Podcast
Questions and Answers
Which of the following is NOT a function of muscles?
Which of the following is NOT a function of muscles?
- Storage of energy (correct)
- Heat production
- Protecting bones and internal organs
- Movement
What characteristic allows muscle cells to respond to stimuli?
What characteristic allows muscle cells to respond to stimuli?
- Excitability (correct)
- Elasticity
- Contractility
- Extensibility
Which connective tissue layer surrounds a muscle fiber?
Which connective tissue layer surrounds a muscle fiber?
- Endomysium (correct)
- Perimysium
- Epimysium
- Sarcoplasm
What are the smallest contractile elements of a muscle unit?
What are the smallest contractile elements of a muscle unit?
Which term describes the functional unit of a muscle?
Which term describes the functional unit of a muscle?
Which type of muscle is under voluntary control?
Which type of muscle is under voluntary control?
How do muscle fascicles contribute to the overall structure of skeletal muscle?
How do muscle fascicles contribute to the overall structure of skeletal muscle?
What is the function of the sarcoplasmic reticulum in muscle cells?
What is the function of the sarcoplasmic reticulum in muscle cells?
What is the primary source of ATP in the first 1-2 seconds of muscle contraction?
What is the primary source of ATP in the first 1-2 seconds of muscle contraction?
What process follows the breakdown of glucose into pyruvate during explosive power generation?
What process follows the breakdown of glucose into pyruvate during explosive power generation?
How does the nervous system increase muscle contraction strength?
How does the nervous system increase muscle contraction strength?
What characteristic is associated with small motor units?
What characteristic is associated with small motor units?
What happens to muscle tension during repeated stimulation, leading to reduced performance?
What happens to muscle tension during repeated stimulation, leading to reduced performance?
Which factor does NOT affect muscle contraction strength?
Which factor does NOT affect muscle contraction strength?
What is the motor unit size dependent on?
What is the motor unit size dependent on?
What happens to the rate of shortening and relaxation in fatigued muscle?
What happens to the rate of shortening and relaxation in fatigued muscle?
What is the primary function of tropomyosin in muscle contraction?
What is the primary function of tropomyosin in muscle contraction?
Which components are essential to form a triad in skeletal muscle?
Which components are essential to form a triad in skeletal muscle?
Which protein connects myosin to the Z line and prevents excessive stretching of the sarcomere?
Which protein connects myosin to the Z line and prevents excessive stretching of the sarcomere?
What role does dystrophin serve in muscle fibers?
What role does dystrophin serve in muscle fibers?
Which type of muscle protein is specifically responsible for linking actin to the Z line?
Which type of muscle protein is specifically responsible for linking actin to the Z line?
The region in a sarcomere that consists solely of thick myofilaments is known as the:
The region in a sarcomere that consists solely of thick myofilaments is known as the:
What occurs when an action potential reaches the triad in skeletal muscle?
What occurs when an action potential reaches the triad in skeletal muscle?
What role does calcium play in muscle contraction?
What role does calcium play in muscle contraction?
Which of the following statements about ATP usage in muscle contraction is true?
Which of the following statements about ATP usage in muscle contraction is true?
What initiates the power stroke during muscle contraction?
What initiates the power stroke during muscle contraction?
Which process occurs first during muscle relaxation?
Which process occurs first during muscle relaxation?
What happens to the tropomyosin during the contraction cycle?
What happens to the tropomyosin during the contraction cycle?
What is the primary function of acetylcholinesterase during muscle contraction?
What is the primary function of acetylcholinesterase during muscle contraction?
How does the muscle fiber return to its resting length after contraction?
How does the muscle fiber return to its resting length after contraction?
What energy source is utilized immediately before ATP in muscle contraction?
What energy source is utilized immediately before ATP in muscle contraction?
Flashcards
Muscle Excitability
Muscle Excitability
The ability of a muscle cell to respond to stimuli by generating an electrical signal, called an action potential.
Muscle Contractility
Muscle Contractility
The unique ability of muscle cells to shorten and thicken, producing force.
Muscle Extensibility
Muscle Extensibility
The capacity of a muscle cell to be stretched without being damaged.
Muscle Elasticity
Muscle Elasticity
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Sarcomere: The Functional Unit of Muscle
Sarcomere: The Functional Unit of Muscle
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Endomysium
Endomysium
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Perimysium
Perimysium
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Epimysium
Epimysium
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Neuromuscular Junction
Neuromuscular Junction
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Sarcoplasmic Reticulum (SR)
Sarcoplasmic Reticulum (SR)
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Sarcomere
Sarcomere
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Myosin
Myosin
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Actin
Actin
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Dystroglycan
Dystroglycan
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Desmin
Desmin
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T-tubules
T-tubules
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Muscle Contraction
Muscle Contraction
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Tropomyosin
Tropomyosin
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Troponin
Troponin
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ATP in Muscle Contraction
ATP in Muscle Contraction
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Actomyosin Cross-Bridge Formation
Actomyosin Cross-Bridge Formation
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Power Stroke
Power Stroke
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Acetylcholinesterase (AChE)
Acetylcholinesterase (AChE)
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SERCA (Sarcoplasmic Reticulum Calcium-ATPase)
SERCA (Sarcoplasmic Reticulum Calcium-ATPase)
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ATP stored in muscle fibers
ATP stored in muscle fibers
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Creatine phosphate
Creatine phosphate
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Aerobic Glycolysis
Aerobic Glycolysis
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Recruitment
Recruitment
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Motor Unit Size
Motor Unit Size
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Muscle Fatigue
Muscle Fatigue
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Fast-twitch muscle fibers
Fast-twitch muscle fibers
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Slow-twitch muscle fibers
Slow-twitch muscle fibers
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Study Notes
Skeletal Muscle Contraction
- Skeletal muscles are responsible for movement, posture maintenance, and heat production.
- Muscles protect bones and internal organs.
- Key features of muscle cells include excitability (responding to stimuli), contractility (shortening and thickening to generate force), extensibility (extending without damage), and elasticity (returning to original shape).
Muscle Types
- Skeletal muscle: Fibers are striated, tubular, and multinucleated. Voluntary.
- Smooth muscle: Fibers are non-striated, spindle-shaped, and uninucleated. Involuntary.
- Cardiac muscle: Fibers are striated, branched, and uninucleated. Involuntary.
Skeletal Muscle Structure
- Organization: Actin (thin) and myosin (thick) filaments are the smallest contractile units, forming myofilaments. Myofilaments combine to form myofibrils, which in turn make up muscle fibers. Muscle fibers come together to form fascicles, ultimately creating skeletal muscle.
- Connective tissue layers: Endomysium (surrounds individual muscle fibers), perimysium (surrounds fascicles), epimysium (surrounds entire muscle).
- Sarcolemma: The membrane surrounding the muscle fiber,
- Sarcoplasm: The cytoplasm of the muscle fiber,
- Sarcoplasmic reticulum (SR): Endoplasmic reticulum of muscle cells, stores calcium.
- Sarcomere: The functional unit of muscle contraction.
- I band, A band, Z line, H zone: Regions within the sarcomere.
Neuromuscular Junction
- The axon terminal of a motor neuron meets the muscle fiber at the motor end plate. This junction is called the neuromuscular junction.
- Acetylcholine is released at the neuromuscular junction, and it binds to receptors on the muscle fiber, triggering a muscle action potential.
- Acetylcholinesterase breaks down acetylcholine to stop the signal.
Molecular Mechanisms of Muscle Contraction
- ATP is crucial for muscle contraction.
- Myosin heads bind to actin, forming cross-bridges.
- A power stroke occurs, and the filaments slide past each other.
- The process repeats as long as calcium and ATP are available.
- Calcium release is necessary for contraction.
Muscle Relaxation
- Acetylcholinesterase breaks down acetylcholine.
- Calcium is reabsorbed by the sarcoplasmic reticulum.
- Myosin heads detach from actin.
- The muscle returns to its resting length.
Energy Metabolism during Muscle Contraction
- Stored ATP is the initial energy source.
- Creatine phosphate is used to regenerate ATP.
- Anaerobic glycolysis provides short-term energy.
- Oxidative phosphorylation provides long-term energy.
Muscle Fatigue
- Muscle fatigue results from repeated stimulation leading to decreased tension.
- Factors contributing to fatigue: depletion of ATP, accumulation of metabolic byproducts (lactic acid), and changes in ion concentrations.
Skeletal Muscle Fiber Types
- Slow-twitch fibers: Endurance activities; high oxidative capacity, lower force production and fatigue rate.
- Fast-twitch fibers: High-intensity activities; Type 2a (fast oxidative-glycolytic); Type 2x/2b (fast glycolytic); higher force production, fatigue quickly.
- Different fiber types contribute varying degrees of speed and power. Muscle hypertrophy involves increases in both the size and number of muscle fibers.
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