletal Muscle
- Epimysium: dense connective tissue surrounding the entire muscle
- Perimysium: thin connective tissue surrounding bundles of muscle fibers (fascicle)
- Endomysium: reticular fiber and fibroblast surrounding individual muscle fibers
Light Microscopic Structure of Skeletal Muscle Fibers
- Long, cylindrical cells with multiple nuclei beneath the sarcolemma
- Cross-striations: alternating dark and light bands
- Myofibrils: thread-like structures arranged in parallel in the muscle fibers
Myofibrils and Sarcomere
- Myofibrils: long, cylindrical filamentous bundles parallel to the long axis of the muscle fibers
- Sarcomere: the segment between two Z lines (½ I band + 1 A band + ½ I band), the unit of structure and function of muscle fibers
- I band: bisected by a dark transverse line, Z line
- A band: a light zone present, H band
- H band: bisected by M line
Myofilaments
- Thick filaments: composed of myosin molecules with a rod and two globular heads, occupying A band
- Thin filaments: composed of actin, tropomyosin, and troponin, inserting into the Z line and extending into the A band
Transverse Tubules and Sarcoplasmic Reticulum
- Transverse (T) tubules: sarcolemma tubular infoldings at A- and I- band boundaries, responsible for rapid conduction of impulses
- Sarcoplasmic reticulum: storing calcium ions, located between two adjacent T tubules
- A triad: a T tubule + 2 terminal cisternae, triggering Ca2+ release
Mechanism of Contraction
- Sliding filament hypothesis: myosin heads combine with actin to form cross-bridges, then pivot, moving thin filaments toward the sarcomere center
Cardiac Muscle
- Found in the heart and proximal portions of the aorta and venae
- Involuntary, striated muscle, contracting spontaneously and displaying a rhythmic beat
- Short, columnar, and branched cells with one or two centrally placed nuclei
- Cross-striations and myofibrils, but less distinct
- Intercalated disks link cells to one another
Ultrastructure of Cardiac Muscle
- Discrete myofibril bundles are not present
- Larger T tubules at Z line level
- Sarcoplasmic reticulum: not well-developed, small terminal cisternae
- Dyads: T tubule and terminal cisternae on one side
- More mitochondria, glycogen, and lipid droplets
Intercalated Disks
- Transverse and lateral portions
- Desmosomes: bind cardiac cells together
- Fascia adherens: supply anchoring sites for actin filaments
- Gap junctions: provide ionic continuity between adjacent cells
Smooth Muscle
- Seen in blood vessels and hollow viscera (visceral muscle)
- Arranged in layers
- Enclosed by a network of type I and type III collagen fibers
- Nonstriated cells
Light Microscopic Structure of Smooth Muscle
- Spindle-shaped cells with an oval, centrally located nucleus
- A range of diameters
- Without striations
Electron Microscopic Structure of Smooth Muscle
- Gap junctions
- Caveolae
- A rudimentary sarcoplasmic reticulum
- Myofibrillar arrays: thick filaments, thin filaments, dense bodies, and intermediate filaments (desmin)
Other Functions of Smooth Muscle
- Supplement fibroblast activity: synthesizing collagen, elastin, and proteoglycans
- Be similar to other contractile cells, such as myofibroblasts and pericytes
Comparative Features
- Skeletal muscle: long, cylindrical, multinucleated, peripheral
- Cardiac muscle: branching, central, single nucleus
- Smooth muscle: spindle, central, single nucleus
This quiz covers the characteristics and functions of skeletal, cardiac, and smooth muscles, including their cellular structure and properties.
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