Mucolytic Agents and Respiratory Conditions
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Questions and Answers

How do mucolytic agents alter mucus in the respiratory tract?

  • By increasing mucus viscoelasticity
  • By promoting exacerbation of COPD
  • By decreasing sputum volume
  • By cleaving disulfide linkages within high molecular weight mucin glycoproteins (correct)
  • What is the primary role of mucolytics in the respiratory tract?

  • Enhance airway clearance (correct)
  • Promote mucus overproduction
  • Increase airway resistance
  • Reduce productive cough
  • Which mucolytic agent improves mucociliary clearance by reducing sputum viscoelasticity?

  • Erdosteine (correct)
  • Serratiopeptidase
  • Mannitol
  • Potassium iodide
  • How do classical mucolytic agents like N-acetylcysteine work?

    <p>By reducing disulfide linkages in mucus glycoproteins</p> Signup and view all the answers

    What is the effect of N-acetylcysteine on exacerbations and hospitalizations in chronic bronchitis patients?

    <p>It reduces exacerbations and hospitalizations</p> Signup and view all the answers

    Which mucolytic agent has antioxidant and anti-inflammatory properties?

    <p>Erdosteine</p> Signup and view all the answers

    What is the role of DNase in mucous plugs?

    <p>Hydrolyzing DNA, increasing sputum volume, and improving cough frequency and viscosity</p> Signup and view all the answers

    Why has the use of DNase been associated with increased respiratory infections?

    <p>As a side effect of its impact on mucus rheology</p> Signup and view all the answers

    Which mucolytic agent is known for reducing cough frequency, severity, sputum volume, and stickiness?

    <p>Carbocisteine</p> Signup and view all the answers

    What effect has Acetylcysteine been shown to have in COPD patients?

    <p>Reducing COPD exacerbations, improving lung function, and increasing survival</p> Signup and view all the answers

    What is the impact of Solmuclitabine on COPD patients compared to placebo?

    <p>Increasing time to exacerbation and FEV1 levels</p> Signup and view all the answers

    Why is further research needed on mucolytics according to the text?

    <p>To understand the potential side effects of mucolytics</p> Signup and view all the answers

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