Muscle Degeneration and Myopathies: Overview

Play an AI-generated podcast conversation about this lesson

What is the primary role of dystrophin in muscle-fiber maintenance?

Maintaining muscle-fiber membrane integrity (correct)

Regulating autophagy in satellite cells

Mediating asymmetric cell divisions

Controlling satellite cell proliferation

Which process is perturbed in mdx satellite cells according to the provided text?

Cell proliferation

Autophagy regulation

Cell polarity mediated by dystrophin (correct)

Dystrophin expression

What is the significance of DMD being referred to as a muscle stem cell disease?

It indicates involvement of satellite cells (correct)

It prevents asymmetric cell divisions

It influences muscle-fiber stability

It affects autophagic gene expression

In what type of cells is dystrophin expressed according to the text?

Muscle stem cells Signup and view all the answers

What role does dystrophin play in satellite cells?

Mediating cell polarity Signup and view all the answers

Based on the text, how is dystrophin involved in cell divisions?

Regulating asymmetric cell divisions Signup and view all the answers

Which primary aspect of muscle biology does Duchenne muscular dystrophy specifically impact?

Satellite cell regulation Signup and view all the answers

What cellular component does dystrophin help regulate in satellite cells?

Cell membrane structure Signup and view all the answers

What is a hallmark of aging according to the text?

Decline in tissue regenerative potential Signup and view all the answers

Which factor is known to mediate satellite cell fate according to the provided information?

Dystrophin Signup and view all the answers

How does aging affect muscle regeneration based on the text?

Decreases satellite cell function Signup and view all the answers

Which disease is specifically mentioned in relation to muscle degeneration in the provided text?

Duchenne muscular dystrophy Signup and view all the answers

What do aged muscle cross-sectional areas show based on the information provided?

Decrease with age Signup and view all the answers

How does niche stiffness influence muscle regeneration according to the text?

Decreases satellite cell activity Signup and view all the answers

Which type of molecules play a role in age-dependent changes related to satellite cells?

Metabolites Signup and view all the answers

In what way does aging impact muscle regeneration according to the text?

Reduces satellite cell function Signup and view all the answers

Which signaling axis is dysregulated in dystrophin-deficient satellite cells according to the text?

p38g/CARM1 Signup and view all the answers

What is the consequence of p38g depletion in satellite cells as mentioned in the text?

Induction of Myf5 mRNA Signup and view all the answers

Which modification is observed at the Myf5 promoter in mdx myoblasts according to the text?

H3K4me3 Signup and view all the answers

What is the molecular explanation provided in the text for the stem cell dysfunction in Duchenne muscular dystrophy?

Dysregulation of the p38g/CARM1 signaling axis Signup and view all the answers

What role does the DGC play in the epigenetic activation of Myf5?

Epigenetic activation following cell division Signup and view all the answers

Which protein interacts with p38g in myofibers, leading to colocalization?

b1-Syntrophin Signup and view all the answers

In dystrophin-deficient satellite cells, what interaction is observed at a reduced level according to the text?

Pax7-CARM1 Signup and view all the answers

What epigenetic change is associated with decreased Myf5 transcription in dystrophin-deficient cells?

H3K4me3 Signup and view all the answers

What is the genetic cause of Duchenne Muscular Dystrophy?

Mutations in the DMD gene Signup and view all the answers

Which process is essential to prevent senescence in satellite cells according to Garcia-Prat et al?

Enhanced autophagy Signup and view all the answers

What is a characteristic feature of Duchenne Muscular Dystrophy?

Progressive muscle wasting Signup and view all the answers

What cellular process is impaired in aged satellite cells according to Chang et al?

Loss of autophagy Signup and view all the answers

Which intervention has been shown to prevent senescence in satellite cells according to Garcia-Prat et al?

Restoring autophagy Signup and view all the answers

What is a consequence of genetic deletion of autophagy in satellite cells?

Mitochondrial dysfunction Signup and view all the answers

Which technique did Conboy et al. use to demonstrate stem cell rejuvenation?

Heterochronic parabiosis Signup and view all the answers

What is the key characteristic of Duchenne Muscular Dystrophy that distinguishes it from other muscle disorders?

Lack of dystrophin due to mutations in the DMD gene Signup and view all the answers

What is the functional consequence of altering the orientation of myofibers?

Impaired differentiation of myoblasts WT Signup and view all the answers

Which protein is involved in Dystrophin-mediated regulation of satellite cell fate?

Pax7me:MLL complex Signup and view all the answers

What is the consequence of phosphorylation of CARM1 by p38g?

Prevents nuclear localization of CARM1 Signup and view all the answers

Which factor is inhibited in mdx myoblasts?

Myogenic factors Signup and view all the answers

What does Dystrophin deficiency lead to?

Impaired cell polarity and asymmetric cell division Signup and view all the answers