Podcast
Questions and Answers
Which of the following is NOT a type of muscle tissue?
Which of the following is NOT a type of muscle tissue?
- Smooth
- Epithelial (correct)
- Cardiac
- Skeletal
Which characteristic is NOT common to all muscle tissues?
Which characteristic is NOT common to all muscle tissues?
- Elasticity
- Excitability
- Striations (correct)
- Contractility
What two kinds of myofilaments are responsible for muscle contraction?
What two kinds of myofilaments are responsible for muscle contraction?
- Collagen and elastin
- Troponin and tropomyosin
- Actin and myosin (correct)
- Sarcomere and sarcoplasm
Which functional characteristic of muscle tissue allows it to recoil and resume its resting length after being stretched?
Which functional characteristic of muscle tissue allows it to recoil and resume its resting length after being stretched?
Which type of muscle tissue is responsible for locomotion?
Which type of muscle tissue is responsible for locomotion?
What is the function of cardiac muscle?
What is the function of cardiac muscle?
Which type of muscle tissue helps maintain blood pressure and propels substances through organs?
Which type of muscle tissue helps maintain blood pressure and propels substances through organs?
What are skeletal muscle fibers supplied with to control contraction?
What are skeletal muscle fibers supplied with to control contraction?
What is the function of arteries in the context of contracting muscle fibers?
What is the function of arteries in the context of contracting muscle fibers?
What must be removed from contracting muscle fibers via veins?
What must be removed from contracting muscle fibers via veins?
What is the sarcolemma?
What is the sarcolemma?
What is the smallest contractile unit of a muscle fiber?
What is the smallest contractile unit of a muscle fiber?
A sarcomere is defined as the region of a myofibril between what structures?
A sarcomere is defined as the region of a myofibril between what structures?
What are the two main types of myofilaments found in sarcomeres?
What are the two main types of myofilaments found in sarcomeres?
What protein primarily composes thick filaments?
What protein primarily composes thick filaments?
In the sarcomere structure, which filaments extend the entire length of the A band?
In the sarcomere structure, which filaments extend the entire length of the A band?
In the sarcomere, which filaments extend across the I band and partway into the A band?
In the sarcomere, which filaments extend across the I band and partway into the A band?
What is the function of the Z disc in the sarcomere?
What is the function of the Z disc in the sarcomere?
What are the heads of the myosin molecule called that interact with actin during muscle contraction?
What are the heads of the myosin molecule called that interact with actin during muscle contraction?
What regulatory proteins are bound to actin in thin filaments?
What regulatory proteins are bound to actin in thin filaments?
What best describes the primary role of the sarcoplasmic reticulum (SR)?
What best describes the primary role of the sarcoplasmic reticulum (SR)?
What is the functional significance of T tubules in muscle cells?
What is the functional significance of T tubules in muscle cells?
According to the sliding filament model of contraction, what happens to the actin and myosin filaments?
According to the sliding filament model of contraction, what happens to the actin and myosin filaments?
Which event directly triggers the sliding of myofilaments, leading to muscle contraction?
Which event directly triggers the sliding of myofilaments, leading to muscle contraction?
What is the role of a nerve ending in skeletal muscle contraction?
What is the role of a nerve ending in skeletal muscle contraction?
What event propagates an electrical current along the sarcolemma?
What event propagates an electrical current along the sarcolemma?
What triggers the final step leading directly to skeletal muscle contraction?
What triggers the final step leading directly to skeletal muscle contraction?
What is the term for the link between the electrical signal and the mechanical contraction in muscle fibers?
What is the term for the link between the electrical signal and the mechanical contraction in muscle fibers?
Skeletal muscles are stimulated by motor neurons of which nervous system?
Skeletal muscles are stimulated by motor neurons of which nervous system?
What structure does each axonal branch form with a single muscle fiber?
What structure does each axonal branch form with a single muscle fiber?
What neurotransmitter is contained within the synaptic vesicles at the axonal endings?
What neurotransmitter is contained within the synaptic vesicles at the axonal endings?
What is the motor end plate?
What is the motor end plate?
What is the synaptic cleft?
What is the synaptic cleft?
What type of channels open to allow Ca2+ to enter the axon terminal at the neuromuscular junction?
What type of channels open to allow Ca2+ to enter the axon terminal at the neuromuscular junction?
What process releases ACh into the synaptic cleft?
What process releases ACh into the synaptic cleft?
How does ACh initiate an action potential in the muscle?
How does ACh initiate an action potential in the muscle?
What enzyme quickly destroys ACh bound to ACh receptors?
What enzyme quickly destroys ACh bound to ACh receptors?
What event is defined as a transient depolarization that includes polarity reversal of the sarcolemma?
What event is defined as a transient depolarization that includes polarity reversal of the sarcolemma?
How does the binding of ACh to its receptors at the motor end plate affect the sarcolemma?
How does the binding of ACh to its receptors at the motor end plate affect the sarcolemma?
During depolarization, caused by ACh, what happens to the interior of the sarcolemma?
During depolarization, caused by ACh, what happens to the interior of the sarcolemma?
During the action potential in a muscle fiber, what ionic event primarily occurs during depolarization?
During the action potential in a muscle fiber, what ionic event primarily occurs during depolarization?
What happens immediately after the depolarization wave passes in a muscle fiber?
What happens immediately after the depolarization wave passes in a muscle fiber?
How is the resting membrane potential restored after repolarization in a muscle fiber?
How is the resting membrane potential restored after repolarization in a muscle fiber?
Which of the following directly triggers the release of calcium ions ($Ca^{2+}$) from the terminal cisternae of the sarcoplasmic reticulum?
Which of the following directly triggers the release of calcium ions ($Ca^{2+}$) from the terminal cisternae of the sarcoplasmic reticulum?
What role does calcium ($Ca^{2+}$) play in excitation-contraction coupling?
What role does calcium ($Ca^{2+}$) play in excitation-contraction coupling?
What happens to calcium ($Ca^{2+}$) levels in the sarcoplasm when a muscle fiber relaxes?
What happens to calcium ($Ca^{2+}$) levels in the sarcoplasm when a muscle fiber relaxes?
During the sequential events of muscle contraction, what directly causes the myosin head to detach from actin?
During the sequential events of muscle contraction, what directly causes the myosin head to detach from actin?
What is the role of ATP hydrolysis in the cross-bridge cycle during muscle contraction?
What is the role of ATP hydrolysis in the cross-bridge cycle during muscle contraction?
What is the difference between isometric and isotonic muscle contractions?
What is the difference between isometric and isotonic muscle contractions?
Which of the following is an example of an isotonic contraction?
Which of the following is an example of an isotonic contraction?
In the context of muscle physiology, what defines a motor unit?
In the context of muscle physiology, what defines a motor unit?
Muscles that control fine movements, such as those in the fingers and eyes, have:
Muscles that control fine movements, such as those in the fingers and eyes, have:
What is a muscle twitch?
What is a muscle twitch?
Which of the following phases is NOT a part of a single muscle twitch?
Which of the following phases is NOT a part of a single muscle twitch?
What occurs during the latent period of a muscle twitch?
What occurs during the latent period of a muscle twitch?
What is the primary mechanism by which graded muscle responses are achieved?
What is the primary mechanism by which graded muscle responses are achieved?
What is wave summation in the context of muscle physiology?
What is wave summation in the context of muscle physiology?
What is the difference between unfused (incomplete) tetanus and fused (complete) tetanus?
What is the difference between unfused (incomplete) tetanus and fused (complete) tetanus?
What is recruitment in muscle contraction?
What is recruitment in muscle contraction?
What is the threshold stimulus in the context of muscle response?
What is the threshold stimulus in the context of muscle response?
What is the 'Treppe' or staircase effect?
What is the 'Treppe' or staircase effect?
Which factor contributes to the 'Treppe' phenomenon?
Which factor contributes to the 'Treppe' phenomenon?
What is muscle tone?
What is muscle tone?
Which of the following is true about muscle tone?
Which of the following is true about muscle tone?
Which of the following factors affects the force of muscle contraction?
Which of the following factors affects the force of muscle contraction?
Why is the degree of muscle stretch important for the force of muscle contraction?
Why is the degree of muscle stretch important for the force of muscle contraction?
In isotonic contractions, what specifically changes in the muscle?
In isotonic contractions, what specifically changes in the muscle?
Which of the following distinguishes concentric from eccentric isotonic contractions?
Which of the following distinguishes concentric from eccentric isotonic contractions?
What is the primary energy source used by muscles during direct phosphorylation?
What is the primary energy source used by muscles during direct phosphorylation?
What is a key product of the anaerobic mechanism (glycolysis and lactic acid formation) in muscle metabolism?
What is a key product of the anaerobic mechanism (glycolysis and lactic acid formation) in muscle metabolism?
What is the approximate net ATP gain per glucose molecule during aerobic respiration in muscle metabolism?
What is the approximate net ATP gain per glucose molecule during aerobic respiration in muscle metabolism?
Which of the following is a condition that defines muscle fatigue?
Which of the following is a condition that defines muscle fatigue?
Which of the following contributes to muscle fatigue?
Which of the following contributes to muscle fatigue?
During intense exercise, why might Na+/K+ pumps fail to restore ionic balances quickly enough in muscle fibers?
During intense exercise, why might Na+/K+ pumps fail to restore ionic balances quickly enough in muscle fibers?
Approximately what percentage of energy released during muscle activity is converted to useful work?
Approximately what percentage of energy released during muscle activity is converted to useful work?
How does the body primarily prevent dangerous heat levels during muscle activity?
How does the body primarily prevent dangerous heat levels during muscle activity?
In a hypothetical scenario, a toxin impairs the function of the sarcoplasmic reticulum, specifically preventing it from effectively sequestering $Ca^{2+}$. Which of the following immediate effects would be most likely observed in skeletal muscle?
In a hypothetical scenario, a toxin impairs the function of the sarcoplasmic reticulum, specifically preventing it from effectively sequestering $Ca^{2+}$. Which of the following immediate effects would be most likely observed in skeletal muscle?
Imagine a new drug that selectively blocks voltage-gated $K^{+}$ channels in neurons responsible for innervating skeletal muscle. What would be the MOST likely direct effect of this drug on muscle contraction?
Imagine a new drug that selectively blocks voltage-gated $K^{+}$ channels in neurons responsible for innervating skeletal muscle. What would be the MOST likely direct effect of this drug on muscle contraction?
What is the specialized function of muscle tissue?
What is the specialized function of muscle tissue?
Elasticity refers to the ability of muscle tissue to forcibly shorten.
Elasticity refers to the ability of muscle tissue to forcibly shorten.
What type of energy is required for muscle contraction?
What type of energy is required for muscle contraction?
The property of muscle tissue that allows it to receive and respond to stimuli is known as ______.
The property of muscle tissue that allows it to receive and respond to stimuli is known as ______.
Match the following muscle properties with their descriptions:
Match the following muscle properties with their descriptions:
Which type of muscle tissue is found connected to bones?
Which type of muscle tissue is found connected to bones?
Cardiac muscle is under voluntary control.
Cardiac muscle is under voluntary control.
Which muscle tissue type features cells that are described as 'spindle shaped'?
Which muscle tissue type features cells that are described as 'spindle shaped'?
Muscle tissue that is described as striated and under involuntary control is ______ muscle.
Muscle tissue that is described as striated and under involuntary control is ______ muscle.
Match the following muscle types with their voluntary/involuntary nature:
Match the following muscle types with their voluntary/involuntary nature:
What is the connective tissue layer that surrounds an entire muscle?
What is the connective tissue layer that surrounds an entire muscle?
A fascicle is a bundle of individual muscle cells (fibers).
A fascicle is a bundle of individual muscle cells (fibers).
What connective tissue type connects muscles to bones?
What connective tissue type connects muscles to bones?
The connective tissue layer that surrounds individual muscle fibers is called the ______.
The connective tissue layer that surrounds individual muscle fibers is called the ______.
Match the connective tissue layers with the structures they surround:
Match the connective tissue layers with the structures they surround:
What is the plasma membrane of a muscle fiber called?
What is the plasma membrane of a muscle fiber called?
The sarcomere is the smallest contractile unit of a muscle cell.
The sarcomere is the smallest contractile unit of a muscle cell.
What is the main function of the sarcoplasmic reticulum?
What is the main function of the sarcoplasmic reticulum?
The T-tubules are membrane canals that reach deep into the muscle fiber and surround ______.
The T-tubules are membrane canals that reach deep into the muscle fiber and surround ______.
Match the structure and its function in the muscle fiber:
Match the structure and its function in the muscle fiber:
During muscle contraction, what happens to the length of the actin and myosin filaments?
During muscle contraction, what happens to the length of the actin and myosin filaments?
During contraction, the overlap between actin and myosin filaments decreases.
During contraction, the overlap between actin and myosin filaments decreases.
Which filament (actin or myosin) 'wants to pull on a rope'?
Which filament (actin or myosin) 'wants to pull on a rope'?
During muscle contraction, the sarcomere ______.
During muscle contraction, the sarcomere ______.
Match the components of the sarcomere with what shortens during muscle contraction:
Match the components of the sarcomere with what shortens during muscle contraction:
Which protein blocks the myosin binding sites on actin?
Which protein blocks the myosin binding sites on actin?
Troponin directly binds to myosin.
Troponin directly binds to myosin.
What ion is responsible for initiating the movement of tropomyosin, exposing the myosin binding sites?
What ion is responsible for initiating the movement of tropomyosin, exposing the myosin binding sites?
The regulatory protein that says 'No' to myosin is ______.
The regulatory protein that says 'No' to myosin is ______.
Match the regulatory protein to its action:
Match the regulatory protein to its action:
The region of the sarcomere that contains only myosin is called the?
The region of the sarcomere that contains only myosin is called the?
The M line anchors actin filaments.
The M line anchors actin filaments.
What structure divides the sarcomere at its ends?
What structure divides the sarcomere at its ends?
The ______ band contains both actin and myosin filaments.
The ______ band contains both actin and myosin filaments.
Match the band/zone of the sarcomere with what it contains:
Match the band/zone of the sarcomere with what it contains:
Action potentials spread along the sarcolemma and into the T tubules.
Action potentials spread along the sarcolemma and into the T tubules.
What ion does the sarcoplasmic reticulum release?
What ion does the sarcoplasmic reticulum release?
In excitation-contraction coupling, myosin binding sites are exposed after the release of ______.
In excitation-contraction coupling, myosin binding sites are exposed after the release of ______.
Match the action during Excitation-Contraction Coupling:
Match the action during Excitation-Contraction Coupling:
What neurotransmitter is used at the neuromuscular junction?
What neurotransmitter is used at the neuromuscular junction?
Muscle fibers are positively charged on the inside when polarized.
Muscle fibers are positively charged on the inside when polarized.
Flashcards
Muscle tissue types
Muscle tissue types
Skeletal, cardiac, and smooth.
Muscle Fibers
Muscle Fibers
Elongated muscle cells, common to skeletal and smooth muscles.
Myofilaments
Myofilaments
Actin and myosin.
Sarcolemma
Sarcolemma
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Sarcoplasm
Sarcoplasm
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Prefixes referring to muscle
Prefixes referring to muscle
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Excitability
Excitability
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Contractility
Contractility
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Extensibility
Extensibility
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Elasticity
Elasticity
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Skeletal Muscle Function
Skeletal Muscle Function
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Cardiac Muscle Function
Cardiac Muscle Function
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Smooth Muscle Function
Smooth Muscle Function
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Muscle Supply
Muscle Supply
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Sarcomere
Sarcomere
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Sarcomere Location
Sarcomere Location
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Myofilament Types
Myofilament Types
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Thick Filaments
Thick Filaments
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Thin Filaments
Thin Filaments
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Z-disc
Z-disc
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Thick Filaments Composition
Thick Filaments Composition
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Thin Filaments Composition
Thin Filaments Composition
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Sarcoplasmic Reticulum (SR)
Sarcoplasmic Reticulum (SR)
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Sarcoplasmic Reticulum Function
Sarcoplasmic Reticulum Function
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T Tubules
T Tubules
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Sliding Filament Model
Sliding Filament Model
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Excitation-Contraction Coupling
Excitation-Contraction Coupling
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Motor Neurons
Motor Neurons
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Neuromuscular Junction
Neuromuscular Junction
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Axonal Endings
Axonal Endings
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Motor End Plate
Motor End Plate
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Synaptic Cleft
Synaptic Cleft
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Voltage-Regulated Calcium Channels
Voltage-Regulated Calcium Channels
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Axonal Vesicle Function
Axonal Vesicle Function
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Acetylcholine (ACh) Function
Acetylcholine (ACh) Function
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Acetylcholinesterase
Acetylcholinesterase
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Action Potential
Action Potential
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ACh Binding
ACh Binding
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Ligand-Gated Channels
Ligand-Gated Channels
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Na+ and K+ Role
Na+ and K+ Role
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Depolarization
Depolarization
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Resting Membrane Potential
Resting Membrane Potential
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Predominant Extracellular Ion
Predominant Extracellular Ion
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Predominant Intracellular Ion
Predominant Intracellular Ion
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Refractory Period
Refractory Period
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Wave Summation
Wave Summation
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Tetanus
Tetanus
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Threshold Stimulus
Threshold Stimulus
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Recruitment
Recruitment
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Treppe
Treppe
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Muscle Tone
Muscle Tone
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Isotonic Contraction
Isotonic Contraction
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Concentric Contraction
Concentric Contraction
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Isometric Contraction
Isometric Contraction
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Muscle Fatigue
Muscle Fatigue
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Motor Unit
Motor Unit
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Muscle Twitch
Muscle Twitch
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Contraction
Contraction
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Mechanical energy
Mechanical energy
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Heat
Heat
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Tendons
Tendons
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Aponeuroses
Aponeuroses
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Myofibrils
Myofibrils
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Sarcoplasmic reticulum
Sarcoplasmic reticulum
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A band
A band
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I band
I band
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H zone
H zone
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Overlap zone
Overlap zone
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M line
M line
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Tropomyosin
Tropomyosin
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Troponin
Troponin
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Titin
Titin
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Synapse
Synapse
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Acetylcholine
Acetylcholine
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Study Notes
Introduction to Muscles and Muscle Tissue
- Muscle tissue is specialized for contraction.
- Muscle tissue contraction creates movement.
- Muscle tissue converts chemical energy to mechanical energy.
- Heat is generated through muscle tissue contraction.
- Muscle tissue exhibits several key properties:
- Contractility: The ability to forcibly shorten.
- Extensibility: The capacity to be stretched.
- Elasticity: The tendency to return to its original length.
- Excitability: The ability to transmit stimuli.
- A main function of muscle is converting chemical energy to mechanical energy.
Types of Muscle Tissue
- There are three types of muscle tissue in the human body: skeletal, cardiac, and smooth.
- Skeletal muscle:
- Location: connected to bones.
- Voluntary control
- Striated
- Has many nuclei per cell.
- Cardiac muscle:
- Location: heart.
- Involuntary control.
- Striated
- Contains one nuclei per cell
- Smooth muscle:
- Location: hollow organs & blood vessels.
- Involuntary control.
- Non-striated
- Contains one nuclei per cell.
- Cardiac is involuntary
- Skeletal muscle cells are the largest.
Structure of a Skeletal Muscle
- Muscles are comprised of muscle fibers, nerves, blood vessels, and connective tissue.
- Muscles are made of many wrapped bundles.
- Muscle: bundle of fascicles, surrounded by epimysium (on surface/outside).
- Fascicle: a bundle of muscle fibers, surrounded by perimysium.
- Muscle Fiber: muscle cell, a long multinucleated cell.
- 1 muscle fiber = length of muscle.
- Surrounded by endomysium (within).
- Connective tissue connects to bones:
- Rope-like tendons.
- Sheet-like aponeuroses.
The Muscle Fiber
- For a muscle fiber to contract, the tissue must shorten.
- Sarcolemma: the plasma membrane wrapping myofibrils (cell membrane).
- T-Tubules: membrane canals that reach deep into the myofibrils.
- Sarcoplasmic Reticulum: endoplasmic reticulum of muscle cells.
- Surrounds myofibrils.
- Stores/releases Ca+2 ions.
- Myofibrils: long, rod-shaped organelles that contain myofilaments.
- Myofilaments: proteins, specifically actin and myosin.
- Sarcomere: the contractile unit that creates striated appearance.
- The smallest contractile unit is the sarcomere.
Sliding Filament Theory and the Sarcomere
- Muscles get shorter because actin slides over myosin.
- Sarcomere shortens, but filaments themselves do not shorten or overlap.
- During contraction, filaments (actin & myosin) stay the same length, the overlap of actin & myosin increases.
- Myosin (thick filament): anchored to the center of the sarcomere, wants to pull on a rope.
- Actin (thin filament): anchored to the ends of the sarcomere (the "rope").
Proteins of the Sarcomere
- Sarcomere is the contractile unit, the myosin pulls on actin.
- Contractile Proteins:
- Myosin: a thick filament, many headed Medusa.
- Actin: a thin filament.
- Regulatory Proteins:
- Tropomyosin: a thread-like protein, that wraps actin blocks the myosin binding sites on actin.
- Troponin: a globular protein that binds to Ca+2 to open the binding sites on actin by moving tropomyosin.
- Tropomyosin says "no" to the myosin.
- Troponin OPENS the binding site.
- Structural Proteins:
- The Elastic Filament Titin helps the sarcomere retain shape.
Structure of the Sarcomere: Bands, Zones, Discs & Lines
- The sarcomere regions were named for how they look on a TEM microscope
- Discs and Lines:
- Z Disc: end of sarcomere, Z is at the end of the alphabet.
- M Line: Myomesin protein anchors myosin, M = Middle.
- Bands and Zones:
- I Band (light band): area with just actin.
- A Band (dark band): area with both actin & myosin.
- Zone: center region with just myosin (Helle = bright).
- Components During Contraction:
- A Band: no change in size.
- I Band: shortens & overlaps.
- H Zone: shortens & disappears.
- Z Disc: no change.
- M Line: no change.
- Z disc is NOT found in the A band.
Steps of Muscle Contraction
- Muscle contraction involves the transmission of a nervous signal and the contraction of the sarcomere.
- A. At the Neuromuscular Junction:
- The muscle cell is stimulated by the nervous system, initiating an action potential.
- Neuromuscular junction: connection between the nervous system and motor end plate of the muscle fiber.
- Acetylcholine (ACh): neurotransmitter used at neuromuscular junction.
-
- Action potential arrives at the axon terminal.
-
- Voltage gated Ca+2 channels open.
-
- Ca+2 enters, axon releases ACh into the synapse.
-
- ACh diffuses across the synaptic cleft and binds to the receptors in the sarcolemma.
-
- Na+ ion channels open in the sarcolemma—starting an action potential in the muscle fiber.
-
- ACh is broken down by the enzyme Acetylcholinesterase, signal stops.
- B. Excitation-Contraction Coupling:
- Transmission from action potential to muscle contraction.
-
- Action potential spreads along the sarcolemma and enters the T tubules.
-
- Sarcoplasmic reticulum releases Ca2+.
-
- Calcium binds to troponin.
-
- Myosin binding sites on actin are exposed.
- Voltage gated channels of the sarcoplasmic reticulum release Ca2+ into the sarcomere.
- C. Cross Bridge Cycle:
- Interaction of actin and myosin that leads to the sarcomere shortening.
-
- Myosin head binds to exposed actin.
-
- Myosin performs the power stroke, moving actin and releasing ADP + P.
-
- ATP binds to the myosin head, releasing the actin.
-
- ATP is hydrolyzed, and the myosin head moves into cocked position (ready to start).
- The events of excitation-contraction coupling involve converting the electrochemical signal to the mechanical movement of contraction.
Neurotransmitters & Action Potentials
- The steps include Neurotransmitters & Action Potentials.
- Neurotransmitters: chemical messengers used at synapses.
- Synapse: the space between the axon and the muscle.
- Acetylcholine: neurotransmitter of the neuromuscular junction.
- Action potential: wave of electric signal that moves along a membrane.
- Muscle fibers are polarized: negative charged inside; positive charged outside.
- Brief change of polarization is caused by movement of Na+ and K+ ions.
- The cell is swimming in a salty sodium sea-positive OUTSIDE.
- During an action potential, the phase where Na+ moves into the cell results in depolarization, while the phase where K+ exits the cell results in repolarization.
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