Muscle Tissue Composition and Types
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Questions and Answers

What is the primary function of skeletal muscle?

  • Facilitating motion and providing stability (correct)
  • Regulating blood flow
  • Involuntary control of heartbeats
  • Surrounding vessels and digestive organs
  • Which type of muscle is involuntary?

  • Skeletal muscle
  • Cardiac muscle
  • Both B and C (correct)
  • Smooth muscle
  • What is the basic structure of muscle tissue?

  • Neuron
  • Myocyte (correct)
  • Adipocyte
  • Fibroblast
  • What distinguishes aerobic muscle fibers from anaerobic muscle fibers?

    <p>Aerobic fibers are associated with endurance (D)</p> Signup and view all the answers

    Which myosin heavy chain composition corresponds to fast twitch glycolytic muscle fibers?

    <p>Type 2B (B)</p> Signup and view all the answers

    Which characteristic is true for muscle fibers predominantly found in postural muscles?

    <p>Related to endurance (C)</p> Signup and view all the answers

    Which part of the muscle fiber structure is responsible for contraction?

    <p>Sarcomere (D)</p> Signup and view all the answers

    What is the diameter range of actin filaments in muscle cells?

    <p>5-8 nm (C)</p> Signup and view all the answers

    What occurs when the sarcomere length is at A(1), which is 3.65 um?

    <p>There is no binding between myosin and actin. (A)</p> Signup and view all the answers

    What is the optimal sarcomere length for force generation?

    <p>2.18 um (B)</p> Signup and view all the answers

    Which of the following most accurately describes the Hill model regarding muscle contraction?

    <p>It defines constants for muscle performance under various loads. (C)</p> Signup and view all the answers

    What is the latency period in muscle contraction?

    <p>The time from action potential to tension development. (D)</p> Signup and view all the answers

    Which component of the circulatory system is primarily responsible for gas exchange?

    <p>Capillaries (B)</p> Signup and view all the answers

    What is the primary function of the circulatory system at the capillary level?

    <p>Enables mass transfer between blood and tissues. (A)</p> Signup and view all the answers

    Which of the following statements about the pulmonary and systemic circulatory systems is true?

    <p>The pulmonary circulation is low pressure and involves gas exchange. (B)</p> Signup and view all the answers

    What is a characteristic of venules compared to large arteries?

    <p>Venules have a larger diameter than large arteries. (D)</p> Signup and view all the answers

    What happens to pulse pressure when high fluid viscosity is present?

    <p>Pulse pressure decreases. (C)</p> Signup and view all the answers

    How does reduced arterial wall viscoelasticity affect blood flow?

    <p>It diminishes buffering of the pressure pulse. (D)</p> Signup and view all the answers

    What occurs to arterial stiffness and diameter as blood moves distally from the heart?

    <p>Arteries increase in stiffness and decrease in diameter. (D)</p> Signup and view all the answers

    What is the effect of branching and tapering on pulse wave velocity?

    <p>Pulse wave velocity increases as you move distally from the heart. (D)</p> Signup and view all the answers

    What phenomenon occurs at points of branching or changes in vessel diameter?

    <p>Partial reflection of the pressure wave back towards the heart. (B)</p> Signup and view all the answers

    What happens to pressure energy in distal vessels due to viscous losses?

    <p>It is converted into heat and dissipated. (D)</p> Signup and view all the answers

    What is the result of increased resistance and branching on blood velocity?

    <p>Blood velocity decreases and dissipates energy. (D)</p> Signup and view all the answers

    What occurs to pressure energy as blood reaches the capillaries?

    <p>It is damped out. (D)</p> Signup and view all the answers

    What triggers the binding of myosin to actin during muscle contraction?

    <p>Movement of tropomyosin on actin (A)</p> Signup and view all the answers

    What occurs during ATP cleavage in muscle contraction?

    <p>The myosin head tips, pulling the actin filament (C)</p> Signup and view all the answers

    Which of the following is true regarding muscle contraction when calcium is present?

    <p>Myosin head binds to a new actin site after relaxation (C)</p> Signup and view all the answers

    What characterizes an isotonic twitch compared to an isometric twitch?

    <p>Constant length with varying tension (A)</p> Signup and view all the answers

    How does the frequency of stimulation affect muscle contraction?

    <p>Increased frequency can lead to fused tetanus (B)</p> Signup and view all the answers

    What is the latent period in a muscle twitch?

    <p>The time between action potential and contraction (A)</p> Signup and view all the answers

    Which factors are dependent on the tension generated during muscle contraction?

    <p>Length, velocity, and time (D)</p> Signup and view all the answers

    What role does troponin play in muscle contraction?

    <p>Exposes actin-binding sites when bound with calcium (B)</p> Signup and view all the answers

    What is the effect of a sustained release of Ca2+ on muscle fibers?

    <p>Induce tetanic muscle contraction (A)</p> Signup and view all the answers

    How does the presence of Mg2+ influence muscular contraction?

    <p>It aids in the cleavage of ATP (D)</p> Signup and view all the answers

    What is the primary function of smooth muscle cells in arterioles?

    <p>To contract and relax to alter flow resistance (A)</p> Signup and view all the answers

    What happens to the aortic root as a person ages?

    <p>It becomes less elastic and expands (A)</p> Signup and view all the answers

    Which phase of the cardiac cycle corresponds with the closing of the AV valves?

    <p>Isovolumetric contraction (D)</p> Signup and view all the answers

    What does the Frank-Starling mechanism entail?

    <p>Increased stretch of ventricular muscles leading to greater contractile force (A)</p> Signup and view all the answers

    Which layer of the arterial wall contains smooth muscle cells and elastin?

    <p>Tunica media (D)</p> Signup and view all the answers

    What is the primary role of pericytes in blood flow regulation?

    <p>To relax or contract arteriole caliber (B)</p> Signup and view all the answers

    What defines the end-diastolic volume (EDV)?

    <p>Volume when the mitral valve closes (A)</p> Signup and view all the answers

    In the context of arterial pulse propagation, what does the term 'systolic pressure' refer to?

    <p>Maximum pressure generated when the artery is open (D)</p> Signup and view all the answers

    Which type of blood flow is superimposed on the mean forward flow?

    <p>Oscillatory flow (A)</p> Signup and view all the answers

    What happens to the pressure in arteries during isovolumetric relaxation?

    <p>Pressure decreases (D)</p> Signup and view all the answers

    Which aspect of arterial function is affected by increased vessel stiffness?

    <p>Increased pulse wave velocity and decreased distensibility (A)</p> Signup and view all the answers

    What percentage of total blood volume is typically maintained in the veins?

    <p>60% (B)</p> Signup and view all the answers

    Which of the following is NOT a component of the heart's structural anatomy?

    <p>Ovaries (A)</p> Signup and view all the answers

    Flashcards

    Skeletal Muscle

    Muscle type attached to bones, enabling voluntary movement.

    Smooth Muscle

    Muscle type found in internal organs, operating involuntarily.

    Cardiac Muscle

    Muscle type forming the heart, enabling the pumping action.

    Muscle Fiber

    A muscle cell, containing myofibrils and sarcomeres (contractile units).

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    Sarcomere

    The functional unit of muscle contraction, composed of overlapping actin and myosin filaments.

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    Aerobic Fiber

    Muscle fiber type producing ATP with oxygen, suitable for endurance activities.

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    Anaerobic Fiber

    Muscle fiber type producing ATP without oxygen, enabling fast contractions but leading to fatigue.

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    Muscle Contraction (Sliding Filament)

    Mechanism where actin and myosin filaments slide past each other, shortening the muscle.

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    Load-Length Relationship

    The force a muscle can generate is dependent on its length. Optimal force is generated at an intermediate length, where there's maximum overlap of actin and myosin filaments. Too short or too long leads to reduced force because of interference or lack of binding sites.

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    Optimal Sarcomere Length

    The length of a sarcomere where the muscle can generate maximum force. This is typically around 2.18 µm.

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    Load-Velocity Relationship

    The speed of muscle contraction is inversely related to the load. A heavier load results in slower contraction, while a lighter load leads to faster contraction.

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    Hill Model

    A mathematical model describing the load-velocity relationship of muscle contraction, relating external load, contraction velocity, and muscle properties.

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    Latency Period

    The time lag between the arrival of a nerve impulse at a muscle and the beginning of muscle contraction, representing the delay in the excitation-contraction coupling process.

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    Viscoelastic Response

    The elastic and damping properties of muscle tissue, influenced by the connective tissue surrounding muscle fibers, contributing to the delayed rise in tension.

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    Vascular Distribution

    The arrangement of blood vessels throughout the body, starting with large arteries and branching down to capillaries, where exchange of oxygen and nutrients occurs.

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    Pulmonary vs. Systemic Circulation

    Pulmonary circulation carries blood to the lungs for gas exchange, while systemic circulation delivers oxygenated blood to the rest of the body.

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    Viscous Losses

    Energy loss during blood flow due to friction between blood and vessel walls, and within the blood itself.

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    Viscoelasticity and Pulse Pressure

    Arterial walls stretch and recoil, absorbing energy from the pressure pulse and smoothing blood flow. Reduced viscoelasticity leads to a less smooth pulse and higher pressure.

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    Arterial Stiffness Distally

    Arteries become stiffer and narrower further from the heart, due to changes in their structure.

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    Pulse Wave Velocity

    The speed at which the pressure wave travels through arteries.

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    Branching and Impedance Mismatch

    When arteries branch or change diameter, there's a change in resistance to the pressure wave (impedance), causing some of the wave to reflect back.

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    Reflected Wave Effects

    Reflected waves add to the original wave, increasing pressure in certain regions, especially distal arteries. This explains why systolic pressure can be higher in the periphery.

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    Energy Dissipation in Capillaries

    As blood flows through capillaries, energy is lost due to friction and branching, reducing the pressure wave and ensuring a smooth, continuous flow.

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    Pressure Damping in Capillaries

    The pressure wave is gradually reduced as blood travels through capillaries, ensuring gentle and steady blood flow at the microvascular level.

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    Blood Flow Regulation

    The body's ability to adjust blood distribution to meet the varying needs of different tissues and organs.

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    Capillary Resistance

    The capillaries offer the greatest resistance to blood flow, primarily due to their small diameter.

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    Arteriole Regulation

    Arterioles, the small arteries, control blood flow into capillary beds by adjusting their diameter.

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    Blood Shunting

    The process of diverting blood away from less active areas (like cold feet) to regions with greater demand (like the vital organs).

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    Venous Blood Reservoir

    Veins act as a reservoir, storing a significant portion of blood (~60% of total volume), providing a reserve in case of loss.

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    Aortic Root Expansion

    The aortic root, the section closest to the heart, expands with age as the aorta loses elasticity.

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    Pericytes and Blood Flow

    Pericytes (smooth muscle cells) surrounding arterioles regulate blood flow by contracting or relaxing to control vessel diameter.

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    The Heart: Two pumps

    The heart operates as two interconnected pumps (right and left sides) working in a series.

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    Pulmonary and Systemic Circuits

    The heart pumps blood through two separate circuits: pulmonary (to lungs) and systemic (to body), with different pressure demands.

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    Heart Output Adaptation

    The heart can adapt its output (volume and pressure) based on demand, like during rest or exercise.

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    Frank-Starling Mechanism

    The heart's ability to increase its contractile force when stretched by increased incoming blood volume.

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    Heart Anatomy

    The heart is composed of specialized chambers: atria (holding) and ventricles (pumping), with valves regulating blood flow between them.

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    Cardiac Cycle Stages

    The heart's rhythmic cycle involves distinct stages: systole (contraction) and diastole (relaxation), each with specific changes in volume and pressure.

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    What happens to myosin heads after ATP cleavage?

    After ATP is cleaved into ADP and Pi, myosin heads tip, pulling the actin filament towards the center of the sarcomere.

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    What's the role of Ca2+ in muscle contraction?

    Calcium ions (Ca2+) bind to troponin, causing a conformational change in tropomyosin, which exposes the myosin binding sites on actin.

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    How does ATP release myosin from actin?

    When ATP binds to the myosin head, it causes the release of the myosin head from the actin binding site, allowing for muscle relaxation.

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    What's the difference between isotonic & isometric twitches?

    Isotonic twitches maintain constant tension while the muscle changes length, like lifting a weight. Isometric twitches maintain constant length while tension changes, like pushing against an immovable wall.

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    How do repeated stimuli affect muscle contraction?

    Increasing stimulation frequencies lead to greater contraction force. This is because subsequent muscle contractions build upon previous ones, achieving a sustained contraction.

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    What is the latent period in muscle contraction?

    The delay between the action potential arrival and the start of muscle contraction, reflecting the time required for excitation-contraction coupling.

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    What is fused tetanus?

    A sustained muscle contraction achieved by repetitive muscle stimulation at sufficiently high frequencies (>30Hz), representing the physiological muscle contraction mode for real life activities.

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    What are the relationship between tension, velocity, and length in muscular contraction?

    The tension generated during muscle contraction depends on the muscle's length, the velocity of the contraction, and the time of the contraction.

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    Why does a muscle generate the most force at its optimal length?

    At the optimum length, there is maximal overlap of actin and myosin filaments, allowing for maximum cross-bridges to form and thus maximal force generation.

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    How does load affect the velocity of muscle contraction?

    As the load increases, the velocity of muscle contraction decreases. This is known as the load-velocity relationship, a fundamental principle in muscle mechanics.

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    Study Notes

    Muscle Tissue Composition, Properties, and Roles

    • Muscles are the engines of the musculoskeletal system, enabling movement and providing stability like in the spine.
    • Three types of muscle tissue exist: skeletal, smooth, and cardiac.

    Skeletal Muscle

    • Skeletal muscle makes up 40-45% of total body weight.
    • It is usually attached to bones via tendons.
    • It is under voluntary control.
    • Skeletal muscle cells (myocytes) are composed of multiple myofibrils containing sarcomeres.
    • Sarcomeres consist of overlapping actin (thin) and myosin (thick) filaments.
    • Actin filaments have a diameter of 5-8 nm, and myosin filaments have a diameter of 12-18 nm.
    • Skeletal muscle fibers contain many mitochondria for energy production.
    • Fibers are long and spindle-shaped, ranging from 10-100 µm in diameter and up to 30 cm in length.

    Smooth Muscle

    • Smooth muscle surrounds the vessels within the gastrointestinal system.
    • It is not under voluntary control.

    Cardiac Muscle

    • Cardiac muscle is the involuntary muscle of the heart.

    Muscle Fiber Types and Energy Production

    • Muscle fibers are categorized by energy production (ATP) methods: aerobic and anaerobic (glycolytic).
    • Aerobic fibers use oxygen to generate ATP and are related to endurance activities (e.g., postural muscles, holding).
    • Anaerobic fibers generate ATP without oxygen and are related to fast contractions, such as in sprinting and heavy lifting.
    • Fiber types are based on myosin heavy chain composition (2A, 2B, and 2X).
    • Most muscles have a mix of fiber types.

    Muscle Contraction (Sliding Filament Theory)

    • Muscle contraction involves the sliding of actin and myosin filaments.
    • Motor neuron signals release calcium (Ca²⁺).
    • Ca²⁺ binding to troponin causes tropomyosin to move, exposing myosin-binding sites.
    • Myosin heads bind to actin, and ATP's breakdown causes a power stroke, pulling on the actin filament.
    • ATP binding releases the myosin head, allowing for another cycle of binding and pulling.
    • Relaxation occurs when Ca²⁺ is sequestered.

    Muscle Twitch

    • A single action potential causes a muscle twitch.
    • A latent period precedes the actual contraction, and the latent period lengthens with increasing load.

    Isotonic vs. Isometric Contractions

    • Isotonic contractions involve a change in muscle length (e.g., lifting a weight).
    • Isometric contractions involve no change in muscle length (e.g., holding a weight).

    Muscle Behavior

    • Tension generated during muscle contraction depends on length, velocity, and time.
    • Load-length relationship shows that optimal force generation happens at a specific muscle length (2.18 µm).
    • Load-velocity relationship shows faster contraction at lower loads.

    Circulatory System

    • The circulatory system consists of the heart and blood vessels (arteries, arterioles, capillaries, venules, and veins).
    • The pulmonary circuit involves low pressure and oxygen/carbon dioxide exchange in the lungs.
    • The systemic circuit involves high pressure and nutrient and waste delivery.
    • Major veins have a larger diameter than arteries. The capillaries and venules have a high surface area for efficient exchange.
    • The aorta and the root have an elastic nature to withstand the pulsatile nature of blood flow. Elasticity in the aortic root decreases with age.
    • Pericytes regulate blood flow to the capillaries.

    Heart

    • The heart is a double pump (pulmonary and systemic).
    • The heart has valves (atrioventricular and semilunar) preventing backflow of blood during the cardiac cycle.
    • Heart rate and pressure change with activity levels.
    • The Frank-Starling mechanism increases the heart's contractility with increased blood volume.

    Heart Contraction Cycle

    • The cardiac cycle includes systole (contraction) and diastole (relaxation).
    • Four distinct stages: ventricular filling, isovolumetric contraction, ventricular ejection, and isovolumetric relaxation.
    • Key points include ventricular volume and pressure changes and valve activity at each stage.

    Arterial Pulse Propagation

    • Arterial pulse propagation reflects wave transmission as blood travels through the arteries.
    • Pulse pressure is the difference between systolic and diastolic pressure.
    • Impedance mismatch at branching points and changes in vessel diameter leads to reflected waves impacting pulse pressure.
    • Factors influencing blood flow in the arteries include viscosity, arterial properties, and branching.

    Arterial Wall Mechanics

    • Arterial wall tension and thickness impact arterial behavior.
    • Pulse propagation through vessels impacts pulse pressure and wave speed.
    • Viscous losses (high fluid viscosity) and changes in arterial properties (stiffness/diameter) influence pressure pulse properties.

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