Dornase Alfa Overview and Usage

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Questions and Answers

What is the generic name for Dornase?

  • Mucolytic
  • Action
  • Pulmozyme
  • Donase Alfa (correct)

What is the trade name for Dornase?

  • Pulmozyme (correct)
  • Mucolytic
  • Donase Alfa
  • Action

What classification does Dornase belong to?

Mucolytic

What is the action of Dornase?

<p>Enzyme action which digests DNA in infected sputum.</p> Signup and view all the answers

What is the dose of Dornase?

<p>Ampule containing 2.5 mg in 2.5 ml of clear colorless solution.</p> Signup and view all the answers

The solution of Dornase should be stored at room temperature.

<p>False (B)</p> Signup and view all the answers

Dornase should not be mixed with other medications.

<p>True (A)</p> Signup and view all the answers

What are the approved nebulizers for Dornase?

<p>PARI LC (reusable) with PARI PRO NEB compressor.</p> Signup and view all the answers

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Study Notes

Dornase Alfa Overview

  • Generic Name: Dornase Alfa is the generic name for the medication used in cystic fibrosis treatment.
  • Trade Name: The trade name for Dornase Alfa is Pulmozyme.

Classification and Action

  • Classification: Dornase Alfa falls under the mucolytic category, which refers to drugs that thin mucus.
  • Mechanism of Action: The enzyme works by digesting DNA in the infected sputum, helping to alleviate respiratory issues associated with cystic fibrosis.

Dosage and Administration

  • Dose Information: Administered via an ampule containing 2.5 mg in 2.5 ml of a clear, colorless solution (Qd - once daily).

Storage Requirements

  • Storage Guidelines: The solution must be refrigerated and should be protected from light to maintain efficacy. Any medication left at room temperature or displaying discoloration should be discarded.

Precautions

  • Medication Mixing: Dornase Alfa should not be mixed with other medications to avoid interactions.

Equipment

  • Approved Nebulizers: Recommended for use with PARI LC (reusable) nebulizers when paired with the PARI PRO NEB compressor.

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