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Questions and Answers
What is the primary characteristic of multiple endocrine neoplasias (MEN)?
What is the primary characteristic of multiple endocrine neoplasias (MEN)?
- Autosomal recessive inheritance
- Increased risk of Hirschsprung's disease
- Increased risk of pheochromocytoma
- Hyperplasia and formation of adenomas or malignant tumours in multiple glands (correct)
Which gene is associated with MEN 1?
Which gene is associated with MEN 1?
- RET proto-oncogene
- von Hippel–Lindau
- CDNK1B
- MEN1 (MENIN) (correct)
What type of mutations in the RET proto-oncogene cause MEN 2a and 2b?
What type of mutations in the RET proto-oncogene cause MEN 2a and 2b?
- Loss-of-function mutations
- Frameshift mutations
- Nonsense mutations
- Gain-of-function mutations (correct)
Which genetic disease is associated with an increased risk of pheochromocytoma?
Which genetic disease is associated with an increased risk of pheochromocytoma?
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Which gene is associated with MEN 4?
Which gene is associated with MEN 4?
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What is the purpose of predictive genetic testing for individuals with MEN syndromes?
What is the purpose of predictive genetic testing for individuals with MEN syndromes?
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