Chapter 4 - Muscle Tissue Types and Characteristics

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Questions and Answers

Which of the following is NOT a type of muscle tissue?

  • Smooth
  • Epithelial (correct)
  • Cardiac
  • Skeletal

Which characteristic is NOT common to all muscle tissues?

  • Elasticity
  • Excitability
  • Striations (correct)
  • Contractility

What two kinds of myofilaments are responsible for muscle contraction?

  • Collagen and elastin
  • Troponin and tropomyosin
  • Actin and myosin (correct)
  • Sarcomere and sarcoplasm

Which functional characteristic of muscle tissue allows it to recoil and resume its resting length after being stretched?

<p>Elasticity (A)</p> Signup and view all the answers

Which type of muscle tissue is responsible for locomotion?

<p>Skeletal muscle (D)</p> Signup and view all the answers

What is the function of cardiac muscle?

<p>Coursing blood through the body (D)</p> Signup and view all the answers

Which type of muscle tissue helps maintain blood pressure and propels substances through organs?

<p>Smooth muscle (D)</p> Signup and view all the answers

What are skeletal muscle fibers supplied with to control contraction?

<p>Nerve ending (A)</p> Signup and view all the answers

What is the function of arteries in the context of contracting muscle fibers?

<p>Oxygen and nutrient delivery (C)</p> Signup and view all the answers

What must be removed from contracting muscle fibers via veins?

<p>Wastes (C)</p> Signup and view all the answers

What is the sarcolemma?

<p>Muscle plasma membrane (A)</p> Signup and view all the answers

What is the smallest contractile unit of a muscle fiber?

<p>Sarcomere (C)</p> Signup and view all the answers

A sarcomere is defined as the region of a myofibril between what structures?

<p>Two successive Z discs (B)</p> Signup and view all the answers

What are the two main types of myofilaments found in sarcomeres?

<p>Thick and thin (D)</p> Signup and view all the answers

What protein primarily composes thick filaments?

<p>Myosin (D)</p> Signup and view all the answers

In the sarcomere structure, which filaments extend the entire length of the A band?

<p>Myosin filaments (A)</p> Signup and view all the answers

In the sarcomere, which filaments extend across the I band and partway into the A band?

<p>Actin filaments (A)</p> Signup and view all the answers

What is the function of the Z disc in the sarcomere?

<p>Anchors thin filaments (B)</p> Signup and view all the answers

What are the heads of the myosin molecule called that interact with actin during muscle contraction?

<p>Cross bridges (C)</p> Signup and view all the answers

What regulatory proteins are bound to actin in thin filaments?

<p>Troponin and tropomyosin (B)</p> Signup and view all the answers

What best describes the primary role of the sarcoplasmic reticulum (SR)?

<p>Regulating intracellular calcium levels (B)</p> Signup and view all the answers

What is the functional significance of T tubules in muscle cells?

<p>Conducting impulses to the deepest regions of the muscle (B)</p> Signup and view all the answers

According to the sliding filament model of contraction, what happens to the actin and myosin filaments?

<p>They slide past each other (A)</p> Signup and view all the answers

Which event directly triggers the sliding of myofilaments, leading to muscle contraction?

<p>Myosin heads bind to actin (A)</p> Signup and view all the answers

What is the role of a nerve ending in skeletal muscle contraction?

<p>To stimulate the muscle (C)</p> Signup and view all the answers

What event propagates an electrical current along the sarcolemma?

<p>Action potential (C)</p> Signup and view all the answers

What triggers the final step leading directly to skeletal muscle contraction?

<p>Increase in intracellular calcium levels (C)</p> Signup and view all the answers

What is the term for the link between the electrical signal and the mechanical contraction in muscle fibers?

<p>Excitation-contraction coupling (C)</p> Signup and view all the answers

Skeletal muscles are stimulated by motor neurons of which nervous system?

<p>Somatic (B)</p> Signup and view all the answers

What structure does each axonal branch form with a single muscle fiber?

<p>Neuromuscular junction (A)</p> Signup and view all the answers

What neurotransmitter is contained within the synaptic vesicles at the axonal endings?

<p>Acetylcholine (ACh) (D)</p> Signup and view all the answers

What is the motor end plate?

<p>A specific part of the sarcolemma that contains ACh receptors (D)</p> Signup and view all the answers

What is the synaptic cleft?

<p>The space separating axonal ends and muscle fibers (C)</p> Signup and view all the answers

What type of channels open to allow Ca2+ to enter the axon terminal at the neuromuscular junction?

<p>Voltage-regulated calcium channels (A)</p> Signup and view all the answers

What process releases ACh into the synaptic cleft?

<p>Exocytosis (B)</p> Signup and view all the answers

How does ACh initiate an action potential in the muscle?

<p>By binding to its receptors on the sarcolemma (A)</p> Signup and view all the answers

What enzyme quickly destroys ACh bound to ACh receptors?

<p>Acetylcholinesterase (C)</p> Signup and view all the answers

What event is defined as a transient depolarization that includes polarity reversal of the sarcolemma?

<p>Action potential (C)</p> Signup and view all the answers

How does the binding of ACh to its receptors at the motor end plate affect the sarcolemma?

<p>It opens chemically gated channels (B)</p> Signup and view all the answers

During depolarization, caused by ACh, what happens to the interior of the sarcolemma?

<p>It becomes more positive (A)</p> Signup and view all the answers

During the action potential in a muscle fiber, what ionic event primarily occurs during depolarization?

<p>An influx of sodium ions (Na+) into the cell. (C)</p> Signup and view all the answers

What happens immediately after the depolarization wave passes in a muscle fiber?

<p>Sodium (Na+) channels close, and potassium (K+) channels open. (A)</p> Signup and view all the answers

How is the resting membrane potential restored after repolarization in a muscle fiber?

<p>The sodium-potassium (Na+-K+) pump actively transports Na+ out of the cell and K+ into the cell. (C)</p> Signup and view all the answers

Which of the following directly triggers the release of calcium ions ($Ca^{2+}$) from the terminal cisternae of the sarcoplasmic reticulum?

<p>The action potential traveling down the T tubules. (C)</p> Signup and view all the answers

What role does calcium ($Ca^{2+}$) play in excitation-contraction coupling?

<p>It binds to troponin, causing tropomyosin to move away from the actin-binding sites. (B)</p> Signup and view all the answers

What happens to calcium ($Ca^{2+}$) levels in the sarcoplasm when a muscle fiber relaxes?

<p>$Ca^{2+}$ is actively transported back into the sarcoplasmic reticulum (SR). (B)</p> Signup and view all the answers

During the sequential events of muscle contraction, what directly causes the myosin head to detach from actin?

<p>Binding of a new ATP molecule to the myosin head. (C)</p> Signup and view all the answers

What is the role of ATP hydrolysis in the cross-bridge cycle during muscle contraction?

<p>It provides the energy for cocking the myosin head into the high-energy configuration. (A)</p> Signup and view all the answers

What is the difference between isometric and isotonic muscle contractions?

<p>Isotonic contractions involve a change in muscle length, while isometric contractions do not. (C)</p> Signup and view all the answers

Which of the following is an example of an isotonic contraction?

<p>Lifting a dumbbell during a bicep curl. (C)</p> Signup and view all the answers

In the context of muscle physiology, what defines a motor unit?

<p>A motor neuron and all the muscle fibers it innervates. (B)</p> Signup and view all the answers

Muscles that control fine movements, such as those in the fingers and eyes, have:

<p>Small motor units with few muscle fibers per neuron. (B)</p> Signup and view all the answers

What is a muscle twitch?

<p>The response of a muscle to a single, brief threshold stimulus. (C)</p> Signup and view all the answers

Which of the following phases is NOT a part of a single muscle twitch?

<p>Refractory period (D)</p> Signup and view all the answers

What occurs during the latent period of a muscle twitch?

<p>Excitation-contraction coupling is taking place. (A)</p> Signup and view all the answers

What is the primary mechanism by which graded muscle responses are achieved?

<p>Changing the number of muscle fibers stimulated and the frequency of stimulation. (B)</p> Signup and view all the answers

What is wave summation in the context of muscle physiology?

<p>The increased force of contraction that occurs when stimuli are delivered rapidly, not allowing the muscle to relax completely. (B)</p> Signup and view all the answers

What is the difference between unfused (incomplete) tetanus and fused (complete) tetanus?

<p>In unfused tetanus, the muscle fibers partially relax between stimuli, while in fused tetanus, there is no relaxation. (B)</p> Signup and view all the answers

What is recruitment in muscle contraction?

<p>The process of increasing the force of contraction by progressively activating more motor units. (B)</p> Signup and view all the answers

What is the threshold stimulus in the context of muscle response?

<p>The stimulus strength at which the first observable muscle contraction occurs. (A)</p> Signup and view all the answers

What is the 'Treppe' or staircase effect?

<p>The increased contraction in response to multiple stimuli of the same strength, resulting in a graded increase in force. (B)</p> Signup and view all the answers

Which factor contributes to the 'Treppe' phenomenon?

<p>Increased efficiency of muscle enzyme systems due to increased heat (A)</p> Signup and view all the answers

What is muscle tone?

<p>The constant, slightly contracted state of all muscles, which does not produce active movements. (C)</p> Signup and view all the answers

Which of the following is true about muscle tone?

<p>It helps maintain muscle health and readiness to respond to stimuli. (D)</p> Signup and view all the answers

Which of the following factors affects the force of muscle contraction?

<p>All of the above. (D)</p> Signup and view all the answers

Why is the degree of muscle stretch important for the force of muscle contraction?

<p>Muscles contract strongest when muscle fibers are 80-120% of their normal resting length. (D)</p> Signup and view all the answers

In isotonic contractions, what specifically changes in the muscle?

<p>Length (D)</p> Signup and view all the answers

Which of the following distinguishes concentric from eccentric isotonic contractions?

<p>Concentric contractions involve muscle shortening; eccentric contractions involve muscle lengthening. (D)</p> Signup and view all the answers

What is the primary energy source used by muscles during direct phosphorylation?

<p>Creatine phosphate (D)</p> Signup and view all the answers

What is a key product of the anaerobic mechanism (glycolysis and lactic acid formation) in muscle metabolism?

<p>Lactic acid (A)</p> Signup and view all the answers

What is the approximate net ATP gain per glucose molecule during aerobic respiration in muscle metabolism?

<p>36 ATP (C)</p> Signup and view all the answers

Which of the following is a condition that defines muscle fatigue?

<p>A state of physiological inability to contract, even when stimulated. (A)</p> Signup and view all the answers

Which of the following contributes to muscle fatigue?

<p>ATP production fails to keep pace with ATP use (D)</p> Signup and view all the answers

During intense exercise, why might Na+/K+ pumps fail to restore ionic balances quickly enough in muscle fibers?

<p>The rate of ion movement exceeds the pump capacity. (B)</p> Signup and view all the answers

Approximately what percentage of energy released during muscle activity is converted to useful work?

<p>40% (C)</p> Signup and view all the answers

How does the body primarily prevent dangerous heat levels during muscle activity?

<p>Radiation of heat from the skin and sweating. (B)</p> Signup and view all the answers

In a hypothetical scenario, a toxin impairs the function of the sarcoplasmic reticulum, specifically preventing it from effectively sequestering $Ca^{2+}$. Which of the following immediate effects would be most likely observed in skeletal muscle?

<p>Muscle rigidity and the inability to relax, due to continuous binding of myosin to actin. (D)</p> Signup and view all the answers

Imagine a new drug that selectively blocks voltage-gated $K^{+}$ channels in neurons responsible for innervating skeletal muscle. What would be the MOST likely direct effect of this drug on muscle contraction?

<p>Prolonged muscle contraction due to extended depolarization of the sarcolemma. (B)</p> Signup and view all the answers

What is the specialized function of muscle tissue?

<p>To facilitate contraction for movement (D)</p> Signup and view all the answers

Elasticity refers to the ability of muscle tissue to forcibly shorten.

<p>False (B)</p> Signup and view all the answers

What type of energy is required for muscle contraction?

<p>chemical</p> Signup and view all the answers

The property of muscle tissue that allows it to receive and respond to stimuli is known as ______.

<p>excitability</p> Signup and view all the answers

Match the following muscle properties with their descriptions:

<p>Contractility = Ability to forcibly shorten Extensibility = Ability to stretch Elasticity = Ability to return to original length Excitability = Ability to respond to stimuli</p> Signup and view all the answers

Which type of muscle tissue is found connected to bones?

<p>Skeletal muscle (D)</p> Signup and view all the answers

Cardiac muscle is under voluntary control.

<p>False (B)</p> Signup and view all the answers

Which muscle tissue type features cells that are described as 'spindle shaped'?

<p>smooth muscle</p> Signup and view all the answers

Muscle tissue that is described as striated and under involuntary control is ______ muscle.

<p>cardiac</p> Signup and view all the answers

Match the following muscle types with their voluntary/involuntary nature:

<p>Skeletal Muscle = Voluntary Cardiac Muscle = Involuntary Smooth Muscle = Involuntary</p> Signup and view all the answers

What is the connective tissue layer that surrounds an entire muscle?

<p>Epimysium (D)</p> Signup and view all the answers

A fascicle is a bundle of individual muscle cells (fibers).

<p>True (A)</p> Signup and view all the answers

What connective tissue type connects muscles to bones?

<p>tendons</p> Signup and view all the answers

The connective tissue layer that surrounds individual muscle fibers is called the ______.

<p>endomysium</p> Signup and view all the answers

Match the connective tissue layers with the structures they surround:

<p>Epimysium = Entire muscle Perimysium = Fascicle Endomysium = Muscle fiber</p> Signup and view all the answers

What is the plasma membrane of a muscle fiber called?

<p>Sarcolemma (C)</p> Signup and view all the answers

The sarcomere is the smallest contractile unit of a muscle cell.

<p>True (A)</p> Signup and view all the answers

What is the main function of the sarcoplasmic reticulum?

<p>store/release calcium ions</p> Signup and view all the answers

The T-tubules are membrane canals that reach deep into the muscle fiber and surround ______.

<p>myofibrils</p> Signup and view all the answers

Match the structure and its function in the muscle fiber:

<p>Sarcolemma = Plasma membrane of muscle fiber Sarcoplasmic Reticulum = Stores and releases calcium ions Sarcomere = Contractile unit of muscle Myofibrils = Long, rod-shaped organelles</p> Signup and view all the answers

During muscle contraction, what happens to the length of the actin and myosin filaments?

<p>The length of actin and myosin filaments remains the same (B)</p> Signup and view all the answers

During contraction, the overlap between actin and myosin filaments decreases.

<p>False (B)</p> Signup and view all the answers

Which filament (actin or myosin) 'wants to pull on a rope'?

<p>myosin</p> Signup and view all the answers

During muscle contraction, the sarcomere ______.

<p>shortens</p> Signup and view all the answers

Match the components of the sarcomere with what shortens during muscle contraction:

<p>Actin = Remains the same length Myosin = Remains the same length Sarcomere = Shortens</p> Signup and view all the answers

Which protein blocks the myosin binding sites on actin?

<p>Tropomyosin (A)</p> Signup and view all the answers

Troponin directly binds to myosin.

<p>False (B)</p> Signup and view all the answers

What ion is responsible for initiating the movement of tropomyosin, exposing the myosin binding sites?

<p>calcium</p> Signup and view all the answers

The regulatory protein that says 'No' to myosin is ______.

<p>tropomyosin</p> Signup and view all the answers

Match the regulatory protein to its action:

<p>Tropomyosin = Blocks the myosin binding sites on actin Troponin = Binds calcium ions, which moves tropomyosin</p> Signup and view all the answers

The region of the sarcomere that contains only myosin is called the?

<p>H zone (A)</p> Signup and view all the answers

The M line anchors actin filaments.

<p>False (B)</p> Signup and view all the answers

What structure divides the sarcomere at its ends?

<p>z disc</p> Signup and view all the answers

The ______ band contains both actin and myosin filaments.

<p>a</p> Signup and view all the answers

Match the band/zone of the sarcomere with what it contains:

<p>I band = Actin only A band = Actin and Myosin H Zone = Myosin only</p> Signup and view all the answers

Action potentials spread along the sarcolemma and into the T tubules.

<p>True (A)</p> Signup and view all the answers

What ion does the sarcoplasmic reticulum release?

<p>calcium</p> Signup and view all the answers

In excitation-contraction coupling, myosin binding sites are exposed after the release of ______.

<p>calcium ions</p> Signup and view all the answers

Match the action during Excitation-Contraction Coupling:

<p>Action Potential = Travels down T Tubules Sarcoplasmic Reticulum = Releases Calcium Calcium = Causes tropomyosin to move from actin binding sites</p> Signup and view all the answers

What neurotransmitter is used at the neuromuscular junction?

<p>Acetylcholine (D)</p> Signup and view all the answers

Muscle fibers are positively charged on the inside when polarized.

<p>False (B)</p> Signup and view all the answers

Flashcards

Muscle tissue types

Skeletal, cardiac, and smooth.

Muscle Fibers

Elongated muscle cells, common to skeletal and smooth muscles.

Myofilaments

Actin and myosin.

Sarcolemma

Muscle plasma membrane.

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Sarcoplasm

Cytoplasm of a muscle cell.

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Prefixes referring to muscle

Myo, mys, and sarco.

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Excitability

The ability to receive and respond to stimuli.

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Contractility

The ability to shorten forcibly.

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Extensibility

The ability to be stretched or extended.

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Elasticity

The ability to recoil and resume original length.

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Skeletal Muscle Function

Responsible for locomotion.

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Cardiac Muscle Function

Responsible for coursing blood through the body.

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Smooth Muscle Function

Helps maintain blood pressure; propels substances through organs.

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Muscle Supply

One nerve, one artery, and one or more veins.

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Sarcomere

The smallest contractile unit of a muscle.

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Sarcomere Location

Region of a myofibril between two successive Z discs.

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Myofilament Types

Thick and thin.

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Thick Filaments

Extend the entire length of an A band.

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Thin Filaments

Extend across the I band and partway into the A band.

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Z-disc

Anchors thin filaments; connects myofibrils.

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Thick Filaments Composition

Composed of the protein myosin.

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Thin Filaments Composition

Composed chiefly of the protein actin.

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Sarcoplasmic Reticulum (SR)

Elaborate, smooth endoplasmic reticulum surrounding myofibrils.

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Sarcoplasmic Reticulum Function

Regulation of intracellular calcium levels.

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T Tubules

Associate with terminal cisternae to form triads.

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Sliding Filament Model

Thin filaments slide past thick filaments.

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Excitation-Contraction Coupling

Electrical signal linked to muscle contraction.

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Motor Neurons

Skeletal muscles are stimulated by them.

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Neuromuscular Junction

Formed from axonal endings and motor end plate.

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Axonal Endings

Contains acetylcholine (ACh).

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Motor End Plate

Contains ACh receptors, helps form neuromuscular junction.

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Synaptic Cleft

Axonal ends and muscle fibers separated by this.

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Voltage-Regulated Calcium Channels

Channels open and allow calcium to enter axon.

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Axonal Vesicle Function

Releases ACh into synaptic cleft via exocytosis.

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Acetylcholine (ACh) Function

Binds receptors on sarcolemma, initiating an action potential.

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Acetylcholinesterase

Quickly destroys ACh bound to its receptors.

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Action Potential

Transient depolarization event along sarcolemma.

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ACh Binding

Binds its receptors at the motor end plate.

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Ligand-Gated Channels

Opens chemically (ligand) gated channels.

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Na+ and K+ Role

Na+ and K+ diffuse in/out, sarcolemma becomes less negative.

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Depolarization

Event where sarcolemma becomes less negative.

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Resting Membrane Potential

Difference in charge across the sarcolemma in a resting muscle cell.

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Predominant Extracellular Ion

The predominant extracellular ion.

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Predominant Intracellular Ion

The predominant intracellular ion.

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Refractory Period

Period where a muscle cannot be stimulated.

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Wave Summation

When stimulation frequency increases, muscle tension increases.

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Tetanus

A rapid increase in muscle tension from frequent stimulation.

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Threshold Stimulus

Threshold for observable muscle contraction.

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Recruitment

Increasing the number of active muscle fibers.

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Treppe

Increased availability of Ca2+ with repeated stimuli.

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Muscle Tone

The constant, slightly contracted state of all muscles.

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Isotonic Contraction

Muscle changes length and moves a load.

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Concentric Contraction

Muscle shortens and does work.

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Isometric Contraction

Muscle increases in tension, but length doesn't change.

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Muscle Fatigue

Muscle's physiological inability to contract.

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Motor Unit

It's a motor neuron and all the muscle fibers it supplies

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Muscle Twitch

Response of a muscle to a single, brief threshold stimulus

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Contraction

Muscle tissue specializes in this action to create movement.

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Mechanical energy

Convert chemical energy into this type of energy.

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Heat

This is what muscles generate in addition to motion

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Tendons

Connects muscles to bones.

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Aponeuroses

Sheets that connect muscles to bones.

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Myofibrils

Long, rod-shaped organelles in the muscle cell.

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Sarcoplasmic reticulum

Muscle cell endoplasmic reticulum that stores/releases Calcium ions

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A band

The area containing the H zone.

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I band

The region of solely actin.

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H zone

The region in the center of the A band.

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Overlap zone

Regions of the sarcomere where the filaments overlap more during muscle contraction.

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M line

Anchors the myosin.

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Tropomyosin

Thin filament: like protein, wraps around actin.

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Troponin

Globular protein. Binds to Calcium

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Titin

Keeps the sarcomere's shape.

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Synapse

Neurotransmitters are released into this space.

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Acetylcholine

Binds receptors on sarcolemma to start an action potential.

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Study Notes

Introduction to Muscles and Muscle Tissue

  • Muscle tissue is specialized for contraction.
  • Muscle tissue contraction creates movement.
  • Muscle tissue converts chemical energy to mechanical energy.
  • Heat is generated through muscle tissue contraction.
  • Muscle tissue exhibits several key properties:
    • Contractility: The ability to forcibly shorten.
    • Extensibility: The capacity to be stretched.
    • Elasticity: The tendency to return to its original length.
    • Excitability: The ability to transmit stimuli.
  • A main function of muscle is converting chemical energy to mechanical energy.

Types of Muscle Tissue

  • There are three types of muscle tissue in the human body: skeletal, cardiac, and smooth.
  • Skeletal muscle:
    • Location: connected to bones.
    • Voluntary control
    • Striated
    • Has many nuclei per cell.
  • Cardiac muscle:
    • Location: heart.
    • Involuntary control.
    • Striated
    • Contains one nuclei per cell
  • Smooth muscle:
    • Location: hollow organs & blood vessels.
    • Involuntary control.
    • Non-striated
    • Contains one nuclei per cell.
  • Cardiac is involuntary
  • Skeletal muscle cells are the largest.

Structure of a Skeletal Muscle

  • Muscles are comprised of muscle fibers, nerves, blood vessels, and connective tissue.
  • Muscles are made of many wrapped bundles.
  • Muscle: bundle of fascicles, surrounded by epimysium (on surface/outside).
  • Fascicle: a bundle of muscle fibers, surrounded by perimysium.
  • Muscle Fiber: muscle cell, a long multinucleated cell.
    • 1 muscle fiber = length of muscle.
    • Surrounded by endomysium (within).
  • Connective tissue connects to bones:
    • Rope-like tendons.
    • Sheet-like aponeuroses.

The Muscle Fiber

  • For a muscle fiber to contract, the tissue must shorten.
  • Sarcolemma: the plasma membrane wrapping myofibrils (cell membrane).
  • T-Tubules: membrane canals that reach deep into the myofibrils.
  • Sarcoplasmic Reticulum: endoplasmic reticulum of muscle cells.
    • Surrounds myofibrils.
    • Stores/releases Ca+2 ions.
  • Myofibrils: long, rod-shaped organelles that contain myofilaments.
  • Myofilaments: proteins, specifically actin and myosin.
  • Sarcomere: the contractile unit that creates striated appearance.
  • The smallest contractile unit is the sarcomere.

Sliding Filament Theory and the Sarcomere

  • Muscles get shorter because actin slides over myosin.
  • Sarcomere shortens, but filaments themselves do not shorten or overlap.
  • During contraction, filaments (actin & myosin) stay the same length, the overlap of actin & myosin increases.
  • Myosin (thick filament): anchored to the center of the sarcomere, wants to pull on a rope.
  • Actin (thin filament): anchored to the ends of the sarcomere (the "rope").

Proteins of the Sarcomere

  • Sarcomere is the contractile unit, the myosin pulls on actin.
  • Contractile Proteins:
    • Myosin: a thick filament, many headed Medusa.
    • Actin: a thin filament.
  • Regulatory Proteins:
    • Tropomyosin: a thread-like protein, that wraps actin blocks the myosin binding sites on actin.
    • Troponin: a globular protein that binds to Ca+2 to open the binding sites on actin by moving tropomyosin.
    • Tropomyosin says "no" to the myosin.
    • Troponin OPENS the binding site.
  • Structural Proteins:
    • The Elastic Filament Titin helps the sarcomere retain shape.

Structure of the Sarcomere: Bands, Zones, Discs & Lines

  • The sarcomere regions were named for how they look on a TEM microscope
  • Discs and Lines:
    • Z Disc: end of sarcomere, Z is at the end of the alphabet.
    • M Line: Myomesin protein anchors myosin, M = Middle.
  • Bands and Zones:
    • I Band (light band): area with just actin.
    • A Band (dark band): area with both actin & myosin.
    • Zone: center region with just myosin (Helle = bright).
  • Components During Contraction:
    • A Band: no change in size.
    • I Band: shortens & overlaps.
    • H Zone: shortens & disappears.
    • Z Disc: no change.
    • M Line: no change.
  • Z disc is NOT found in the A band.

Steps of Muscle Contraction

  • Muscle contraction involves the transmission of a nervous signal and the contraction of the sarcomere.
  • A. At the Neuromuscular Junction:
    • The muscle cell is stimulated by the nervous system, initiating an action potential.
    • Neuromuscular junction: connection between the nervous system and motor end plate of the muscle fiber.
    • Acetylcholine (ACh): neurotransmitter used at neuromuscular junction.
      1. Action potential arrives at the axon terminal.
      1. Voltage gated Ca+2 channels open.
      1. Ca+2 enters, axon releases ACh into the synapse.
      1. ACh diffuses across the synaptic cleft and binds to the receptors in the sarcolemma.
      1. Na+ ion channels open in the sarcolemma—starting an action potential in the muscle fiber.
      1. ACh is broken down by the enzyme Acetylcholinesterase, signal stops.
  • B. Excitation-Contraction Coupling:
    • Transmission from action potential to muscle contraction.
      1. Action potential spreads along the sarcolemma and enters the T tubules.
      1. Sarcoplasmic reticulum releases Ca2+.
      1. Calcium binds to troponin.
      1. Myosin binding sites on actin are exposed.
    • Voltage gated channels of the sarcoplasmic reticulum release Ca2+ into the sarcomere.
  • C. Cross Bridge Cycle:
    • Interaction of actin and myosin that leads to the sarcomere shortening.
      1. Myosin head binds to exposed actin.
      1. Myosin performs the power stroke, moving actin and releasing ADP + P.
      1. ATP binds to the myosin head, releasing the actin.
      1. ATP is hydrolyzed, and the myosin head moves into cocked position (ready to start).
    • The events of excitation-contraction coupling involve converting the electrochemical signal to the mechanical movement of contraction.

Neurotransmitters & Action Potentials

  • The steps include Neurotransmitters & Action Potentials.
  • Neurotransmitters: chemical messengers used at synapses.
  • Synapse: the space between the axon and the muscle.
  • Acetylcholine: neurotransmitter of the neuromuscular junction.
  • Action potential: wave of electric signal that moves along a membrane.
  • Muscle fibers are polarized: negative charged inside; positive charged outside.
  • Brief change of polarization is caused by movement of Na+ and K+ ions.
    • The cell is swimming in a salty sodium sea-positive OUTSIDE.
  • During an action potential, the phase where Na+ moves into the cell results in depolarization, while the phase where K+ exits the cell results in repolarization.

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