Podcast
Questions and Answers
What is the typical age range for the onset of symptoms in children with Rett syndrome?
What is the typical age range for the onset of symptoms in children with Rett syndrome?
- 2 to 6 years
- Birth to 6 months
- 6 to 18 months (correct)
- 20 to 30 months
Which statement about Tourette syndrome is true?
Which statement about Tourette syndrome is true?
- It is always diagnosed before the age of six.
- It primarily affects boys and accounts for a large percentage of cases.
- All individuals with Tourette syndrome have coprolalia.
- Tics generally diminish by a person's early 20s. (correct)
How common is Rett syndrome among infant girls?
How common is Rett syndrome among infant girls?
- 1 in every 5,000 to 10,000
- 1 in every 10,000 to 23,000 (correct)
- 1 in every 50,000
- 1 in every 1,000
Which of the following describes the nature of tics in Tourette syndrome?
Which of the following describes the nature of tics in Tourette syndrome?
Which of the following is NOT typically a symptom of Tourette syndrome?
Which of the following is NOT typically a symptom of Tourette syndrome?
What type of muscle is responsible for moving the body in response to the environment?
What type of muscle is responsible for moving the body in response to the environment?
Which type of muscle fibers are primarily used for non-strenuous activities?
Which type of muscle fibers are primarily used for non-strenuous activities?
What happens to glucose utilization during prolonged bicycling?
What happens to glucose utilization during prolonged bicycling?
Which of the following reflects a characteristic of reflexes?
Which of the following reflects a characteristic of reflexes?
What is a common reflex displayed by infants?
What is a common reflex displayed by infants?
What is the main difference between slow-twitch and fast-twitch muscle fibers?
What is the main difference between slow-twitch and fast-twitch muscle fibers?
During which type of activity do muscles predominantly use anaerobic processes?
During which type of activity do muscles predominantly use anaerobic processes?
Which statement best describes the relationship between voluntary and involuntary movements?
Which statement best describes the relationship between voluntary and involuntary movements?
What is a primary characteristic of ataxia?
What is a primary characteristic of ataxia?
Which part of the body is most commonly affected in focal dystonia?
Which part of the body is most commonly affected in focal dystonia?
What is a common symptom of Huntington's disease?
What is a common symptom of Huntington's disease?
Which of the following disorders is characterized by involuntary muscle spasms?
Which of the following disorders is characterized by involuntary muscle spasms?
Multiple System Atrophy (MSA) can cause which of the following symptoms?
Multiple System Atrophy (MSA) can cause which of the following symptoms?
What typically can trigger myoclonus in a patient?
What typically can trigger myoclonus in a patient?
In Parkinson's disease, which neurotransmitter is primarily lost due to nerve cell degeneration?
In Parkinson's disease, which neurotransmitter is primarily lost due to nerve cell degeneration?
Which of the following is NOT a common symptom of Parkinson's disease?
Which of the following is NOT a common symptom of Parkinson's disease?
What age range is most commonly associated with the onset of Huntington's disease?
What age range is most commonly associated with the onset of Huntington's disease?
Rett syndrome primarily causes which type of disorder?
Rett syndrome primarily causes which type of disorder?
Which of the following is a characteristic feature of myoclonus?
Which of the following is a characteristic feature of myoclonus?
What impact can dystonia have on an individual?
What impact can dystonia have on an individual?
How prevalent is Huntington's disease in the U.S. population?
How prevalent is Huntington's disease in the U.S. population?
Which of the following disorders is characterized by jerking or uncontrolled movements?
Which of the following disorders is characterized by jerking or uncontrolled movements?
What is the primary function of the Babinski reflex in infants?
What is the primary function of the Babinski reflex in infants?
What effect does damage to the cerebral cortex have on infant reflexes?
What effect does damage to the cerebral cortex have on infant reflexes?
What role do the basal ganglia primarily serve in motor control?
What role do the basal ganglia primarily serve in motor control?
Which area of the brain is primarily involved in voluntary muscle control?
Which area of the brain is primarily involved in voluntary muscle control?
What is the significance of the motor map in the primary motor cortex?
What is the significance of the motor map in the primary motor cortex?
What does a ballistic movement refer to in the context of reflexes?
What does a ballistic movement refer to in the context of reflexes?
What is the role of the cerebellum in motor control?
What is the role of the cerebellum in motor control?
Which reflex is triggered when the cheek of an infant is touched?
Which reflex is triggered when the cheek of an infant is touched?
If a physician observes the Babinski reflex in an adult, what might they suspect?
If a physician observes the Babinski reflex in an adult, what might they suspect?
What happens when the pulmonary artery is blocked?
What happens when the pulmonary artery is blocked?
How does the motor cortex receive information for executing movements?
How does the motor cortex receive information for executing movements?
Why are certain parts of the body represented larger in the motor cortex?
Why are certain parts of the body represented larger in the motor cortex?
Which of the following might indicate impairment in the basal ganglia?
Which of the following might indicate impairment in the basal ganglia?
What happens to reflexes as a person ages?
What happens to reflexes as a person ages?
Flashcards
What is Rett Syndrome?
What is Rett Syndrome?
A rare genetic disorder that primarily affects girls, causing developmental delays and severe disabilities.
What is Tourette Syndrome?
What is Tourette Syndrome?
A neurological disorder characterized by involuntary movements and vocalizations called tics.
What are tics?
What are tics?
Involuntary movements or vocalizations that often occur in Tourette Syndrome.
What is coprolalia?
What is coprolalia?
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What is copropraxia?
What is copropraxia?
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Infant Reflexes
Infant Reflexes
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Babinski Reflex
Babinski Reflex
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Rooting Reflex
Rooting Reflex
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Reflex Suppression
Reflex Suppression
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Frontal Cortex
Frontal Cortex
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Ballistic Movement
Ballistic Movement
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Feedback Correction
Feedback Correction
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Motor Cortex
Motor Cortex
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Area 4 (Primary Motor Cortex)
Area 4 (Primary Motor Cortex)
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Area 6
Area 6
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Basal Ganglia
Basal Ganglia
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Caudate Nucleus
Caudate Nucleus
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Cerebellum
Cerebellum
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Parkinson's Disease
Parkinson's Disease
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Smooth Muscles
Smooth Muscles
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Skeletal Muscles
Skeletal Muscles
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Cardiac Muscles
Cardiac Muscles
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Slow-Twitch Fibers
Slow-Twitch Fibers
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Fast-Twitch Fibers
Fast-Twitch Fibers
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Reflexes
Reflexes
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Stretch Reflex
Stretch Reflex
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Voluntary Movement
Voluntary Movement
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Dystonia
Dystonia
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Ataxia
Ataxia
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Huntington's Disease
Huntington's Disease
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Multiple System Atrophy (MSA)
Multiple System Atrophy (MSA)
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Myoclonus
Myoclonus
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Rett Syndrome
Rett Syndrome
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Subcortical Myoclonus
Subcortical Myoclonus
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Cortical Myoclonus
Cortical Myoclonus
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Spinal Myoclonus
Spinal Myoclonus
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Hemifacial Spasm
Hemifacial Spasm
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Spasmodic Torticollis
Spasmodic Torticollis
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Blepharospasm
Blepharospasm
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Meige Syndrome
Meige Syndrome
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Writer's Cramp
Writer's Cramp
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General Dystonia
General Dystonia
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Study Notes
Muscle Types and Movements
- Animal movement relies on muscle contractions.
- Vertebrate muscles are categorized into three types:
- Smooth muscles: Control digestive system and internal organs.
- Skeletal (striated) muscles: Control body movement relative to environment.
- Cardiac muscles: Intermediate properties between smooth and skeletal muscles.
Fast and Slow Muscle Fibers
- Human muscles have a mix of fast-twitch and slow-twitch fibers.
- Fast-twitch fibers contract quickly and fatigue rapidly, using anaerobic (no oxygen) processes initially, then needing oxygen for recovery.
- Slow-twitch fibers contract less vigorously and don't fatigue easily, using aerobic (oxygen-dependent) processes.
Voluntary and Involuntary Movements
- Reflexes are automatic responses to stimuli, insensitive to reinforcement, punishment, or motivation.
- Examples include the stretch reflex and pupil constriction.
- Most behaviors involve a mix of voluntary, involuntary, reflexive, and non-reflexive components.
- It's difficult to simultaneously make opposing voluntary movements on the same side of the body.
Infant Reflexes
- Infants possess reflexes not typically present in adults, such as:
- Grasp reflex
- Babinski reflex
- Rooting reflex
- These reflexes fade with age, but the connection persists and is suppressed by brain signals (especially the frontal cortex).
- If the cerebral cortex is damaged, infant reflexes may reappear. This is a simple test for brain damage (though not definitive).
- Infant reflexes may temporarily return with alcohol, carbon dioxide or other chemical effects decreasing activity in the cerebral cortex.
Ballistic vs. Feedback Movements
- Ballistic movements (like reflexes) happen as a whole and cannot be altered once initiated.
- Most behaviors involve feedback correction.
The Motor Cortex
-
Voluntary movements are controlled by the brain, primarily the motor cortex.
-
Located in the frontal lobe, just in front of the central sulcus.
-
Divided into:
- Area 4 (primary motor cortex) - Thin band along the sulcus.
- Area 6 - Wider area in front of Area 4, with sub-areas.
-
The motor cortex receives input from various brain regions to execute goal-directed movements:
- Parietal lobe (body position)
- Frontal lobe (goals & strategy)
- Temporal lobe (memory)
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Brain stimulation experiments (Hitzig & Fritsch, 1870) mapped different body parts to specific cortical areas by stimulating and damaging corresponding regions.
-
Parts of the body requiring precise movements occupy larger areas in the motor map than others.
Basal Ganglia
- Basal ganglia (deep brain structures) include the caudate nucleus, putamen, and globus pallidus.
- These structures receive input from multiple cortical areas, process the information, and relay it back to the motor cortex via the thalamus.
- Function in selecting and triggering coordinated voluntary movements, evidenced by Parkinson's disease hindering these functions.
Cerebellum
- Involved in fine coordination of movements, acting like an internal "clock" regulating the sequence and duration of movements.
- Receives input concerning the intended movement from sensory & motor cortexes.
- Sends output about required direction, force, and duration back to the motor cortex, operating along with the basal ganglia.
Movement Disorders
- Ataxia: Degenerative disorder affecting brain, brainstem, or spinal cord, leading to clumsiness, incoordination, and frequent falls.
- Dystonia: Neurological disorder characterized by involuntary muscle spasms, typically stemming from dysfunctional basal ganglia. Can affect various body parts.
- Huntington’s Disease: Progressive, degenerative, fatal disease of nerve cells in the brain, onset usually between 35 and 50, with symptoms including uncontrollable movements and mental decline. Hereditary with a 50% chance for offspring with affected parent.
- Multiple System Atrophy (MSA): Progressive neurodegenerative disease affecting multiple systems (movement, blood pressure, etc.). Symptoms vary.
- Myoclonus: Twitching or spasming of muscles. Different types (cortical, subcortical, spinal, peripheral); various causes including diseases.
- Parkinson’s Disease: Progressive disorder caused by degeneration of dopamine-producing cells in the substantia nigra; characterized by tremors, rigidity, slowed movements, postural issues, balance problems.
- Rett Syndrome: Progressive neurological disorder with symptoms including reduced muscle tone, autistic-like behaviors, repetitive hand movements, irregular breathing, developmental delays, and seizures; most often affects girls.
- Tourette Syndrome: Hereditary neurological disorder with involuntary movements and vocalizations (tics), often starting between ages 6 and 15; verbal tics may include socially unacceptable words. Tics frequently disappear in early 20's.
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