Muscle Biology Quiz - Anatomy and Functions
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Questions and Answers

What is the primary function of tendons in the musculoskeletal system?

  • To attach skeletal muscle to bone (correct)
  • To provide structural support to bones
  • To contract and produce movement
  • To store energy for muscle contractions
  • What component accounts for the alternating dark and light bands seen in a myofibril?

  • The density of muscle nuclei
  • The types of muscle fibers present
  • The arrangement of myofilaments (correct)
  • The thickness of connective tissue
  • Which structure represents the functional unit of a muscle?

  • Fascicle
  • Myofibril
  • Muscle fiber
  • Sarcomere (correct)
  • What is contained within the H-zone of a myofibril?

    <p>Thick filaments only (C)</p> Signup and view all the answers

    What distinguishes the I-band in a myofibril?

    <p>Presence of thin filaments only (C)</p> Signup and view all the answers

    Which muscle type is characterized by striations and strong, short contractions?

    <p>Skeletal muscle (C)</p> Signup and view all the answers

    What is the primary function of smooth muscle?

    <p>Propulsion of contents through hollow internal organs (B)</p> Signup and view all the answers

    What is the role of cardiac muscle in the body?

    <p>Continuous strong contractions to pump blood (A)</p> Signup and view all the answers

    Which tissue type comprises the majority of body weight?

    <p>Muscle tissue (D)</p> Signup and view all the answers

    What distinguishes striated muscle from unstriated muscle?

    <p>Striations and the type of contraction (A)</p> Signup and view all the answers

    What characteristic is common to skeletal muscle fibers?

    <p>Peripheral nuclei (A)</p> Signup and view all the answers

    How does muscle tissue primarily convert energy?

    <p>Chemical energy to mechanical energy (D)</p> Signup and view all the answers

    Which of the following muscle types is classified as involuntary?

    <p>Cardiac muscle (A), Smooth muscle (C)</p> Signup and view all the answers

    What is the primary role of myoglobin in muscle cells?

    <p>To store oxygen and give color to the muscle (D)</p> Signup and view all the answers

    Which structure separates individual muscle cells within a fascicle?

    <p>Endomysium (A)</p> Signup and view all the answers

    What neurotransmitter is released at the myoneural junction to stimulate muscle contraction?

    <p>Acetylcholine (B)</p> Signup and view all the answers

    Which of the following best describes the composition of skeletal muscle in terms of protein content?

    <p>Proteins account for 20% of muscle composition (B)</p> Signup and view all the answers

    What is the function of lactic acid in muscle cells?

    <p>To accumulate during muscle fatigue (B)</p> Signup and view all the answers

    What is the typical innervation ratio for motor neurons to muscle fibers in eye muscles?

    <p>1:23 (D)</p> Signup and view all the answers

    Which layer of connective tissue surrounds large bundles of muscle?

    <p>Epimysium (C)</p> Signup and view all the answers

    What is the structural unit of contraction within muscle fibers?

    <p>Sarcomere (B)</p> Signup and view all the answers

    Which of the following statements about myosin is true?

    <p>Myosin has 2 binding sites, one for actin and one for ATPase. (A)</p> Signup and view all the answers

    What is the main characteristic of skeletal muscle?

    <p>It consists of striated fibers with peripheral nuclei. (D)</p> Signup and view all the answers

    Which type of muscle is primarily responsible for strong, continuous contractions?

    <p>Cardiac muscle (B)</p> Signup and view all the answers

    Which statement correctly describes tendons?

    <p>Tendons are cord-like structures made mostly of collagen fibers. (C)</p> Signup and view all the answers

    What distinguishes cardiac muscle from skeletal muscle?

    <p>Cardiac muscle shows branching fibers. (D)</p> Signup and view all the answers

    What is the primary role of myosin-binding proteins in the sarcomere?

    <p>They assist in the alignment of myofilaments. (D)</p> Signup and view all the answers

    Which component is part of the thin filament structure?

    <p>Tropomyosin (B)</p> Signup and view all the answers

    In a contracted sarcomere, how does the H zone change?

    <p>It decreases in width. (C)</p> Signup and view all the answers

    What is the molecular weight of G-actin?

    <p>43,000 (A)</p> Signup and view all the answers

    What is the primary function of tropomyosin in muscle contraction?

    <p>It covers the myosin binding sites on actin. (A)</p> Signup and view all the answers

    Which protein is known to provide elasticity to the sarcomere?

    <p>Nebulin (B)</p> Signup and view all the answers

    What does the A band in the sarcomere represent?

    <p>The region where thick and thin filaments overlap. (B)</p> Signup and view all the answers

    What is the diameter range of thin filaments?

    <p>5-8 nm (B)</p> Signup and view all the answers

    What type of muscle has branching fibers and central nuclei?

    <p>Cardiac muscle (D)</p> Signup and view all the answers

    Which type of muscle contraction is characterized as being stronger and continuous?

    <p>Cardiac muscle contraction (A)</p> Signup and view all the answers

    What structure is primarily responsible for coordinating the contraction of cardiac muscle tissue?

    <p>SA Node (C)</p> Signup and view all the answers

    Which characteristic is NOT associated with smooth muscle?

    <p>Strong, short contractions (A)</p> Signup and view all the answers

    In cardiac muscle cells, what are the structures that bind cells together called?

    <p>Intercalated discs (C)</p> Signup and view all the answers

    Flashcards

    Muscle Tissue

    A type of tissue that can contract and generate force, responsible for movement in the body.

    Skeletal Muscle

    A type of muscle tissue that is attached to bones, responsible for voluntary movements.

    Cardiac Muscle

    A type of muscle tissue found in the heart, responsible for continuous, involuntary pumping of blood.

    Smooth Muscle

    A type of muscle tissue found in the walls of internal organs, responsible for involuntary movements like digestion.

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    Sarcolemma

    The outer membrane of a muscle cell, responsible for transmitting electrical signals.

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    Muscle Fiber

    The basic unit of a skeletal muscle, consisting of a single muscle cell containing multiple nuclei.

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    Muscle Striations

    Striations are the alternating light and dark bands visible in skeletal and cardiac muscle, which are responsible for their striped appearance.

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    Peripheral Nuclei in Muscle Fibers

    The nuclei of a muscle fiber are located at the periphery of the cell, unlike other cell types.

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    Motor Unit

    A functional unit of muscle, composed of a motor neuron and all the muscle fibers it innervates.

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    Innervation Ratio

    The ratio of motor neurons to muscle fibers in a motor unit, determines the precision of movement.

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    Myoneural Junction

    The specialized junction between a motor neuron and a muscle fiber.

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    Motor End Plate

    The specialized area of the muscle fiber membrane where the neurotransmitter acetylcholine is released by the motor neuron.

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    Sarcoplasm

    The cytoplasm of a muscle cell, excluding the myofibrils.

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    Sarcoplasmic Reticulum

    The smooth endoplasmic reticulum of a muscle cell, responsible for storing and releasing calcium ions for muscle contraction.

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    Sarcomere

    The contractile unit of a muscle fiber, composed of repeating units of actin and myosin filaments.

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    Fascicle

    A bundle of muscle fibers, containing multiple muscle cells, that works together to generate force. Think of it as a group of soldiers working together.

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    Muscle fiber/cell

    The basic unit of a muscle, a long cylindrical cell with multiple nuclei and specialized proteins for contraction. Imagine it as a tiny engine that drives movement.

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    Myofibril

    Located within a muscle fiber, these are bundles of myofilaments, the proteins responsible for muscle contraction. Think of them as the functional units within the muscle cell.

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    Z-disc

    A dense protein structure that anchors thin filaments and acts as a boundary between sarcomeres. It helps to align the myofibrils and facilitates muscle contraction.

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    Myosin

    A protein that makes up the thick filaments in muscle fibers, responsible for muscle contraction by binding to actin.

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    Actin

    A protein that forms the thin filaments in muscle fibers, providing binding sites for myosin during contraction.

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    C Protein

    The protein that links myosin to actin in muscle fibers, playing a crucial role in muscle contraction.

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    A Band

    The region of the sarcomere that contains only thick filaments (myosin), appearing as a dark band under a microscope.

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    I Band

    The region of the sarcomere that contains only thin filaments (actin), appearing as a light band under a microscope.

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    H Zone

    The region of the sarcomere that contains only thick filaments (myosin) with no overlap of thin filaments.

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    Z Line

    The protein that anchors thin filaments (actin) at the ends of sarcomeres, defining the boundaries of each sarcomere.

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    Intercalated discs

    The specialized junctions between cardiac muscle cells, allowing for rapid and efficient transmission of electrical signals for synchronized contraction.

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    SA Node

    A specialized region of cardiac muscle that initiates electrical impulses, acting as the 'pacemaker' of the heart.

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    Purkinje fibres

    A group of specialized cardiac muscle fibers that conduct electrical impulses rapidly throughout the heart, ensuring coordinated contraction.

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    AV Node

    A node in the heart that delays the electrical signal, allowing the atria to contract before the ventricles.

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    Cardiocytes

    Cardiac muscle cells, responsible for the heart's contraction, contain myofibrils, striations, and are connected by intercalated discs.

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    What is the structure of thick filaments?

    Thick filaments are composed of two symmetrical halves, each a mirror image of the other. The main constituent is myosin, a protein with a molecular weight of 480,000. It has two ends: a globular end with two heads, and a rod-like tail. Each myosin molecule consists of six peptide chains: two identical heavy chains and four light chains.

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    What are the binding sites on a myosin molecule?

    Myosin molecules possess two binding sites: one for actin and the other for ATP. The actin binding site facilitates interaction with thin filaments, while the ATPase site is crucial for hydrolysing ATP, providing energy for muscle contraction.

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    What is the distinguishing feature of skeletal muscle?

    Skeletal muscle is characterized by its striated appearance. It exhibits alternating light and dark bands due to the organized arrangement of actin and myosin filaments.

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    How do skeletal muscles attach to bones?

    Tendons are cord-like structures primarily composed of collagen fibers that attach muscles to bones. They allow for strong and durable connections across joints. Aponeuroses are sheet-like structures that also attach muscles, but indirectly to bones, cartilages, or other connective tissue coverings.

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    How does cardiac muscle differ from skeletal muscle?

    Cardiac muscle is characterized by strong, continuous contractions that are involuntary and rhythmic. Its fibers are branched, have striations, and exhibit centrally located nuclei.

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    Study Notes

    Muscle Tissue Structure

    •  Muscle tissue is a type of excitable tissue.
    •  Muscle tissue makes up a large portion of the body, approximately 50%.
    •  Muscle tissue has three main types: skeletal, cardiac, and smooth.
    •  Skeletal muscle is responsible for movement of the body and manipulation of objects.
    •  Cardiac muscle powers the heart's pumping action.
    •  Smooth muscle moves substances through hollow internal organs.

    Four Tissue Types

    •  Epithelial tissue lines and protects surfaces, including skin and mucous membranes.
    •  Muscle tissue is responsible for movement. Types include skeletal, smooth, and cardiac muscles.
    •  Nervous tissue is involved in communication and control, comprising the brain and spinal cord.
    •  Connective tissue supports other tissues, including loose connective tissue (e.g., ligaments, tendons) and dense connective tissue (e.g., bone, cartilage, and blood).

    Muscle Structure

    •  Skeletal muscle cells are also called muscle fibers. They're long and cylindrical, and contain multiple nuclei.
    •  Muscle fibers are made up of myofibrils.
    •  Myofibrils are composed of myofilaments.  
    •  Myofilaments, primarily actin and myosin, are responsible for muscle contraction.
    •  Muscle cells are organized into fascicles, then bundles of fascicles form a muscle. 
    •  Tendons connect muscles to bones while aponeuroses attach to bones, cartilages, or other connective tissues.
    •  Structure includes sarcolemma (outer membrane), sarcoplasm (cytoplasm), and sarcoplasmic reticulum (specialized smooth ER important for calcium ion storage).

    Skeletal Muscle Cells

    •  A motor unit is comprised of a single motor neuron that innervates the entire muscle fiber.
    •  Myoneural junction is the synapse between the motor neuron and muscle fiber.
    •  Acetylcholine is the neurotransmitter released at the myoneural junction for muscle contraction.
    •  Motor end plate is the specialized area of the sarcolemma under the axon terminal.
    •  The innervation ratio varies depending on the muscle, from 1:100 to 1:2000.

    Basic Units of Muscle Organisation

    •  Sarcolemma is the plasma membrane, which has a well-developed basement membrane outside.
    •  Sarcoplasm is the cytoplasm excluding the myofibrils.
    •  Sarcoplasmic Reticulum is the smooth endoplasmic reticulum found within the muscle cell.
    •  Epimysium is a thick connective tissue layer surrounding a bundle of fascicles. 
    •  Perimysium is the connective tissue wrapping each fascicle.
    •  Endomysium is a thin connective tissue layer encasing individual muscle fibers.
    •  Fascicle is a bundle of muscle cells encased by perimysium.
    •  Skeletal muscles are connected to bones via tendons.

    Skeletal Muscle - Myofibrils

    •  Myofibrils are made up of sarcomeres, repeating units arranged end-to-end.
    •  Each sarcomere gives the skeletal muscle its striated appearance.
    •  Sarcomeres contain myofilaments. 
    •  Myofilaments are actin and myosin filaments, which interact for contraction.

    Myofilament Components

    •  Components include Z-discs, A band, I band, H zone, and M line.
    •  Z-discs are dense membranes separating sarcomeres.
    •  A band contains thick myosin filaments (sometimes overlapped by thin actin).
    •  I band contains thin actin filaments.
    •  H zone is the center part of A band, mainly containing thick filaments.
    •  M line supports the thick filaments in the center of sarcomere.
    •  Myofilaments include thick myosin and thin actin filaments.

    Myofilaments (Actin and Myosin)

    •  Actin is a thin filament protein that plays a key role in muscle contraction.
    •  Thin filaments consist of 3 proteins: actin, tropomyosin, and troponin.
    •  Myosin is a thick filament protein that binds to actin during contraction.
    •  Muscle contraction involves binding myosin to actin with the use of ATP, leading to shortening of the sarcomeres.

    Regulatory Proteins

    •  Regulatory proteins include Tropomyosin and Troponin.
    •  Troponin is a complex of 3 proteins: TnC (Ca2+ binding), TnI (inhibitory), and TnT (tropomyosin binding).
    •  Under resting conditions, tropomyosin covers the myosin-binding sites on actin, preventing contraction. Calcium ion release causes tropomyosin to move, allowing myosin to bind to actin.
    •  Tropomyosin binds to actin and prevents the binding of myosin to actin.

    Thin Filaments

    •  Thin filaments have a length of about 1 µm and a diameter of 5-8 nm.
    •  Nebulin and Titin are elasticity-related proteins within thin filaments and are important during contraction. 

    Thick Filaments

    •  Thick filaments are made up of myosin protein molecules. Myosin has a head and a tail region.
    •  The heads bind to actin molecules to initiate cross-bridge formation during muscle contraction.

    Cardiac Muscle

    •  Structure includes intercalated discs which are specific for cardiac muscle.
    •  Cardiac muscle cells are also called cardiocytes. 
    •  Cardiocytes are branched muscle cells and are connected via gap junctions.
    •  Cardiac muscle is under involuntary control and responsible for the rhythmic contractions of the heart.

    Smooth Muscle

    •  Smooth muscle cells are spindle-shaped with a single nucleus.
    •  Smooth muscle cells are typically located in walls of hollow organs, such as blood vessels, intestines, and the digestive system.
    •  Smooth muscle is under involuntary control.
    •  Smooth muscle contraction is often slow and sustained. - Smooth muscles exist in two main types, multi-unit and single-unit. They differ in their innervation(how they receive signaling) and their response to stimuli.

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