Multiple Myeloma Diagnosis Criteria Quiz

Diagnosis requires myeloma-defining events (MDE) and specific biomarkers.

Specific events showing the presence of the disease. Include organ damage (CRAB features) and/or specific biomarkers.

Signs of organ damage attributed to myeloma: Hypercalcemia, Renal failure, Anemia, and Lytic bone lesions

High blood calcium levels caused by the disease (typically >0.25 mmol/L, or >1mg/dL).

Kidney dysfunction caused by the disease (typically creatinine clearance < 177 µmol/L, or 2 mg/dL).

Low red blood cell count caused by the disease.

Bone damage creating holes or weakening spots in the bone structure caused by the disease.

Specific measurable indicators in the body of the presence of the disease.

10% or more clonal plasma cells in bone marrow, or biopsy-proven plasmacytoma (tumors in bone or outside bone marrow).

Proportion of different types of light chains. Ratio ≥100, involved FLC level ≥100 mg/L, and 24-hour urinary monoclonal protein excretion >2200 mg, indicates a certain degree of the disease.

More than one lesion found on a magnetic resonance imaging (MRI) scan.