Muscle Contraction and Relaxation
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Questions and Answers

Which protein is involved in calcium-induced calcium release in cardiac muscle?

  • Troponin-C (correct)
  • Myosin
  • Actin
  • Tropomyosin

What is the role of the sodium-calcium exchanger in cardiac muscle?

  • To pump sodium ions out of the sarcoplasmic reticulum
  • To pump calcium ions out of the sarcoplasmic reticulum (correct)
  • To pump calcium ions into the sarcoplasmic reticulum
  • To pump sodium ions into the sarcoplasmic reticulum

What is the relationship between intracellular free calcium concentration and force generation by cardiac muscle?

  • Force generation is independent of intracellular free calcium concentration
  • As intracellular free calcium concentration increases, force generation increases (correct)
  • Intracellular free calcium concentration does not affect force generation
  • As intracellular free calcium concentration increases, force generation decreases

Which of the following is responsible for the strength of contraction of each myocardial cell?

<p>Excitation-contraction coupling processes (C)</p> Signup and view all the answers

What is the main role of the T-tubular system in cardiac muscle?

<p>Carry action potentials into the cell interior (A)</p> Signup and view all the answers

What is the function of the sarcoplasmic reticulum in excitation-contraction coupling?

<p>Store and release Ca2+ (C)</p> Signup and view all the answers

How does Ca2+ induce muscle contraction in cardiac muscle?

<p>Ca2+ binds to troponin C, unblocking actin active sites (D)</p> Signup and view all the answers

Which of the following is NOT a mechanism that impacts contractility in the heart?

<p>Decreasing extracellular Na+ (C)</p> Signup and view all the answers

What is the effect of heart rate on contractility in the heart?

<p>Increased heart rate increases contractility (D)</p> Signup and view all the answers

Can cardiac muscle be tetanized?

<p>No, because the duration of the effective refractory period is approximately equal to the duration of the mechanical event (D)</p> Signup and view all the answers

How do defects in the sarcoplasmic reticulum Ca pump (SERCA) affect contractility in the heart?

<p>They decrease contractility (C)</p> Signup and view all the answers

Which mechanism actively transports Ca2+ out of the cell by exchanging 3 Na+ for 1 Ca2+?

<p>Na+-Ca2+ exchanger (NCX) (B)</p> Signup and view all the answers

Which mechanism actively transports Ca2+ back into the sarcoplasmic reticulum (SR) by using ATP?

<p>ATP-dependent Ca2+-pump (SERCA) (A)</p> Signup and view all the answers

What is the term for the intrinsic ability of cardiac muscle to develop force at a given muscle length?

<p>Contractility (A)</p> Signup and view all the answers

Which mechanism increases the force of cardiac contractility by increasing the rate and magnitude of Ca2+ release from the sarcoplasmic reticulum (SR)?

<p>Sympathetic stimulation of cardiac contractility (A)</p> Signup and view all the answers

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