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Questions and Answers
What is the primary function of skeletal muscles in the body?
What is the primary function of skeletal muscles in the body?
Which of the following is NOT a defining characteristic of skeletal muscle fibers?
Which of the following is NOT a defining characteristic of skeletal muscle fibers?
What is the process by which smaller cells fuse together to form long skeletal muscle fibers?
What is the process by which smaller cells fuse together to form long skeletal muscle fibers?
What is the fundamental unit of contraction in a skeletal muscle fiber?
What is the fundamental unit of contraction in a skeletal muscle fiber?
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Which protein is primarily responsible for forming the thin filaments in a sarcomere?
Which protein is primarily responsible for forming the thin filaments in a sarcomere?
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What is the role of the Z lines in a sarcomere?
What is the role of the Z lines in a sarcomere?
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How does the myosin pull the Z lines together during muscle contraction?
How does the myosin pull the Z lines together during muscle contraction?
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Imagine you are observing a muscle fiber under a microscope. What would you expect to see if the muscle is contracted?
Imagine you are observing a muscle fiber under a microscope. What would you expect to see if the muscle is contracted?
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What is the primary function of the T tubules in muscle fiber contraction?
What is the primary function of the T tubules in muscle fiber contraction?
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What is the role of the sarcoplasmic reticulum (SR) in muscle contraction?
What is the role of the sarcoplasmic reticulum (SR) in muscle contraction?
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What is the role of troponin in muscle contraction?
What is the role of troponin in muscle contraction?
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How does the muscle fiber relax after contraction?
How does the muscle fiber relax after contraction?
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What is the function of the calcium pumps in the sarcoplasmic reticulum?
What is the function of the calcium pumps in the sarcoplasmic reticulum?
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Which of the following events occurs immediately after the arrival of the action potential at the T tubules?
Which of the following events occurs immediately after the arrival of the action potential at the T tubules?
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What is the relationship between the size of a motor unit and the type of muscle fiber it controls?
What is the relationship between the size of a motor unit and the type of muscle fiber it controls?
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How does the nervous system regulate the strength of muscle contraction in a single fiber?
How does the nervous system regulate the strength of muscle contraction in a single fiber?
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What is the role of ATP in muscle relaxation?
What is the role of ATP in muscle relaxation?
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How does the action potential spread throughout a muscle fiber?
How does the action potential spread throughout a muscle fiber?
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Which of the following is NOT a factor involved in motor unit recruitment?
Which of the following is NOT a factor involved in motor unit recruitment?
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What is the term for the process of activating more and more motor neurons to increase the force of muscle contraction?
What is the term for the process of activating more and more motor neurons to increase the force of muscle contraction?
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What is the difference between a twitch and a tetanus in muscle contraction?
What is the difference between a twitch and a tetanus in muscle contraction?
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Which of the following statements accurately describes the role of Ca2+ in muscle contraction?
Which of the following statements accurately describes the role of Ca2+ in muscle contraction?
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Which of the following types of muscle fibers would be most abundant in muscles responsible for fine motor control?
Which of the following types of muscle fibers would be most abundant in muscles responsible for fine motor control?
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Which of the following is an example of a situation where motor unit recruitment would be necessary?
Which of the following is an example of a situation where motor unit recruitment would be necessary?
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What causes tetanus in a muscle fiber?
What causes tetanus in a muscle fiber?
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How does the immediate energy system in muscle contribute to contraction?
How does the immediate energy system in muscle contribute to contraction?
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Which of the following correctly describes the relationship between Ca2+ concentration and muscle tension?
Which of the following correctly describes the relationship between Ca2+ concentration and muscle tension?
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What is the role of the T-tubules in muscle contraction?
What is the role of the T-tubules in muscle contraction?
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Which of the following correctly describes the role of ATP in muscle contraction?
Which of the following correctly describes the role of ATP in muscle contraction?
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What is the primary energy system used during strenuous exercise when oxygen delivery is limited?
What is the primary energy system used during strenuous exercise when oxygen delivery is limited?
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What is the main by-product produced by the glycolytic system?
What is the main by-product produced by the glycolytic system?
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Which of the following statements is TRUE about the oxidative system?
Which of the following statements is TRUE about the oxidative system?
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How does the creatine phosphate system contribute to muscle contraction?
How does the creatine phosphate system contribute to muscle contraction?
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What is the primary reason for muscle fatigue during intense exercise?
What is the primary reason for muscle fatigue during intense exercise?
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How do skeletal muscles generate movement?
How do skeletal muscles generate movement?
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How do gap junctions contribute to the coordinated contraction of cardiac muscle tissue?
How do gap junctions contribute to the coordinated contraction of cardiac muscle tissue?
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Which of the following statements accurately describes the structure and function of smooth muscle?
Which of the following statements accurately describes the structure and function of smooth muscle?
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How does the structure of smooth muscle cells differ from skeletal muscle cells?
How does the structure of smooth muscle cells differ from skeletal muscle cells?
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Which of the statements is TRUE regarding the process of muscle contraction in skeletal muscle?
Which of the statements is TRUE regarding the process of muscle contraction in skeletal muscle?
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Flashcards
Skeletal Muscle
Skeletal Muscle
Type of muscle under voluntary control for movement.
Muscle Fiber
Muscle Fiber
A long, cylindrical cell of skeletal muscle that contains multiple nuclei.
Myofibrils
Myofibrils
Bundles of contractile proteins within muscle fibers, organized into sarcomeres.
Sarcomeres
Sarcomeres
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Actin Filaments
Actin Filaments
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Myosin Filaments
Myosin Filaments
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Z Lines
Z Lines
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Muscle Contraction Process
Muscle Contraction Process
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Summation of Twitches
Summation of Twitches
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Ca2+ Pump Limitations
Ca2+ Pump Limitations
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Tetanus
Tetanus
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Calcium Release Dynamics
Calcium Release Dynamics
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Immediate ATP System
Immediate ATP System
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Muscle Fiber Structure
Muscle Fiber Structure
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Action Potential Spread
Action Potential Spread
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Transverse Tubules (T-tubules)
Transverse Tubules (T-tubules)
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Sarcoplasmic Reticulum (SR)
Sarcoplasmic Reticulum (SR)
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Calcium Release
Calcium Release
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Troponin Binding
Troponin Binding
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Calcium Pump
Calcium Pump
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Muscle Relaxation
Muscle Relaxation
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Motor Unit
Motor Unit
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Muscle Fiber Control
Muscle Fiber Control
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Motor Unit Recruitment
Motor Unit Recruitment
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Large Motor Units
Large Motor Units
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Small Motor Units
Small Motor Units
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Twitch Response
Twitch Response
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Temporal Summation
Temporal Summation
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Calcium's Role
Calcium's Role
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Glycolytic System
Glycolytic System
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Oxidative System
Oxidative System
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Anaerobic Process
Anaerobic Process
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Aerobic Process
Aerobic Process
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Muscle Contraction
Muscle Contraction
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Endurance Training Effect
Endurance Training Effect
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Skeletal System Function
Skeletal System Function
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Cardiac Muscle
Cardiac Muscle
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Intercalated Discs
Intercalated Discs
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Smooth Muscle Characteristics
Smooth Muscle Characteristics
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Study Notes
Lecture 5: Muscular System, Part 1
- Skeletal muscle is responsible for voluntary movement like walking and breathing.
- Most skeletal muscles are attached to bones via tendons.
- Cardiac muscle is responsible for the beating of the heart.
- Smooth muscle regulates involuntary functions like blood flow and digestive tract movement.
- Skeletal muscle fibers are very large and long, typically up to 30 cm long and 0.1 mm in diameter.
- Each skeletal muscle fiber has multiple nuclei.
- These large cells develop through the fusion of smaller cells.
- Myoblasts fuse to create skeletal muscle fibers.
- Skeletal muscles generate force and movement by shortening.
- Muscles are grouped, bundles of fibers create force, and tendons attach to the bone
- To understand how a muscle generates force, one needs to look at the cellular and molecular structure of muscles.
- A skeletal muscle is made up of bundles of long fibers (cells) which run along the length of the muscle.
- Each muscle fiber is a bundle of smaller myofibrils
- Myofibrils are bundles of organized contractile protein molecules called sarcomeres, these generate force.
Molecular Basis of Muscle Contraction
- Muscle fiber contraction depends on interactions between thin filaments (mostly actin) and thick filaments (mostly myosin).
- Thin filaments are anchored to the Z lines.
- Thick filaments pull on the thin filaments to shorten the distance between Z lines.
- Myosin's globular heads bind to actin, forming cross-bridges and pulling the thin filament towards the center of the sarcomere.
- Muscle contraction involves repeated cycles of myosin binding and releases.
- The myosin head has a tail region and a globular head region
- The myosin heads attach to actin, energy (ATP) is required and the thin filament moves towards the center of the sarcomere.
How the Myosin Pulls the Z lines Together, The Sliding Filament Model
- Myosin heads change shape which moves of the thin filament and shortens the sarcomere.
- The thin filament moves toward the center of the sarcomere.
- Millions myosin molecules in each muscle fiber.
- The number of myosin molecules activated determines the strength of the contraction.
How do we regulate Muscle Contraction?
- Tropomyosin blocks the myosin-binding sites on actin.
- Troponin, a regulatory protein, is controlled by Ca2+ ions.
- When a calcium ion binds to troponin, the troponin-tropomyosin complex moves, exposing the myosin-binding site to allow contractions.
- A low concentration of Ca2+ means only some troponin to generate a weak contraction. High concentrations generates a strong contractile force
Where does the Ca++ Come From? The Neuromuscular Junction
- Muscles are controlled by the nervous system.
- Muscles and nerves meet at the neuromuscular junction. This is a specialized type of synapse.
- Muscles receive the nerve action potentials to begin contraction.
- The sarcoplasmic reticulum (SR) stores Ca2+.
- The arrival of an action potential in the T tubules triggers Ca2+ release from the SR into the cytoplasm.
- Calcium binds to troponin.
- When Ca2+ is removed from the cytoplasm by active transport back into the sarcoplasmic reticulum, the contraction ends.
Powering Muscle Contraction
- Muscles use three systems to obtain ATP for power
- Immediate system: using creatine phosphate to rapidly generate ATP
- Glycolytic system: metabolizes carbohydrates to produce ATP, but also produces lactic acid.
- Oxidative system: metabolizes carbohydrates and fatty acids to generate large amounts of ATP
- The efficiency of these systems varies depending on duration and intensity of the activities.
Types of Skeletal Muscle Fibers
- The body has slow and fast twitch muscle fibers.
- Slow oxidative fibers are adapted for endurance.
- Fast oxidative fibers are adapted for both speed and endurance.
- Fast glycolytic fibers are adapted for fast, powerful contractions.
Fast-Twitch and Slow-Twitch Fibers
- Fast-twitch fibers enable brief, rapid, powerful contractions.
- Slow-twitch fibers contract more slowly but can sustain longer contractions.
- All slow-twitch fibers are oxidative
- relative fiber types vary considerably from muscle to muscle and person to person.
- a typical person has about 45% fast twitch and 55% slow twitch fibers
- endurance athletes show a higher level of slow twitch fibers, compared to sprint athletes..
Skeletal Systems Transform Muscle Contraction Into Locomotion
- The skeleton provides a rigid structure for muscles to attach.
- Skeletal muscles are arranged in antagonistic pairs, so that one muscle contracts while the other relaxes (e.g. biceps and triceps).
Cardiac Muscle
- Cardiac muscle is unique to the heart.
- Striated cells connected via intercalated discs that electrically interact
- Cardiac muscle cells can generate action potentials without neural input
Smooth Muscle
- Smooth muscle is structurally simple with cells branching and interdigitiating, capable of considerable pressure.
- Found in organs like digestive track, respiratory system, and circulatory system
- Contractions are relatively slow and can be initiated by the muscles itself, or by the autonomic nervous system.
- Smooth muscle lacks striations because the actin and myosin are not regularly arrayed
- Calcium ions enter the cytosol through the plasma membrane to initiate contraction, as opposed to skeletal muscles which have a sarcoplasmic reticulum
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Description
Test your knowledge on skeletal muscle anatomy and physiology with this quiz. Explore key concepts such as muscle fiber structure, contraction mechanisms, and the roles of crucial proteins and organelles. Perfect for students in anatomy or physiology courses.