Muscle Tissue Overview and Structure

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Questions and Answers

What is the primary function of structural proteins in muscle cells?

They maintain the alignment of thick and thin filaments, provide elasticity, and link myofibrils to the sarcolemma and extracellular matrix.

Describe the structure and function of myosin in muscle contraction.

Myosin is shaped like a twisted golf club, functioning as a motor protein that converts ATP's energy into mechanical energy necessary for force production.

What roles do tropomyosin and troponin play in muscle contraction?

Tropomyosin covers the Actin binding sites during relaxation, while troponin binds calcium, causing tropomyosin to move and expose these binding sites for contraction.

How does titin contribute to muscle function?

<p>Titin anchors thick filaments to Z discs and M lines, helps sarcomeres return to resting length, and prevents overstretching.</p> Signup and view all the answers

Explain the Sliding Filament Mechanism in skeletal muscle contraction.

<p>The Sliding Filament Mechanism describes how thick and thin filaments slide over one another, resulting in the shortening of the muscle during contraction.</p> Signup and view all the answers

What is the significance of the two binding sites on myosin heads?

<p>One binding site is for actin while the other is for ATP, both necessary for myosin to interact with actin and generate force during contraction.</p> Signup and view all the answers

What structural role does myomesin play in muscle cells?

<p>Myomesin forms the M line, which holds thick filaments in proper alignment within the sarcomere.</p> Signup and view all the answers

How does calcium influence the activity of troponin during muscle contraction?

<p>Calcium binds to troponin, activating it and causing it to pull tropomyosin away, which exposes the actin binding sites for myosin.</p> Signup and view all the answers

What role do T tubules play in muscle fiber functionality?

<p>T tubules tunnel from the surface to the inner aspects of muscle fibers, allowing action potentials to propagate deep within the fiber.</p> Signup and view all the answers

Define the function of the sarcoplasmic reticulum in muscle contraction.

<p>The sarcoplasmic reticulum encircles myofibrils and releases calcium ions when an action potential arrives, initiating muscle contraction.</p> Signup and view all the answers

What are sarcomeres and why are they important?

<p>Sarcomeres are the basic functional units of muscle contraction, extending from one Z disc to the next and containing thick and thin filaments.</p> Signup and view all the answers

Differentiate between thick and thin filaments in muscle fibers.

<p>Thick filaments are primarily composed of myosin, while thin filaments consist of actin, troponin, and tropomyosin.</p> Signup and view all the answers

What is the significance of the Z-discs in sarcomeres?

<p>Z-discs separate one sarcomere from another and anchor the thin filaments.</p> Signup and view all the answers

What is the function of contractile proteins in myofibrils?

<p>Contractile proteins generate force during muscle contraction.</p> Signup and view all the answers

Explain the role of regulatory proteins in muscle contraction.

<p>Regulatory proteins help switch contractile proteins on and off, regulating muscle contraction.</p> Signup and view all the answers

Identify the bands and line present in a sarcomere and their significance.

<p>The A band contains thick filaments, the I band contains thin filaments, and the H band contains thick filaments; the M line holds thick filaments together.</p> Signup and view all the answers

What is the process by which RBM produces red blood cells, white blood cells, and platelets?

<p>Hemopoiesis</p> Signup and view all the answers

What is the name of the region between the diaphysis and the epiphysis of a bone?

<p>Metaphysis</p> Signup and view all the answers

Identify the tough outer covering of a bone.

<p>Periosteum</p> Signup and view all the answers

What are the specialized bone-building cells called?

<p>Osteoblasts</p> Signup and view all the answers

Which zone in bone growth features chondrocytes arranged like stacks of coins?

<p>Proliferation zone</p> Signup and view all the answers

Name the three types of muscle tissue and indicate whether they are voluntary or involuntary.

<p>Skeletal muscle (voluntary), Cardiac muscle (involuntary), and Smooth muscle (involuntary).</p> Signup and view all the answers

What role does epimysium play in skeletal muscle structure?

<p>Epimysium is a dense connective tissue that covers the entire skeletal muscle, helping to bind muscle fibers together.</p> Signup and view all the answers

Explain the function of tendons in relation to muscles.

<p>Tendons connect muscles to bones, providing strength and stability to the musculoskeletal system.</p> Signup and view all the answers

Describe the composition and significance of a muscle fiber.

<p>Muscle fibers are the cells of muscle tissue, arising from the fusion of myoblasts, and have multiple nuclei, which are crucial for muscle function and repair.</p> Signup and view all the answers

What is the sarcolemma and what is its importance in muscle fibers?

<p>The sarcolemma is the plasma membrane of muscle fibers, playing a key role in the regulation of ion exchange and muscle contraction.</p> Signup and view all the answers

Identify the connective tissue that surrounds fascicles in skeletal muscles.

<p>Fascicles are surrounded by a connective tissue called perimysium.</p> Signup and view all the answers

How do somatic motor neurons relate to skeletal muscles?

<p>Somatic motor neurons are responsible for innervating skeletal muscles, enabling voluntary movements.</p> Signup and view all the answers

Discuss how the structure of skeletal muscles contributes to their reddish appearance.

<p>The reddish appearance of skeletal muscles is due to their high vascularization, which provides oxygen and nutrients.</p> Signup and view all the answers

What causes muscle contraction at the sarcomere level?

<p>Myosin heads attach to and walk along the thin filaments, pulling them towards the M line.</p> Signup and view all the answers

What is the primary function of Slow Oxidative (SO) muscle fibers?

<p>The primary function is maintaining posture and providing aerobic endurance.</p> Signup and view all the answers

Describe the characteristics of Fast Glycolytic (FG) muscle fibers.

<p>FG fibers have a low capacity for generating ATP, utilize anaerobic metabolism, and are suited for rapid, intense movements of short duration.</p> Signup and view all the answers

What are the components of a myofibril?

<p>Myofibrils consist of thick (myosin) and thin (actin, tropomyosin, troponin) filaments.</p> Signup and view all the answers

How do Fast Oxidative Glycolytic (FOG) fibers differ from Slow Oxidative fibers?

<p>FOG fibers have an intermediate capacity for ATP generation and utilize both aerobic and anaerobic metabolism.</p> Signup and view all the answers

What role do troponin and tropomyosin play in muscle contraction?

<p>Troponin and tropomyosin are regulatory proteins that control the interaction between actin and myosin during muscle contraction.</p> Signup and view all the answers

What happens to the lengths of thin and thick filaments during muscle contraction?

<p>The lengths of thin and thick filaments do not change during muscle contraction.</p> Signup and view all the answers

What are the different types of skeletal muscle fibers classified based on ATP generation capacity?

<p>The three types are Slow Oxidative (SO), Fast Oxidative Glycolytic (FOG), and Fast Glycolytic (FG) fibers.</p> Signup and view all the answers

Flashcards

What is skeletal muscle?

Skeletal Muscle is attached to the skeleton and is responsible for voluntary movement of the body.

What is cardiac muscle?

Cardiac muscle forms the heart wall and is responsible for pumping blood throughout the body. It is involuntary, meaning you don't consciously control its contractions.

What is smooth muscle?

Smooth muscle is found in the walls of hollow structures like blood vessels, airways, and organs. It is responsible for involuntary movements like digestion and blood vessel constriction.

Describe the structure of skeletal muscle.

Skeletal muscle is composed of bundles of muscle fibers held together by connective tissue coverings.

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What is epimysium?

Epimysium is the dense connective tissue covering that surrounds the entire skeletal muscle.

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What are fascicles?

Fascicles are bundles of muscle fibers within a skeletal muscle, covered by perimysium.

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What is perimysium?

Perimysium is the connective tissue that surrounds each fascicle within a skeletal muscle.

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What is endomysium?

Endomysium is the delicate connective tissue that wraps around individual muscle fibers.

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Sarcolemma

The plasma membrane surrounding a muscle fiber, it conducts action potentials to trigger muscle contraction.

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Sarcoplasmic Reticulum

A network of interconnected sacs that store and release calcium ions (Ca2+) within a muscle fiber, essential for muscle contraction.

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Sarcomere

The basic unit of muscle contraction, extending from one Z-disc to the next within a myofibril.

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Myofilaments

Fine protein fibers that run the length of a muscle fiber, composed of either 'thick' or 'thin' filaments.

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Thin Filament

A type of myofilament composed primarily of the protein actin, also includes troponin and tropomyosin.

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Thick Filament

A type of myofilament composed primarily of the protein myosin, responsible for generating the force of muscle contraction.

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Contractile Proteins

Proteins that directly participate in the process of generating force during muscle contraction.

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Regulatory Proteins

Proteins that regulate the interaction between contractile proteins, switching the process of contraction on and off.

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Myosin tail function

The twisted tail of the myosin molecule forms the shaft of the thick filament and points towards the M-line.

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Myosin head structure and function

Myosin heads, shaped like golf clubs, bind to actin and ATP. Each head has two binding sites, one for actin and one for ATP.

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Tropomyosin's role in muscle relaxation

Tropomyosin is a rope-like protein that covers the actin binding sites during relaxation, preventing myosin from binding to actin.

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Troponin's role in muscle contraction

Troponin, a protein with three binding sites, binds to calcium during contraction.

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Troponin activation and its effect on tropomyosin

When calcium binds to troponin, it activates troponin, which pulls tropomyosin away from actin, exposing the actin binding sites for myosin.

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Sliding filament mechanism

The sliding filament mechanism describes how thick and thin filaments slide past each other during muscle contraction, shortening the sarcomere.

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Titin's function in muscle contraction

Titin is a giant, elastic protein that anchors the thick filament to the Z disc and M line, helping sarcomeres return to their resting length after contraction.

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Myomesin's function

Myomesin molecules form the M line, which holds the thick filaments in alignment, ensuring proper sarcomere structure.

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What process does RBM produce RBC, WBC, and platelets?

The process by which red blood cells (RBCs), white blood cells (WBCs), and platelets are formed in the bone marrow.

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What is the region between diaphysis and epiphysis called?

The region in a long bone that lies between the diaphysis (shaft) and the epiphysis (end).

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What is the outer covering of bone called?

The tough outer covering of bone tissue made of dense connective tissue. It helps protect the bone and provides attachment for tendons and ligaments.

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What are bone building cells called?

Specialized cells that build and maintain bone tissue. Osteoblasts are immature cells that actively produce bone matrix, while mature bone cells are called osteocytes.

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What are the concentric rings in compact bone called?

Concentric rings of bone tissue that surround the central canal in compact bone. They form the basic functional unit of compact bone, also called an osteon.

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What is a sarcomere?

The functional unit of contraction in a muscle fiber, responsible for muscle shortening during contraction. It contains thick (myosin) and thin (actin) filaments arranged in a specific structure.

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What is a fascicle?

A bundle of muscle fibers within a skeletal muscle, covered by perimysium.

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What is the sarcolemma?

The specialized plasma membrane of a muscle fiber, responsible for carrying electrical signals that trigger muscle contraction.

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What is myosin?

This protein forms thick filaments within the sarcomere and interacts with actin to generate muscle contraction. It has heads that bind to actin and swivel to pull the thin filaments toward the center of the sarcomere.

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What is actin?

This protein forms thin filaments within the sarcomere, interacts with myosin to generate muscle contraction. It is also associated with tropomyosin and troponin.

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What are slow-oxidative (SO) muscle fibers?

A type of skeletal muscle fiber that is well-suited for prolonged, low-intensity activity. They contain lots of mitochondria and blood capillaries for aerobic metabolism.

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Study Notes

Muscle Tissue Overview

  • Skeletal muscle is responsible for moving the skeleton
  • Cardiac muscle forms the heart wall
  • Smooth muscle is found in hollow structures like blood vessels and organs
  • Muscle comprises the largest tissue group in the body, making up 40-50% of total body mass

Skeletal Muscle Structure

  • Whole muscle is covered by a dense connective tissue called epimysium
  • Muscle is divided into smaller bundles called fascicles, covered by perimysium
  • Fascicles are further divided into smaller bundles called muscle fibers, covered by endomysium
  • Muscle fibers are the cells of muscle tissue

Connective Tissue Coverings

  • Skeletal muscle is connected to the skeleton by tendons
  • Muscles appear reddish due to high vascularization
  • Tendons are whitish due to minimal vascularization and collagen fibers

Muscle Structure

  • Whole muscle is enveloped by epimysium
  • Fascicles are bundles of muscle fibers within the perimysium
  • Muscle fibers are the cells of muscle, enveloped by endomysium

Tendons

  • Tendons are continuous connective tissue masses (endomysium, perimysium, and epimysium) emerging from the muscle ends
  • At bone, tendons connect to the bone periosteum
  • This arrangement provides strength to the muscles

Nerves and Blood Supply

  • Skeletal muscles receive blood and nerves
  • These nerves are called somatic motor neurons
  • Arteries and veins generally accompany the nerves into the skeletal muscles

Muscle Fiber (muscle cell)

  • Muscle fibers are the cells of muscle tissue
  • During embryonic development, muscle fibers arise from the fusion of many myoblast cells
  • Each mature muscle fiber has many nuclei

Sarcolemma, Nuclei, Tubules

  • Sarcolemma is the plasma membrane of a muscle fiber
  • Multiple nuclei are situated beneath the sarcolemma
  • T-tubules tunnel from the muscle fiber surface to the interior, facilitating signal propagation

Myofibrils and Sarcoplasmic Reticulum

  • Muscle fibers consist of myofibrils, which are contractile elements
  • Sarcoplasmic reticulum surrounds myofibrils, storing calcium
  • Action potentials trigger calcium release from the sarcoplasmic reticulum

Filaments and Sarcomere

  • Myofibrils contain filaments (thin and thick)
  • Sarcomeres are the functional units of muscle contraction
  • Z-discs separate one sarcomere from another
  • Sarcomere length remains constant during contraction

Sarcomere: Bands and Lines

  • A band extends the entire length of thick filaments
  • I band consists of thin filaments only
  • H band comprises thick filaments only
  • M line holds thick filaments together in the center of the sarcomere

Muscle Proteins

  • Myofibrils contain contractile, regulatory, and structural proteins
  • Contractile proteins generate force during contraction
  • Regulatory proteins control contractile proteins
  • Structural proteins maintain filament alignment, provide elasticity

Contractile Proteins

  • Myosin and actin are the two contractile proteins
  • Myosin functions as a motor protein, converting ATP energy into force
  • Myosin has heads with actin-binding and ATP-binding sites

Contractile and Regulatory Proteins

  • Thin filaments primarily consist of actin, with tropomyosin and troponin
  • Tropomyosin covers actin-binding sites during relaxation
  • Troponin, upon calcium binding, moves tropomyosin to expose actin-binding sites, allowing for myosin binding

Two Structural Proteins

  • Titin spans a sarcomere from Z-disc to M-line, providing elasticity and anchoring thick filaments
  • Myomesin forms the M-line, holding thick filaments in alignment

Introduction to Sliding Filament Mechanism

  • Muscle shortening during contraction results from thick and thin filament sliding past each other
  • Myosin heads attach to and "walk" along thin filaments, pulling them towards the M-line
  • Sarcomeres shorten while filament lengths remain constant

Types of Skeletal Muscle Fibers

  • Different fiber types (e.g., Slow Oxidative (SO), Fast Oxidative Glycolytic (FOG), and Fast Glycolytic (FG)) have varying ATP generation capacities and fatigue resistance levels

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