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Ageing - Sarcopenia
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Ageing - Sarcopenia

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Questions and Answers

What are the degenerative pathways in muscle?

Increase mitochondrial ROS, increased inflammatory cytokines, muscle protein homeostasis changes (mTOR, AKt and FOXO pathways)

Cross sectional area of muscle after age 70 is reduced by what?

  • 40%
  • 30% (correct)
  • 20%
  • 50%
  • How much strength is reduced after age 70?

  • 40% (correct)
  • 50%
  • 20%
  • 30%
  • Selective loss of (insert here) fibres, and reinnervation to increase (insert here) fibres

    <p>Type II, and type I</p> Signup and view all the answers

    What does this result in?

    <p>Slow contractions, reduced force development, reduced limb acceleration</p> Signup and view all the answers

    How much fewer motor units are lower limb muscles supplied with after age 75?

    <p>30%</p> Signup and view all the answers

    How much fewer extensor digitorum brevis motor units after 60 years?

    <p>50%</p> Signup and view all the answers

    How much fewer motor units at vastus lateralis after age 65?

    <p>50-60%</p> Signup and view all the answers

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