Preformulation - Dissolution

<p>Solubility (D)</p> Signup and view all the answers

<p>Different materials have distinct melting points based on their bond strengths. (A)</p> Signup and view all the answers

<p>They must dissolve in the gastrointestinal fluid. (C)</p> Signup and view all the answers

<p>Deaggregation of solid drug particles. (B)</p> Signup and view all the answers

<p>Energy in the form of heat of fusion. (D)</p> Signup and view all the answers

<p>It begins the absorption process. (B)</p> Signup and view all the answers

<p>A combination of the solid with a solvent. (C)</p> Signup and view all the answers

<p>Transfer of dissolved drugs into systemic circulation. (C)</p> Signup and view all the answers

<p>Disintegration, deaggregation, dissolution. (C)</p> Signup and view all the answers

<p>Heat energy to break down molecular bonds. (A)</p> Signup and view all the answers

<p>Interaction between solute and solvent (A)</p> Signup and view all the answers

<p>It describes the rate of drug dissolution based on diffusion. (B)</p> Signup and view all the answers

<p>Diffusion properties of the solute (C)</p> Signup and view all the answers

<p>Ambient light conditions (D)</p> Signup and view all the answers

<p>-2UsL &lt; Uss + ULL (C)</p> Signup and view all the answers

<p>Diffusion coefficient (A)</p> Signup and view all the answers

<p>It determines the concentration difference in the solution. (C)</p> Signup and view all the answers

<p>A discrete structure formed when solvent surrounds solute molecules. (D)</p> Signup and view all the answers

<p>They enhance the rate of dissolution. (B)</p> Signup and view all the answers

<p>Heat is released when the solute and solvent interact. (A)</p> Signup and view all the answers

<p>They become part of the bulk solution. (D)</p> Signup and view all the answers

<p>The crystalline form of the drug (C)</p> Signup and view all the answers

<p>CB (B)</p> Signup and view all the answers

<p>It improves the rate at which the drug dissolves. (A)</p> Signup and view all the answers

The process of a solid drug substance dissolving in a solvent.

The amount of a solid substance that dissolves in a specific amount of solvent at a given temperature.

The temperature at which a solid changes into a liquid.

The amount of heat absorbed or released when a substance changes its state (solid to liquid or vice versa).

A measure of the strength of the bonds holding a crystal lattice together. Weaker bonds melt at lower temperatures.

The process of a solid drug breaking down into smaller particles in a liquid (usually body fluids).

Before a drug can be absorbed into the body, it usually needs to dissolve in fluids like the stomach or intestines.

The process of a solid drug breaking down into smaller particles. It's the first step of dissolution.

The process where clumps of drug particles are broken down into smaller, individual particles.

The study of drug dissolution in laboratory settings.

The study of drug dissolution in a living organism.

A law in chemistry that explains how the heat required for dissolving a solid in a liquid relates to the heat of fusion of the solid.

Breaking bonds between solute molecules and solvent molecules requires energy, making it an endothermic process.

The energy released when new bonds form between solute and solvent molecules, resulting in an exothermic process.

The process of solute molecules being surrounded and stabilized by solvent molecules.

The change in energy when a solute dissolves in a solvent. It accounts for both bond breaking and formation.

The maximum concentration of a dissolved substance in a solvent at a given temperature.

The rate at which a solid drug dissolves in a solvent. It describes how fast the drug dissolves.

A model that describes dissolution based on the simple diffusion of solute molecules through a thin layer of solvent.

An equation that describes the dissolution rate based on the simple diffusion model.

The thickness of the layer of solvent surrounding the solid drug.

The ability of a substance (like a drug) to move through a medium (like the diffusion layer).

The surface area of the solid drug exposed to the solvent.

The factors that can influence how fast a drug dissolves. These can be related to the drug itself, the solvent, or the environment.

Substances added to a formulation (like a tablet) that can affect drug dissolution.